MA39025A1 - Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase - Google Patents

Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Info

Publication number
MA39025A1
MA39025A1 MA39025A MA39025A MA39025A1 MA 39025 A1 MA39025 A1 MA 39025A1 MA 39025 A MA39025 A MA 39025A MA 39025 A MA39025 A MA 39025A MA 39025 A1 MA39025 A1 MA 39025A1
Authority
MA
Morocco
Prior art keywords
ghrelin
piperidyl
inhibitor
ethyl
acyl transferase
Prior art date
Application number
MA39025A
Other languages
English (en)
Other versions
MA39025B1 (fr
Inventor
Maria Angeles Martinez-Grau
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA39025A1 publication Critical patent/MA39025A1/fr
Publication of MA39025B1 publication Critical patent/MA39025B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La présente invention concerne de nouveaux inhibiteurs de la ghréline o-acyl transférase (goat) et leurs sels et des compositions pharmaceutiques de ceux-ci.
MA39025A 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase MA39025B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13382460 2013-11-14
PCT/US2014/064202 WO2015073281A1 (fr) 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Publications (2)

Publication Number Publication Date
MA39025A1 true MA39025A1 (fr) 2017-05-31
MA39025B1 MA39025B1 (fr) 2018-05-31

Family

ID=49622771

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39025A MA39025B1 (fr) 2013-11-14 2014-11-06 Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase

Country Status (40)

Country Link
US (1) US9035051B1 (fr)
EP (1) EP3068775B1 (fr)
JP (1) JP6159484B2 (fr)
KR (1) KR101739243B1 (fr)
CN (1) CN105636948B (fr)
AP (1) AP2016009189A0 (fr)
AR (1) AR098274A1 (fr)
AU (1) AU2014348967B2 (fr)
BR (1) BR112016009488B1 (fr)
CA (1) CA2926224C (fr)
CL (1) CL2016001023A1 (fr)
CR (1) CR20160184A (fr)
CY (1) CY1119489T1 (fr)
DK (1) DK3068775T3 (fr)
DO (1) DOP2016000070A (fr)
EA (1) EA028550B1 (fr)
ES (1) ES2647790T3 (fr)
HK (1) HK1222860A1 (fr)
HR (1) HRP20171648T1 (fr)
HU (1) HUE035590T2 (fr)
IL (1) IL244856A (fr)
JO (1) JO3302B1 (fr)
LT (1) LT3068775T (fr)
MA (1) MA39025B1 (fr)
ME (1) ME02841B (fr)
MX (1) MX2016006223A (fr)
NO (1) NO3068775T3 (fr)
NZ (1) NZ718373A (fr)
PE (1) PE20160609A1 (fr)
PH (1) PH12016500895A1 (fr)
PL (1) PL3068775T3 (fr)
PT (1) PT3068775T (fr)
RS (1) RS56533B1 (fr)
SG (1) SG11201602953YA (fr)
SI (1) SI3068775T1 (fr)
TN (1) TN2016000145A1 (fr)
TW (1) TWI538677B (fr)
UA (1) UA118034C2 (fr)
WO (1) WO2015073281A1 (fr)
ZA (1) ZA201602202B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR104673A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
AR104672A1 (es) * 2015-04-15 2017-08-09 Lilly Co Eli Inhibidores de grelina o-aciltransferasa
MY197064A (en) 2016-08-05 2023-05-24 Boehringer Ingelheim Int Oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors
CN106478519B (zh) * 2016-10-10 2018-12-11 上海再启生物技术有限公司 一种2-甲基-4-氨基-6-氯嘧啶的制备方法
JOP20200187A1 (ar) * 2018-02-02 2020-07-29 Boehringer Ingelheim Int مشتقات ترايازولو بيريميدين للاستخدام كمثبطات جريلين o- أسيل ترانسفيراز (goat)
WO2019149658A1 (fr) 2018-02-02 2019-08-08 Boehringer Ingelheim International Gmbh Dérivés d'oxadiazolopyridine à substitution pyrazole et indazole destinés à être utilisés en tant qu'inhibiteurs de la ghréline o-acyl transférase (goat)
JOP20200190A1 (ar) 2018-02-02 2020-07-29 Boehringer Ingelheim Int مشتقات أوكسادايازولو بيريدين بها استبدال ببنزيل -، (بيريدين -3- يل) ميثيل - أو (بيريدين -4- يل) ميثيل كمثبطات جريلين o- أسيل ترانسفيراز (goat)
US11319310B2 (en) 2018-02-02 2022-05-03 Boehringer Ingelheim International Gmbh Heterocyclyl-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
CN108610337A (zh) * 2018-05-30 2018-10-02 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108558852A (zh) * 2018-05-30 2018-09-21 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN108774221A (zh) * 2018-05-30 2018-11-09 王丽萍 一种goat抑制剂及其在肥胖和糖尿病中的应用
CN108516971A (zh) * 2018-05-30 2018-09-11 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
CN108558849A (zh) * 2018-05-30 2018-09-21 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
JP2023526351A (ja) 2020-05-22 2023-06-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070708A1 (fr) * 2000-03-23 2001-09-27 Merck & Co., Inc. Piperidines substituees en tant qu'agonistes du recepteur de la melanocortine
WO2005026211A2 (fr) 2003-09-05 2005-03-24 Eli Lilly And Company Anticorps anti-ghreline
JP2008515771A (ja) 2004-07-14 2008-05-15 イーライ リリー アンド カンパニー 抗グレリン抗体
WO2006055347A2 (fr) 2004-11-15 2006-05-26 Eli Lilly And Company Anticorps de desacyle ghreline et utilisations therapeutiques de ceux-ci
ATE466289T1 (de) 2005-01-26 2010-05-15 Kistler Holding Ag Masseisolierter piezoelektrischer sensor zur messung von beschleunigung oder druck
EP1856154A1 (fr) 2005-02-23 2007-11-21 Eli Lilly And Company Anticorps anti-ghreline humanises
JP4975739B2 (ja) * 2005-05-17 2012-07-11 シェーリング コーポレイション 脂質異常症の処置のための、ニコチン酸受容体アゴニストとしての複素環
CN101175759A (zh) * 2005-05-17 2008-05-07 先灵公司 作为治疗血脂异常的烟酸受体激动剂的杂环化合物
WO2007079239A2 (fr) * 2005-12-30 2007-07-12 Acadia Pharmaceuticals Inc. Composes bicycliques a base d'azote en tant que modulateurs de recepteur de ghreline et leurs utilisations
US8129376B2 (en) * 2008-03-20 2012-03-06 Sundaresan Kumar Piperidine derivatives as inhibitors of stearoyl-CoA desaturase
AR091516A1 (es) * 2012-06-22 2015-02-11 Actelion Pharmaceuticals Ltd Derivados de 1-[m-carboxamido(hetero)aril-metil]-heterociclil-carboxamida

Also Published As

Publication number Publication date
HK1222860A1 (zh) 2017-07-14
CA2926224C (fr) 2017-05-02
EA201690764A1 (ru) 2016-07-29
US9035051B1 (en) 2015-05-19
UA118034C2 (uk) 2018-11-12
AR098274A1 (es) 2016-05-18
KR20160068926A (ko) 2016-06-15
CN105636948A (zh) 2016-06-01
HUE035590T2 (en) 2018-05-28
BR112016009488B1 (pt) 2021-01-19
WO2015073281A1 (fr) 2015-05-21
AU2014348967B2 (en) 2017-05-04
TN2016000145A1 (en) 2017-10-06
LT3068775T (lt) 2017-11-27
PT3068775T (pt) 2017-11-20
JP2016537371A (ja) 2016-12-01
NZ718373A (en) 2017-12-22
MX2016006223A (es) 2016-08-08
PE20160609A1 (es) 2016-07-03
CL2016001023A1 (es) 2016-11-18
PL3068775T3 (pl) 2018-01-31
IL244856A (en) 2017-07-31
EP3068775A1 (fr) 2016-09-21
JP6159484B2 (ja) 2017-07-05
MA39025B1 (fr) 2018-05-31
ME02841B (fr) 2018-01-20
CN105636948B (zh) 2017-10-24
TW201529073A (zh) 2015-08-01
CR20160184A (es) 2016-06-17
KR101739243B1 (ko) 2017-05-23
ES2647790T3 (es) 2017-12-26
RS56533B1 (sr) 2018-02-28
TWI538677B (zh) 2016-06-21
SI3068775T1 (sl) 2017-10-30
ZA201602202B (en) 2019-10-30
NO3068775T3 (fr) 2018-02-03
PH12016500895B1 (en) 2016-06-20
EA028550B1 (ru) 2017-11-30
SG11201602953YA (en) 2016-05-30
AP2016009189A0 (en) 2016-05-31
HRP20171648T1 (hr) 2017-12-15
EP3068775B1 (fr) 2017-09-06
IL244856A0 (en) 2016-05-31
CA2926224A1 (fr) 2015-05-21
PH12016500895A1 (en) 2016-06-20
JO3302B1 (ar) 2018-09-16
AU2014348967A1 (en) 2016-04-28
DOP2016000070A (es) 2016-05-30
CY1119489T1 (el) 2018-03-07
DK3068775T3 (en) 2017-10-23
US20150133474A1 (en) 2015-05-14
BR112016009488A8 (pt) 2018-01-30

Similar Documents

Publication Publication Date Title
MA39025B1 (fr) Pipéridyl-éthyl-pyrimidine substituée utilisée comme inhibiteur de la ghréline o-acyl transférase
MX2018001990A (es) Composiciones que comprenden un inhibidor de p13k y un inhibidor de hdac.
EA201792205A1 (ru) Гетероциклические соединения как ингибиторы lsd1
EA201792519A1 (ru) Противогрибковые соединения
PH12017502051A1 (en) TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
EA201891438A1 (ru) Кислотно-аддитивные соли производных пиперазина
ECSP15037311A (es) Formulación combinada de dos compuestos antivirales
MA38050B1 (fr) Inhibiteurs de gdf-8
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
BR112018003343A2 (pt) compostos heteroarila como inibidores de irak e usos dos mesmos
EA201890239A2 (ru) Фумараты как пролекарства и их применение при лечении различных заболеваний
BR112018003812A2 (pt) compostos de heteroarila como inibidores de irak e usos dos mesmos
EA201690753A1 (ru) Комбинации ингибиторов гистондеацетилазы и иммуномодулирующих лекарственных средств
CY1112077T1 (el) Θεραπεια με πιρφενιδονη αποφευγοντας την φλουβοξαμινη
ECSP13012394A (es) Nuevas formas de dosificación de liberación modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa
TR201908247T4 (tr) Sodyum glikoz birlikte taşıyıcı 1 inhibitörleri.
EA201890331A1 (ru) Пиридинондикарбоксамиды для применения в качестве ингибиторов бромодомена
SA519410093B1 (ar) مركبات بيريميدو بيريميدينون مفيدة كمثبطات دبليو إى إى-1 كيناز
EA201590787A1 (ru) Замещенные пиридопиразины в качестве ингибиторов syk
EA201500851A1 (ru) ЭСТРА-1,3,5(10),16-ТЕТРАЕН-3-КАРБОКСАМИДЫ ДЛЯ ИНГИБИРОВАНИЯ 17β-ГИДРОКСИСТЕРОИД-ДЕГИДРОГЕНАЗЫ (AKR1C3)
MA42776B1 (fr) Composés utiles pour l'inhibition du ror-gamma-t
EA201791992A1 (ru) Ингибиторы грелин-o-ацилтрансферазы
BR112017018342A2 (pt) inibidores de grelina o-acil transferase
MA39824A (fr) Composés azole amido-substitués
EA201270728A1 (ru) Пуриновые соединения