CY1111494T1 - ΑΝΑΣΥΝΔΥΑΣΜΕΝΟΣ ΑΔΕΝΟΪΟΣ ΤΟΥ Αd26 ΟΡΟΤΥΠΟΥ - Google Patents
ΑΝΑΣΥΝΔΥΑΣΜΕΝΟΣ ΑΔΕΝΟΪΟΣ ΤΟΥ Αd26 ΟΡΟΤΥΠΟΥInfo
- Publication number
- CY1111494T1 CY1111494T1 CY20111100030T CY111100030T CY1111494T1 CY 1111494 T1 CY1111494 T1 CY 1111494T1 CY 20111100030 T CY20111100030 T CY 20111100030T CY 111100030 T CY111100030 T CY 111100030T CY 1111494 T1 CY1111494 T1 CY 1111494T1
- Authority
- CY
- Cyprus
- Prior art keywords
- serotypes
- natural
- proteins
- tropics
- capsid
- Prior art date
Links
- 108090000565 Capsid Proteins Proteins 0.000 abstract 3
- 102100023321 Ceruloplasmin Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 101710145505 Fiber protein Proteins 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- QGMRQYFBGABWDR-UHFFFAOYSA-N sodium;5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC(=O)NC1=O QGMRQYFBGABWDR-UHFFFAOYSA-N 0.000 abstract 1
- 230000010415 tropism Effects 0.000 abstract 1
- 241000701161 unidentified adenovirus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Οι ορότυποι διαφέρουν στο φυσικό τροπισμό αυτών. Οι ορότυποι 2, 4, 5 και 7 αδενοϊού έχουν όλοι μία φυσική θυγατρική σχέση προς τους επιθηλίους του πνεύμονα και άλλους αναπνευστικούς ιστούς. Αντιθέτως, οι ορότυποι 40 και 41 έχουν φυσική θυγατρική σχέση προς τη γαστροεντερική οδό. Οι ορότυποι που περιγράφονται παραπάνω, διαφέρουν σε τουλάχιστον πρωτεΐνες καψιδίου (με βάση πεντόνιο, εξόνιο), πρωτεΐνες υπεύθυνες για σύνδεση κυττάρου (πρωτεΐνη ίνας) και πρωτεΐνες που ενέχονται σε αντιγραφή αδενοϊού. Αυτή η διαφορά στο τροπισμό και πρωτεΐνη καψιδίου μεταξύ οροτύπων έχει οδηγήσει σε πολλές ερευνητικές προσπάθειες που στοχεύουν την επανακατεύθυνση του τροπισμού αδενοϊού με τροποποίηση των πρωτεϊνών καψιδίου.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99201545 | 1999-05-17 | ||
EP07106044A EP1816204B1 (en) | 1999-05-17 | 2000-05-16 | Recombinant Adenovirus of the Ad26 serotype |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111494T1 true CY1111494T1 (el) | 2015-08-05 |
Family
ID=8240209
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100996T CY1106762T1 (el) | 1999-05-17 | 2007-07-25 | Ανασυνδυασμενος ανθρωπινος αδενοϊος οροτυπου 35 |
CY20111100030T CY1111494T1 (el) | 1999-05-17 | 2011-01-10 | ΑΝΑΣΥΝΔΥΑΣΜΕΝΟΣ ΑΔΕΝΟΪΟΣ ΤΟΥ Αd26 ΟΡΟΤΥΠΟΥ |
CY20111101074T CY1112008T1 (el) | 1999-05-17 | 2011-11-07 | Ανασυνδυασμενος αδενοϊος οροτυπου ad11 |
CY20111101075T CY1112189T1 (el) | 1999-05-17 | 2011-11-07 | Ανασυνδυασμενος αδενοϊος βασιζομενος στον οροτυπο 48 (ad48) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100996T CY1106762T1 (el) | 1999-05-17 | 2007-07-25 | Ανασυνδυασμενος ανθρωπινος αδενοϊος οροτυπου 35 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111101074T CY1112008T1 (el) | 1999-05-17 | 2011-11-07 | Ανασυνδυασμενος αδενοϊος οροτυπου ad11 |
CY20111101075T CY1112189T1 (el) | 1999-05-17 | 2011-11-07 | Ανασυνδυασμενος αδενοϊος βασιζομενος στον οροτυπο 48 (ad48) |
Country Status (14)
Country | Link |
---|---|
EP (6) | EP1816205B1 (el) |
JP (2) | JP4843145B2 (el) |
KR (1) | KR100741247B1 (el) |
AT (6) | ATE278792T1 (el) |
AU (1) | AU777041B2 (el) |
CA (1) | CA2372655C (el) |
CY (4) | CY1106762T1 (el) |
DE (4) | DE60043126D1 (el) |
DK (6) | DK1816205T3 (el) |
ES (5) | ES2289426T3 (el) |
IL (3) | IL146479A0 (el) |
NZ (1) | NZ515582A (el) |
PT (5) | PT1818408E (el) |
WO (1) | WO2000070071A1 (el) |
Families Citing this family (102)
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ATE445705T1 (de) | 1995-06-15 | 2009-10-15 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante adenoviren zur gentherapie |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US7094398B1 (en) | 1999-06-01 | 2006-08-22 | University Of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
US6558948B1 (en) | 1999-11-23 | 2003-05-06 | Stefan Kochanek | Permanent amniocytic cell line, its production and use for the production of gene transfer vectors |
EP1191105A1 (en) * | 2000-09-25 | 2002-03-27 | Galapagos Genomics B.V. | Gene delivery vectors provided with a tissue tropism for T-lymphocytes |
US6849446B2 (en) | 2000-05-31 | 2005-02-01 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
CA2421864A1 (en) * | 2000-09-20 | 2002-03-28 | Crucell Holland B.V. | Transduction of dendritic cells using adenoviral vectors |
DE60138403D1 (de) | 2000-09-26 | 2009-05-28 | Crucell Holland Bv | Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten |
AU2002211087A1 (en) * | 2000-10-06 | 2002-04-15 | Crucell Holland B.V. | Gene delivery vectors for stem cells |
EP1195440A1 (en) * | 2000-10-06 | 2002-04-10 | Introgene B.V. | Gene delivery vectors for stem cells |
ATE449859T1 (de) | 2001-01-04 | 2009-12-15 | Goeran Wadell | Virusvektor zur gentherapie |
US7109029B2 (en) | 2001-02-23 | 2006-09-19 | Cell Genesys, Inc. | Vector constructs |
US20040002060A1 (en) * | 2002-01-24 | 2004-01-01 | Novartis Ag | Fiber shaft modifications for efficient targeting |
IL164802A0 (en) * | 2002-04-25 | 2005-12-18 | Crucell Holland Bv | Stable adenoviral vectors and methods for propagation thereof |
IL164803A0 (en) * | 2002-04-25 | 2005-12-18 | Crucell Holland Bv | Means and methods for the production of adenovirusvectors |
JP4237449B2 (ja) * | 2002-06-05 | 2009-03-11 | 国立医薬品食品衛生研究所長 | アデノウィルスベクター |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
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CN104263703B9 (zh) | 2004-05-26 | 2019-12-17 | 普西奥克瑟斯医疗有限公司 | 用于治疗癌症的嵌合腺病毒 |
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WO2006053871A2 (en) | 2004-11-16 | 2006-05-26 | Crucell Holland B.V. | Multivalent vaccines comprising recombinant viral vectors |
US8574595B2 (en) | 2005-04-11 | 2013-11-05 | Crucell Holland B.V. | Virus purification using ultrafiltration |
ATE463559T1 (de) | 2005-07-22 | 2010-04-15 | Crucell Holland Bv | Zelllinie zur produktion von coronaviren |
US20100143302A1 (en) * | 2006-03-16 | 2010-06-10 | Crucell Holland B.V. | Recombinant Adenoviruses Based on Serotype 26 and 48, and Use Thereof |
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EP2920313B1 (en) | 2012-11-16 | 2019-06-12 | Beth Israel Deaconess Medical Center, Inc. | Recombinant adenoviruses and use thereof |
JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
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EA035504B1 (ru) | 2014-09-03 | 2020-06-25 | Бавариан Нордик А/С | Способы и композиции для индуцирования защитного иммунитета против филовирусной инфекции |
BR112017004202A2 (pt) | 2014-09-03 | 2019-09-03 | Bavarian Nordic As | composições para intensificar respostas imunes e seus usos |
KR101971808B1 (ko) | 2014-09-26 | 2019-04-23 | 베쓰 이스라엘 디코니스 메디칼 센터 인크 | 인간 면역 결핍 바이러스 감염에 대한 방어 면역을 유도하기 위한 방법 및 조성물 |
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JP6735288B2 (ja) | 2015-04-14 | 2020-08-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 双方向性プロモーターを有する2つの導入遺伝子を発現する組換えアデノウイルス |
CN107690479B (zh) | 2015-04-30 | 2022-02-18 | 皮斯奥克斯治疗公司 | 编码b7蛋白质的溶瘤腺病毒 |
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DK3319633T3 (da) | 2015-07-07 | 2021-02-01 | Janssen Vaccines & Prevention Bv | Vaccine mod rsv |
JP6470872B2 (ja) | 2015-08-20 | 2019-02-13 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 治療用hpv18ワクチン |
MA47522B1 (fr) | 2015-12-15 | 2021-11-30 | Janssen Vaccines & Prevention Bv | Antigènes, vecteurs, compositions du virus de l'immunodéficience humaine et leurs procédés d'utilisation |
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