CY1108286T1 - Παραγωγα [1,4]διαζεπινο[6,7,1-ij]κινολινης ως αντιψυχωτικοι και κατα της παχυσαρκιας παραγοντες - Google Patents

Παραγωγα [1,4]διαζεπινο[6,7,1-ij]κινολινης ως αντιψυχωτικοι και κατα της παχυσαρκιας παραγοντες

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Publication number
CY1108286T1
CY1108286T1 CY20081100902T CY081100902T CY1108286T1 CY 1108286 T1 CY1108286 T1 CY 1108286T1 CY 20081100902 T CY20081100902 T CY 20081100902T CY 081100902 T CY081100902 T CY 081100902T CY 1108286 T1 CY1108286 T1 CY 1108286T1
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CY
Cyprus
Prior art keywords
kinolin
diazepino
deficit
products
obstacle factors
Prior art date
Application number
CY20081100902T
Other languages
English (en)
Inventor
Sivaramakrishnan P Ramamoorthy
Usa
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wyeth filed Critical Wyeth
Publication of CY1108286T1 publication Critical patent/CY1108286T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ενώσεις του τύπου 1 ή φαρμακευτικώς αποδεκτό άλας αυτών παρέχονται: Ι όπου το R1 έως R7 ορίζονται εδώ. Οι ενώσεις του τύπου Ι είναι 5HT2c αγωνιστές ή μερικοί αγωνιστές και είναι χρήσιμες για θεραπεία ποικιλίας διαταραχών.
CY20081100902T 2002-04-25 2008-08-25 Παραγωγα [1,4]διαζεπινο[6,7,1-ij]κινολινης ως αντιψυχωτικοι και κατα της παχυσαρκιας παραγοντες CY1108286T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37559202P 2002-04-25 2002-04-25
EP03728523A EP1497293B1 (en) 2002-04-25 2003-04-24 (1,4)diazepino(6,7,1-ij)quinoline derivatives as anti psychotic and antiobesity agents

Publications (1)

Publication Number Publication Date
CY1108286T1 true CY1108286T1 (el) 2014-02-12

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CY20081100902T CY1108286T1 (el) 2002-04-25 2008-08-25 Παραγωγα [1,4]διαζεπινο[6,7,1-ij]κινολινης ως αντιψυχωτικοι και κατα της παχυσαρκιας παραγοντες

Country Status (28)

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US (2) US7129237B2 (el)
EP (1) EP1497293B1 (el)
JP (1) JP4537075B2 (el)
KR (1) KR101009269B1 (el)
CN (2) CN100376575C (el)
AR (1) AR039669A1 (el)
AT (1) ATE398127T1 (el)
AU (1) AU2003234213C1 (el)
BR (1) BR0309664A (el)
CA (1) CA2481321C (el)
CR (1) CR7510A (el)
CY (1) CY1108286T1 (el)
DE (1) DE60321559D1 (el)
DK (1) DK1497293T3 (el)
EC (1) ECSP045379A (el)
ES (1) ES2307937T3 (el)
HK (1) HK1069388A1 (el)
IL (1) IL164806A0 (el)
MX (1) MXPA04010372A (el)
NO (1) NO329505B1 (el)
NZ (1) NZ536115A (el)
PT (1) PT1497293E (el)
RU (1) RU2312866C2 (el)
SI (1) SI1497293T1 (el)
TW (1) TWI312781B (el)
UA (1) UA79782C2 (el)
WO (1) WO2003091250A1 (el)
ZA (1) ZA200409501B (el)

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PT1497293E (pt) 2008-09-05
US7129237B2 (en) 2006-10-31
AR039669A1 (es) 2005-03-02
TWI312781B (en) 2009-08-01
HK1069388A1 (en) 2005-05-20
RU2312866C2 (ru) 2007-12-20
AU2003234213C1 (en) 2010-05-20
JP4537075B2 (ja) 2010-09-01
DE60321559D1 (de) 2008-07-24
CN1662533A (zh) 2005-08-31
KR20050000405A (ko) 2005-01-03
CN1955179B (zh) 2010-07-14
ZA200409501B (en) 2007-04-25
AU2003234213A1 (en) 2003-11-10
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NO20044501L (no) 2005-01-18
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US7687620B2 (en) 2010-03-30
CR7510A (es) 2008-07-29
CN1955179A (zh) 2007-05-02
AU2003234213B2 (en) 2009-11-12
MXPA04010372A (es) 2005-02-03
KR101009269B1 (ko) 2011-01-18
US20070004707A1 (en) 2007-01-04
CA2481321C (en) 2012-01-03
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DK1497293T3 (da) 2008-09-15
WO2003091250A1 (en) 2003-11-06
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EP1497293A1 (en) 2005-01-19
RU2004134361A (ru) 2005-05-10
IL164806A0 (en) 2005-12-18
US20040009970A1 (en) 2004-01-15
SI1497293T1 (sl) 2008-10-31
BR0309664A (pt) 2005-02-22
UA79782C2 (en) 2007-07-25
ATE398127T1 (de) 2008-07-15
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