CY1111344T1 - Αερολυματα που περιεχουν νανοσωματιδιακα φαρμακα - Google Patents
Αερολυματα που περιεχουν νανοσωματιδιακα φαρμακαInfo
- Publication number
- CY1111344T1 CY1111344T1 CY20111100300T CY111100300T CY1111344T1 CY 1111344 T1 CY1111344 T1 CY 1111344T1 CY 20111100300 T CY20111100300 T CY 20111100300T CY 111100300 T CY111100300 T CY 111100300T CY 1111344 T1 CY1111344 T1 CY 1111344T1
- Authority
- CY
- Cyprus
- Prior art keywords
- formulations
- aerosol
- containing nanoparticle
- aerosols containing
- methods
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η εφεύρεση αποκαλύπτει υδατικά εναιωρήματα σκευασμάτων νανοσωματιδιακών αερολυμάτων, σκεύασμα νανοσωματιδιακού αερολύματος ξηρής σκόνης, σκευάσματα αερολύματος που βασίζονται σε προωθητικό, μεθόδους χρήσης των σκευασμάτων σε συσκευές χορήγησης αερολυμάτων, και μεθόδους παρασκευής τέτοιων σκευασμάτων. Τα νανοσωματίδια των υδατικών εναιωρημάτων ή σκευασμάτων ξηρής σκόνης αποτελούνται από σωματίδια αδιάλυτου φαρμάκου που έχουν επιφανειακό τροποποιητή πάνω στην επιφάνεια αυτών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/190,138 US7521068B2 (en) | 1998-11-12 | 1998-11-12 | Dry powder aerosols of nanoparticulate drugs |
EP99956981A EP1128814B1 (en) | 1998-11-12 | 1999-11-12 | Aerosols comprising nanoparticle drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111344T1 true CY1111344T1 (el) | 2015-08-05 |
Family
ID=22700162
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100300T CY1111344T1 (el) | 1998-11-12 | 2011-03-21 | Αερολυματα που περιεχουν νανοσωματιδιακα φαρμακα |
CY20121100709T CY1112978T1 (el) | 1998-11-12 | 2012-08-07 | Αερολυματα που περιεχουν νανοσωματιδιακα φαρμακα |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100709T CY1112978T1 (el) | 1998-11-12 | 2012-08-07 | Αερολυματα που περιεχουν νανοσωματιδιακα φαρμακα |
Country Status (12)
Country | Link |
---|---|
US (4) | US7521068B2 (el) |
EP (2) | EP2263652B1 (el) |
JP (1) | JP4758548B2 (el) |
AT (2) | ATE493971T1 (el) |
AU (1) | AU1346900A (el) |
CA (1) | CA2350074C (el) |
CY (2) | CY1111344T1 (el) |
DE (1) | DE69943112D1 (el) |
DK (2) | DK1128814T3 (el) |
ES (2) | ES2359298T3 (el) |
PT (1) | PT2263652E (el) |
WO (1) | WO2000027363A1 (el) |
Families Citing this family (213)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0810853B1 (en) * | 1995-02-24 | 2004-08-25 | Elan Pharma International Limited | Aerosols containing nanoparticle dispersions |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US20080102121A1 (en) * | 1998-11-02 | 2008-05-01 | Elan Pharma International Limited | Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
US6969529B2 (en) | 2000-09-21 | 2005-11-29 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers |
US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
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GB0107106D0 (en) * | 2001-03-21 | 2001-05-09 | Boehringer Ingelheim Pharma | Powder inhaler formulations |
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US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
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-
1998
- 1998-11-12 US US09/190,138 patent/US7521068B2/en not_active Expired - Lifetime
-
1999
- 1999-11-12 ES ES99956981T patent/ES2359298T3/es not_active Expired - Lifetime
- 1999-11-12 DE DE69943112T patent/DE69943112D1/de not_active Expired - Lifetime
- 1999-11-12 CA CA002350074A patent/CA2350074C/en not_active Expired - Fee Related
- 1999-11-12 AU AU13469/00A patent/AU1346900A/en not_active Abandoned
- 1999-11-12 EP EP10179894A patent/EP2263652B1/en not_active Expired - Lifetime
- 1999-11-12 EP EP99956981A patent/EP1128814B1/en not_active Expired - Lifetime
- 1999-11-12 ES ES10179894T patent/ES2387749T3/es not_active Expired - Lifetime
- 1999-11-12 DK DK99956981.7T patent/DK1128814T3/da active
- 1999-11-12 AT AT99956981T patent/ATE493971T1/de active
- 1999-11-12 DK DK10179894.0T patent/DK2263652T3/da active
- 1999-11-12 WO PCT/US1999/026799 patent/WO2000027363A1/en active Application Filing
- 1999-11-12 PT PT10179894T patent/PT2263652E/pt unknown
- 1999-11-12 AT AT10179894T patent/ATE556702T1/de active
- 1999-11-12 JP JP2000580594A patent/JP4758548B2/ja not_active Expired - Fee Related
-
2000
- 2000-06-19 US US09/597,738 patent/US6811767B1/en not_active Expired - Lifetime
-
2009
- 2009-01-26 US US12/320,431 patent/US8124057B2/en not_active Expired - Fee Related
-
2011
- 2011-03-21 CY CY20111100300T patent/CY1111344T1/el unknown
-
2012
- 2012-02-24 US US13/404,790 patent/US20120213829A1/en not_active Abandoned
- 2012-08-07 CY CY20121100709T patent/CY1112978T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2387749T3 (es) | 2012-10-01 |
ATE493971T1 (de) | 2011-01-15 |
EP1128814A1 (en) | 2001-09-05 |
EP1128814B1 (en) | 2011-01-05 |
EP2263652A1 (en) | 2010-12-22 |
CY1112978T1 (el) | 2016-04-13 |
JP4758548B2 (ja) | 2011-08-31 |
US20020102294A1 (en) | 2002-08-01 |
DK1128814T3 (da) | 2011-03-07 |
US20120213829A1 (en) | 2012-08-23 |
DK2263652T3 (da) | 2012-08-20 |
ATE556702T1 (de) | 2012-05-15 |
PT2263652E (pt) | 2012-08-09 |
US6811767B1 (en) | 2004-11-02 |
US20090181100A1 (en) | 2009-07-16 |
US8124057B2 (en) | 2012-02-28 |
WO2000027363A9 (en) | 2000-11-30 |
US7521068B2 (en) | 2009-04-21 |
WO2000027363B1 (en) | 2000-07-13 |
JP2002529396A (ja) | 2002-09-10 |
ES2359298T3 (es) | 2011-05-20 |
CA2350074C (en) | 2004-03-23 |
DE69943112D1 (de) | 2011-02-17 |
WO2000027363A1 (en) | 2000-05-18 |
AU1346900A (en) | 2000-05-29 |
EP2263652B1 (en) | 2012-05-09 |
CA2350074A1 (en) | 2000-05-18 |
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