EA202190134A1 - Соединения аминокислот с неразветвленными линкерами и способы их применения - Google Patents
Соединения аминокислот с неразветвленными линкерами и способы их примененияInfo
- Publication number
- EA202190134A1 EA202190134A1 EA202190134A EA202190134A EA202190134A1 EA 202190134 A1 EA202190134 A1 EA 202190134A1 EA 202190134 A EA202190134 A EA 202190134A EA 202190134 A EA202190134 A EA 202190134A EA 202190134 A1 EA202190134 A1 EA 202190134A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- unbranged
- linkers
- methods
- application
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 title 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 2
- 201000004071 non-specific interstitial pneumonia Diseases 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Devices That Are Associated With Refrigeration Equipment (AREA)
Abstract
Изобретение относится к соединениям формулы (A)или их солям, где R1, R2, R5a, R5b, R6a, R6b, R7a, R7b, R8a, R8b, R9a, R9b, R10a, R10b, R11a, R11b, R21, n и G являются такими, как описано в данном документе. Соединения формулы (I) и их фармацевтические композиции являются ингибиторами интегрина V6, которые пригодны для лечения фиброза, такого как идиопатический фиброз легких (IPF), и неспецифической интерстициальной пневмонии (NSIP).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690939P | 2018-06-27 | 2018-06-27 | |
| PCT/US2019/039624 WO2020006315A1 (en) | 2018-06-27 | 2019-06-27 | Amino acid compounds with unbranched linkers and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190134A1 true EA202190134A1 (ru) | 2021-03-26 |
Family
ID=68987528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190134A EA202190134A1 (ru) | 2018-06-27 | 2019-06-27 | Соединения аминокислот с неразветвленными линкерами и способы их применения |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US11396506B2 (ru) |
| EP (1) | EP3813818A4 (ru) |
| JP (2) | JP7425757B2 (ru) |
| KR (1) | KR20210043561A (ru) |
| CN (1) | CN112689507A (ru) |
| AU (1) | AU2019295769B2 (ru) |
| BR (1) | BR112020026278A2 (ru) |
| CA (1) | CA3104682A1 (ru) |
| CL (1) | CL2020003382A1 (ru) |
| CR (1) | CR20210041A (ru) |
| CU (1) | CU24693B1 (ru) |
| DO (1) | DOP2020000255A (ru) |
| EA (1) | EA202190134A1 (ru) |
| EC (1) | ECSP21005655A (ru) |
| IL (2) | IL279717B2 (ru) |
| JO (1) | JOP20200330A1 (ru) |
| MX (1) | MX2020014086A (ru) |
| PE (1) | PE20210137A1 (ru) |
| PH (1) | PH12020552260A1 (ru) |
| SG (1) | SG11202013027RA (ru) |
| WO (1) | WO2020006315A1 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
| EP3558303A4 (en) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | AMINO ACID COMPOUNDS AND METHOD FOR USE |
| JP2020504120A (ja) | 2016-12-29 | 2020-02-06 | セントルイス ユニバーシティ | インテグリンアンタゴニスト |
| RU2769702C2 (ru) | 2017-02-28 | 2022-04-05 | Морфик Терапьютик, Инк. | Ингибиторы интегрина avb6 |
| MA47692A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| BR112020018064A2 (pt) | 2018-03-07 | 2020-12-22 | Pliant Therapeutics, Inc. | Compostos de aminoácidos e métodos de uso |
| IL279717B2 (en) | 2018-06-27 | 2024-05-01 | Pliant Therapeutics Inc | Amino acid compounds with non-branched linkers and methods of use |
| FI3814348T3 (fi) | 2018-06-27 | 2023-09-22 | Bristol Myers Squibb Co | Substituoituja naftyridinoniyhdisteitä, jotka ovat käyttökelpoisia t-solun aktivoijina |
| MX2021002181A (es) | 2018-08-29 | 2021-07-15 | Morphic Therapeutic Inc | Inhibicion de la integrina alfa v beta 6. |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| SG11202110889WA (en) | 2019-04-08 | 2021-10-28 | Pliant Therapeutics Inc | Dosage forms and regimens for amino acid compounds |
| US20230055657A1 (en) * | 2019-12-20 | 2023-02-23 | Novartis Ag | Combination treatment of liver diseases using integrin inhibitors |
| AU2020408067B2 (en) * | 2019-12-20 | 2024-03-28 | Novartis Ag | Combination treatment of liver diseases using integrin inhibitors |
| AU2021381516A1 (en) | 2020-11-19 | 2023-06-22 | Pliant Therapeutics, Inc. | Integrin inhibitor and uses thereof |
| GB202209228D0 (en) | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Modified amino acids and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
| HUP0100397A3 (en) | 1997-12-17 | 2002-10-28 | Merck & Co Inc | Tetrahydro- or octahydrobenzonaphtyridin and quinolin derivatives, pharmaceutical compositions thereof and process for their preparation |
| US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| WO2007141473A1 (en) | 2006-06-09 | 2007-12-13 | Astrazeneca Ab | N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors |
| US20080182842A1 (en) * | 2007-01-29 | 2008-07-31 | Astrazeneca Ab | L-alanine derivatives as a5beta1 antagonists |
| GB201305668D0 (en) * | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
| WO2015048819A1 (en) | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
| JP2018515424A (ja) | 2015-03-10 | 2018-06-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗アルファｖベータ１インテグリン阻害剤及び使用方法 |
| CN104817604B (zh) | 2015-03-16 | 2017-08-04 | 邦泰生物工程(深圳)有限公司 | 一种β‑烟酰胺单核苷酸的纯化方法 |
| CN108040467A (zh) * | 2015-04-30 | 2018-05-15 | 赛弗卢尔生命科学公司 | 四氢萘啶基丙酸衍生物及其用途 |
| EP3481814B1 (en) | 2016-07-05 | 2022-04-27 | The Rockefeller University | Tetrahydronaphthyridinepentanamide integrin antagonists |
| EP3509590A4 (en) | 2016-09-07 | 2020-12-02 | Pliant Therapeutics, Inc. | N-ACYL AMINO ACID COMPOUNDS AND METHOD OF USING |
| AR110139A1 (es) * | 2016-11-08 | 2019-02-27 | Bristol Myers Squibb Co | COMPUESTOS MONO Y ESPIROCÍCLICOS QUE CONTIENEN CICLOBUTANO Y AZETIDINA COMO INHIBIDORES DE LA INTEGRINA aV |
| EP3558303A4 (en) | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | AMINO ACID COMPOUNDS AND METHOD FOR USE |
| RU2769702C2 (ru) | 2017-02-28 | 2022-04-05 | Морфик Терапьютик, Инк. | Ингибиторы интегрина avb6 |
| MA47692A (fr) * | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| BR112020018064A2 (pt) | 2018-03-07 | 2020-12-22 | Pliant Therapeutics, Inc. | Compostos de aminoácidos e métodos de uso |
| IL279717B2 (en) | 2018-06-27 | 2024-05-01 | Pliant Therapeutics Inc | Amino acid compounds with non-branched linkers and methods of use |
| MX2021002181A (es) | 2018-08-29 | 2021-07-15 | Morphic Therapeutic Inc | Inhibicion de la integrina alfa v beta 6. |
| EP3843728A4 (en) | 2018-08-29 | 2022-05-25 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN |
| EP3843727A4 (en) | 2018-08-29 | 2022-08-17 | Morphic Therapeutic, Inc. | INTEGRIN (ALPHA-V)(BETA-6) INHIBITORS |
| TW202028179A (zh) | 2018-10-08 | 2020-08-01 | 美商普萊恩醫療公司 | 胺基酸化合物及使用方法 |
| SG11202110889WA (en) | 2019-04-08 | 2021-10-28 | Pliant Therapeutics Inc | Dosage forms and regimens for amino acid compounds |
| MX2022005904A (es) | 2019-11-15 | 2022-09-07 | Pliant Therapeutics Inc | Composiciones y metodos para la activacion de integrinas. |
| MX2022013753A (es) | 2020-05-07 | 2023-01-30 | Pliant Therapeutics Inc | Tratamiento de enfermedades respiratorias con compuestos de aminoacidos. |
| AU2021381516A1 (en) | 2020-11-19 | 2023-06-22 | Pliant Therapeutics, Inc. | Integrin inhibitor and uses thereof |
| TW202308637A (zh) | 2021-04-30 | 2023-03-01 | 美商普萊恩醫療公司 | 整合素抑制劑之擴大劑量方案 |
| CA3173754A1 (en) | 2021-09-03 | 2024-03-02 | Pliant Therapeutics, Inc. | Therapeutic modulation of integrins |
| IL312083A (en) | 2021-10-14 | 2024-06-01 | Pliant Therapeutics Inc | Integrin inhibitors and their uses in combination with other substances |
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2019
- 2019-06-27 IL IL279717A patent/IL279717B2/en unknown
- 2019-06-27 CA CA3104682A patent/CA3104682A1/en active Pending
- 2019-06-27 JP JP2020572976A patent/JP7425757B2/ja active Active
- 2019-06-27 AU AU2019295769A patent/AU2019295769B2/en active Active
- 2019-06-27 SG SG11202013027RA patent/SG11202013027RA/en unknown
- 2019-06-27 PE PE2020002165A patent/PE20210137A1/es unknown
- 2019-06-27 EA EA202190134A patent/EA202190134A1/ru unknown
- 2019-06-27 MX MX2020014086A patent/MX2020014086A/es unknown
- 2019-06-27 WO PCT/US2019/039624 patent/WO2020006315A1/en active Application Filing
- 2019-06-27 IL IL308960A patent/IL308960A/en unknown
- 2019-06-27 KR KR1020217002250A patent/KR20210043561A/ko active Search and Examination
- 2019-06-27 BR BR112020026278-1A patent/BR112020026278A2/pt unknown
- 2019-06-27 CN CN201980050125.6A patent/CN112689507A/zh active Pending
- 2019-06-27 CR CR20210041A patent/CR20210041A/es unknown
- 2019-06-27 CU CU2021000001A patent/CU24693B1/es unknown
- 2019-06-27 JO JOP/2020/0330A patent/JOP20200330A1/ar unknown
- 2019-06-27 US US16/455,490 patent/US11396506B2/en active Active
- 2019-06-27 EP EP19826330.3A patent/EP3813818A4/en active Pending
-
2020
- 2020-12-23 PH PH12020552260A patent/PH12020552260A1/en unknown
- 2020-12-23 DO DO2020000255A patent/DOP2020000255A/es unknown
- 2020-12-23 CL CL2020003382A patent/CL2020003382A1/es unknown
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2021
- 2021-01-26 EC ECSENADI20215655A patent/ECSP21005655A/es unknown
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2022
- 2022-02-23 US US17/679,002 patent/US11858931B2/en active Active
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2024
- 2024-01-19 JP JP2024006536A patent/JP2024055873A/ja active Pending
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