CY1112565T1 - Μεθοδος παραγωγης - Google Patents

Μεθοδος παραγωγης

Info

Publication number
CY1112565T1
CY1112565T1 CY20111101020T CY111101020T CY1112565T1 CY 1112565 T1 CY1112565 T1 CY 1112565T1 CY 20111101020 T CY20111101020 T CY 20111101020T CY 111101020 T CY111101020 T CY 111101020T CY 1112565 T1 CY1112565 T1 CY 1112565T1
Authority
CY
Cyprus
Prior art keywords
oxo
production
theophenecarboxamide
oxiranylmethyl
morpholinone
Prior art date
Application number
CY20111101020T
Other languages
English (en)
Inventor
Mathias Berwe
Christian Thomas
Joachim Rehse
Dirk Grotjohann
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34716548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112565(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of CY1112565T1 publication Critical patent/CY1112565T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Η παρούσα εφεύρεση αφορά μια διεργασία για την παρασκευή 5-χλωρο-N-({(5S)-2-οξο-3-[4-(3-οξο-4-μορφολινυλ)φαινυλ]-1,3-οξαζολιδιν-5-υλ}μεθυλ)-2-θεοφαινοκαρβοξαμιδίου ξεκινώντας από 2-[(2S)-2-οξιρανυλμεθυλ]-1H-ισοϊνδολο-1,3(2H)-διόνη, 4-(4-αμινοφαινυλ)-3-μορφολινόνη και 5-χλωροθειοφαινο-2-καρβονυλ χλωρίδιο.
CY20111101020T 2004-01-15 2011-10-27 Μεθοδος παραγωγης CY1112565T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004002044A DE102004002044A1 (de) 2004-01-15 2004-01-15 Herstellverfahren
EP04804455A EP1720866B1 (de) 2004-01-15 2004-12-31 Herstellverfahren

Publications (1)

Publication Number Publication Date
CY1112565T1 true CY1112565T1 (el) 2016-02-10

Family

ID=34716548

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101020T CY1112565T1 (el) 2004-01-15 2011-10-27 Μεθοδος παραγωγης

Country Status (33)

Country Link
US (1) US7351823B2 (el)
EP (1) EP1720866B1 (el)
JP (2) JP5311742B2 (el)
KR (1) KR20130004257A (el)
CN (1) CN1906191B (el)
AR (1) AR047389A1 (el)
AT (1) ATE518856T1 (el)
AU (1) AU2004313694B2 (el)
BR (1) BRPI0418405B8 (el)
CA (1) CA2553237C (el)
CY (1) CY1112565T1 (el)
DE (1) DE102004002044A1 (el)
DK (1) DK1720866T3 (el)
EC (1) ECSP066703A (el)
ES (1) ES2369140T3 (el)
GT (1) GT200400277A (el)
HK (1) HK1103722A1 (el)
HN (1) HN2005000016A (el)
HR (1) HRP20110796T1 (el)
IL (1) IL176767A (el)
MA (1) MA28290A1 (el)
MY (1) MY138944A (el)
NO (1) NO335553B1 (el)
NZ (1) NZ548506A (el)
PE (1) PE20050763A1 (el)
PL (1) PL1720866T3 (el)
PT (1) PT1720866E (el)
RU (1) RU2383540C2 (el)
SI (1) SI1720866T1 (el)
TW (1) TWI340137B (el)
UY (1) UY28718A1 (el)
WO (1) WO2005068456A1 (el)
ZA (1) ZA200605747B (el)

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DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
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DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) * 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
DE102005047564A1 (de) * 2005-10-04 2007-05-31 Bayer Healthcare Ag Amorphe Form von 5-Chlor-N-({(5S)2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl)-methyl)-2-thiophencarboxamid
WO2007039132A1 (de) * 2005-10-04 2007-04-12 Bayer Healthcare Ag Neue polymorphe form und die amorphe form von 5-chlor-n- ( { ( 5s ) -2-0x0-3-[4-( 3-oxo-4-morpholinyl) - phenyl] -1,3-oxazolidin-5-yl} -methyl) -2- thiophencarboxamid
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102006007146A1 (de) 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102006051625A1 (de) * 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
WO2009018807A1 (de) * 2007-08-06 2009-02-12 Schebo Biotech Ag Oxazolidinone als faktor xa- inhibitoren, verfahren zu ihrer herstellung und ihre verwendung in der therapie
US8706950B2 (en) 2008-03-01 2014-04-22 Kabushiki Kaisha Toshiba Memory system
DE102008028071A1 (de) 2008-06-12 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Neue Cokristall-Verbindung von Rivaroxaban und Malonsäure
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US7816355B1 (en) * 2009-04-28 2010-10-19 Apotex Pharmachem Inc Processes for the preparation of rivaroxaban and intermediates thereof
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PL2459555T3 (pl) 2009-07-31 2022-03-28 Krka, D.D., Novo Mesto Sposoby krystalizacji rywaroksabanu
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DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
EP2388260A1 (de) 2010-05-21 2011-11-23 Archimica GmbH Herstellungsverfahren für einen Inhibitor eines Blutgerinnungsfaktors
CN102311400A (zh) * 2010-06-29 2012-01-11 翔真生物科技股份有限公司 制备5-左旋-氨甲基-3-芳基-2-恶唑烷酮类的方法
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CN102250076A (zh) * 2011-05-27 2011-11-23 横店集团家园化工有限公司 一种利伐沙班中间体及利伐沙班的制备方法
CN102827154B (zh) * 2011-06-14 2015-04-22 上海科胜药物研发有限公司 一种合成利伐沙班中间体4-{4-[(5s)-5-(氨基甲基)-2-氧代-1,3-恶唑烷-3-基]苯基}吗啉-3-酮的方法
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CN106008490B (zh) * 2016-01-11 2019-01-04 南京生命能科技开发有限公司 一种利伐沙班的新晶体及其制备方法
CN106977507A (zh) * 2017-04-21 2017-07-25 上海华源医药科技发展有限公司 一种利伐沙班的制备方法
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CN111699184B (zh) * 2018-02-26 2023-05-23 住友化学株式会社 噁唑烷酮化合物的制造方法
JP7339754B2 (ja) * 2019-03-27 2023-09-06 ダイト株式会社 中間体の製造方法
CN112521380A (zh) * 2020-12-14 2021-03-19 哈尔滨珍宝制药有限公司 一种利伐沙班中间体a的合成方法及其在制备利伐沙班中的应用
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid

Also Published As

Publication number Publication date
JP5311742B2 (ja) 2013-10-09
CN1906191A (zh) 2007-01-31
JP2007517816A (ja) 2007-07-05
WO2005068456A1 (de) 2005-07-28
ATE518856T1 (de) 2011-08-15
DK1720866T3 (da) 2011-11-21
BRPI0418405A (pt) 2007-05-15
AR047389A1 (es) 2006-01-18
AU2004313694B2 (en) 2011-06-02
CN1906191B (zh) 2010-05-26
HN2005000016A (es) 2009-06-01
UY28718A1 (es) 2005-08-31
ES2369140T3 (es) 2011-11-25
CA2553237A1 (en) 2005-07-28
NO20063677L (no) 2006-10-11
NO335553B1 (no) 2014-12-29
IL176767A (en) 2011-04-28
BRPI0418405B8 (pt) 2021-05-25
NZ548506A (en) 2009-06-26
HRP20110796T1 (hr) 2011-12-31
AU2004313694A1 (en) 2005-07-28
EP1720866B1 (de) 2011-08-03
US7351823B2 (en) 2008-04-01
PE20050763A1 (es) 2005-12-02
PT1720866E (pt) 2011-10-12
GT200400277A (es) 2005-08-18
EP1720866A1 (de) 2006-11-15
KR20130004257A (ko) 2013-01-09
TW200604195A (en) 2006-02-01
CA2553237C (en) 2012-04-17
RU2006129341A (ru) 2008-02-20
ZA200605747B (en) 2007-10-31
SI1720866T1 (sl) 2012-01-31
BRPI0418405B1 (pt) 2018-03-13
JP2012097106A (ja) 2012-05-24
PL1720866T3 (pl) 2012-01-31
DE102004002044A1 (de) 2005-08-04
TWI340137B (en) 2011-04-11
IL176767A0 (en) 2006-10-31
US20050182055A1 (en) 2005-08-18
RU2383540C2 (ru) 2010-03-10
ECSP066703A (es) 2006-10-31
HK1103722A1 (en) 2007-12-28
MA28290A1 (fr) 2006-11-01
MY138944A (en) 2009-08-28

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