ATE548381T1 - Modifizierte erythropoietin (epo)-polypeptide mit erhöhter proteaseresistenz und pharmazeutische zusammensetzungen daraus - Google Patents

Modifizierte erythropoietin (epo)-polypeptide mit erhöhter proteaseresistenz und pharmazeutische zusammensetzungen daraus

Info

Publication number
ATE548381T1
ATE548381T1 AT09765524T AT09765524T ATE548381T1 AT E548381 T1 ATE548381 T1 AT E548381T1 AT 09765524 T AT09765524 T AT 09765524T AT 09765524 T AT09765524 T AT 09765524T AT E548381 T1 ATE548381 T1 AT E548381T1
Authority
AT
Austria
Prior art keywords
polypeptides
epo
pharmaceutical compositions
protease resistance
modified
Prior art date
Application number
AT09765524T
Other languages
English (en)
Inventor
Thierry Guyon
Gilles Borrelly
Xavier Gallet
Lila Drittanti
Manuel Vega
Original Assignee
Hanall Biopharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanall Biopharma Co Ltd filed Critical Hanall Biopharma Co Ltd
Application granted granted Critical
Publication of ATE548381T1 publication Critical patent/ATE548381T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT09765524T 2008-05-29 2009-05-29 Modifizierte erythropoietin (epo)-polypeptide mit erhöhter proteaseresistenz und pharmazeutische zusammensetzungen daraus ATE548381T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13037608P 2008-05-29 2008-05-29
PCT/EP2009/003862 WO2009152944A1 (en) 2008-05-29 2009-05-29 Modified erythropoietin (epo)polypeptides that exhibit increased protease resistance and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ATE548381T1 true ATE548381T1 (de) 2012-03-15

Family

ID=40943614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09765524T ATE548381T1 (de) 2008-05-29 2009-05-29 Modifizierte erythropoietin (epo)-polypeptide mit erhöhter proteaseresistenz und pharmazeutische zusammensetzungen daraus

Country Status (7)

Country Link
US (1) US20120264686A9 (de)
EP (1) EP2297197B1 (de)
JP (1) JP2011520472A (de)
KR (1) KR101275950B1 (de)
CN (1) CN102186879A (de)
AT (1) ATE548381T1 (de)
WO (1) WO2009152944A1 (de)

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ATE466085T1 (de) 2002-09-09 2010-05-15 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
JP2010510794A (ja) 2006-11-28 2010-04-08 ハナル ファーマシューティカル カンパニー リミテッド 修飾型エリスロポエチンポリペプチド及びこの治療用用途
DK2501716T3 (en) * 2009-11-19 2015-04-07 Solis Biodyne Oü Formations to increase polypeptidstabilitet and activity and related practices
US8822663B2 (en) 2010-08-06 2014-09-02 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
RS63430B1 (sr) 2010-10-01 2022-08-31 Modernatx Inc Ribonukleinske kiseline koje sadrže n1-metil-pseudouracile i njihove primene
AU2012251919B2 (en) 2011-01-19 2016-12-15 Ferrumax Pharmaceuticals, Inc. Compositions for regulating iron homeostasis and methods of using same
EP2691101A2 (de) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DK3682905T3 (da) 2011-10-03 2022-02-28 Modernatx Inc Modificerede nukleosider, nukleotider og nukleinsyrer og anvendelser deraf
DE12858350T1 (de) 2011-12-16 2021-10-07 Modernatx, Inc. Modifizierte mrna zusammensetzungen
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
HK1206601A1 (en) 2012-04-02 2016-01-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of biologics and proteins associated with human disease
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
HRP20220607T1 (hr) 2012-11-26 2022-06-24 Modernatx, Inc. Terminalno modificirana rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
WO2015051214A1 (en) 2013-10-03 2015-04-09 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP3194429A4 (de) * 2014-09-18 2018-06-13 Askgene Pharma, Inc. Neuartige feline erythropoietinrezeptor-agonisten
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR101947342B1 (ko) * 2017-05-05 2019-02-12 주식회사 유비프로틴 Gm-csf 반감기를 증가시키는 방법
CN107898812A (zh) * 2017-12-06 2018-04-13 广州瑞铂茵健康管理咨询有限公司 一种基于脐带干细胞及活性成分的软骨损伤混合修复液
CN110093336B (zh) * 2018-01-29 2023-03-24 上海雅心生物技术有限公司 一种稳定的胰蛋白酶及其制备方法
US12089930B2 (en) 2018-03-05 2024-09-17 Marquette University Method and apparatus for non-invasive hemoglobin level prediction
CN110241130B (zh) * 2018-03-09 2023-04-14 中国科学院分子植物科学卓越创新中心 控制植物粒数和粒重的gsn1基因、编码蛋白及其应用
AR113091A1 (es) * 2018-09-27 2020-01-22 Univ Nacional Del Litoral Eritropoyetina humana modificada
US20230151071A1 (en) * 2020-04-09 2023-05-18 United States Government As Represented By The Department Of Veterans Affairs Compositions comprising recombinant epo and methods of use thereof
WO2021222806A1 (en) * 2020-05-01 2021-11-04 Icahn School Of Medicine At Mount Sinai Compositions and methods for preventing, detecting, and treating inflammatory bowel disease
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JP2023550742A (ja) * 2020-11-18 2023-12-05 チュラポーン ファンデーション エリスロポエチンバリアント及びその使用
WO2022159414A1 (en) 2021-01-22 2022-07-28 University Of Rochester Erythropoietin for gastroinfestinal dysfunction
CN117069825A (zh) * 2022-05-17 2023-11-17 广州汉腾生物科技有限公司 重组促红细胞生成素及其应用

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ATE466085T1 (de) 2002-09-09 2010-05-15 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US20050202438A1 (en) 2002-09-09 2005-09-15 Rene Gantier Rational directed protein evolution using two-dimensional rational mutagenesis scanning
EP1539950A1 (de) 2002-09-09 2005-06-15 Nautilus Biotech Rationelle gerichtete eiweiss evolution durch zweidimensionale rationelle mutagenese-abtastung
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US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides

Also Published As

Publication number Publication date
KR101275950B1 (ko) 2013-06-25
EP2297197B1 (de) 2012-03-07
JP2011520472A (ja) 2011-07-21
WO2009152944A1 (en) 2009-12-23
EP2297197A1 (de) 2011-03-23
KR20110022638A (ko) 2011-03-07
CN102186879A (zh) 2011-09-14
US20120094906A1 (en) 2012-04-19
US20120264686A9 (en) 2012-10-18

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