JPS56138196A - Imidazo (2,1-b)benzothiazole derivative - Google Patents

Imidazo (2,1-b)benzothiazole derivative

Info

Publication number
JPS56138196A
JPS56138196A JP4099880A JP4099880A JPS56138196A JP S56138196 A JPS56138196 A JP S56138196A JP 4099880 A JP4099880 A JP 4099880A JP 4099880 A JP4099880 A JP 4099880A JP S56138196 A JPS56138196 A JP S56138196A
Authority
JP
Japan
Prior art keywords
formula
agent
compound
halogen
alkoxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4099880A
Other languages
Japanese (ja)
Inventor
Toshiyasu Mase
Kiyoshi Murase
Kenichi Tomioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Priority to JP4099880A priority Critical patent/JPS56138196A/en
Publication of JPS56138196A publication Critical patent/JPS56138196A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The titled compound of formula I [any one of R1,R2,R3,R4,R5 and R6 is a group of formula IV (X is O, hydroxyimino, etc.; Y is H, OH, alkoxyl, etc.); the other five are H, halogen, lower alkyl, alkoxyl, etc.] and a salt thereof.
EXAMPLE: 2-(p-Ghlorophenyl)imidazo[2,1-b]benzothiazole-7-carboxylic acid.
USE: An immunological function regulating agent, an antiallergic agent, an antiasthmatic agent, an antirheumatic agent, an carcinostatic agent and a remedy for an autoimmune disease.
PROCESS: A compound of formula II [any one of R11,R12,R13 and R14 is a group of formula V (Y1 is lower alkoxyl); the other three are H, halogen, etc.] is reacted with a compound of formula III (R9 is H, lower alkyl, etc.; R10 is lower alkyl, etc.; Z is halogen) to give the compound of formula Ia.
COPYRIGHT: (C)1981,JPO&Japio
JP4099880A 1980-03-29 1980-03-29 Imidazo (2,1-b)benzothiazole derivative Pending JPS56138196A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4099880A JPS56138196A (en) 1980-03-29 1980-03-29 Imidazo (2,1-b)benzothiazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4099880A JPS56138196A (en) 1980-03-29 1980-03-29 Imidazo (2,1-b)benzothiazole derivative

Publications (1)

Publication Number Publication Date
JPS56138196A true JPS56138196A (en) 1981-10-28

Family

ID=12596084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4099880A Pending JPS56138196A (en) 1980-03-29 1980-03-29 Imidazo (2,1-b)benzothiazole derivative

Country Status (1)

Country Link
JP (1) JPS56138196A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same
WO1996028454A1 (en) * 1995-03-13 1996-09-19 Nikken Chemicals Co., Ltd. Imidazothiazole compounds
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
US7820657B2 (en) 2006-03-17 2010-10-26 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8883783B2 (en) 2007-09-19 2014-11-11 Ambit Biosciences Corporation Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968708A (en) * 1988-06-22 1990-11-06 Nikken Chemicals Co., Ltd. Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same
WO1996028454A1 (en) * 1995-03-13 1996-09-19 Nikken Chemicals Co., Ltd. Imidazothiazole compounds
US5919799A (en) * 1995-03-13 1999-07-06 Nikken Chemicals Co., Ltd. Imidazothiazole compound
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
US7820657B2 (en) 2006-03-17 2010-10-26 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8129374B2 (en) 2006-03-17 2012-03-06 Ambit Bioscience Corporation Method of using imidazolothiazole compounds for the treatment of disease
US8557810B2 (en) 2006-03-17 2013-10-15 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8921546B2 (en) 2006-03-17 2014-12-30 Ambit Biosciences Corporation Imidazolothiazole compounds for the treatment of disease
US8883783B2 (en) 2007-09-19 2014-11-11 Ambit Biosciences Corporation Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith
US9585892B2 (en) 2007-09-19 2017-03-07 Ambit Biosciences Solid forms comprising N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith

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