CY1107221T1 - Παραγωγα τριαζολιου ως ανταγωνιστες υποδοχεα ταχυκινινης - Google Patents
Παραγωγα τριαζολιου ως ανταγωνιστες υποδοχεα ταχυκινινηςInfo
- Publication number
- CY1107221T1 CY1107221T1 CY20081100235T CY081100235T CY1107221T1 CY 1107221 T1 CY1107221 T1 CY 1107221T1 CY 20081100235 T CY20081100235 T CY 20081100235T CY 081100235 T CY081100235 T CY 081100235T CY 1107221 T1 CY1107221 T1 CY 1107221T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tachykinini
- competitives
- triazoli
- receptors
- products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37612102P | 2002-04-26 | 2002-04-26 | |
| EP03723929A EP1501809B1 (en) | 2002-04-26 | 2003-04-22 | Triazole derivatives as tachykinin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107221T1 true CY1107221T1 (el) | 2012-11-21 |
Family
ID=29270766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100235T CY1107221T1 (el) | 2002-04-26 | 2008-02-28 | Παραγωγα τριαζολιου ως ανταγωνιστες υποδοχεα ταχυκινινης |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7320994B2 (enExample) |
| EP (1) | EP1501809B1 (enExample) |
| JP (1) | JP4559087B2 (enExample) |
| KR (1) | KR100755577B1 (enExample) |
| CN (1) | CN1312136C (enExample) |
| AR (1) | AR039329A1 (enExample) |
| AT (1) | ATE384053T1 (enExample) |
| AU (1) | AU2003230829B8 (enExample) |
| BR (1) | BRPI0309534B8 (enExample) |
| CA (1) | CA2483159C (enExample) |
| CR (1) | CR7548A (enExample) |
| CY (1) | CY1107221T1 (enExample) |
| DE (1) | DE60318697T2 (enExample) |
| DK (1) | DK1501809T3 (enExample) |
| EA (1) | EA007720B1 (enExample) |
| EC (1) | ECSP045391A (enExample) |
| ES (1) | ES2298513T3 (enExample) |
| HR (1) | HRP20041008B1 (enExample) |
| IL (2) | IL164675A0 (enExample) |
| MX (1) | MXPA04010622A (enExample) |
| MY (1) | MY141559A (enExample) |
| NO (1) | NO333647B1 (enExample) |
| NZ (1) | NZ535886A (enExample) |
| PE (1) | PE20040600A1 (enExample) |
| PL (1) | PL212090B1 (enExample) |
| PT (1) | PT1501809E (enExample) |
| TW (1) | TWI265807B (enExample) |
| UA (1) | UA79113C2 (enExample) |
| WO (1) | WO2003091226A1 (enExample) |
| ZA (1) | ZA200408670B (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| EP1638944A1 (en) * | 2003-06-12 | 2006-03-29 | Eli Lilly And Company | Tachykinin receptor antagonists |
| HRP20100207T1 (hr) * | 2003-10-24 | 2010-05-31 | Eli Lilly And Company | Novi kristalni oblici {2-[1-(3,5-bistrifluormetilbenzil)-5-piridin-4-il-1h-[1,2,3]triazol-4-il]piridin-3-il}(2-klorfenil)metanona |
| CA2581623A1 (en) | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
| WO2006083711A1 (en) * | 2005-02-01 | 2006-08-10 | Eli Lilly And Company | Tachykinin receptor antagonists |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| JP5147109B2 (ja) * | 2005-06-07 | 2013-02-20 | 塩野義製薬株式会社 | Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
| JP4860696B2 (ja) * | 2005-07-25 | 2012-01-25 | エフ．ホフマン−ラ ロシュ アーゲー | 置換トリアゾール誘導体及びそのニューロキニン３レセプターアンタゴニストとしての使用 |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| US20100305095A1 (en) * | 2006-08-18 | 2010-12-02 | Kim Zachary Travis | Use of HPPD Inhibitors in the Treatment of Depression and/or Withdrawal Symptoms Associated with Addictive Drugs |
| EP2065377B1 (en) | 2006-09-21 | 2011-11-23 | Eisai R&D Management Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| DK2121610T3 (da) * | 2006-12-20 | 2014-06-30 | Lilly Co Eli | Hidtil ukendt mellemprodukt og fremgangsmåde, som er anvendelige ved fremstilling af {2-[1-(3,5-bis-trifluormethyl-benzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorphenyl)-methanon |
| AU2008285644A1 (en) * | 2007-08-08 | 2009-02-12 | Neurosearch A/S | Novel 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
| GB0722077D0 (en) * | 2007-11-09 | 2007-12-19 | Smithkline Beecham Corp | Compounds |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| MX2010013920A (es) * | 2008-06-26 | 2011-02-21 | Amgen Inc | Alcoholes alquinilicos como inhibidores de cinasas. |
| GB0823002D0 (en) * | 2008-12-17 | 2009-01-28 | Syngenta Participations Ag | Isoxazoles derivatives with plant growth regulating properties |
| US9782397B2 (en) | 2011-07-04 | 2017-10-10 | Irbm Science Park S.P.A. | Treatment of corneal neovascularization |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| CN113262221A (zh) * | 2015-03-04 | 2021-08-17 | 万达制药公司 | 使用川地匹坦的治疗方法 |
| US10287287B2 (en) | 2015-08-17 | 2019-05-14 | Eli Lilly And Company | Process development of a pyridine-containing NK-1 receptor antagonist |
| HUE049918T2 (hu) | 2016-05-31 | 2020-11-30 | Kalvista Pharmaceuticals Ltd | Pirazol-származékok mint plazma kallikrein inhibitorok |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| EP4487912A3 (en) | 2017-09-13 | 2025-03-26 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| DK3710000T3 (da) * | 2017-11-17 | 2025-06-16 | Vanda Pharmaceuticals Inc | Tradipitant til anvendelse til behandling af gastroparese |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| SI3716952T1 (sl) | 2017-11-29 | 2022-04-29 | Kalvista Pharmaceuticals Limited | Farmacevtske oblike, ki obsegajo zaviralec plazemskega kalikreina |
| EP3758688B1 (en) | 2018-02-26 | 2024-03-27 | Ospedale San Raffaele S.r.l. | Nk-1 antagonists for use in the treatment of ocular pain |
| BR112020024906A2 (pt) * | 2018-06-08 | 2021-03-09 | Vanda Pharmaceuticals Inc. | Métodos para tratar um indivíduo que está sofrendo ou está em risco de sofrer uma consequência indesejada de uso de opioides e uma ânsia por um opioide, e, tradipitant para uso no tratamento de um indivíduo que está sofrendo ou está em risco de sofrer uma consequência indesejada de uso de opioides. |
| US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| CA3089238A1 (en) * | 2018-09-28 | 2020-04-02 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| EP3890735A1 (en) | 2018-12-03 | 2021-10-13 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| WO2020132513A1 (en) | 2018-12-21 | 2020-06-25 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| CN114206852A (zh) | 2019-08-09 | 2022-03-18 | 卡尔维斯塔制药有限公司 | 血浆激肽释放酶抑制剂 |
| US20230226046A1 (en) | 2020-02-25 | 2023-07-20 | Vanda Pharmaceuticals Inc. | Improved treatment of atopic dermatitis with tradipitant |
| US20230134843A1 (en) | 2020-03-11 | 2023-05-04 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
| WO2021195205A1 (en) | 2020-03-26 | 2021-09-30 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| AU2021246889A1 (en) | 2020-04-03 | 2022-10-13 | Nerre Therapeutics Limited | An NK-1 receptor antagonist for treating a disease selecting from sepsis, septic shock,, acute respiratory distress syndrome (ARDS) or multiple organ dysfunction syndrome (MODS) |
| CN113563306B (zh) * | 2020-04-28 | 2022-07-01 | 新发药业有限公司 | 一种2-(4-苯氧基苯基)-6-(哌啶-4-)基烟酰胺的制备方法 |
| IL298589A (en) | 2020-06-02 | 2023-01-01 | Nerre Therapeutics Ltd | Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs |
| CN111662235B (zh) * | 2020-06-23 | 2023-12-22 | 黄淮学院 | 一种苯甲酰基哒嗪衍生物及其制备方法 |
| WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| US20240350469A1 (en) | 2021-08-31 | 2024-10-24 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| AU2023413130A1 (en) | 2022-12-21 | 2025-06-05 | Vanda Pharmaceuticals Inc. | Methods of treatment with tradipitant |
| CN116082253B (zh) * | 2023-02-25 | 2025-04-25 | 浙大城市学院 | 一种1-n-取代的1,2,3-三唑-4-甲酰胺衍生物及其制备方法 |
| WO2024223617A1 (en) * | 2023-04-24 | 2024-10-31 | Fundamental Pharma Gmbh | Effective means to modulate nmda receptor-mediated toxicity |
| US20250255855A1 (en) | 2024-02-09 | 2025-08-14 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL50699A0 (en) | 1975-10-28 | 1976-12-31 | Ici America Inc | Triazole derivatives |
| AU7947594A (en) * | 1993-10-27 | 1995-05-22 | Merck Sharp & Dohme Limited | Substituted amides as tachykinin antagonists |
| US6175013B1 (en) * | 1994-06-10 | 2001-01-16 | Eli Lilly And Company | Imidazolinyl tachykinin receptor antagonists |
| US5998444A (en) * | 1995-10-24 | 1999-12-07 | Zeneca Ltd. | Piperidinyl compounds as NK1 or NK2 antagonists |
| WO1997040025A1 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles |
| DK0915880T3 (da) * | 1996-07-24 | 2008-02-11 | Bristol Myers Squibb Pharma Co | Azolotriaziner og pyrimidiner |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| HUP0002929A3 (en) | 1997-08-06 | 2002-01-28 | Lilly Co Eli | 2-acylaminopropanamines as tachykinin receptor antagonists and pharmaceutical compositions containing the same |
| JP2003522739A (ja) * | 1999-12-17 | 2003-07-29 | シェーリング コーポレイション | 選択的ニューロキニンアンタゴニスト |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| DE10036818A1 (de) * | 2000-07-28 | 2002-02-07 | Solvay Pharm Gmbh | Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten |
| JP2002123925A (ja) | 2000-10-13 | 2002-04-26 | Fuji Photo Film Co Ltd | 磁気記録媒体 |
| EP1501808B1 (en) * | 2002-04-26 | 2008-07-02 | Eli Lilly And Company | Tachykinin receptor antagonists |
-
2003
- 2003-04-22 AT AT03723929T patent/ATE384053T1/de active
- 2003-04-22 PL PL373504A patent/PL212090B1/pl unknown
- 2003-04-22 HR HRP20041008AA patent/HRP20041008B1/hr not_active IP Right Cessation
- 2003-04-22 NZ NZ535886A patent/NZ535886A/en not_active IP Right Cessation
- 2003-04-22 WO PCT/US2003/010681 patent/WO2003091226A1/en not_active Ceased
- 2003-04-22 AU AU2003230829A patent/AU2003230829B8/en not_active Expired
- 2003-04-22 AR ARP030101377A patent/AR039329A1/es unknown
- 2003-04-22 ES ES03723929T patent/ES2298513T3/es not_active Expired - Lifetime
- 2003-04-22 TW TW092109375A patent/TWI265807B/zh not_active IP Right Cessation
- 2003-04-22 BR BRPI0309534A patent/BRPI0309534B8/pt not_active IP Right Cessation
- 2003-04-22 CA CA2483159A patent/CA2483159C/en not_active Expired - Lifetime
- 2003-04-22 MY MYPI20031515A patent/MY141559A/en unknown
- 2003-04-22 MX MXPA04010622A patent/MXPA04010622A/es active IP Right Grant
- 2003-04-22 PE PE2003000400A patent/PE20040600A1/es not_active Application Discontinuation
- 2003-04-22 EA EA200401431A patent/EA007720B1/ru not_active IP Right Cessation
- 2003-04-22 DE DE60318697T patent/DE60318697T2/de not_active Expired - Lifetime
- 2003-04-22 JP JP2003587786A patent/JP4559087B2/ja not_active Expired - Lifetime
- 2003-04-22 KR KR1020047017206A patent/KR100755577B1/ko not_active Expired - Lifetime
- 2003-04-22 DK DK03723929T patent/DK1501809T3/da active
- 2003-04-22 PT PT03723929T patent/PT1501809E/pt unknown
- 2003-04-22 US US10/512,249 patent/US7320994B2/en not_active Expired - Lifetime
- 2003-04-22 UA UA20041008646A patent/UA79113C2/uk unknown
- 2003-04-22 CN CNB038091046A patent/CN1312136C/zh not_active Expired - Lifetime
- 2003-04-22 EP EP03723929A patent/EP1501809B1/en not_active Expired - Lifetime
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2004
- 2004-10-18 IL IL16467504A patent/IL164675A0/xx not_active IP Right Cessation
- 2004-10-25 CR CR7548A patent/CR7548A/es unknown
- 2004-10-26 ZA ZA200408670A patent/ZA200408670B/xx unknown
- 2004-10-26 EC EC2004005391A patent/ECSP045391A/es unknown
- 2004-11-24 NO NO20045120A patent/NO333647B1/no not_active IP Right Cessation
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2008
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2009
- 2009-04-07 IL IL198122A patent/IL198122A0/en unknown
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