MA39025B1 - Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase - Google Patents

Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Info

Publication number
MA39025B1
MA39025B1 MA39025A MA39025A MA39025B1 MA 39025 B1 MA39025 B1 MA 39025B1 MA 39025 A MA39025 A MA 39025A MA 39025 A MA39025 A MA 39025A MA 39025 B1 MA39025 B1 MA 39025B1
Authority
MA
Morocco
Prior art keywords
ghrelin
piperidyl
inhibitor
ethyl
acyl transferase
Prior art date
Application number
MA39025A
Other languages
English (en)
Other versions
MA39025A1 (fr
Inventor
Maria Angeles Martinez-Grau
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA39025A1 publication Critical patent/MA39025A1/fr
Publication of MA39025B1 publication Critical patent/MA39025B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La présente invention concerne de nouveaux inhibiteurs de la ghréline o-acyl transférase (goat) et leurs sels et des compositions pharmaceutiques de ceux-ci.
MA39025A 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase MA39025B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13382460 2013-11-14
PCT/US2014/064202 WO2015073281A1 (fr) 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Publications (2)

Publication Number Publication Date
MA39025A1 MA39025A1 (fr) 2017-05-31
MA39025B1 true MA39025B1 (fr) 2018-05-31

Family

ID=49622771

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39025A MA39025B1 (fr) 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Country Status (40)

Country Link
US (1) US9035051B1 (fr)
EP (1) EP3068775B1 (fr)
JP (1) JP6159484B2 (fr)
KR (1) KR101739243B1 (fr)
CN (1) CN105636948B (fr)
AP (1) AP2016009189A0 (fr)
AR (1) AR098274A1 (fr)
AU (1) AU2014348967B2 (fr)
BR (1) BR112016009488B1 (fr)
CA (1) CA2926224C (fr)
CL (1) CL2016001023A1 (fr)
CR (1) CR20160184A (fr)
CY (1) CY1119489T1 (fr)
DK (1) DK3068775T3 (fr)
DO (1) DOP2016000070A (fr)
EA (1) EA028550B1 (fr)
ES (1) ES2647790T3 (fr)
HK (1) HK1222860A1 (fr)
HR (1) HRP20171648T1 (fr)
HU (1) HUE035590T2 (fr)
IL (1) IL244856A (fr)
JO (1) JO3302B1 (fr)
LT (1) LT3068775T (fr)
MA (1) MA39025B1 (fr)
ME (1) ME02841B (fr)
MX (1) MX2016006223A (fr)
NO (1) NO3068775T3 (fr)
NZ (1) NZ718373A (fr)
PE (1) PE20160609A1 (fr)
PH (1) PH12016500895A1 (fr)
PL (1) PL3068775T3 (fr)
PT (1) PT3068775T (fr)
RS (1) RS56533B1 (fr)
SG (1) SG11201602953YA (fr)
SI (1) SI3068775T1 (fr)
TN (1) TN2016000145A1 (fr)
TW (1) TWI538677B (fr)
UA (1) UA118034C2 (fr)
WO (1) WO2015073281A1 (fr)
ZA (1) ZA201602202B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR104673A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
AR104672A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
ES2874587T3 (es) * 2016-08-05 2021-11-05 Boehringer Ingelheim Int Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT)
CN106478519B (zh) * 2016-10-10 2018-12-11 上海再启生物技术有限公司 一种2-甲基-4-氨基-6-氯嘧啶的制备方法
WO2019149658A1 (fr) 2018-02-02 2019-08-08 Boehringer Ingelheim International Gmbh Dérivés d'oxadiazolopyridine à substitution pyrazole et indazole destinés à être utilisés en tant qu'inhibiteurs de la ghréline o-acyl transférase (goat)
CA3087925A1 (fr) * 2018-02-02 2019-08-08 Boehringer Ingelheim International Gmbh Derives de triazolopyrimidine destines a etre utilises en tant qu'inhibiteurs de la ghreline o-acyltransferase (goat)
EP3746451B1 (fr) * 2018-02-02 2023-07-12 Boehringer Ingelheim International GmbH Dérivés d'oxadiazolopyridine à substitution benzyle, (pyridin-3-yl)méthyle ou (pyridin-4-yl)méthyle utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat)
MX2020008116A (es) * 2018-02-02 2020-09-25 Boehringer Ingelheim Int Derivados de oxadiazolopiridina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltransferasa (goat).
CN108774221A (zh) * 2018-05-30 2018-11-09 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN108516971A (zh) * 2018-05-30 2018-09-11 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108610337A (zh) * 2018-05-30 2018-10-02 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108558852A (zh) * 2018-05-30 2018-09-21 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN108558849A (zh) * 2018-05-30 2018-09-21 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
JP2023526351A (ja) 2020-05-22 2023-06-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの製造方法
EP4153600A1 (fr) 2020-05-22 2023-03-29 Boehringer Ingelheim International GmbH Procédé continu de fabrication de 7-amino-5-méthyl-[1,2,5] oxadiazolo [3,4-b] pyridine-carboxylate d'alkyle

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2403686C (fr) * 2000-03-23 2010-01-26 Merck & Co., Inc. Piperidines substituees en tant qu'agonistes du recepteur de la melanocortine
WO2005026211A2 (fr) 2003-09-05 2005-03-24 Eli Lilly And Company Anticorps anti-ghreline
US20070237775A1 (en) 2004-07-14 2007-10-11 Eli Lilly And Company Anti-Ghrelin Antibodies
US20090060920A1 (en) 2004-11-15 2009-03-05 Eli Lilly And Company Desacyl ghrelin antibodies and therapeutic uses thereof
JP4909284B2 (ja) 2005-01-26 2012-04-04 キストラー ホールディング アクチエンゲゼルシャフト 加速度又は圧力測定用の接地絶縁された圧電型センサ
WO2006091381A1 (fr) 2005-02-23 2006-08-31 Eli Lilly And Company Anticorps anti-ghreline humanises
WO2006124490A2 (fr) * 2005-05-17 2006-11-23 Schering Corporation Heterocycles utilises comme agonistes du recepteur de l'acide nicotinique dans le traitement de la dyslipidemie
CN101175759A (zh) * 2005-05-17 2008-05-07 先灵公司 作为治疗血脂异常的烟酸受体激动剂的杂环化合物
US20070213359A1 (en) * 2005-12-30 2007-09-13 Acadia Pharmaceuticals Inc. Bicyclic-nitrogen compounds as modulators of ghrelin receptor and uses thereof
EP2268143A4 (fr) * 2008-03-20 2012-06-27 Forest Lab Holdings Ltd Nouveaux dérivés de pipéridine servant d'inhibiteurs de stéaroyle-coa-désaturase
AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida

Also Published As

Publication number Publication date
HRP20171648T1 (hr) 2017-12-15
DOP2016000070A (es) 2016-05-30
JP2016537371A (ja) 2016-12-01
ES2647790T3 (es) 2017-12-26
EA028550B1 (ru) 2017-11-30
US9035051B1 (en) 2015-05-19
TWI538677B (zh) 2016-06-21
EA201690764A1 (ru) 2016-07-29
TN2016000145A1 (en) 2017-10-06
PT3068775T (pt) 2017-11-20
CA2926224A1 (fr) 2015-05-21
US20150133474A1 (en) 2015-05-14
HK1222860A1 (zh) 2017-07-14
EP3068775B1 (fr) 2017-09-06
JO3302B1 (ar) 2018-09-16
ZA201602202B (en) 2019-10-30
CL2016001023A1 (es) 2016-11-18
AU2014348967A1 (en) 2016-04-28
CY1119489T1 (el) 2018-03-07
DK3068775T3 (en) 2017-10-23
TW201529073A (zh) 2015-08-01
CN105636948A (zh) 2016-06-01
WO2015073281A1 (fr) 2015-05-21
SI3068775T1 (sl) 2017-10-30
UA118034C2 (uk) 2018-11-12
RS56533B1 (sr) 2018-02-28
IL244856A0 (en) 2016-05-31
PL3068775T3 (pl) 2018-01-31
LT3068775T (lt) 2017-11-27
NO3068775T3 (fr) 2018-02-03
SG11201602953YA (en) 2016-05-30
MX2016006223A (es) 2016-08-08
KR101739243B1 (ko) 2017-05-23
AU2014348967B2 (en) 2017-05-04
BR112016009488A8 (pt) 2018-01-30
AP2016009189A0 (en) 2016-05-31
EP3068775A1 (fr) 2016-09-21
KR20160068926A (ko) 2016-06-15
CN105636948B (zh) 2017-10-24
PH12016500895B1 (en) 2016-06-20
CR20160184A (es) 2016-06-17
PH12016500895A1 (en) 2016-06-20
CA2926224C (fr) 2017-05-02
HUE035590T2 (en) 2018-05-28
PE20160609A1 (es) 2016-07-03
AR098274A1 (es) 2016-05-18
NZ718373A (en) 2017-12-22
MA39025A1 (fr) 2017-05-31
IL244856A (en) 2017-07-31
ME02841B (fr) 2018-01-20
BR112016009488B1 (pt) 2021-01-19
JP6159484B2 (ja) 2017-07-05

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