CY1114701T1 - Συνθεσεις και μεθοδοι για αυξηση ασβεστοποιησης οστων - Google Patents

Συνθεσεις και μεθοδοι για αυξηση ασβεστοποιησης οστων

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Publication number
CY1114701T1
CY1114701T1 CY20131100883T CY131100883T CY1114701T1 CY 1114701 T1 CY1114701 T1 CY 1114701T1 CY 20131100883 T CY20131100883 T CY 20131100883T CY 131100883 T CY131100883 T CY 131100883T CY 1114701 T1 CY1114701 T1 CY 1114701T1
Authority
CY
Cyprus
Prior art keywords
methods
tgf
bone
compositions
balancing
Prior art date
Application number
CY20131100883T
Other languages
English (en)
Inventor
Mary E Brunkow
David J Galas
Brian Kovacevich
John T Mulligan
Bryan W Paeper
Ness Jeffrey Van
David G Winkler
Original Assignee
Ucb Manufacturing, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33563705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114701(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Manufacturing, Inc. filed Critical Ucb Manufacturing, Inc.
Publication of CY1114701T1 publication Critical patent/CY1114701T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/495—Transforming growth factor [TGF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

Αποκαλύπτεται πρωτότυπη κατηγορία ή οικογένεια ΤGF-β-δεσμευόμενων πρωτεϊνών. Αποκαλύπτονται επίσης προσδιορισμοί για επιλογή μορίων για αύξηση ασβεστοποίησης οστών και μέθοδοι για χρησιμοποίηση τέτοιων μορίων. Συγκεκριμένα, παρέχονται συνθέσεις και μέθοδοι που σχετίζονται με αντισώματα που δεσμεύονται ειδικά με ΤGF-β-δεσμευόμενες πρωτεΐνες. Αυτές οι μέθοδοι και συνθέσεις σχετίζονται με αλλαγή της οστικής πυκνότητας μέσω παρεμβολής στην αλληλεπίδραση μεταξύ ΤGF-β-δεσμευόμενης πρωτεΐνης σκληροστίνης και μέλους της υπερ-οικογένειας ΤGF-β, ιδίως οστικής μορφογόνου πρωτεΐνης. Η αύξηση οστικής πυκνότητας έχει χρησιμότητα σε ασθένειες και παθήσεις στις οποίες χαμηλή οστική πυκνότητα χαρακτηρίζει την πάθηση, όπως οστεοπενία, οστεοπόρωση, και κατάγματα οστών.
CY20131100883T 2003-06-16 2013-10-09 Συνθεσεις και μεθοδοι για αυξηση ασβεστοποιησης οστων CY1114701T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/463,190 US20040009535A1 (en) 1998-11-27 2003-06-16 Compositions and methods for increasing bone mineralization
EP04776552.4A EP1638999B1 (en) 2003-06-16 2004-06-15 Compositions and methods for increasing bone mineralization

Publications (1)

Publication Number Publication Date
CY1114701T1 true CY1114701T1 (el) 2016-10-05

Family

ID=33563705

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100883T CY1114701T1 (el) 2003-06-16 2013-10-09 Συνθεσεις και μεθοδοι για αυξηση ασβεστοποιησης οστων

Country Status (25)

Country Link
US (3) US20040009535A1 (el)
EP (3) EP2338906A1 (el)
JP (2) JP4818107B2 (el)
KR (1) KR101221147B1 (el)
CN (2) CN103319596A (el)
AU (1) AU2004253870B2 (el)
BR (1) BRPI0411535A (el)
CA (1) CA2529578C (el)
CY (1) CY1114701T1 (el)
DK (1) DK1638999T3 (el)
EA (2) EA022991B1 (el)
ES (1) ES2428767T3 (el)
HK (1) HK1088907A1 (el)
HR (1) HRP20131014T1 (el)
IL (2) IL172599A (el)
ME (2) ME00023B (el)
NO (1) NO20060235L (el)
NZ (1) NZ544617A (el)
PL (1) PL1638999T3 (el)
PT (1) PT1638999E (el)
RS (1) RS52769B (el)
SG (1) SG185824A1 (el)
SI (1) SI1638999T1 (el)
WO (1) WO2005003158A2 (el)
ZA (1) ZA200600384B (el)

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HK1088907A1 (en) 2006-11-17
JP2008505843A (ja) 2008-02-28
EA014525B1 (ru) 2010-12-30
US20040009535A1 (en) 2004-01-15
PL1638999T3 (pl) 2014-04-30
PT1638999E (pt) 2013-09-03
AU2004253870A1 (en) 2005-01-13
RS52769B (sr) 2013-10-31
US7985834B2 (en) 2011-07-26
JP4818107B2 (ja) 2011-11-16
IL172599A0 (en) 2006-04-10
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ZA200600384B (en) 2008-10-29
CN103319596A (zh) 2013-09-25
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NO20060235L (no) 2006-03-14
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WO2005003158A2 (en) 2005-01-13
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CN1835968B (zh) 2013-01-30
EA022991B1 (ru) 2016-04-29
ES2428767T3 (es) 2013-11-11
SG185824A1 (en) 2012-12-28
EP1638999B1 (en) 2013-07-24
US20100151524A1 (en) 2010-06-17
SI1638999T1 (sl) 2013-12-31
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