CY1105829T1 - Αρυλο-βορονικα οξεα, δια νοσηλειαν παχυσαρκιας - Google Patents

Αρυλο-βορονικα οξεα, δια νοσηλειαν παχυσαρκιας

Info

Publication number
CY1105829T1
CY1105829T1 CY20061101748T CY061101748T CY1105829T1 CY 1105829 T1 CY1105829 T1 CY 1105829T1 CY 20061101748 T CY20061101748 T CY 20061101748T CY 061101748 T CY061101748 T CY 061101748T CY 1105829 T1 CY1105829 T1 CY 1105829T1
Authority
CY
Cyprus
Prior art keywords
group
substituted
optionally
phenyl
amine
Prior art date
Application number
CY20061101748T
Other languages
Greek (el)
English (en)
Inventor
Stephen Randall Holmes-Farley
W. Harry Mandeville, Iii
Original Assignee
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corporation filed Critical Genzyme Corporation
Publication of CY1105829T1 publication Critical patent/CY1105829T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY20061101748T 2001-06-29 2006-12-05 Αρυλο-βορονικα οξεα, δια νοσηλειαν παχυσαρκιας CY1105829T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30208101P 2001-06-29 2001-06-29
US35946702P 2002-02-22 2002-02-22
PCT/US2002/020923 WO2003002570A1 (en) 2001-06-29 2002-07-01 Aryl boronic acids for treating obesity

Publications (1)

Publication Number Publication Date
CY1105829T1 true CY1105829T1 (el) 2011-02-02

Family

ID=26972758

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101748T CY1105829T1 (el) 2001-06-29 2006-12-05 Αρυλο-βορονικα οξεα, δια νοσηλειαν παχυσαρκιας

Country Status (12)

Country Link
US (3) US6858592B2 (cg-RX-API-DMAC7.html)
EP (1) EP1404685B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004535452A (cg-RX-API-DMAC7.html)
AT (1) ATE339426T1 (cg-RX-API-DMAC7.html)
AU (2) AU2002316499B2 (cg-RX-API-DMAC7.html)
CA (1) CA2489681A1 (cg-RX-API-DMAC7.html)
CY (1) CY1105829T1 (cg-RX-API-DMAC7.html)
DE (1) DE60214713T2 (cg-RX-API-DMAC7.html)
DK (1) DK1404685T3 (cg-RX-API-DMAC7.html)
ES (1) ES2275888T3 (cg-RX-API-DMAC7.html)
PT (1) PT1404685E (cg-RX-API-DMAC7.html)
WO (1) WO2003002570A1 (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
AU2003223930A1 (en) * 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
AU2003291567A1 (en) * 2002-11-19 2004-06-15 Genzyme Corporation Polymeric boronic acid derivatives as lipase inhibitors
AU2005304318A1 (en) * 2004-11-12 2006-05-18 Trustees Of Tufts College Lipase inhibitors
US7696347B2 (en) * 2005-03-14 2010-04-13 Eisai R&D Management Co., Ltd. Oxymethyl boron compounds
US7622492B2 (en) 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
US10157355B2 (en) 2005-11-15 2018-12-18 General Electric Company Method to view schedule interdependencies and provide proactive clinical process decision support in day view form
US7801058B2 (en) * 2006-07-27 2010-09-21 Mobitrum Corporation Method and system for dynamic information exchange on mesh network devices
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
WO2009012596A1 (en) * 2007-07-24 2009-01-29 The University Of British Columbia Substituted aryl-fluoroborates as imaging agents
AU2009233711B2 (en) * 2008-04-09 2015-02-12 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
WO2010118155A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US8709489B2 (en) 2009-09-30 2014-04-29 Surmodics, Inc. Emulsions containing arylboronic acids and medical articles made therefrom
BR112012019120A2 (pt) 2010-02-03 2016-06-28 Infinity Pharmaceuticais Inc forma sólida, composição farmacêutica, método de preparação do composto 1, método de tratamento de uma condição mediada por faah
US8546617B1 (en) 2012-03-23 2013-10-01 Empire Technology Development Llc Dioxaborinanes and uses thereof
WO2014021845A1 (en) * 2012-07-31 2014-02-06 Empire Technology Development Llc Polymerizable organoboron alkyd resin anti fouling coatings
WO2014062794A1 (en) * 2012-10-17 2014-04-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for improving glucose uptake
CA2903281C (en) 2013-03-08 2022-11-29 The University Of British Columbia Substituted organofluoroborates as imaging agents
EP3913068B1 (en) 2015-10-12 2023-08-02 Advanced Cell Diagnostics, Inc. In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
CN106243343B (zh) * 2016-08-11 2018-04-03 江苏大学 一种苯硼酸功能化嵌段聚合物的合成及应用
CA3118223A1 (en) 2018-12-18 2020-06-25 Provincial Health Services Authority Dual mode 18f-labelled theranostic compounds and uses thereof
WO2022082312A1 (en) 2020-10-21 2022-04-28 Provincial Health Services Authority Novel cxcr4-targeting compounds
EP4313033A4 (en) * 2021-03-24 2025-04-23 Trustees Of Tufts College BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496722A (en) 1981-05-01 1985-01-29 The Children's Medical Center Corporation Reporter compounds
GB8819224D0 (en) 1988-08-12 1988-09-14 Merck Patent Gmbh Process for preparation of rod-like compounds
DE3930663C1 (en) 1989-09-14 1990-11-15 Merck Patent Gmbh, 6100 Darmstadt, De Cross-coupling metal organic cpds. and e.g. halogen cpds. - includes using transition metal-palladium catalyst and opt. metal alcoholate
EP0478050A1 (en) 1990-09-24 1992-04-01 Unilever N.V. Detergent composition
GB9024775D0 (en) 1990-11-14 1991-01-02 Axis Research Chemical compounds
IE914573A1 (en) 1991-01-17 1992-07-29 Ici Plc Boron compounds
HUT65823A (en) 1991-04-30 1994-07-28 Procter & Gamble Liquid detergents with an aryl boronic acid and process for using thereof
GB9119920D0 (en) 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds
CH683522A5 (de) 1992-03-13 1994-03-31 Hoffmann La Roche Verfahren zur Herstellung von Diarylen.
JP3257029B2 (ja) 1992-04-22 2002-02-18 日本油脂株式会社 フェニルボロン酸誘導体及び製造方法
CA2096496A1 (en) 1992-05-29 1993-11-30 Bradley C. Pearce Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia
US5290817A (en) 1992-06-09 1994-03-01 The Du Pont Merck Pharmaceutical Co. Substituted 1-benzylindanes and their use as inhibitors of phospholipase A2
EP0674635B1 (en) 1992-12-21 2001-03-28 Syngenta Limited Quinuclidine derivatives as squalene synthase inhibitors
GB2276162A (en) 1993-03-17 1994-09-21 Glaxo Group Ltd Aniline and benazilide derivatives
JP3894949B2 (ja) 1993-06-30 2007-03-22 ザ、ウェルカム、ファンデーション、リミテッド 抗アテローム性動脈硬化症ジアリール化合物
BR9407048A (pt) 1993-07-09 1996-08-13 Novo Nordisk As Composiçao liquida
JP3412198B2 (ja) * 1993-08-31 2003-06-03 日本油脂株式会社 変性マレイン酸共重合体および用途
JPH09503773A (ja) 1993-10-19 1997-04-15 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ−１ｄレセプター拮抗剤用のベンズアニリド誘導体
CZ220296A3 (en) 1994-01-27 1996-10-16 Ciba Geigy Ag Process for preparing derivatives of arylacetic acid esters and intermediates employed in the process
US5631364A (en) * 1994-03-31 1997-05-20 Axis Biochemicals Asa Labelled boronic acid derivatives
SI9400289A (en) 1994-07-13 1996-02-29 Ponikvar Jadranka Buturovic A method for preventing blood coagulation in a haemodialysis circuit or haemodialysis analogy procedure in the extra-body circuit.
JPH11505509A (ja) 1994-12-09 1999-05-21 スミスクライン・ビーチャム・コーポレイション 二環式フィブリノーゲン拮抗薬
JPH10511855A (ja) 1995-01-09 1998-11-17 ノボ ノルディスク アクティーゼルスカブ 液体酵素組成物の安定化
DE69608551T2 (de) 1995-03-27 2001-01-18 Smithkline Beecham P.L.C., Brentford Bicyclische amin-derivate und ihre verwendung als antipsychotische wirkstoffe
UA58494C2 (uk) 1995-06-07 2003-08-15 Зенека Лімітед Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
JP3895377B2 (ja) 1995-06-13 2007-03-22 ノボザイムス アクティーゼルスカブ 酵素安定剤としての４−置換フェニルボロン酸
US5631371A (en) 1995-11-22 1997-05-20 Bayer Corporation Method for the preparation of substituted 3-(phenylimino)-3H-phenothiazines and phenoxazines
GB9603137D0 (en) 1996-02-15 1996-04-17 Merck Sharp & Dohme Therapeutic agents
WO1998022820A1 (en) 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
US6159979A (en) 1997-04-18 2000-12-12 Smithkline Beecham P.L.C. Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity
US6075014A (en) 1997-06-13 2000-06-13 Northwestern University Inhibitors of β-lactamases and uses therefor
US6184363B1 (en) 1997-06-13 2001-02-06 Northwestern University Inhibitors of β-lactamases and uses therefor
US6239138B1 (en) 1997-07-25 2001-05-29 Smithkline Beecham Corporation Vitronectin receptor antagonist
CO5011067A1 (es) 1997-11-03 2001-02-28 Novartis Ag Derivados de bifenilo como productos farmaceuticos, su pre- paracion y composiciones farmaceuticas que los contienen
US6264937B1 (en) 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
ES2183532T3 (es) 1998-03-18 2003-03-16 Ciba Sc Holding Ag Reacciones de copulacion con catalizadores de paladio.
US6525099B1 (en) 1998-07-31 2003-02-25 Eli Lilly And Company N-substituted sulfonamide derivatives
WO2000014083A1 (en) 1998-09-09 2000-03-16 Inflazyme Pharmaceuticals Ltd. SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO
GB9824310D0 (en) 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
DE19857765A1 (de) 1998-12-15 2000-06-21 Clariant Gmbh Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren
AU3124300A (en) 1998-12-16 2000-07-03 Northwestern University Inhibitors of beta-lactamases and uses therefor
EP1147214B1 (en) 1999-01-13 2011-01-05 The Research Foundation Of State University Of New York A novel method for designing protein kinase inhibitors
WO2000061571A1 (en) 1999-04-14 2000-10-19 Pacific Corporation 4,5-diaryl-3(2h)-furanone derivatives as cyclooxygenase-2 inhibitors
JP4507294B2 (ja) 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1881050B1 (en) 2000-11-30 2013-01-09 Canon Kabushiki Kaisha Luminescence device and display apparatus
JP3589450B2 (ja) 2001-03-13 2004-11-17 独立行政法人 科学技術振興機構 アミド脱水縮合触媒として有用なパーフルオロアルキルフェニルホウ酸
US6858592B2 (en) * 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
AU2003243594A1 (en) 2002-06-13 2003-12-31 Johns Hopkins University Novel boronic chalcone derivatives and uses thereof
US7045652B2 (en) * 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids

Also Published As

Publication number Publication date
US20050107336A1 (en) 2005-05-19
WO2003002570A1 (en) 2003-01-09
CA2489681A1 (en) 2003-01-09
US6858592B2 (en) 2005-02-22
EP1404685A1 (en) 2004-04-07
DE60214713D1 (de) 2006-10-26
US20060128664A1 (en) 2006-06-15
DE60214713T2 (de) 2007-09-06
HK1065046A1 (en) 2005-02-08
US7049304B2 (en) 2006-05-23
ATE339426T1 (de) 2006-10-15
ES2275888T3 (es) 2007-06-16
AU2005220192A1 (en) 2005-12-01
EP1404685B1 (en) 2006-09-13
AU2002316499B2 (en) 2005-08-04
US20030064963A1 (en) 2003-04-03
DK1404685T3 (da) 2007-01-22
JP2004535452A (ja) 2004-11-25
PT1404685E (pt) 2007-01-31
US7456156B2 (en) 2008-11-25

Similar Documents

Publication Publication Date Title
DK1404685T3 (da) Arylboronsyrer til behandling af fedme
CY1105811T1 (el) Ενωσεις ενισχυτη ταξολης
ES2404685T3 (es) Derivados heterobifuncionales de poli(etilenglicol) y métodos para su preparación
CA2448319A1 (en) Cytotoxins, prodrugs, linkers and stabilizers useful therefor
CY1121142T1 (el) Τυποποιηση ενωσεων βορονικου οξεος
CA2662973A1 (en) Lysine-based polymeric linkers
CA3024371C (en) Multi-arm polymeric targeting anticancer conjugate
DE60030263D1 (de) Neue phosphor enthaltende medikamentenvorläuferverbindungen
CY1110631T1 (el) Διαλυτοποιημενα δηλητηρια τοποϊσομερασης
CY1110605T1 (el) Διαδικασια για την παρασκευη ενωσεων πυριμιδινης
HUP9903766A2 (en) Pyridyl alkene- and pyridyl alkine- acid amides, use of them as cytostatics and immunosuppressives, process for their preparation and pharmaceuticals containing the same
CY1112086T1 (el) Συνδυασμος γλυκοπυρρολικου αλατος και ενος αγωνιστη βητα2 αδρενεργικων υποδοχεων
BR9914167A (pt) Composto, método de tratamento, inibição do crescimento de, ou erradicação de neoplasmas, e de doença de rim policìstico, em um mamìfero em necessidade do mesmo, composição farmacêutica, e processo para preparar o composto
CY1107047T1 (el) Παραγωγα δολαστατινης 15
KR20100051722A (ko) 피리딜 이황화 부분을 포함하는 폴리머 링커
CA2321149A1 (en) Antitumor agents
HUP0104033A2 (hu) Benzoilpiridazin-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás az előállításukra és alkalmazásuk
DE69703878D1 (de) Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen
CA2582589A1 (en) Lipopolymer conjugates
DE69901088D1 (de) 1,2-Dithiolan Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen
RU99109978A (ru) Бис(акридинкарбоксамид) и бис(феназинкарбоксамид), полезные в качестве противоопухолевых агентов
CY1105595T1 (el) Νεα αλατα δεσλοραταδινης, μεθοδος συνθεσης τους και φαρμακευτικα σκευασματα αυτων
ATE238274T1 (de) Naphthalin derivate
RU2219928C2 (ru) Средства для лечения и профилактики неоплазм
ATE258160T1 (de) Verfahren zur herstellung von tris(äther-aminen)