MX2018005203A - Compuestos de pirrolo-, pirazolo-, imidazo-pirimidina y pirrolo-, pirazolo-, imidazo-piridina que inhiben cinasas 1 y 2 de interaccion con proteina cinasas activadas por mitogenos (mnk1 y mnk2). - Google Patents

Compuestos de pirrolo-, pirazolo-, imidazo-pirimidina y pirrolo-, pirazolo-, imidazo-piridina que inhiben cinasas 1 y 2 de interaccion con proteina cinasas activadas por mitogenos (mnk1 y mnk2).

Info

Publication number
MX2018005203A
MX2018005203A MX2018005203A MX2018005203A MX2018005203A MX 2018005203 A MX2018005203 A MX 2018005203A MX 2018005203 A MX2018005203 A MX 2018005203A MX 2018005203 A MX2018005203 A MX 2018005203A MX 2018005203 A MX2018005203 A MX 2018005203A
Authority
MX
Mexico
Prior art keywords
mnk2
pyrazolo
pyrrolo
imidazo
pyrimidine
Prior art date
Application number
MX2018005203A
Other languages
English (en)
Inventor
H Reich Siegfried
A Sprengeler Paul
E Webber Stephen
T Ernst Justin
Original Assignee
Effector Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Effector Therapeutics Inc filed Critical Effector Therapeutics Inc
Publication of MX2018005203A publication Critical patent/MX2018005203A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona sí­ntesis, formulaciones farmacéuticamente aceptables y usos de los compuestos de acuerdo con la fórmula (I) o un estereoisómero, tautómero o una sal farmacéuticamente aceptable del mismo. Para los compuestos de la fórmula (I) A1, A2, A3, A4, A5, A6, A7, W1, R1, R2, R3, R4, R5a, R5b, R6, R7, R7a, R7b, R8, R8a, R8b, R9, R9a, R9b y R10 y los subí­ndices ``m´´ y ``n´´ son como se definen en la especificación. Los compuestos de fórmula (I) de la invención son inhibidores de Mnk y encuentran utilidad en diversas aplicaciones terapéuticas que incluyen pero que no se limitan al tratamiento de inflamación y diversos cánceres.
MX2018005203A 2015-10-29 2016-10-28 Compuestos de pirrolo-, pirazolo-, imidazo-pirimidina y pirrolo-, pirazolo-, imidazo-piridina que inhiben cinasas 1 y 2 de interaccion con proteina cinasas activadas por mitogenos (mnk1 y mnk2). MX2018005203A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562247966P 2015-10-29 2015-10-29
PCT/US2016/059407 WO2017075412A1 (en) 2015-10-29 2016-10-28 Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit mnk1 and mnk2

Publications (1)

Publication Number Publication Date
MX2018005203A true MX2018005203A (es) 2018-07-06

Family

ID=57256471

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018005203A MX2018005203A (es) 2015-10-29 2016-10-28 Compuestos de pirrolo-, pirazolo-, imidazo-pirimidina y pirrolo-, pirazolo-, imidazo-piridina que inhiben cinasas 1 y 2 de interaccion con proteina cinasas activadas por mitogenos (mnk1 y mnk2).

Country Status (13)

Country Link
US (2) US20170121339A1 (es)
EP (1) EP3368533A1 (es)
JP (1) JP6888006B2 (es)
KR (1) KR20180070696A (es)
CN (1) CN108602814A (es)
AU (1) AU2016343980A1 (es)
BR (1) BR112018008711A2 (es)
CA (1) CA3002558A1 (es)
EA (1) EA034440B1 (es)
IL (1) IL258867A (es)
MX (1) MX2018005203A (es)
SG (1) SG11201803234TA (es)
WO (1) WO2017075412A1 (es)

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TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
MX2019009653A (es) 2017-02-14 2019-12-19 Effector Therapeutics Inc Inhibidores de mnk sustituidos con piperidina y metodos relacionados con los mismos.
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
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US20220251097A1 (en) * 2019-08-01 2022-08-11 St. Jude Childrens's Research Hospital Molecules and methods related to treatment of uncontrolled cellular proliferation
JP7311207B2 (ja) 2019-11-18 2023-07-19 成都嘉葆薬銀医薬科技有限公司 Ｍｎｋ阻害剤としてのピロロトリアジン系化合物
IL299512A (en) * 2020-06-30 2023-02-01 4E Therapeutics Inc pyridine-1,5 - discussions that suppress MNK and methods of using them
US20240092799A1 (en) * 2020-08-20 2024-03-21 Hepagene Therapeutics (HK) Limited Mnk inhibitors
CN117355528A (zh) 2021-05-08 2024-01-05 成都嘉葆药银医药科技有限公司 吡咯并三嗪类化合物的盐型、其晶型及其制备方法

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Also Published As

Publication number Publication date
JP2018531972A (ja) 2018-11-01
KR20180070696A (ko) 2018-06-26
BR112018008711A2 (pt) 2018-10-30
CA3002558A1 (en) 2017-05-04
EA201891050A1 (ru) 2018-11-30
EP3368533A1 (en) 2018-09-05
SG11201803234TA (en) 2018-05-30
US20190330216A1 (en) 2019-10-31
CN108602814A (zh) 2018-09-28
JP6888006B2 (ja) 2021-06-16
EA034440B1 (ru) 2020-02-07
IL258867A (en) 2018-06-28
US20170121339A1 (en) 2017-05-04
AU2016343980A1 (en) 2018-06-07
US11014926B2 (en) 2021-05-25
WO2017075412A1 (en) 2017-05-04

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