CU20200066A7 - Compuestos de aminoácidos como inhibidores de la integrina y composiciones farmacéuticas que los contienen - Google Patents
Compuestos de aminoácidos como inhibidores de la integrina y composiciones farmacéuticas que los contienenInfo
- Publication number
- CU20200066A7 CU20200066A7 CU2020000066A CU20200066A CU20200066A7 CU 20200066 A7 CU20200066 A7 CU 20200066A7 CU 2020000066 A CU2020000066 A CU 2020000066A CU 20200066 A CU20200066 A CU 20200066A CU 20200066 A7 CU20200066 A7 CU 20200066A7
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutical compositions
- amino acid
- formula
- compositions containing
- integrin inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000006495 integrins Human genes 0.000 title abstract 2
- 108010044426 integrins Proteins 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 AMINO ACID COMPOUNDS Chemical class 0.000 title 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 2
- 201000004071 non-specific interstitial pneumonia Diseases 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
<p>La invención se refiere a compuestos de la fórmula (A) y la fórmula (I):</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>o una sal de estos, en donde R¹, R², R¹°, R¹¹, R¹², R¹³, R¹4, R¹5, R¹6, q y p son como se describen en la presente. Los compuestos de la fórmula (A) y la fórmula (I) y las composiciones farmacéuticas de estos son inhibidores de la integrina que son útiles para tratar la fibrosis, tal como la fibrosis pulmonar idiopática (IPF) y la neumonía intersticial inespecífica (NSIP). </p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862639988P | 2018-03-07 | 2018-03-07 | |
| US201862690933P | 2018-06-27 | 2018-06-27 | |
| PCT/US2019/021243 WO2019173653A1 (en) | 2018-03-07 | 2019-03-07 | Amino acid compounds and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20200066A7 true CU20200066A7 (es) | 2021-04-07 |
| CU24684B1 CU24684B1 (es) | 2023-10-06 |
Family
ID=67844341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2020000066A CU24684B1 (es) | 2018-03-07 | 2019-03-07 | Compuestos de aminoácidos como inhibidores de la integrina |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10793564B2 (es) |
| EP (2) | EP4328230A3 (es) |
| JP (3) | JP6866535B2 (es) |
| KR (1) | KR20200139676A (es) |
| CN (1) | CN112135612A (es) |
| AU (1) | AU2019230209B2 (es) |
| BR (1) | BR112020018064A2 (es) |
| CA (1) | CA3093225A1 (es) |
| CL (1) | CL2020002290A1 (es) |
| CO (1) | CO2020011085A2 (es) |
| CR (1) | CR20200452A (es) |
| CU (1) | CU24684B1 (es) |
| DK (1) | DK3761980T3 (es) |
| EC (1) | ECSP20063227A (es) |
| FI (1) | FI3761980T3 (es) |
| HR (1) | HRP20240234T1 (es) |
| IL (2) | IL277146B2 (es) |
| JO (1) | JOP20200212A1 (es) |
| LT (1) | LT3761980T (es) |
| MX (2) | MX2020009253A (es) |
| PE (1) | PE20201502A1 (es) |
| PH (1) | PH12020551395A1 (es) |
| PT (1) | PT3761980T (es) |
| RS (1) | RS65170B1 (es) |
| SG (1) | SG11202008609UA (es) |
| TW (1) | TW201938158A (es) |
| WO (1) | WO2019173653A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201823208A (zh) | 2016-09-07 | 2018-07-01 | 美商普萊恩醫療公司 | N－醯基胺基酸化合物及其使用方法 |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| US20180244648A1 (en) | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2019173653A1 (en) | 2018-03-07 | 2019-09-12 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| WO2020006018A1 (en) | 2018-06-27 | 2020-01-02 | Bristol-Myers Squibb Company | Substituted naphthyridinone compounds useful as t cell activators |
| EA202190134A1 (ru) | 2018-06-27 | 2021-03-26 | Плайэнт Терапьютикс, Инк. | Соединения аминокислот с неразветвленными линкерами и способы их применения |
| CR20210109A (es) | 2018-08-29 | 2021-06-24 | Morphic Therapeutic Inc | INHIBICIÓN DE LA INTEGRINA av ß6 |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| AU2019373242B2 (en) | 2018-10-30 | 2023-07-13 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
| US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
| CR20210213A (es) | 2018-10-30 | 2021-06-24 | Gilead Sciences Inc | Derivados de quinolina como inhibidores de la integrina alfa4beta7 |
| CA3136745A1 (en) * | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| AU2020329207B2 (en) | 2019-08-14 | 2024-02-29 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| TW202135811A (zh) * | 2019-12-20 | 2021-10-01 | 瑞士商諾華公司 | 使用整聯蛋白抑制劑組合治療肝臟疾病 |
| EP4146264A1 (en) * | 2020-05-07 | 2023-03-15 | Pliant Therapeutics, Inc. | Treatment of respiratory diseases with amino acid compounds |
| KR20230121761A (ko) * | 2020-11-19 | 2023-08-21 | 플라이언트 테라퓨틱스, 인크. | 인테그린 억제제 및 그의 용도 |
| KR20240024060A (ko) * | 2021-04-30 | 2024-02-23 | 플라이언트 테라퓨틱스, 인크. | 인테그린 억제제에 대한 확장된 투여량 요법 |
| WO2023225119A1 (en) * | 2022-05-18 | 2023-11-23 | Pliant Therapeutics, Inc. | Stabilization of integrin inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6361764B2 (en) | 1996-12-13 | 2002-03-26 | Societe L'oreal S.A. | Insoluble s-triazine derivatives and their use as UV filters |
| US6048861A (en) * | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| KR20010033248A (ko) | 1997-12-17 | 2001-04-25 | 폴락 돈나 엘. | 인테그린 수용체 길항제 |
| JP2004511434A (ja) * | 2000-06-15 | 2004-04-15 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸 |
| JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| BR0210122A (pt) | 2001-06-01 | 2004-06-15 | Elan Pharm Inc | Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| BR0314180A (pt) | 2002-09-10 | 2005-08-09 | Pharmacia & Upjohn Co Llc | Aminoéteres substituìdos para o tratamento da doença de alzheimer |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| LT2299987T (lt) | 2008-06-06 | 2018-05-25 | Boehringer Ingelheim International Gmbh | Farmacinės vaisto formos kapsulė, apimanti indolinono darinio suspensijos kompoziciją |
| UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| JP6215324B2 (ja) * | 2012-07-18 | 2017-10-18 | セントルイス ユニバーシティ | インテグリンアンタゴニストとしてのβアミノ酸誘導体 |
| GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| CA2981371A1 (en) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
| GB201604681D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
| CN109996453A (zh) | 2016-04-14 | 2019-07-09 | 马斯公司 | 用于调节厚味味道的调节钙敏感受体活性的化合物和含有该化合物的宠物食品 |
| WO2018009501A1 (en) | 2016-07-05 | 2018-01-11 | The Rockefeller University | Tetrahydronaphthyridinepentanamide integrin antagonists |
| TW201823208A (zh) | 2016-09-07 | 2018-07-01 | 美商普萊恩醫療公司 | N－醯基胺基酸化合物及其使用方法 |
| WO2018108669A1 (en) | 2016-12-12 | 2018-06-21 | Boehringer Ingelheim International Gmbh | Nintedanib for use in methods for the treatment of interstitial lung diseases by coadministration with olodaterol |
| US10696672B2 (en) | 2016-12-23 | 2020-06-30 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
| US20180244648A1 (en) | 2017-02-28 | 2018-08-30 | Lazuli, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2019173653A1 (en) * | 2018-03-07 | 2019-09-12 | Pliant Therapeutics, Inc. | Amino acid compounds and methods of use |
| EA202190134A1 (ru) | 2018-06-27 | 2021-03-26 | Плайэнт Терапьютикс, Инк. | Соединения аминокислот с неразветвленными линкерами и способы их применения |
| CR20210109A (es) | 2018-08-29 | 2021-06-24 | Morphic Therapeutic Inc | INHIBICIÓN DE LA INTEGRINA av ß6 |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP3843728A4 (en) | 2018-08-29 | 2022-05-25 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| CA3136745A1 (en) | 2019-04-08 | 2020-10-15 | Pliant Therapeutics, Inc. | Dosage forms and regimens for amino acid compounds |
| EP4146264A1 (en) | 2020-05-07 | 2023-03-15 | Pliant Therapeutics, Inc. | Treatment of respiratory diseases with amino acid compounds |
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2019
- 2019-03-07 WO PCT/US2019/021243 patent/WO2019173653A1/en active Application Filing
- 2019-03-07 RS RS20240183A patent/RS65170B1/sr unknown
- 2019-03-07 CR CR20200452A patent/CR20200452A/es unknown
- 2019-03-07 PE PE2020001357A patent/PE20201502A1/es unknown
- 2019-03-07 JO JOP/2020/0212A patent/JOP20200212A1/ar unknown
- 2019-03-07 BR BR112020018064-5A patent/BR112020018064A2/pt unknown
- 2019-03-07 TW TW108107688A patent/TW201938158A/zh unknown
- 2019-03-07 HR HRP20240234TT patent/HRP20240234T1/hr unknown
- 2019-03-07 FI FIEP19765136.7T patent/FI3761980T3/fi active
- 2019-03-07 MX MX2020009253A patent/MX2020009253A/es unknown
- 2019-03-07 CN CN201980030750.4A patent/CN112135612A/zh active Pending
- 2019-03-07 EP EP23205993.1A patent/EP4328230A3/en active Pending
- 2019-03-07 CU CU2020000066A patent/CU24684B1/es unknown
- 2019-03-07 US US16/296,194 patent/US10793564B2/en active Active
- 2019-03-07 IL IL277146A patent/IL277146B2/en unknown
- 2019-03-07 JP JP2020521559A patent/JP6866535B2/ja active Active
- 2019-03-07 DK DK19765136.7T patent/DK3761980T3/da active
- 2019-03-07 PT PT197651367T patent/PT3761980T/pt unknown
- 2019-03-07 AU AU2019230209A patent/AU2019230209B2/en active Active
- 2019-03-07 KR KR1020207026985A patent/KR20200139676A/ko not_active Application Discontinuation
- 2019-03-07 IL IL305296A patent/IL305296A/en unknown
- 2019-03-07 CA CA3093225A patent/CA3093225A1/en active Pending
- 2019-03-07 LT LTEPPCT/US2019/021243T patent/LT3761980T/lt unknown
- 2019-03-07 EP EP19765136.7A patent/EP3761980B1/en active Active
- 2019-03-07 SG SG11202008609UA patent/SG11202008609UA/en unknown
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2020
- 2020-06-26 US US16/914,209 patent/US11560376B2/en active Active
- 2020-09-04 MX MX2022014456A patent/MX2022014456A/es unknown
- 2020-09-04 CL CL2020002290A patent/CL2020002290A1/es unknown
- 2020-09-07 CO CONC2020/0011085A patent/CO2020011085A2/es unknown
- 2020-09-07 PH PH12020551395A patent/PH12020551395A1/en unknown
- 2020-10-06 EC ECSENADI202063227A patent/ECSP20063227A/es unknown
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2021
- 2021-04-07 JP JP2021065309A patent/JP7273882B2/ja active Active
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2022
- 2022-12-19 US US18/084,307 patent/US20230271960A1/en active Pending
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2023
- 2023-04-28 JP JP2023074346A patent/JP2023106425A/ja active Pending
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