CY1117583T1 - Στερεες μορφες περιλαμβανοντας ν-(5-τριτοταγες-βουτυλ-ισοξαζολ-3-υλ)-ν΄-{4-[7-(2-μορφολιν-4-υλ-αιθοξυ)ιμιδαζο[2,1-β][1,3]βενζοθειαζολ-2-υλ]φαινυλ}ουρια,συνθεσεις εξ΄ αυτης, και χρησεις μετ΄ αυτης - Google Patents

Στερεες μορφες περιλαμβανοντας ν-(5-τριτοταγες-βουτυλ-ισοξαζολ-3-υλ)-ν΄-{4-[7-(2-μορφολιν-4-υλ-αιθοξυ)ιμιδαζο[2,1-β][1,3]βενζοθειαζολ-2-υλ]φαινυλ}ουρια,συνθεσεις εξ΄ αυτης, και χρησεις μετ΄ αυτης

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Publication number
CY1117583T1
CY1117583T1 CY20161100450T CY161100450T CY1117583T1 CY 1117583 T1 CY1117583 T1 CY 1117583T1 CY 20161100450 T CY20161100450 T CY 20161100450T CY 161100450 T CY161100450 T CY 161100450T CY 1117583 T1 CY1117583 T1 CY 1117583T1
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Cyprus
Prior art keywords
solid forms
isoxazol
morpholin
imidazo
ethoxy
Prior art date
Application number
CY20161100450T
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English (en)
Inventor
Shripad Bhagwat
Wei Lai
Stephan D Parent
Melanie J Roe
Alan Schwartz
Valeriya N Smolenskaya
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Ambit Biosciences Corporation
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Publication date
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Publication of CY1117583T1 publication Critical patent/CY1117583T1/el

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Στερεές μορφές περιλαμβάνοντας Ν-(5-τριτοταγές-βουτυλ-ισοξαζολ-3-υλ)-Ν'-{4-[7-(2-μορφολιν-4-υλ-αιθοξυ)ιμιδαζο[2,1-b][1,3]βενζοθειαζολ-2-υλ]φαινυλ}ουρία, συνθέσεις περιλαμβάνοντας τις στερεές μορφές, μέθοδοι παρασκευής των στερεών μορφών και μέθοδοι της χρήσης αυτών για την αγωγή διαφόρων παθήσεων και/ή διαταραχών αποκαλύπτονται.
CY20161100450T 2007-09-19 2016-05-24 Στερεες μορφες περιλαμβανοντας ν-(5-τριτοταγες-βουτυλ-ισοξαζολ-3-υλ)-ν΄-{4-[7-(2-μορφολιν-4-υλ-αιθοξυ)ιμιδαζο[2,1-β][1,3]βενζοθειαζολ-2-υλ]φαινυλ}ουρια,συνθεσεις εξ΄ αυτης, και χρησεις μετ΄ αυτης CY1117583T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99463507P 2007-09-19 2007-09-19
EP08832577.4A EP2201018B1 (en) 2007-09-19 2008-09-19 Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-ý7-(2-morpholin-4-yl-ethoxy)imidazoý2,1-b¨ý1,3¨benzothiazol-2-yl¨phenyl}urea, compositions thereof, and uses therewith

Publications (1)

Publication Number Publication Date
CY1117583T1 true CY1117583T1 (el) 2017-04-26

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Family Applications (1)

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CY20161100450T CY1117583T1 (el) 2007-09-19 2016-05-24 Στερεες μορφες περιλαμβανοντας ν-(5-τριτοταγες-βουτυλ-ισοξαζολ-3-υλ)-ν΄-{4-[7-(2-μορφολιν-4-υλ-αιθοξυ)ιμιδαζο[2,1-β][1,3]βενζοθειαζολ-2-υλ]φαινυλ}ουρια,συνθεσεις εξ΄ αυτης, και χρησεις μετ΄ αυτης

Country Status (20)

Country Link
US (2) US8883783B2 (el)
EP (1) EP2201018B1 (el)
JP (1) JP5462168B2 (el)
KR (2) KR20150104231A (el)
CN (1) CN101868465B (el)
AR (1) AR068528A1 (el)
AU (1) AU2008302744B2 (el)
BR (1) BRPI0816904B8 (el)
CA (1) CA2696776C (el)
CY (1) CY1117583T1 (el)
DK (1) DK2201018T3 (el)
ES (1) ES2573292T3 (el)
HR (1) HRP20160520T1 (el)
HU (1) HUE027982T2 (el)
IL (1) IL203926A (el)
MX (1) MX2010002295A (el)
PL (1) PL2201018T3 (el)
SI (1) SI2201018T1 (el)
TW (1) TWI437988B (el)
WO (1) WO2009038757A2 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ571566A (en) * 2006-03-17 2011-07-29 Ambit Biosciences Corp Imidazolothiazole compounds for the treatment of disease
BRPI0816904B8 (pt) 2007-09-19 2021-12-07 Ambit Biosciences Corp Forma cristalna b da forma sólida do sal de bis-hcl, composição farmacêutica, e, uso de uma forma sólida
WO2009061446A1 (en) * 2007-11-08 2009-05-14 Ambit Biosciences Corp. Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease
MX2011009989A (es) 2009-03-23 2011-10-14 Ambit Biosciences Corp Metodos de tratamiento utilizando terapia de combinacion.
CA2761940C (en) 2009-05-14 2018-04-10 Ambit Biosciences Corporation Spray-dried pharmaceutical composition comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidaze[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
WO2011056764A1 (en) 2009-11-05 2011-05-12 Ambit Biosciences Corp. Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles
JP5762426B2 (ja) * 2009-11-05 2015-08-12 アムビト ビオスシエンセス コルポラチオン イミダゾ［２，１−ｂ］［１，３］ベンゾチアゾール誘導体の調製方法
CN103172648B (zh) * 2011-12-20 2016-05-25 上海迪诺医药科技有限公司 三杂环衍生物、制备方法及应用
JP6116847B2 (ja) 2012-10-01 2017-04-19 アムビト バイオサイエンシス コーポレーションＡｍｂｉｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ シクロデキストリンとの混合体を含有する錠剤
CN104513257B (zh) * 2013-09-26 2017-02-15 广东东阳光药业有限公司 取代脲衍生物及其在药物中的应用
CN107427501B (zh) 2015-02-20 2023-12-01 第一三共株式会社 通过联合使用治疗癌症的方法
US11213529B2 (en) * 2017-07-13 2022-01-04 Sunshine Lake Pharma Co., Ltd. Salt of substituted urea derivative and use thereof in medicine
CN110763544A (zh) * 2019-09-20 2020-02-07 南京聚谱检测科技有限公司 一种激光剥蚀样品制靶用快干可精磨粘合剂
CN111413421A (zh) * 2020-02-20 2020-07-14 广东电科院能源技术有限责任公司 污泥燃烧后灰尘中氯离子含量的测试方法、控制方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129432C (el) 1964-02-29
NL129626C (el) 1964-04-08
US3210370A (en) 1964-06-22 1965-10-05 Upjohn Co Process for preparing 2, 2'-methylene-bisareneimiazoles
FR2463774A1 (fr) 1979-08-21 1981-02-27 Yamanouchi Pharma Co Ltd Derives du 2-phenylimidazo(2,1-b)benzothiazole
US4354970A (en) 1980-03-07 1982-10-19 Eastman Kodak Company Indoline coupled isothiazole azo dyes
JPS56138196A (en) 1980-03-29 1981-10-28 Yamanouchi Pharmaceut Co Ltd Imidazo (2,1-b)benzothiazole derivative
JPS5740492A (en) 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
JPS57149288A (en) 1981-03-12 1982-09-14 Yamanouchi Pharmaceut Co Ltd Imidazo(2,1-b)benzothiazole derivative
JPS58109491A (ja) * 1981-12-23 1983-06-29 Yamanouchi Pharmaceut Co Ltd ２−フエニルイミダゾ〃２，１−ｂ「あ」ベンゾチアゾ−ル誘導体
US4464384A (en) * 1981-12-23 1984-08-07 Yamanouchi Pharmaceutical Co., Ltd. 2-Phenylimidazo[2,1-b]benzothiazole compounds, salts thereof, process of producing them, and pharmaceutical compositions containing them
US5236952A (en) 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
US4880824A (en) 1987-09-21 1989-11-14 Ortho Pharmaceutical Corporation Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers
EP0524055A1 (fr) 1991-07-19 1993-01-20 Synthelabo Dérivés d'imidazo[2,1-b]benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique
JPH05107705A (ja) 1991-10-17 1993-04-30 Konica Corp 新規な写真用カプラー
EP0571253B1 (fr) 1992-05-19 1998-11-04 Adir Et Compagnie Dérivés du benzimidazole à activité antidiabétique et antiagrégante plaquettaire
FR2699920B1 (fr) 1992-12-24 1995-02-10 Synthelabo Dérivés d'imidazo [2,1-b] benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique.
FR2700546B1 (fr) 1993-01-15 1995-02-17 Synthelabo Dérivés d'imidazo[2,1-b]benzoxazole-3-acétamide, leur préparation et leur application en thérapeutique.
EP0607076A1 (fr) 1993-01-15 1994-07-20 Synthelabo Dérivés de 9h-imidazo 1,2-a benzimidazole-3-acétamide à activité GABA
JPH07291976A (ja) 1994-04-27 1995-11-07 Otsuka Pharmaceut Factory Inc イミダゾ〔２，１−ｂ〕チアゾール誘導体
FR2722501B1 (fr) 1994-07-13 1996-08-09 Synthelabo Derives de 9h-imidazo(1,2-a)benzimidazole-3-acetamide, leur preparation et leur application en therapeutique
WO1996028454A1 (fr) 1995-03-13 1996-09-19 Nikken Chemicals Co., Ltd. Composes imidazothiazole
WO1998006724A1 (fr) 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Agonistes du recepteur du glutamate metabotropique
US6127387A (en) 1996-12-10 2000-10-03 Thomas Jefferson University Use of CD4-binding small molecules to inhibit immune responses
FR2759698B1 (fr) 1997-02-20 1999-03-19 Synthelabo Derives de 1,4-diphenylimidazole-5-acetamide, leur preparation et leur application en therapeutique
JPH11106340A (ja) 1997-10-02 1999-04-20 Sumitomo Pharmaceut Co Ltd Ｓｔａｔ６活性化阻害剤
DE69831013T2 (de) 1997-12-22 2006-04-20 Bayer Pharmaceuticals Corp., West Haven Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
DE19905278A1 (de) 1999-02-09 2000-08-10 Bayer Ag Oxazolidinone und ihre Verwendung als antibakterielle Mittel
GB2351081A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
JP2001048786A (ja) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd 三環式ヘテロアリール誘導体
DE19948434A1 (de) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
JP2001192386A (ja) 1999-10-29 2001-07-17 Meiji Seika Kaisha Ltd 新規トリアゾール誘導体及びこれを有効成分とする抗真菌剤
DE10019714A1 (de) 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
US20040067991A1 (en) 2000-07-06 2004-04-08 Greig Nigel H Tetrahydrobenzothiazole analogues as neuroprotective agents
US6696441B1 (en) 2000-08-11 2004-02-24 The Regents Of The University Of California Inhibition of p53-induced stress response
US7601846B2 (en) 2001-06-26 2009-10-13 The Regents Of The University Of California Compounds having activity as inhibitors of apoptosis
WO2003031587A2 (en) 2001-10-09 2003-04-17 The Regents Of The University Of California Use of stat-6 inhibitors as therapeutic agents
US20040127719A1 (en) 2002-03-08 2004-07-01 Kexin Yang Alpha-isocyanocarboxylate solid support templates, method of preparation and for using the same
TW200409746A (en) * 2002-07-26 2004-06-16 Theravance Inc Crystalline β2 adrenergic receptor agonist
MXPA05005474A (es) 2002-11-25 2005-07-25 Pharmacia Corp Acidos y amidas heteroarilsulfonilmetil hidroxamicos y su uso como inhibidores de proteasas.
DE60326270D1 (de) 2002-12-18 2009-04-02 Mallinckrodt Inc Synthese von heteroaryl acetamiden
KR100647583B1 (ko) 2003-10-07 2006-11-17 삼성에스디아이 주식회사 이미다졸 고리 함유 화합물 및 이를 이용한 유기 전계발광 소자
US7767670B2 (en) 2003-11-13 2010-08-03 Ambit Biosciences Corporation Substituted 3-carboxamido isoxazoles as kinase modulators
NZ571566A (en) * 2006-03-17 2011-07-29 Ambit Biosciences Corp Imidazolothiazole compounds for the treatment of disease
BRPI0816904B8 (pt) 2007-09-19 2021-12-07 Ambit Biosciences Corp Forma cristalna b da forma sólida do sal de bis-hcl, composição farmacêutica, e, uso de uma forma sólida
WO2009061446A1 (en) 2007-11-08 2009-05-14 Ambit Biosciences Corp. Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease

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WO2009038757A2 (en) 2009-03-26
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US20150238499A1 (en) 2015-08-27
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US20090131426A1 (en) 2009-05-21
JP2010539237A (ja) 2010-12-16
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CN101868465A (zh) 2010-10-20
EP2201018A2 (en) 2010-06-30
HRP20160520T1 (hr) 2016-07-29
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MX2010002295A (es) 2010-03-22
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CA2696776A1 (en) 2009-03-26
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AU2008302744B2 (en) 2014-01-30
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BRPI0816904A2 (pt) 2015-03-17
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