ATE339426T1 - Arylborsäuren für die behandlung von fettsucht - Google Patents
Arylborsäuren für die behandlung von fettsuchtInfo
- Publication number
- ATE339426T1 ATE339426T1 AT02746808T AT02746808T ATE339426T1 AT E339426 T1 ATE339426 T1 AT E339426T1 AT 02746808 T AT02746808 T AT 02746808T AT 02746808 T AT02746808 T AT 02746808T AT E339426 T1 ATE339426 T1 AT E339426T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- substituted
- sup
- group
- optionally
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 phenyl boronic acid compound Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- HXITXNWTGFUOAU-UHFFFAOYSA-N dihydroxy-phenylborane Natural products OB(O)C1=CC=CC=C1 HXITXNWTGFUOAU-UHFFFAOYSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000005496 phosphonium group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30208101P | 2001-06-29 | 2001-06-29 | |
US35946702P | 2002-02-22 | 2002-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE339426T1 true ATE339426T1 (de) | 2006-10-15 |
Family
ID=26972758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02746808T ATE339426T1 (de) | 2001-06-29 | 2002-07-01 | Arylborsäuren für die behandlung von fettsucht |
Country Status (13)
Country | Link |
---|---|
US (3) | US6858592B2 (de) |
EP (1) | EP1404685B1 (de) |
JP (1) | JP2004535452A (de) |
AT (1) | ATE339426T1 (de) |
AU (2) | AU2002316499B2 (de) |
CA (1) | CA2489681A1 (de) |
CY (1) | CY1105829T1 (de) |
DE (1) | DE60214713T2 (de) |
DK (1) | DK1404685T3 (de) |
ES (1) | ES2275888T3 (de) |
HK (1) | HK1065046A1 (de) |
PT (1) | PT1404685E (de) |
WO (1) | WO2003002570A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
US6858592B2 (en) * | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
WO2003105860A1 (en) * | 2002-06-14 | 2003-12-24 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
WO2004046211A1 (en) * | 2002-11-19 | 2004-06-03 | Genzyme Corporation | Polymeric boronic acid derivatives as lipase inhibitors |
EP1824861A2 (de) * | 2004-11-12 | 2007-08-29 | Trustees of the Tufts College | Lipaseinhibitoren |
US7696347B2 (en) * | 2005-03-14 | 2010-04-13 | Eisai R&D Management Co., Ltd. | Oxymethyl boron compounds |
US7622492B2 (en) | 2005-08-31 | 2009-11-24 | Hoffmann-La Roche Inc. | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase |
US10157355B2 (en) | 2005-11-15 | 2018-12-18 | General Electric Company | Method to view schedule interdependencies and provide proactive clinical process decision support in day view form |
US7801058B2 (en) * | 2006-07-27 | 2010-09-21 | Mobitrum Corporation | Method and system for dynamic information exchange on mesh network devices |
JO3598B1 (ar) * | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
US8574546B2 (en) * | 2007-07-24 | 2013-11-05 | The University Of British Columbia | Substituted aryl-fluoroborates as imaging agents |
JP5637982B2 (ja) * | 2008-04-09 | 2014-12-10 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 脂肪酸アミド加水分解酵素の阻害剤 |
CA2757679A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8709489B2 (en) | 2009-09-30 | 2014-04-29 | Surmodics, Inc. | Emulsions containing arylboronic acids and medical articles made therefrom |
MX361692B (es) | 2010-02-03 | 2018-12-13 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de ácido graso. |
US8546617B1 (en) | 2012-03-23 | 2013-10-01 | Empire Technology Development Llc | Dioxaborinanes and uses thereof |
WO2014021845A1 (en) * | 2012-07-31 | 2014-02-06 | Empire Technology Development Llc | Polymerizable organoboron alkyd resin anti fouling coatings |
US9120938B2 (en) | 2012-07-31 | 2015-09-01 | Empire Technology Development Llc | Polymerizable organoboron alkyd resin anti fouling coatings |
EP2909216B1 (de) * | 2012-10-17 | 2016-12-21 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Zusammensetzungen und verfahren zur verbesserung der glucoseaufnahme |
US10556023B2 (en) | 2013-03-08 | 2020-02-11 | The University Of British Columbia | Substituted organofluoroborates as imaging agents |
US11078528B2 (en) | 2015-10-12 | 2021-08-03 | Advanced Cell Diagnostics, Inc. | In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto |
CN106243343B (zh) * | 2016-08-11 | 2018-04-03 | 江苏大学 | 一种苯硼酸功能化嵌段聚合物的合成及应用 |
WO2022204368A1 (en) * | 2021-03-24 | 2022-09-29 | Trustees Of Tufts College | Boronic acid compounds, compositions and methods |
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US4496722A (en) * | 1981-05-01 | 1985-01-29 | The Children's Medical Center Corporation | Reporter compounds |
GB8819224D0 (en) | 1988-08-12 | 1988-09-14 | Merck Patent Gmbh | Process for preparation of rod-like compounds |
DE3930663C1 (en) | 1989-09-14 | 1990-11-15 | Merck Patent Gmbh, 6100 Darmstadt, De | Cross-coupling metal organic cpds. and e.g. halogen cpds. - includes using transition metal-palladium catalyst and opt. metal alcoholate |
EP0478050A1 (de) | 1990-09-24 | 1992-04-01 | Unilever N.V. | Detergentzusammensetzung |
GB9024775D0 (en) | 1990-11-14 | 1991-01-02 | Axis Research | Chemical compounds |
IE914573A1 (en) | 1991-01-17 | 1992-07-29 | Ici Plc | Boron compounds |
WO1992019707A1 (en) * | 1991-04-30 | 1992-11-12 | The Procter & Gamble Company | Liquid detergents with an aryl boronic acid |
GB9119920D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
CH683522A5 (de) | 1992-03-13 | 1994-03-31 | Hoffmann La Roche | Verfahren zur Herstellung von Diarylen. |
JP3257029B2 (ja) | 1992-04-22 | 2002-02-18 | 日本油脂株式会社 | フェニルボロン酸誘導体及び製造方法 |
CA2096496A1 (en) | 1992-05-29 | 1993-11-30 | Bradley C. Pearce | Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia |
US5290817A (en) * | 1992-06-09 | 1994-03-01 | The Du Pont Merck Pharmaceutical Co. | Substituted 1-benzylindanes and their use as inhibitors of phospholipase A2 |
AU5708694A (en) | 1992-12-21 | 1994-07-19 | Zeneca Limited | Quinuclidine derivatives as squalene synthase inhibitors |
GB2276162A (en) | 1993-03-17 | 1994-09-21 | Glaxo Group Ltd | Aniline and benazilide derivatives |
HUT73813A (en) | 1993-06-30 | 1996-09-30 | Wellcome Found | Anti-athero-sclerotic diaryl compounds, process to prepare them and pharmaceutical compositions contg. them |
CN1127014A (zh) * | 1993-07-09 | 1996-07-17 | 诺沃挪第克公司 | 作为酶稳定剂的一烃基硼酸或二烃基硼酸衍生物 |
JP3412198B2 (ja) * | 1993-08-31 | 2003-06-03 | 日本油脂株式会社 | 変性マレイン酸共重合体および用途 |
EP0724580A1 (de) | 1993-10-19 | 1996-08-07 | Smithkline Beecham Plc | Benzamilid-derivate als 5ht-1d-rezeptor antagonisten |
DK0741693T3 (da) * | 1994-01-27 | 1999-10-11 | Novartis Ag | Fremgangsmåde og apparat til fremstilling af kontaktlinser |
US5631364A (en) | 1994-03-31 | 1997-05-20 | Axis Biochemicals Asa | Labelled boronic acid derivatives |
SI9400289A (en) | 1994-07-13 | 1996-02-29 | Ponikvar Jadranka Buturovic | A method for preventing blood coagulation in a haemodialysis circuit or haemodialysis analogy procedure in the extra-body circuit. |
EP0796252A4 (de) | 1994-12-09 | 1998-02-04 | Smithkline Beecham Corp | Bicyclische fibrinogen antagonisten |
JPH10511855A (ja) | 1995-01-09 | 1998-11-17 | ノボ ノルディスク アクティーゼルスカブ | 液体酵素組成物の安定化 |
EP0817767B1 (de) | 1995-03-27 | 2000-05-24 | Smithkline Beecham Plc | Bicyclische amin-derivate und ihre verwendung als antipsychotische wirkstoffe |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
DE69621131T2 (de) * | 1995-06-13 | 2002-11-28 | Novozymes As | 4-substituierte-phenylboronsäuren als enzymstabilisatoren |
US5631371A (en) * | 1995-11-22 | 1997-05-20 | Bayer Corporation | Method for the preparation of substituted 3-(phenylimino)-3H-phenothiazines and phenoxazines |
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WO1998022820A1 (en) | 1996-11-21 | 1998-05-28 | Lawrence Livermore National Laboratory | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
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US6075014A (en) | 1997-06-13 | 2000-06-13 | Northwestern University | Inhibitors of β-lactamases and uses therefor |
US6184363B1 (en) * | 1997-06-13 | 2001-02-06 | Northwestern University | Inhibitors of β-lactamases and uses therefor |
JP2002510328A (ja) | 1997-07-25 | 2002-04-02 | スミスクライン・ビーチャム・コーポレイション | ビトロネクチン受容体アンタゴニスト |
CO5011067A1 (es) | 1997-11-03 | 2001-02-28 | Novartis Ag | Derivados de bifenilo como productos farmaceuticos, su pre- paracion y composiciones farmaceuticas que los contienen |
US6264937B1 (en) * | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
CA2321791A1 (en) | 1998-03-18 | 1999-09-23 | Ciba Specialty Chemicals Holding Inc. | Coupling reactions with palladium catalysts |
AU5235599A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | N-substituted sulfonamide derivatives |
US6458829B1 (en) | 1998-09-09 | 2002-10-01 | Inflazyme Pharmaceuticals Ltd. | Substituted γ-phenyl-Δ-lactones and analogs thereof and uses related thereto |
GB9824310D0 (en) | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
DE19857765A1 (de) * | 1998-12-15 | 2000-06-21 | Clariant Gmbh | Verfahren zur Herstellung von para-Oxadiazolyl-phenyl-boronsäuren |
WO2000035904A1 (en) | 1998-12-16 | 2000-06-22 | Northwestern University | INHIBITORS OF β-LACTAMASES AND USES THEREFOR |
AU3208200A (en) | 1999-01-13 | 2000-08-01 | Research Foundation Of The State University Of New York, The | A novel method for designing protein kinase inhibitors |
BRPI0011172B8 (pt) | 1999-04-14 | 2021-05-25 | Pacific Corp | derivados do 4,5-diaril-3(2h)-furanona como inibidores de ciclooxigenase-2 |
JP4507294B2 (ja) | 1999-05-27 | 2010-07-21 | チッソ株式会社 | ビアリール誘導体の製造方法 |
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US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
CN1285601C (zh) | 2000-11-30 | 2006-11-22 | 佳能株式会社 | 发光器件和显示器 |
JP3589450B2 (ja) | 2001-03-13 | 2004-11-17 | 独立行政法人 科学技術振興機構 | アミド脱水縮合触媒として有用なパーフルオロアルキルフェニルホウ酸 |
US6858592B2 (en) * | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
AU2003243594A1 (en) | 2002-06-13 | 2003-12-31 | Johns Hopkins University | Novel boronic chalcone derivatives and uses thereof |
US7045652B2 (en) * | 2002-07-03 | 2006-05-16 | Pfizer Inc | Processes for preparing substituted aryl boronic acids |
-
2002
- 2002-06-27 US US10/187,397 patent/US6858592B2/en not_active Expired - Lifetime
- 2002-07-01 WO PCT/US2002/020923 patent/WO2003002570A1/en active IP Right Grant
- 2002-07-01 AU AU2002316499A patent/AU2002316499B2/en not_active Ceased
- 2002-07-01 AT AT02746808T patent/ATE339426T1/de not_active IP Right Cessation
- 2002-07-01 EP EP02746808A patent/EP1404685B1/de not_active Expired - Lifetime
- 2002-07-01 JP JP2003508951A patent/JP2004535452A/ja active Pending
- 2002-07-01 CA CA002489681A patent/CA2489681A1/en not_active Abandoned
- 2002-07-01 PT PT02746808T patent/PT1404685E/pt unknown
- 2002-07-01 ES ES02746808T patent/ES2275888T3/es not_active Expired - Lifetime
- 2002-07-01 DE DE60214713T patent/DE60214713T2/de not_active Expired - Fee Related
- 2002-07-01 DK DK02746808T patent/DK1404685T3/da active
-
2004
- 2004-10-07 HK HK04107699A patent/HK1065046A1/xx not_active IP Right Cessation
- 2004-12-30 US US11/027,643 patent/US7049304B2/en not_active Expired - Lifetime
-
2005
- 2005-10-05 AU AU2005220192A patent/AU2005220192A1/en not_active Abandoned
-
2006
- 2006-01-31 US US11/343,598 patent/US7456156B2/en not_active Expired - Fee Related
- 2006-12-05 CY CY20061101748T patent/CY1105829T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2002316499B2 (en) | 2005-08-04 |
CA2489681A1 (en) | 2003-01-09 |
US20050107336A1 (en) | 2005-05-19 |
US7456156B2 (en) | 2008-11-25 |
DK1404685T3 (da) | 2007-01-22 |
US7049304B2 (en) | 2006-05-23 |
AU2005220192A1 (en) | 2005-12-01 |
WO2003002570A1 (en) | 2003-01-09 |
DE60214713T2 (de) | 2007-09-06 |
EP1404685A1 (de) | 2004-04-07 |
PT1404685E (pt) | 2007-01-31 |
ES2275888T3 (es) | 2007-06-16 |
JP2004535452A (ja) | 2004-11-25 |
CY1105829T1 (el) | 2011-02-02 |
US20030064963A1 (en) | 2003-04-03 |
DE60214713D1 (de) | 2006-10-26 |
US6858592B2 (en) | 2005-02-22 |
EP1404685B1 (de) | 2006-09-13 |
HK1065046A1 (en) | 2005-02-08 |
US20060128664A1 (en) | 2006-06-15 |
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UEP | Publication of translation of european patent specification |
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REN | Ceased due to non-payment of the annual fee |