CS9101165A2 - Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceutical - Google Patents
Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceuticalInfo
- Publication number
- CS9101165A2 CS9101165A2 CS911165A CS116591A CS9101165A2 CS 9101165 A2 CS9101165 A2 CS 9101165A2 CS 911165 A CS911165 A CS 911165A CS 116591 A CS116591 A CS 116591A CS 9101165 A2 CS9101165 A2 CS 9101165A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- peptides
- bradykinin
- amino acid
- direct bond
- production
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 102400000967 Bradykinin Human genes 0.000 abstract 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- 101710097732 Bradykinin-related peptides Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4013270A DE4013270A1 (de) | 1990-04-26 | 1990-04-26 | Peptide mit bradykinin-antagonistischer wirkung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS9101165A2 true CS9101165A2 (en) | 1991-12-17 |
| CZ280682B6 CZ280682B6 (cs) | 1996-04-17 |
Family
ID=6405107
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0455133B1 (cs) |
| JP (1) | JP2552402B2 (cs) |
| KR (1) | KR100195569B1 (cs) |
| CN (1) | CN1034416C (cs) |
| AT (1) | ATE149519T1 (cs) |
| AU (1) | AU641004B2 (cs) |
| CA (1) | CA2041268C (cs) |
| CY (1) | CY2113B1 (cs) |
| CZ (1) | CZ280682B6 (cs) |
| DE (2) | DE4013270A1 (cs) |
| DK (1) | DK0455133T3 (cs) |
| ES (1) | ES2099102T3 (cs) |
| FI (1) | FI109541B (cs) |
| GR (1) | GR3023172T3 (cs) |
| HK (1) | HK1006843A1 (cs) |
| HU (1) | HU208028B (cs) |
| IE (1) | IE911387A1 (cs) |
| IL (1) | IL97944A (cs) |
| LV (1) | LV10290B (cs) |
| NO (1) | NO300779B1 (cs) |
| NZ (1) | NZ237928A (cs) |
| PT (1) | PT97466B (cs) |
| RU (1) | RU2056432C1 (cs) |
| SK (1) | SK279286B6 (cs) |
| ZA (1) | ZA913121B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06508116A (ja) * | 1991-04-01 | 1994-09-14 | コルテク，インコーポレイテッド | ブラジキニンアンタゴニスト |
| TW199863B (cs) * | 1991-12-21 | 1993-02-11 | Hoechst Ag | |
| TW258739B (cs) * | 1992-04-04 | 1995-10-01 | Hoechst Ag | |
| KR100360639B1 (ko) * | 1994-03-09 | 2003-01-30 | 코르텍, 인크. | N-치환글리신함유브라디키닌길항제펩티드 |
| FR2739553B1 (fr) * | 1995-10-06 | 1998-01-02 | Oreal | Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
| DE19612067A1 (de) * | 1996-03-27 | 1997-10-02 | Hoechst Ag | Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| DE3926822A1 (de) * | 1989-08-14 | 1991-02-21 | Hoechst Ag | Peptide mit bradykinin-antagonistischer wirkung |
-
1990
- 1990-04-26 DE DE4013270A patent/DE4013270A1/de not_active Withdrawn
-
1991
- 1991-04-24 FI FI911978A patent/FI109541B/fi active
- 1991-04-24 AU AU75304/91A patent/AU641004B2/en not_active Expired
- 1991-04-24 CZ CS911165A patent/CZ280682B6/cs not_active IP Right Cessation
- 1991-04-24 PT PT97466A patent/PT97466B/pt not_active IP Right Cessation
- 1991-04-24 IL IL9794491A patent/IL97944A/en not_active IP Right Cessation
- 1991-04-24 SK SK1165-91A patent/SK279286B6/sk not_active IP Right Cessation
- 1991-04-24 NZ NZ237928A patent/NZ237928A/xx unknown
- 1991-04-25 ZA ZA913121A patent/ZA913121B/xx unknown
- 1991-04-25 EP EP91106663A patent/EP0455133B1/de not_active Expired - Lifetime
- 1991-04-25 AT AT91106663T patent/ATE149519T1/de not_active IP Right Cessation
- 1991-04-25 CA CA002041268A patent/CA2041268C/en not_active Expired - Lifetime
- 1991-04-25 IE IE138791A patent/IE911387A1/en unknown
- 1991-04-25 NO NO911649A patent/NO300779B1/no not_active IP Right Cessation
- 1991-04-25 ES ES91106663T patent/ES2099102T3/es not_active Expired - Lifetime
- 1991-04-25 CN CN91102638A patent/CN1034416C/zh not_active Expired - Lifetime
- 1991-04-25 DE DE59108573T patent/DE59108573D1/de not_active Expired - Lifetime
- 1991-04-25 DK DK91106663.7T patent/DK0455133T3/da active
- 1991-04-25 JP JP3121848A patent/JP2552402B2/ja not_active Expired - Lifetime
- 1991-04-25 KR KR1019910006649A patent/KR100195569B1/ko not_active Expired - Lifetime
- 1991-04-25 HU HU911392A patent/HU208028B/hu unknown
-
1992
- 1992-07-27 RU SU925052268A patent/RU2056432C1/ru active
- 1992-12-23 LV LVP-92-699A patent/LV10290B/lv unknown
-
1997
- 1997-04-18 GR GR970400829T patent/GR3023172T3/el unknown
-
1998
- 1998-06-22 HK HK98105879A patent/HK1006843A1/xx not_active IP Right Cessation
- 1998-09-29 CY CY9800030A patent/CY2113B1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT52527A (en) | Process for producing bradiquinine-antagonistic peptides and pharmaceutical compositions containing them as active components | |
| CS397990A3 (en) | Process for preparing peptides | |
| CS9101165A2 (en) | Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceutical |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20110424 |