CY1109340T1 - Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη - Google Patents
Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερηInfo
- Publication number
- CY1109340T1 CY1109340T1 CY20091100919T CY091100919T CY1109340T1 CY 1109340 T1 CY1109340 T1 CY 1109340T1 CY 20091100919 T CY20091100919 T CY 20091100919T CY 091100919 T CY091100919 T CY 091100919T CY 1109340 T1 CY1109340 T1 CY 1109340T1
- Authority
- CY
- Cyprus
- Prior art keywords
- bcl
- present
- oligomer
- disorder
- treatment
- Prior art date
Links
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 title abstract 9
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 title abstract 9
- 230000000692 anti-sense effect Effects 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 239000012830 cancer therapeutic Substances 0.000 abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22797000P | 2000-08-25 | 2000-08-25 | |
| US23700900P | 2000-09-29 | 2000-09-29 | |
| US09/709,170 US7795232B1 (en) | 2000-08-25 | 2000-11-10 | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| EP01968097A EP1313514B1 (en) | 2000-08-25 | 2001-08-23 | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1109340T1 true CY1109340T1 (el) | 2014-07-02 |
Family
ID=27397795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100919T CY1109340T1 (el) | 2000-08-25 | 2009-09-02 | Μεθοδοι θεραπειας bcl-2 διαταραχης χρησιμοποιωντας bcl-2 αντιπληροφοριακα ολιγομερη |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7795232B1 (https=) |
| EP (2) | EP1313514B1 (https=) |
| JP (1) | JP2004507480A (https=) |
| KR (1) | KR20030034153A (https=) |
| CN (1) | CN1471408A (https=) |
| AP (1) | AP2003002761A0 (https=) |
| AT (1) | ATE432717T1 (https=) |
| AU (2) | AU2001288373B2 (https=) |
| BG (1) | BG107641A (https=) |
| BR (1) | BR0113447A (https=) |
| CA (1) | CA2419480A1 (https=) |
| CY (1) | CY1109340T1 (https=) |
| CZ (1) | CZ301582B6 (https=) |
| DE (1) | DE60138892D1 (https=) |
| DK (1) | DK1313514T3 (https=) |
| DZ (1) | DZ3471A1 (https=) |
| EA (1) | EA005424B1 (https=) |
| EE (1) | EE200300074A (https=) |
| ES (1) | ES2327904T3 (https=) |
| GE (1) | GEP20063934B (https=) |
| HR (1) | HRP20030102A2 (https=) |
| HU (1) | HUP0303125A2 (https=) |
| IL (1) | IL154409A0 (https=) |
| MX (1) | MXPA03001575A (https=) |
| NO (1) | NO20030858L (https=) |
| OA (1) | OA12586A (https=) |
| PL (1) | PL363050A1 (https=) |
| PT (1) | PT1313514E (https=) |
| SK (1) | SK3652003A3 (https=) |
| UA (1) | UA77945C2 (https=) |
| WO (1) | WO2002017852A2 (https=) |
| YU (1) | YU13603A (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5855911A (en) | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| US7309692B1 (en) | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
| US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| CA2992643C (en) | 2002-03-13 | 2019-06-18 | Genomic Health, Inc. | Gene expression profiling in biopsied tumor tissues |
| EP1572970A4 (en) * | 2002-11-14 | 2006-11-15 | Genta Salus Llc | OLIOGONUCLEOTIDES INHIBITORS DIRECTED ON BCL-2 |
| AU2003295598B2 (en) | 2002-11-15 | 2009-12-24 | Genomic Health, Inc. | Gene expression profiling of EGFR positive cancer |
| DE10258677A1 (de) * | 2002-12-13 | 2004-06-24 | Elez, Vera, Dr. | Kombinations-antisense-Oligonukleotid-Krebstherapie |
| US20040231909A1 (en) | 2003-01-15 | 2004-11-25 | Tai-Yang Luh | Motorized vehicle having forward and backward differential structure |
| CA2516553C (en) | 2003-02-20 | 2013-04-16 | Genomic Health, Inc. | Use of intronic rna to measure gene expression |
| EP1640452A4 (en) | 2003-05-30 | 2009-12-23 | Nippon Shinyaku Co Ltd | OLIGOBICATENARY RNA INHIBITING BCL-2 EXPRESSION AND MEDICINAL COMPOSITION CONTAINING THE SAME |
| ES2609234T3 (es) | 2003-06-24 | 2017-04-19 | Genomic Health, Inc. | Predicción de la probabilidad de recidiva de cáncer |
| US7526387B2 (en) | 2003-07-10 | 2009-04-28 | Genomic Health, Inc. | Expression profile algorithm and test for cancer prognosis |
| CA2551267C (en) | 2003-12-23 | 2012-05-01 | Genomic Health, Inc. | Universal amplification of fragmented rna |
| GB0406415D0 (en) * | 2004-03-22 | 2004-04-21 | Inst Of Cancer Res The | Materials and methods for treatment of cancer |
| CA2563074C (en) | 2004-04-09 | 2014-05-20 | Genomic Health, Inc. | Gene expression markers for predicting response to chemotherapy |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| AU2013203202B2 (en) * | 2004-08-26 | 2017-02-16 | Engeneic Molecular Delivery Pty Ltd | Delivering functional nucleic acids to mammalian cells via bacterially derived intact minicells |
| EP2386640B1 (en) | 2004-08-26 | 2015-01-28 | EnGeneIC Molecular Delivery Pty Ltd | Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells |
| JP5020088B2 (ja) | 2004-11-05 | 2012-09-05 | ジェノミック ヘルス， インコーポレイテッド | 遺伝子発現マーカーを使用する、化学療法に対する反応の予測 |
| EP1815014B1 (en) | 2004-11-05 | 2012-03-21 | Genomic Health, Inc. | Molecular indicators of breast cancer prognosis and prediction of treatment response |
| CA2631677C (en) * | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| TWI403320B (zh) | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法 |
| CN100368424C (zh) * | 2006-07-21 | 2008-02-13 | 福建金山生物制药股份有限公司 | 抑制肿瘤的反义核苷酸 |
| US20080171718A1 (en) * | 2006-11-08 | 2008-07-17 | Brown Bob D | Methods and Compositions for Treating Cancer Using BCL-2 Antisense Oligomers, Tyrosine Kinase Inhibitors, and Chemotherapeutic Agents |
| DE102007020554A1 (de) * | 2007-04-27 | 2008-10-30 | Henkel Ag & Co. Kgaa | Nukleinsäurehaltige kosmetische und/oder pharmazeutische Zubereitungen zur Behandlung epithelialen Deckgewebes |
| US20090098118A1 (en) | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| WO2009071681A2 (en) * | 2007-12-07 | 2009-06-11 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of bcl-2 |
| JP2012509878A (ja) * | 2008-11-21 | 2012-04-26 | アイシス ファーマシューティカルズ， インコーポレーテッド | ドセタキセルおよびアンチセンスオリゴヌクレオチドを含む、抗腫瘍併用療法 |
| AU2010277554B2 (en) | 2009-07-30 | 2015-02-19 | Antisense Pharma Gmbh | Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system |
| KR101853509B1 (ko) * | 2010-01-06 | 2018-04-30 | 큐알엔에이, 인크. | 췌장 발달 유전자에 대한 천연 안티센스 전사체의 억제에 의한 췌장 발달 유전자와 관련된 질환의 치료 |
| KR20240129101A (ko) * | 2015-07-07 | 2024-08-27 | 제넨테크, 인크. | 항-her2 항체-약물 접합체 및 bcl-2 억제제를 사용한 병용 요법 |
| ES2965461T3 (es) | 2015-08-03 | 2024-04-15 | Biokine Therapeutics Ltd | Inhibidor de CXCR4 para el tratamiento del cáncer |
| CN115515686A (zh) * | 2020-03-18 | 2022-12-23 | 纽约州州立大学研究基金会 | 修饰的短干扰rna组合物及其在癌症治疗中的用途 |
| WO2021231486A1 (en) * | 2020-05-13 | 2021-11-18 | Unity Biotechnology, Inc. | Cancer treatment by senescence induction followed by a senolytic |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5015568A (en) | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
| US5202429A (en) | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5098890A (en) | 1988-11-07 | 1992-03-24 | Temple University-Of The Commonwealth System Of Higher Education | Antisence oligonucleotides to c-myb proto-oncogene and uses thereof |
| US5831066A (en) | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US5734033A (en) | 1988-12-22 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Antisense oligonucleotides inhibiting human bcl-2 gene expression |
| CA2025907A1 (en) | 1989-09-21 | 1991-03-22 | Franklin D. Collins | Method of transporting compositions across the blood brain barrier |
| EP0633934A1 (en) | 1992-04-02 | 1995-01-18 | Imperial Cancer Research Technology Limited | Modified cells and method of treatment |
| JPH08506087A (ja) | 1992-10-21 | 1996-07-02 | テンプル ユニバーシティ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | ガン処置のための抗腫瘍薬とアンチセンスオリゴヌクレオチドの組み合わせ |
| US5550019A (en) | 1993-05-26 | 1996-08-27 | La Jolla Cancer Research Foundation | Methods of identifying compounds which alter apoptosis |
| US5783683A (en) * | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
| US6214986B1 (en) * | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
-
2000
- 2000-11-10 US US09/709,170 patent/US7795232B1/en not_active Expired - Fee Related
-
2001
- 2001-08-23 UA UA2003032532A patent/UA77945C2/uk unknown
- 2001-08-23 DK DK01968097T patent/DK1313514T3/da active
- 2001-08-23 WO PCT/US2001/026414 patent/WO2002017852A2/en not_active Ceased
- 2001-08-23 ES ES01968097T patent/ES2327904T3/es not_active Expired - Lifetime
- 2001-08-23 PL PL01363050A patent/PL363050A1/xx not_active IP Right Cessation
- 2001-08-23 DZ DZ013471A patent/DZ3471A1/fr active
- 2001-08-23 JP JP2002522827A patent/JP2004507480A/ja not_active Withdrawn
- 2001-08-23 OA OA1200300058A patent/OA12586A/en unknown
- 2001-08-23 MX MXPA03001575A patent/MXPA03001575A/es active IP Right Grant
- 2001-08-23 AU AU2001288373A patent/AU2001288373B2/en not_active Ceased
- 2001-08-23 AT AT01968097T patent/ATE432717T1/de active
- 2001-08-23 CZ CZ20030848A patent/CZ301582B6/cs not_active IP Right Cessation
- 2001-08-23 EA EA200300294A patent/EA005424B1/ru not_active IP Right Cessation
- 2001-08-23 EE EEP200300074A patent/EE200300074A/xx unknown
- 2001-08-23 PT PT01968097T patent/PT1313514E/pt unknown
- 2001-08-23 BR BR0113447-7A patent/BR0113447A/pt not_active IP Right Cessation
- 2001-08-23 KR KR10-2003-7002605A patent/KR20030034153A/ko not_active Ceased
- 2001-08-23 AP APAP/P/2003/002761A patent/AP2003002761A0/en unknown
- 2001-08-23 HR HR20030102A patent/HRP20030102A2/hr not_active Application Discontinuation
- 2001-08-23 EP EP01968097A patent/EP1313514B1/en not_active Expired - Lifetime
- 2001-08-23 IL IL15440901A patent/IL154409A0/xx unknown
- 2001-08-23 AU AU8837301A patent/AU8837301A/xx active Pending
- 2001-08-23 CN CNA018177107A patent/CN1471408A/zh active Pending
- 2001-08-23 SK SK365-2003A patent/SK3652003A3/sk unknown
- 2001-08-23 CA CA002419480A patent/CA2419480A1/en not_active Abandoned
- 2001-08-23 YU YU13603A patent/YU13603A/sh unknown
- 2001-08-23 DE DE60138892T patent/DE60138892D1/de not_active Expired - Lifetime
- 2001-08-23 GE GE5129A patent/GEP20063934B/en unknown
- 2001-08-23 EP EP09007273A patent/EP2135623A1/en not_active Withdrawn
- 2001-08-23 HU HU0303125A patent/HUP0303125A2/hu unknown
-
2003
- 2003-02-24 NO NO20030858A patent/NO20030858L/no unknown
- 2003-03-18 BG BG107641A patent/BG107641A/bg unknown
-
2009
- 2009-09-02 CY CY20091100919T patent/CY1109340T1/el unknown
-
2010
- 2010-04-02 US US12/753,285 patent/US20100216867A1/en not_active Abandoned
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