CY1113715T1 - Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119 - Google Patents
Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119Info
- Publication number
- CY1113715T1 CY1113715T1 CY20131100168T CY131100168T CY1113715T1 CY 1113715 T1 CY1113715 T1 CY 1113715T1 CY 20131100168 T CY20131100168 T CY 20131100168T CY 131100168 T CY131100168 T CY 131100168T CY 1113715 T1 CY1113715 T1 CY 1113715T1
- Authority
- CY
- Cyprus
- Prior art keywords
- gpr119
- regulators
- protein
- pyrason
- pyridon
- Prior art date
Links
- 102100033839 Glucose-dependent insulinotropic receptor Human genes 0.000 title abstract 6
- 101000996752 Homo sapiens Glucose-dependent insulinotropic receptor Proteins 0.000 title abstract 6
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical compound OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 108091006027 G proteins Proteins 0.000 abstract 3
- 102000030782 GTP binding Human genes 0.000 abstract 3
- 108091000058 GTP-Binding Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8105808P | 2008-07-16 | 2008-07-16 | |
| US8106908P | 2008-07-16 | 2008-07-16 | |
| US8106008P | 2008-07-16 | 2008-07-16 | |
| EP09790426A EP2313395B1 (en) | 2008-07-16 | 2009-07-15 | Pyridone and pyridazone analogues as gpr119 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113715T1 true CY1113715T1 (el) | 2016-06-22 |
Family
ID=41137417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100168T CY1113715T1 (el) | 2008-07-16 | 2013-02-22 | Αναλογα πυριδονης και πυριδαζονης ως ρυθμιστες toy gpr119 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8372837B2 (enExample) |
| EP (1) | EP2313395B1 (enExample) |
| JP (1) | JP2011528362A (enExample) |
| CN (1) | CN102159566A (enExample) |
| AR (1) | AR073254A1 (enExample) |
| BR (1) | BRPI0915918A2 (enExample) |
| CA (1) | CA2730929A1 (enExample) |
| CY (1) | CY1113715T1 (enExample) |
| DK (1) | DK2313395T3 (enExample) |
| EA (1) | EA018268B1 (enExample) |
| ES (1) | ES2400587T3 (enExample) |
| HR (1) | HRP20130120T1 (enExample) |
| MX (1) | MX2011000394A (enExample) |
| PL (1) | PL2313395T3 (enExample) |
| PT (1) | PT2313395E (enExample) |
| SI (1) | SI2313395T1 (enExample) |
| SM (1) | SMT201300040B (enExample) |
| TW (1) | TW201006821A (enExample) |
| WO (1) | WO2010009183A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| US8481731B2 (en) | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| US8293729B2 (en) | 2009-06-24 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| WO2011030139A1 (en) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
| US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
| PH12012501853A1 (en) | 2010-04-08 | 2013-01-07 | Bristol Myers Squibb Co | Pyrimidinylpiperidinyloxypyridinone analogues as gpr119 modulators |
| EA201270778A1 (ru) | 2010-05-06 | 2013-04-30 | Бристол-Майерс Сквибб Компани | Бициклические гетероарильные аналоги в качестве модуляторов рецептора gpr119 |
| WO2011140161A1 (en) | 2010-05-06 | 2011-11-10 | Bristol-Myers Squibb Company | Benzofuranyl analogues as gpr119 modulators |
| CN103080101A (zh) | 2010-05-17 | 2013-05-01 | 阵列生物制药公司 | 作为gpr119调节剂的哌啶基取代的内酰胺 |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| PH12013500671A1 (en) | 2010-10-08 | 2018-04-11 | Cadila Healthcare Ltd | Novel gpr 119 agonists |
| WO2012170867A1 (en) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of gpr-119 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9174965B2 (en) | 2012-05-16 | 2015-11-03 | Bristol-Myers Squibb Company | Pyrimidinylpiperidinyloxypyridone analogues as GPR119 modulators |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| CN103664795B (zh) * | 2012-09-06 | 2017-10-03 | 华东理工大学 | 哒嗪酮类化合物及其用途 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US9499553B2 (en) | 2013-03-13 | 2016-11-22 | Chugai Seiyaku Kabushiki Kaisha | Dihydropyridazine-3,5-dione derivative and pharmaceuticals containing the same |
| HUE050577T2 (hu) * | 2013-03-13 | 2020-12-28 | Chugai Pharmaceutical Co Ltd | Dihidropiridazin-3,5-dion-származék |
| NO2986357T3 (enExample) | 2013-04-18 | 2018-07-14 | ||
| WO2014175621A1 (en) * | 2013-04-25 | 2014-10-30 | Yuhan Corporation | Novel triazolone derivatives or salts thereof and pharmaceutical composition comprising the same |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| CN104370806B (zh) * | 2014-06-17 | 2017-07-07 | 中国海洋大学 | 一种吡啶酮生物碱类化合物及其制备方法和用途 |
| EA202092269A1 (ru) * | 2018-03-23 | 2020-12-14 | Кармот Терапьютикс, Инк. | Модуляторы сопряженных с g-белком рецепторов |
| UA127065C2 (uk) * | 2018-04-25 | 2023-03-29 | Баєр Акціенгезельшафт | Нові гетероарил-триазольні та гетероарил-тетразольні сполуки як пестициди |
| TWI842743B (zh) | 2018-09-27 | 2024-05-21 | 美商富曼西公司 | 酮之中間體 |
| CN110845426A (zh) * | 2019-11-29 | 2020-02-28 | 都创(上海)医药科技有限公司 | 一种2-氯-5-氰基嘧啶化合物制备方法 |
| TW202140440A (zh) | 2020-02-28 | 2021-11-01 | 美商克力歐普股份有限公司 | Gpr40激動劑 |
| WO2021231630A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| AU2021275038A1 (en) | 2020-05-19 | 2022-12-22 | Kallyope, Inc. | AMPK activators |
| CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
| PE20240890A1 (es) | 2021-05-13 | 2024-04-24 | Carmot Therapeutics Inc | Moduladores de los receptores acoplados a proteinas g |
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| US5776983A (en) | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
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| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| US5491134A (en) | 1994-09-16 | 1996-02-13 | Bristol-Myers Squibb Company | Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives |
| US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
| US5620997A (en) | 1995-05-31 | 1997-04-15 | Warner-Lambert Company | Isothiazolones |
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-
2009
- 2009-07-10 TW TW098123477A patent/TW201006821A/zh unknown
- 2009-07-15 PT PT97904262T patent/PT2313395E/pt unknown
- 2009-07-15 CA CA2730929A patent/CA2730929A1/en not_active Abandoned
- 2009-07-15 US US13/003,914 patent/US8372837B2/en active Active
- 2009-07-15 HR HRP20130120AT patent/HRP20130120T1/hr unknown
- 2009-07-15 WO PCT/US2009/050618 patent/WO2010009183A1/en not_active Ceased
- 2009-07-15 DK DK09790426.2T patent/DK2313395T3/da active
- 2009-07-15 EA EA201100210A patent/EA018268B1/ru not_active IP Right Cessation
- 2009-07-15 JP JP2011518862A patent/JP2011528362A/ja active Pending
- 2009-07-15 CN CN2009801362083A patent/CN102159566A/zh active Pending
- 2009-07-15 PL PL09790426T patent/PL2313395T3/pl unknown
- 2009-07-15 BR BRPI0915918A patent/BRPI0915918A2/pt not_active IP Right Cessation
- 2009-07-15 EP EP09790426A patent/EP2313395B1/en not_active Not-in-force
- 2009-07-15 ES ES09790426T patent/ES2400587T3/es active Active
- 2009-07-15 MX MX2011000394A patent/MX2011000394A/es active IP Right Grant
- 2009-07-15 AR ARP090102687A patent/AR073254A1/es not_active Application Discontinuation
- 2009-07-15 SI SI200930537T patent/SI2313395T1/sl unknown
-
2013
- 2013-01-18 US US13/744,604 patent/US20130131074A1/en not_active Abandoned
- 2013-02-22 CY CY20131100168T patent/CY1113715T1/el unknown
- 2013-04-03 SM SM201300040T patent/SMT201300040B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102159566A (zh) | 2011-08-17 |
| TW201006821A (en) | 2010-02-16 |
| BRPI0915918A2 (pt) | 2018-07-10 |
| DK2313395T3 (da) | 2013-03-18 |
| EA201100210A1 (ru) | 2011-08-30 |
| EA018268B1 (ru) | 2013-06-28 |
| EP2313395B1 (en) | 2012-12-19 |
| US20130131074A1 (en) | 2013-05-23 |
| US8372837B2 (en) | 2013-02-12 |
| MX2011000394A (es) | 2011-03-01 |
| EP2313395A1 (en) | 2011-04-27 |
| SI2313395T1 (sl) | 2013-04-30 |
| US20110263548A1 (en) | 2011-10-27 |
| AR073254A1 (es) | 2010-10-28 |
| SMT201300040B (it) | 2013-05-06 |
| CA2730929A1 (en) | 2010-01-21 |
| WO2010009183A1 (en) | 2010-01-21 |
| ES2400587T3 (es) | 2013-04-10 |
| PT2313395E (pt) | 2013-03-07 |
| PL2313395T3 (pl) | 2013-05-31 |
| JP2011528362A (ja) | 2011-11-17 |
| HRP20130120T1 (hr) | 2013-03-31 |
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