CY1111272T1 - Αναλυση σακχαρικων εμβολιων χωρις παρεμβολες - Google Patents
Αναλυση σακχαρικων εμβολιων χωρις παρεμβολεςInfo
- Publication number
- CY1111272T1 CY1111272T1 CY20111100075T CY111100075T CY1111272T1 CY 1111272 T1 CY1111272 T1 CY 1111272T1 CY 20111100075 T CY20111100075 T CY 20111100075T CY 111100075 T CY111100075 T CY 111100075T CY 1111272 T1 CY1111272 T1 CY 1111272T1
- Authority
- CY
- Cyprus
- Prior art keywords
- saccharides
- analysis
- glucose
- serological
- serological groups
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 6
- 230000000405 serological effect Effects 0.000 abstract 5
- 150000002772 monosaccharides Chemical group 0.000 abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 3
- 239000008103 glucose Substances 0.000 abstract 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract 2
- 229930182830 galactose Natural products 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 abstract 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- 108010060123 Conjugate Vaccines Proteins 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 229940031670 conjugate vaccine Drugs 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Seasonings (AREA)
Abstract
Η εφεύρεση βασίζεται σε μεθόδους που επιτρέπουν την ανάλυση μικτών σακχαριτών μηνιγγιτιδοκόκκου από πολλαπλές ορολογικές ομάδες ακόμη και αν μοιράζονται μονάδες μονοσακχαριτών. Με ένα συνδυασμό σακχαριτών από τις ορολογικές ομάδες C, W135 και Υ, η εφεύρεση αναλύει περιεκτικότητα σε σιαλικό οξύ, γλυκόζη και γαλακτόζη. Τα αποτελέσματα της γλυκόζης και γαλακτόζης χρησιμοποιούνται για την άμεση ποσοτικοποίηση σακχαριτών από τις ορολογικές ομάδες Υ και W135, αντίστοιχα, και η συνδυασμένη περιεκτικότητα γλυκόζης και γαλακτόζης αφαιρείται από την περιεκτικότητα σιαλικού οξέος για να ποσοτικοποιηθούν οι σακχαρίτες από την ορολογική ομάδα C. Οι τρεις ορολογικές ομάδες μπορούν με αυτόν τον τρόπο να διαχωριστούν αν και οι περιεκτικότητες τους σε μονοσακχαρίτες επικαλύπτονται. Οι τρεις διαφορετικές αναλύσεις μονοσακχαριτών μπορούν να γίνουν στο ίδιο υλικό, χωρίς παρεμβολή μεταξύ των μονοσακχαριτών και χωρίς παρεμβολή από οποιοδήποτε άλλο σακχαρικό υλικό στην σύνθεση (π.χ. σταθεροποιητές λυοφίλησης). Η μέθοδος μπορεί να χρησιμοποιηθεί για την ανάλυση ολικού και ελεύθερου σακχαρίτου σε συζευγμένα εμβόλια και απλοποιεί τον ποιοτικό έλεγχο εμβολίων που περιέχουν καψικούς σακχαρίτες από πολλαπλές ορολογικές ομάδες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0406013.3A GB0406013D0 (en) | 2004-03-17 | 2004-03-17 | Analysis of saccharide vaccines without interference |
EP05718447A EP1725872B8 (en) | 2004-03-17 | 2005-03-17 | Analysis of saccharide vaccines without interference |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111272T1 true CY1111272T1 (el) | 2015-08-05 |
Family
ID=32117883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100075T CY1111272T1 (el) | 2004-03-17 | 2011-01-24 | Αναλυση σακχαρικων εμβολιων χωρις παρεμβολες |
Country Status (19)
Country | Link |
---|---|
US (3) | US8137680B2 (el) |
EP (4) | EP3035056A1 (el) |
JP (2) | JP4692852B2 (el) |
CN (1) | CN1981195B (el) |
AT (2) | ATE487137T1 (el) |
AU (2) | AU2005224459B2 (el) |
BR (1) | BRPI0508890A (el) |
CA (1) | CA2560224C (el) |
CY (1) | CY1111272T1 (el) |
DE (2) | DE602005024523D1 (el) |
ES (1) | ES2353701T3 (el) |
GB (1) | GB0406013D0 (el) |
HK (1) | HK1098192A1 (el) |
NZ (2) | NZ549907A (el) |
PL (1) | PL1725872T3 (el) |
PT (1) | PT1725872E (el) |
RU (1) | RU2371725C2 (el) |
SI (1) | SI1725872T1 (el) |
WO (2) | WO2005090985A1 (el) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
GB0411387D0 (en) * | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
GB0524782D0 (en) * | 2005-12-05 | 2006-01-11 | Chiron Srl | Analysis of samples |
GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
US8797995B2 (en) * | 2007-01-18 | 2014-08-05 | Cisco Technology, Inc. | Device-assisted layer 3 handoff for mobile services |
GB0713880D0 (en) * | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
US8207298B2 (en) * | 2008-05-01 | 2012-06-26 | Archemix Corp. | Methods of separating biopolymer conjugated molecules from unconjugated molecules |
TW201009337A (en) * | 2008-05-30 | 2010-03-01 | Intervet Int Bv | Analytical method to monitor vaccine potency and stability |
US20100098021A1 (en) * | 2008-10-16 | 2010-04-22 | Cisco Technology, Inc. | Policy-driven layer 3 handoff for mobile services |
NZ602249A (en) * | 2010-03-10 | 2014-10-31 | Inovobiologic Inc | Food comprising glucomannan, xanthan gum and alginate for the treatment of metabolic disorders |
RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
MY198910A (en) | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
US10124051B2 (en) | 2012-05-22 | 2018-11-13 | Glaxosmithkline Biologicals Sa | Meningococcus serogroup X conjugate |
CN102735809B (zh) * | 2012-06-29 | 2015-04-29 | 成都欧林生物科技股份有限公司 | 测定Hib结合疫苗中高分子结合物含量的方法 |
EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CA3108739A1 (en) | 2018-08-06 | 2020-02-13 | Nielsen Biosciences, Inc. | Treatment of warts |
KR20220075374A (ko) | 2019-10-01 | 2022-06-08 | 바이오로지칼 이 리미티드 | 탄수화물의 정량화를 위한 방법 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB323103A (en) | 1928-12-07 | 1929-12-24 | Fred Cunningham Firth | Improvements relating to shaper mechanism for winding yarn on weft bobbins in spinning mules |
US4057685A (en) | 1972-02-02 | 1977-11-08 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4459286A (en) | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
US4663160A (en) | 1983-03-14 | 1987-05-05 | Miles Laboratories, Inc. | Vaccines for gram-negative bacteria |
US4761283A (en) | 1983-07-05 | 1988-08-02 | The University Of Rochester | Immunogenic conjugates |
US4808700A (en) | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
JPH01125328A (ja) | 1987-07-30 | 1989-05-17 | Centro Natl De Biopreparados | 髄膜炎菌ワクチン |
NL8802046A (nl) | 1988-08-18 | 1990-03-16 | Gen Electric | Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen. |
DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
CA2006700A1 (en) | 1989-01-17 | 1990-07-17 | Antonello Pessi | Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines |
JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
DE69130136T2 (de) * | 1990-06-21 | 1999-03-11 | Oxford Glycosciences Uk Ltd | Automatisiertes Verfahren zur Spaltung von Biomolekülen |
ATE128628T1 (de) | 1990-08-13 | 1995-10-15 | American Cyanamid Co | Faser-hemagglutinin von bordetella pertussis als träger für konjugierten impfstoff. |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
IL102687A (en) | 1992-07-30 | 1997-06-10 | Yeda Res & Dev | Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them |
PT658118E (pt) | 1992-08-31 | 2002-05-31 | Baxter Healthcare Sa | Vacinas contra neisseria meningitidis do grupo c |
US5425946A (en) | 1992-08-31 | 1995-06-20 | North American Vaccine, Inc. | Vaccines against group C Neisseria meningitidis |
ATE400295T1 (de) | 1995-06-07 | 2008-07-15 | Glaxosmithkline Biolog Sa | Vakzine mit einem polysaccharide antigen- trägerprotein konjugat und freiem trägerprotein |
US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
HUP0100623A3 (en) * | 1997-12-23 | 2003-11-28 | Baxter Healthcare S A Wallisel | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines |
US7018637B2 (en) | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
AU2945199A (en) | 1998-03-18 | 1999-10-11 | Ronai, Peter | Amorphous glasses for stabilising sensitive products |
EP1109576B1 (en) | 1998-08-19 | 2009-10-21 | Baxter Healthcare SA | Immunogenic beta-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide |
EP1880735A3 (en) | 1999-03-19 | 2008-03-12 | GlaxoSmithKline Biologicals S.A. | Vaccine |
FR2791895B1 (fr) | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
JP2002541808A (ja) | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | ポリサッカリド結合体ワクチンのための組換えトキシンaタンパク質キャリア |
DK2289545T3 (en) | 2000-01-17 | 2016-09-05 | Glaxosmithkline Biologicals Sa | Supplemented OMV vaccine against meningococcus |
GB0007432D0 (en) | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
CA2416137C (en) | 2000-07-27 | 2013-01-29 | Dan Granoff | Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
JP2005504718A (ja) * | 2001-01-23 | 2005-02-17 | アヴェンティス パストゥール | 多価髄膜炎菌多糖−タンパク質複合ワクチン |
AU2002309706A1 (en) | 2001-05-11 | 2002-11-25 | Aventis Pasteur, Inc. | Novel meningitis conjugate vaccine |
GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
CN1410532A (zh) * | 2002-03-21 | 2003-04-16 | 上海凡华生物技术有限公司 | 一种人/山羊肝嵌合模型的建立及其鉴定方法 |
MXPA04009339A (es) | 2002-03-26 | 2005-01-25 | Chiron Srl | Sacaridos modificados que tienen estabilidad mejorada en agua. |
JP4061960B2 (ja) | 2002-04-26 | 2008-03-19 | 株式会社日立製作所 | コンピュータシステム |
CN1428434A (zh) * | 2002-11-14 | 2003-07-09 | 中国科学院水生生物研究所 | 一种检测微囊藻产毒的方法 |
BRPI0410341B8 (pt) | 2003-05-07 | 2021-05-25 | Sanofi Pasteur Inc | conjugados de polissacarídeo-proteína derivatizados de meningococos multivalentes e vacina |
CN1819843A (zh) * | 2003-05-07 | 2006-08-16 | 安万特巴斯德公司 | 增强脑膜炎球菌疫苗接种免疫原性的方法 |
CN102023212B (zh) * | 2010-09-28 | 2014-04-02 | 汕头大学医学院 | 一种流感病毒神经氨酸酶抗体的快速检测方法 |
-
2004
- 2004-03-17 GB GBGB0406013.3A patent/GB0406013D0/en not_active Ceased
-
2005
- 2005-03-17 ES ES05718447T patent/ES2353701T3/es active Active
- 2005-03-17 BR BRPI0508890-9A patent/BRPI0508890A/pt not_active IP Right Cessation
- 2005-03-17 NZ NZ549907A patent/NZ549907A/en not_active IP Right Cessation
- 2005-03-17 US US10/593,005 patent/US8137680B2/en not_active Expired - Fee Related
- 2005-03-17 PL PL05718447T patent/PL1725872T3/pl unknown
- 2005-03-17 PT PT05718447T patent/PT1725872E/pt unknown
- 2005-03-17 CA CA2560224A patent/CA2560224C/en not_active Expired - Fee Related
- 2005-03-17 EP EP15192029.5A patent/EP3035056A1/en not_active Withdrawn
- 2005-03-17 DE DE602005024523T patent/DE602005024523D1/de active Active
- 2005-03-17 EP EP05718410A patent/EP1725871B8/en not_active Revoked
- 2005-03-17 DE DE602005026635T patent/DE602005026635D1/de active Active
- 2005-03-17 SI SI200531221T patent/SI1725872T1/sl unknown
- 2005-03-17 JP JP2007503446A patent/JP4692852B2/ja not_active Expired - Fee Related
- 2005-03-17 EP EP10179759A patent/EP2290366A1/en not_active Withdrawn
- 2005-03-17 AU AU2005224459A patent/AU2005224459B2/en not_active Ceased
- 2005-03-17 RU RU2006136270/15A patent/RU2371725C2/ru not_active IP Right Cessation
- 2005-03-17 WO PCT/IB2005/000946 patent/WO2005090985A1/en active Application Filing
- 2005-03-17 EP EP05718447A patent/EP1725872B8/en not_active Not-in-force
- 2005-03-17 US US10/593,006 patent/US20080305126A1/en not_active Abandoned
- 2005-03-17 AT AT05718447T patent/ATE487137T1/de active
- 2005-03-17 NZ NZ570193A patent/NZ570193A/en not_active IP Right Cessation
- 2005-03-17 CN CN200580015039XA patent/CN1981195B/zh not_active Expired - Fee Related
- 2005-03-17 AT AT05718410T patent/ATE500510T1/de active
- 2005-03-17 WO PCT/IB2005/000987 patent/WO2005090986A2/en active Application Filing
-
2007
- 2007-05-28 HK HK07105566.6A patent/HK1098192A1/xx not_active IP Right Cessation
-
2010
- 2010-08-18 JP JP2010183515A patent/JP2011013226A/ja not_active Withdrawn
-
2011
- 2011-01-24 CY CY20111100075T patent/CY1111272T1/el unknown
- 2011-03-03 AU AU2011200950A patent/AU2011200950A1/en not_active Abandoned
-
2012
- 2012-03-12 US US13/418,211 patent/US20120171241A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1111272T1 (el) | Αναλυση σακχαρικων εμβολιων χωρις παρεμβολες | |
Bensing et al. | Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins | |
Purmohamad et al. | Global estimate of Neisseria meningitidis serogroups proportion in invasive meningococcal disease: a systematic review and meta-analysis | |
Cohen et al. | Modulation of glycan recognition by clustered saccharide patches | |
Park et al. | Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis | |
Zhu et al. | Engineering and dissecting the glycosylation pathway of a streptococcal serine-rich repeat adhesin | |
Bröker et al. | Meningococcal serogroup Y disease in Europe: continuation of high importance in some European regions in 2013 | |
NO20076343L (no) | Immunogen sammensetning | |
Cody et al. | High rates of recombination in otitis media isolates of non-typeable Haemophilus influenzae | |
Salemi | The intra-host evolutionary and population dynamics of human immunodeficiency virus type 1: a phylogenetic perspective | |
Heikema et al. | Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oculomotor weakness in Guillain–Barré syndrome and Miller Fisher syndrome | |
Li et al. | Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses | |
Southern et al. | Immunogenicity of one, two or three doses of a meningococcal C conjugate vaccine conjugated to tetanus toxoid, given as a three-dose primary vaccination course in UK infants at 2, 3 and 4 months of age with acellular pertussis-containing DTP/Hib vaccine | |
MA32018B1 (fr) | Vaccin | |
Azzari et al. | Evolving role of 13-valent pneumococcal conjugate vaccine in clinical practice | |
Gamougam et al. | Continuing effectiveness of serogroup A meningococcal conjugate vaccine, Chad, 2013 | |
Lockwood et al. | Release of polypeptide chain initiation factor IF-2 during initiation complex formation | |
Schweizer | When it comes to drug discovery not all Gram‐negative bacterial biodefence pathogens are created equal: Burkholderia pseudomallei is different | |
Calzas et al. | Evaluation of the immunomodulatory properties of Streptococcus suis and Group B Streptococcus capsular polysaccharides on the humoral response | |
Tullius et al. | The lbgAB gene cluster of Haemophilus ducreyi encodes a β-1, 4-galactosyltransferase and an α-1, 6-dd-heptosyltransferase involved in lipooligosaccharide biosynthesis | |
Rinaldi et al. | Ganglioside antibodies and neuropathies | |
Takahashi et al. | The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity | |
Nakamura et al. | Binding properties of Clostridium botulinum type C progenitor toxin to mucins | |
Heo | Meningococcal disease in Korea: An epidemiologic study of the underestimated infectious disease | |
Matthews et al. | Evaluation of cefixime in the treatment of bacterial maxillary sinusitis. |