CU24684B1 - Compuestos de aminoácidos como inhibidores de la integrina - Google Patents
Compuestos de aminoácidos como inhibidores de la integrinaInfo
- Publication number
- CU24684B1 CU24684B1 CU2020000066A CU20200066A CU24684B1 CU 24684 B1 CU24684 B1 CU 24684B1 CU 2020000066 A CU2020000066 A CU 2020000066A CU 20200066 A CU20200066 A CU 20200066A CU 24684 B1 CU24684 B1 CU 24684B1
- Authority
- CU
- Cuba
- Prior art keywords
- sup
- formula
- amino acids
- integrin inhibitors
- acids compounds
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- -1 AMINO ACIDS COMPOUNDS Chemical class 0.000 title 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 2
- 201000004071 non-specific interstitial pneumonia Diseases 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
<p>La invención se refiere a compuestos de la fórmula (A) y la fórmula (I):</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>, en donde R¹, R², R¹°, R¹¹, R¹², R¹³, R<sup>14</sup>, R<sup>15</sup>, R<sup>16</sup>, q y p son como se describen en la presente. Los compuestos de la fórmula (A) y la fórmula (I) son inhibidores de la integrina, útiles para tratar la fibrosis, tal como la fibrosis pulmonar idiopática (IPF) y la neumonía intersticial inespecífica (NSIP). </p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862639988P | 2018-03-07 | 2018-03-07 | |
| US201862690933P | 2018-06-27 | 2018-06-27 | |
| PCT/US2019/021243 WO2019173653A1 (en) | 2018-03-07 | 2019-03-07 | Amino acid compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20200066A7 CU20200066A7 (es) | 2021-04-07 |
| CU24684B1 true CU24684B1 (es) | 2023-10-06 |
Family
ID=67844341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2020000066A CU24684B1 (es) | 2018-03-07 | 2019-03-07 | Compuestos de aminoácidos como inhibidores de la integrina |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US10793564B2 (es) |
| EP (2) | EP3761980B1 (es) |
| JP (3) | JP6866535B2 (es) |
| KR (1) | KR20200139676A (es) |
| CN (1) | CN112135612A (es) |
| AU (1) | AU2019230209B2 (es) |
| BR (1) | BR112020018064A2 (es) |
| CA (1) | CA3093225A1 (es) |
| CL (1) | CL2020002290A1 (es) |
| CO (1) | CO2020011085A2 (es) |
| CR (1) | CR20200452A (es) |
| CU (1) | CU24684B1 (es) |
| DK (1) | DK3761980T3 (es) |
| EC (1) | ECSP20063227A (es) |
| ES (1) | ES2972512T3 (es) |
| FI (1) | FI3761980T3 (es) |
| HR (1) | HRP20240234T1 (es) |
| HU (1) | HUE065887T2 (es) |
| IL (2) | IL305296A (es) |
| JO (1) | JOP20200212A1 (es) |
| LT (1) | LT3761980T (es) |
| MD (1) | MD3761980T2 (es) |
| MX (2) | MX2020009253A (es) |
| PE (1) | PE20201502A1 (es) |
| PH (1) | PH12020551395A1 (es) |
| PL (1) | PL3761980T3 (es) |
| PT (1) | PT3761980T (es) |
| RS (1) | RS65170B1 (es) |
| SG (1) | SG11202008609UA (es) |
| SI (1) | SI3761980T1 (es) |
| TW (1) | TW201938158A (es) |
| WO (1) | WO2019173653A1 (es) |
| ZA (1) | ZA202005437B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
| EP3558303A4 (en) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | AMINO ACID COMPOUNDS AND METHOD FOR USE |
| WO2018160522A1 (en) | 2017-02-28 | 2018-09-07 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| CA3054604A1 (en) | 2017-02-28 | 2018-09-07 | Morphic Therapeutic, Inc. | Inhibitors of .alpha.v.beta.6 integrin |
| JOP20200212A1 (ar) | 2018-03-07 | 2020-09-01 | Pliant Therapeutics Inc | مركبات حمض أميني وطرق استخدامها |
| HUE064531T2 (hu) | 2018-06-27 | 2024-04-28 | Bristol Myers Squibb Co | Szubsztituált naftiridinon vegyületek mint T-sejt aktivátorok |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| TW202035400A (zh) | 2018-08-29 | 2020-10-01 | 美商莫菲克醫療股份有限公司 | 抑制αvβ6整合素 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CA3115820A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of .alpha.4.beta.7 integrin |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| AU2019373245C1 (en) | 2018-10-30 | 2022-10-27 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4β7 integrin |
| KR20240015737A (ko) | 2018-10-30 | 2024-02-05 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체 |
| CA3136745A1 (en) * | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
| EP4076454A1 (en) * | 2019-12-20 | 2022-10-26 | Novartis AG | Combination treatment of liver diseases using integrin inhibitors |
| AU2021268889A1 (en) * | 2020-05-07 | 2022-12-15 | Pliant Therapeutics, Inc. | Treatment of respiratory diseases with amino acid compounds |
| MX2023005889A (es) * | 2020-11-19 | 2023-06-06 | Pliant Therapeutics Inc | Inhibidor de integrina y usos de este. |
| JP2024517765A (ja) * | 2021-04-30 | 2024-04-23 | プライアント・セラピューティクス・インコーポレイテッド | インテグリン阻害剤の拡大投与レジメン |
| WO2023225119A1 (en) * | 2022-05-18 | 2023-11-23 | Pliant Therapeutics, Inc. | Stabilization of integrin inhibitors |
| WO2024119067A1 (en) | 2022-12-02 | 2024-06-06 | Neumora Therapeutics, Inc. | Methods of treating neurological disorders |
| WO2024125634A1 (zh) * | 2022-12-16 | 2024-06-20 | 西藏海思科制药有限公司 | 一种四氢萘啶类化合物及其在医药上的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6361764B2 (en) | 1996-12-13 | 2002-03-26 | Societe L'oreal S.A. | Insoluble s-triazine derivatives and their use as UV filters |
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| IL136495A0 (en) * | 1997-12-17 | 2001-06-14 | Merck & Co Inc | Integrin receptor antagonists |
| WO2001096334A2 (en) * | 2000-06-15 | 2001-12-20 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
| JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| ATE396174T1 (de) | 2001-06-01 | 2008-06-15 | Elan Pharm Inc | Hydroxyalkylaminderivate als beta-secretase- inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US7566730B2 (en) | 2002-09-10 | 2009-07-28 | Elan Pharmaceuticals, Inc. | Substituted aminoethers for the treatment of Alzheimer's disease |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| RS57142B1 (sr) | 2008-06-06 | 2018-07-31 | Boehringer Ingelheim Int | Farmaceutski dozni oblik u vidu kapsule koji sadrži formulaciju suspenzije indolinon derivata |
| UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| CN104640857B (zh) * | 2012-07-18 | 2017-07-04 | 圣路易斯大学 | 作为整合素拮抗剂的β氨基酸衍生物 |
| GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| US10214522B2 (en) | 2015-03-10 | 2019-02-26 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| GB201604681D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
| EP3442352A4 (en) | 2016-04-14 | 2020-03-11 | Mars, Incorporated | COMPOUNDS THAT MODULATE CALCIUM SENSITIVE RECEPTOR ACTIVITY TO MODULATE KOKUMI TASTE AND PET FOOD PRODUCTS CONTAINING THE SAME |
| JP2019524702A (ja) * | 2016-07-05 | 2019-09-05 | ザ ロックフェラー ユニバーシティー | テトラヒドロナフチルリジンペンタンアミドインテグリンアンタゴニスト |
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
| CN110062625A (zh) | 2016-12-12 | 2019-07-26 | 勃林格殷格翰国际有限公司 | 尼达尼布通过与奥达特罗共给予用于治疗间质性肺病的方法 |
| EP3558303A4 (en) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | AMINO ACID COMPOUNDS AND METHOD FOR USE |
| CA3054604A1 (en) | 2017-02-28 | 2018-09-07 | Morphic Therapeutic, Inc. | Inhibitors of .alpha.v.beta.6 integrin |
| WO2018160522A1 (en) | 2017-02-28 | 2018-09-07 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| JOP20200212A1 (ar) | 2018-03-07 | 2020-09-01 | Pliant Therapeutics Inc | مركبات حمض أميني وطرق استخدامها |
| TWI841573B (zh) | 2018-06-27 | 2024-05-11 | 美商普萊恩醫療公司 | 具有未分支連接子之胺基酸化合物及使用方法 |
| EP3843727A4 (en) | 2018-08-29 | 2022-08-17 | Morphic Therapeutic, Inc. | INTEGRIN (ALPHA-V)(BETA-6) INHIBITORS |
| EP3843728A4 (en) | 2018-08-29 | 2022-05-25 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN |
| TW202035400A (zh) | 2018-08-29 | 2020-10-01 | 美商莫菲克醫療股份有限公司 | 抑制αvβ6整合素 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CA3136745A1 (en) | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| AU2021268889A1 (en) | 2020-05-07 | 2022-12-15 | Pliant Therapeutics, Inc. | Treatment of respiratory diseases with amino acid compounds |
-
2019
- 2019-03-07 JO JOP/2020/0212A patent/JOP20200212A1/ar unknown
- 2019-03-07 JP JP2020521559A patent/JP6866535B2/ja active Active
- 2019-03-07 CR CR20200452A patent/CR20200452A/es unknown
- 2019-03-07 ES ES19765136T patent/ES2972512T3/es active Active
- 2019-03-07 MX MX2020009253A patent/MX2020009253A/es unknown
- 2019-03-07 CN CN201980030750.4A patent/CN112135612A/zh active Pending
- 2019-03-07 CU CU2020000066A patent/CU24684B1/es unknown
- 2019-03-07 IL IL305296A patent/IL305296A/en unknown
- 2019-03-07 EP EP19765136.7A patent/EP3761980B1/en active Active
- 2019-03-07 KR KR1020207026985A patent/KR20200139676A/ko not_active Application Discontinuation
- 2019-03-07 HU HUE19765136A patent/HUE065887T2/hu unknown
- 2019-03-07 SG SG11202008609UA patent/SG11202008609UA/en unknown
- 2019-03-07 MD MDE20210065T patent/MD3761980T2/ro unknown
- 2019-03-07 AU AU2019230209A patent/AU2019230209B2/en active Active
- 2019-03-07 US US16/296,194 patent/US10793564B2/en active Active
- 2019-03-07 IL IL277146A patent/IL277146B2/en unknown
- 2019-03-07 CA CA3093225A patent/CA3093225A1/en active Pending
- 2019-03-07 WO PCT/US2019/021243 patent/WO2019173653A1/en active Application Filing
- 2019-03-07 TW TW108107688A patent/TW201938158A/zh unknown
- 2019-03-07 PL PL19765136.7T patent/PL3761980T3/pl unknown
- 2019-03-07 HR HRP20240234TT patent/HRP20240234T1/hr unknown
- 2019-03-07 PE PE2020001357A patent/PE20201502A1/es unknown
- 2019-03-07 EP EP23205993.1A patent/EP4328230A3/en active Pending
- 2019-03-07 BR BR112020018064-5A patent/BR112020018064A2/pt unknown
- 2019-03-07 DK DK19765136.7T patent/DK3761980T3/da active
- 2019-03-07 LT LTEPPCT/US2019/021243T patent/LT3761980T/lt unknown
- 2019-03-07 PT PT197651367T patent/PT3761980T/pt unknown
- 2019-03-07 SI SI201930710T patent/SI3761980T1/sl unknown
- 2019-03-07 FI FIEP19765136.7T patent/FI3761980T3/fi active
- 2019-03-07 RS RS20240183A patent/RS65170B1/sr unknown
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2020
- 2020-06-26 US US16/914,209 patent/US11560376B2/en active Active
- 2020-08-31 ZA ZA2020/05437A patent/ZA202005437B/en unknown
- 2020-09-04 MX MX2022014456A patent/MX2022014456A/es unknown
- 2020-09-04 CL CL2020002290A patent/CL2020002290A1/es unknown
- 2020-09-07 CO CONC2020/0011085A patent/CO2020011085A2/es unknown
- 2020-09-07 PH PH12020551395A patent/PH12020551395A1/en unknown
- 2020-10-06 EC ECSENADI202063227A patent/ECSP20063227A/es unknown
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2021
- 2021-04-07 JP JP2021065309A patent/JP7273882B2/ja active Active
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2022
- 2022-12-19 US US18/084,307 patent/US20230271960A1/en not_active Abandoned
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2023
- 2023-04-28 JP JP2023074346A patent/JP2023106425A/ja active Pending
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