SI2201018T1 - Trdne oblike, ki obsegajo N-(5-terc.butil-izoksazol-3-il)-N'-(4-Y7-(2- morfolin-4-il-etoksi)imidazoY2,1-B"Y 1,3"benzotiazol-2-ilfenil)sečnina, njihove sestave in uporabe z njimi - Google Patents

Trdne oblike, ki obsegajo N-(5-terc.butil-izoksazol-3-il)-N'-(4-Y7-(2- morfolin-4-il-etoksi)imidazoY2,1-B"Y 1,3"benzotiazol-2-ilfenil)sečnina, njihove sestave in uporabe z njimi

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Publication number
SI2201018T1
SI2201018T1 SI200831613A SI200831613A SI2201018T1 SI 2201018 T1 SI2201018 T1 SI 2201018T1 SI 200831613 A SI200831613 A SI 200831613A SI 200831613 A SI200831613 A SI 200831613A SI 2201018 T1 SI2201018 T1 SI 2201018T1
Authority
SI
Slovenia
Prior art keywords
imidazoy2
benzothiazol
isoxazol
morpholin
ethoxy
Prior art date
Application number
SI200831613A
Other languages
English (en)
Inventor
Shripad Bhagwat
Wei Lai
Stephan D. Parent
Melanie J. Roe
Alan Schwartz
Valeriya N. Smolenskaya
Original Assignee
Ambit Biosciences Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambit Biosciences Corporation filed Critical Ambit Biosciences Corporation
Publication of SI2201018T1 publication Critical patent/SI2201018T1/sl

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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SI200831613A 2007-09-19 2008-09-19 Trdne oblike, ki obsegajo N-(5-terc.butil-izoksazol-3-il)-N'-(4-Y7-(2- morfolin-4-il-etoksi)imidazoY2,1-B"Y 1,3"benzotiazol-2-ilfenil)sečnina, njihove sestave in uporabe z njimi SI2201018T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99463507P 2007-09-19 2007-09-19
EP08832577.4A EP2201018B1 (en) 2007-09-19 2008-09-19 Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-ý7-(2-morpholin-4-yl-ethoxy)imidazoý2,1-b¨ý1,3¨benzothiazol-2-yl¨phenyl}urea, compositions thereof, and uses therewith
PCT/US2008/010884 WO2009038757A2 (en) 2007-09-19 2008-09-19 Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith

Publications (1)

Publication Number Publication Date
SI2201018T1 true SI2201018T1 (sl) 2016-09-30

Family

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Family Applications (1)

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SI200831613A SI2201018T1 (sl) 2007-09-19 2008-09-19 Trdne oblike, ki obsegajo N-(5-terc.butil-izoksazol-3-il)-N'-(4-Y7-(2- morfolin-4-il-etoksi)imidazoY2,1-B"Y 1,3"benzotiazol-2-ilfenil)sečnina, njihove sestave in uporabe z njimi

Country Status (20)

Country Link
US (2) US8883783B2 (sl)
EP (1) EP2201018B1 (sl)
JP (1) JP5462168B2 (sl)
KR (2) KR20150104231A (sl)
CN (1) CN101868465B (sl)
AR (1) AR068528A1 (sl)
AU (1) AU2008302744B2 (sl)
BR (1) BRPI0816904B8 (sl)
CA (1) CA2696776C (sl)
CY (1) CY1117583T1 (sl)
DK (1) DK2201018T3 (sl)
ES (1) ES2573292T3 (sl)
HR (1) HRP20160520T1 (sl)
HU (1) HUE027982T2 (sl)
IL (1) IL203926A (sl)
MX (1) MX2010002295A (sl)
PL (1) PL2201018T3 (sl)
SI (1) SI2201018T1 (sl)
TW (1) TWI437988B (sl)
WO (1) WO2009038757A2 (sl)

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KR20150104231A (ko) 2007-09-19 2015-09-14 암비트 바이오사이언시즈 코포레이션 Ｎ-(5-ｔｅｒｔ-부틸-이속사졸-3-일)-Ｎ''-[4-[7-(2-모르폴린-4-일-에톡시)이미다조[2,1-Ｂ][1,3]벤조티아졸-2-일]페닐]우레아를 포함하는 고체 형태, 그의 조성물 및 그의 용도
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CA2696776C (en) 2015-12-15
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AU2008302744B2 (en) 2014-01-30
US20150238499A1 (en) 2015-08-27
HUE027982T2 (en) 2016-11-28
TW200920360A (en) 2009-05-16
CA2696776A1 (en) 2009-03-26
WO2009038757A3 (en) 2009-05-28
US8883783B2 (en) 2014-11-11
US9585892B2 (en) 2017-03-07
ES2573292T3 (es) 2016-06-07
HRP20160520T1 (hr) 2016-07-29
BRPI0816904B1 (pt) 2021-08-10
WO2009038757A2 (en) 2009-03-26
BRPI0816904A2 (pt) 2015-03-17
KR101572701B1 (ko) 2015-11-27
PL2201018T3 (pl) 2016-11-30
KR20100061734A (ko) 2010-06-08
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US20090131426A1 (en) 2009-05-21
JP5462168B2 (ja) 2014-04-02
CN101868465A (zh) 2010-10-20
CN101868465B (zh) 2013-12-25
TWI437988B (zh) 2014-05-21
EP2201018A2 (en) 2010-06-30
IL203926A (en) 2016-02-29
AU2008302744A1 (en) 2009-03-26
AR068528A1 (es) 2009-11-18
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EP2201018B1 (en) 2016-03-16
MX2010002295A (es) 2010-03-22

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