CY1115249T1 - Συνθεση εις τη φυση απαντωσων εκτεϊνασκιδινων και σχετικων ενωσεων - Google Patents

Συνθεση εις τη φυση απαντωσων εκτεϊνασκιδινων και σχετικων ενωσεων

Info

Publication number
CY1115249T1
CY1115249T1 CY20141100504T CY141100504T CY1115249T1 CY 1115249 T1 CY1115249 T1 CY 1115249T1 CY 20141100504 T CY20141100504 T CY 20141100504T CY 141100504 T CY141100504 T CY 141100504T CY 1115249 T1 CY1115249 T1 CY 1115249T1
Authority
CY
Cyprus
Prior art keywords
nature
composition
related compounds
response effects
compounds
Prior art date
Application number
CY20141100504T
Other languages
English (en)
Inventor
Roberto Menchaca
Valentin Martinez
Alberto Rodriguez
Natividad Rodriguez
Pilar Gallego
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar, S.A.U.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar, S.A.U. filed Critical Pharma Mar, S.A.U.
Publication of CY1115249T1 publication Critical patent/CY1115249T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Οι ενώσεις εκτεϊνασκιδίνης με έναν δακτύλιο κινόνης για δακτύλιο Ε είναι δραστικές ως αντικαρκινικοί παράγοντες. Δίδονται σχετικές μέθοδοι και ενώσεις.
CY20141100504T 2002-02-04 2014-07-04 Συνθεση εις τη φυση απαντωσων εκτεϊνασκιδινων και σχετικων ενωσεων CY1115249T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0202544.3A GB0202544D0 (en) 2002-02-04 2002-02-04 The synthesis of naturally occuring ecteinascidins and related compounds
EP10181699.9A EP2305689B1 (en) 2002-02-04 2003-02-04 The synthesis of naturally occuring ecteinascidins and related compounds

Publications (1)

Publication Number Publication Date
CY1115249T1 true CY1115249T1 (el) 2017-01-04

Family

ID=9930352

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100504T CY1115249T1 (el) 2002-02-04 2014-07-04 Συνθεση εις τη φυση απαντωσων εκτεϊνασκιδινων και σχετικων ενωσεων

Country Status (16)

Country Link
US (3) US7767659B2 (el)
EP (2) EP1472261A2 (el)
JP (2) JP2005523275A (el)
CN (1) CN1646539A (el)
AU (1) AU2003244453B2 (el)
CA (2) CA2749205C (el)
CY (1) CY1115249T1 (el)
DK (1) DK2305689T3 (el)
ES (1) ES2466025T3 (el)
GB (1) GB0202544D0 (el)
MX (1) MXPA04007527A (el)
NZ (1) NZ534034A (el)
PT (1) PT2305689E (el)
RU (1) RU2306316C9 (el)
SI (1) SI2305689T1 (el)
WO (1) WO2003066638A2 (el)

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GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
CN103038240A (zh) 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
CN104974056B (zh) * 2015-07-20 2017-01-11 上海皓元生物医药科技有限公司 一种用于制备曲贝替定的高纯度中间体的手性拆分方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN107739387B (zh) * 2017-10-16 2020-01-03 上海皓元生物医药科技有限公司 一种制备曲贝替定的关键中间体化合物的方法
CN109912629B (zh) * 2017-12-13 2021-12-24 浙江中科创越药业有限公司 天然产物Trabectedin的制备
CN112679513B (zh) * 2019-10-18 2023-08-25 南通诺泰生物医药技术有限公司 一种制备曲贝替定的关键中间体的方法
CN112679512B (zh) * 2019-10-18 2023-08-25 南通诺泰生物医药技术有限公司 曲贝替定中间体及其制备方法
AR121894A1 (es) 2020-04-21 2022-07-20 Pharma Mar Sa Conjugados de anticuerpos de fármacos
EP4303221A1 (en) * 2021-03-03 2024-01-10 The University of Tokyo Novel tetrahydroisoquinoline alkaloid compound containing macrocycle
CN115677728A (zh) * 2022-11-02 2023-02-03 成都科岭源医药技术有限公司 一种海鞘素类化合物中间体的制备方法

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JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
JP2562162B2 (ja) 1986-06-09 1996-12-11 ユニバーシティ・オブ・イリノイ エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
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AU2005288696A1 (en) 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
PL1827500T3 (pl) 2004-10-26 2009-09-30 Pharma Mar Sa Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
ES2290844T3 (es) 2004-10-29 2008-02-16 Pharma Mar S.A., Sociedad Unipersonal Composiciones que comprenden ecteinascidinas y un disacarido.
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MX2010012501A (es) 2008-05-16 2010-12-20 Pharma Mar Sa Terapia de combinacion con un alcaloide antitumoral.

Also Published As

Publication number Publication date
RU2306316C9 (ru) 2008-03-27
US20070093658A1 (en) 2007-04-26
ES2466025T3 (es) 2014-06-09
CN1646539A (zh) 2005-07-27
CA2473175C (en) 2011-11-15
EP1472261A2 (en) 2004-11-03
AU2003244453B2 (en) 2009-03-05
WO2003066638A3 (en) 2003-12-18
PT2305689E (pt) 2014-06-03
SI2305689T1 (sl) 2014-07-31
US7947671B2 (en) 2011-05-24
US20100216987A1 (en) 2010-08-26
WO2003066638A2 (en) 2003-08-14
US7767659B2 (en) 2010-08-03
DK2305689T3 (da) 2014-07-14
EP2305689B1 (en) 2014-04-09
EP2305689A1 (en) 2011-04-06
JP2005523275A (ja) 2005-08-04
MXPA04007527A (es) 2006-04-28
JP5357831B2 (ja) 2013-12-04
AU2003244453A1 (en) 2003-09-02
CA2749205A1 (en) 2003-08-14
CA2473175A1 (en) 2003-08-14
NZ534034A (en) 2007-02-23
GB0202544D0 (en) 2002-03-20
US7795260B2 (en) 2010-09-14
RU2004126700A (ru) 2005-06-27
RU2306316C2 (ru) 2007-09-20
JP2010215645A (ja) 2010-09-30
CA2749205C (en) 2015-01-06
US20090163507A1 (en) 2009-06-25

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