JPS56138196A - Imidazo (2,1-b)benzothiazole derivative - Google Patents
Imidazo (2,1-b)benzothiazole derivativeInfo
- Publication number
- JPS56138196A JPS56138196A JP4099880A JP4099880A JPS56138196A JP S56138196 A JPS56138196 A JP S56138196A JP 4099880 A JP4099880 A JP 4099880A JP 4099880 A JP4099880 A JP 4099880A JP S56138196 A JPS56138196 A JP S56138196A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- agent
- compound
- halogen
- alkoxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:The titled compound of formula I [any one of R1,R2,R3,R4,R5 and R6 is a group of formula IV (X is O, hydroxyimino, etc.; Y is H, OH, alkoxyl, etc.); the other five are H, halogen, lower alkyl, alkoxyl, etc.] and a salt thereof.
EXAMPLE: 2-(p-Ghlorophenyl)imidazo[2,1-b]benzothiazole-7-carboxylic acid.
USE: An immunological function regulating agent, an antiallergic agent, an antiasthmatic agent, an antirheumatic agent, an carcinostatic agent and a remedy for an autoimmune disease.
PROCESS: A compound of formula II [any one of R11,R12,R13 and R14 is a group of formula V (Y1 is lower alkoxyl); the other three are H, halogen, etc.] is reacted with a compound of formula III (R9 is H, lower alkyl, etc.; R10 is lower alkyl, etc.; Z is halogen) to give the compound of formula Ia.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4099880A JPS56138196A (en) | 1980-03-29 | 1980-03-29 | Imidazo (2,1-b)benzothiazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4099880A JPS56138196A (en) | 1980-03-29 | 1980-03-29 | Imidazo (2,1-b)benzothiazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56138196A true JPS56138196A (en) | 1981-10-28 |
Family
ID=12596084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4099880A Pending JPS56138196A (en) | 1980-03-29 | 1980-03-29 | Imidazo (2,1-b)benzothiazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56138196A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
WO1996028454A1 (en) * | 1995-03-13 | 1996-09-19 | Nikken Chemicals Co., Ltd. | Imidazothiazole compounds |
WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
-
1980
- 1980-03-29 JP JP4099880A patent/JPS56138196A/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4968708A (en) * | 1988-06-22 | 1990-11-06 | Nikken Chemicals Co., Ltd. | Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same |
WO1996028454A1 (en) * | 1995-03-13 | 1996-09-19 | Nikken Chemicals Co., Ltd. | Imidazothiazole compounds |
US5919799A (en) * | 1995-03-13 | 1999-07-06 | Nikken Chemicals Co., Ltd. | Imidazothiazole compound |
WO1998006724A1 (en) * | 1996-08-09 | 1998-02-19 | Yamanouchi Pharmaceutical Co., Ltd. | Metabotropic glutamate receptor agonists |
US7820657B2 (en) | 2006-03-17 | 2010-10-26 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
US8129374B2 (en) | 2006-03-17 | 2012-03-06 | Ambit Bioscience Corporation | Method of using imidazolothiazole compounds for the treatment of disease |
US8557810B2 (en) | 2006-03-17 | 2013-10-15 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
US8921546B2 (en) | 2006-03-17 | 2014-12-30 | Ambit Biosciences Corporation | Imidazolothiazole compounds for the treatment of disease |
US8883783B2 (en) | 2007-09-19 | 2014-11-11 | Ambit Biosciences Corporation | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
US9585892B2 (en) | 2007-09-19 | 2017-03-07 | Ambit Biosciences | Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5498795A (en) | Cephalosporin derivative and its preparation | |
JPS5791997A (en) | 5'-o-acylnucleoside and its preparation | |
JPS56103168A (en) | Thiazole derivative, its preparation, and antihistaminic agent containing the same | |
JPS56138196A (en) | Imidazo (2,1-b)benzothiazole derivative | |
JPS57149288A (en) | Imidazo(2,1-b)benzothiazole derivative | |
JPS5721375A (en) | 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation | |
JPS5612377A (en) | Novel thiazole derivative, its preparation, and drug for ulcer having andigestive action | |
JPS5681574A (en) | Preparation of 2,2-disubstituted thiazolidine | |
JPS55124766A (en) | Antihistaminic | |
JPS572298A (en) | Erythromycin derivative | |
JPS5668685A (en) | 2-phenylimidazo 2,1-b benzothiazole derivative and its preparation | |
JPS5655383A (en) | Amizine derivative and its preparation | |
JPS57123175A (en) | Preparation of thiazolidine derivative | |
JPS54103879A (en) | Novel penicillamine | |
JPS54115373A (en) | Preparation of heterocyclic compound | |
JPS5759897A (en) | Thiazolineazatidinone | |
JPS55157574A (en) | 5-fluorouracyl derivative and its preparation | |
JPS57188595A (en) | 7alpha-methoxycephem compound and its preparation | |
JPS56115780A (en) | Phenoxyalkaneacid derivative substituted by heterocyclic ring containing nitrogen and sulfur, and its preparation | |
JPS57154183A (en) | Omega-piperazinylalkanoylalkylene dioxybenzenes and their acid addition salts | |
JPS5793971A (en) | Preparation of piperazine derivative | |
JPS56122353A (en) | Pyridinol derivative and its preparation | |
JPS5612379A (en) | Novel piperidine derivative, its preparation, and drug for ulcer comprising it | |
JPS57171983A (en) | Aminophenyltetrazole derivative and salt thereof | |
JPS57200372A (en) | Novel 5-substituted-2-((n-morpholino)-n-nitrosoamino- methyl)oxadiazole derivative and preventing agent for thrombosis containing the same as principal constituent |