CS9101165A2 - Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceutical - Google Patents

Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceutical

Info

Publication number
CS9101165A2
CS9101165A2 CS911165A CS116591A CS9101165A2 CS 9101165 A2 CS9101165 A2 CS 9101165A2 CS 911165 A CS911165 A CS 911165A CS 116591 A CS116591 A CS 116591A CS 9101165 A2 CS9101165 A2 CS 9101165A2
Authority
CS
Czechoslovakia
Prior art keywords
peptides
bradykinin
amino acid
direct bond
production
Prior art date
Application number
CS911165A
Other languages
Czech (cs)
Inventor
Gerhard Dr Breipohl
Stephan Dr Henke
Jochen Dr Knolle
Bernward Prof Dr Scholkens
Franz Dr Hock
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS9101165A2 publication Critical patent/CS9101165A2/en
Publication of CZ280682B6 publication Critical patent/CZ280682B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
CS911165A 1990-04-26 1991-04-24 Peptides exhibiting bradykinin-antagonistic effect, process for their preparation, their application and pharmaceutical containing said peptides CZ280682B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4013270A DE4013270A1 (en) 1990-04-26 1990-04-26 PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT

Publications (2)

Publication Number Publication Date
CS9101165A2 true CS9101165A2 (en) 1991-12-17
CZ280682B6 CZ280682B6 (en) 1996-04-17

Family

ID=6405107

Country Status (25)

Country Link
EP (1) EP0455133B1 (en)
JP (1) JP2552402B2 (en)
KR (1) KR100195569B1 (en)
CN (1) CN1034416C (en)
AT (1) ATE149519T1 (en)
AU (1) AU641004B2 (en)
CA (1) CA2041268C (en)
CY (1) CY2113B1 (en)
CZ (1) CZ280682B6 (en)
DE (2) DE4013270A1 (en)
DK (1) DK0455133T3 (en)
ES (1) ES2099102T3 (en)
FI (1) FI109541B (en)
GR (1) GR3023172T3 (en)
HK (1) HK1006843A1 (en)
HU (1) HU208028B (en)
IE (1) IE911387A1 (en)
IL (1) IL97944A (en)
LV (1) LV10290B (en)
NO (1) NO300779B1 (en)
NZ (1) NZ237928A (en)
PT (1) PT97466B (en)
RU (1) RU2056432C1 (en)
SK (1) SK279286B6 (en)
ZA (1) ZA913121B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2106677A1 (en) * 1991-04-01 1992-10-02 John C. Cheronis Bradykinin antagonists
TW199863B (en) * 1991-12-21 1993-02-11 Hoechst Ag
TW258739B (en) * 1992-04-04 1995-10-01 Hoechst Ag
EP0813544B1 (en) * 1994-03-09 2004-10-27 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
FR2739553B1 (en) * 1995-10-06 1998-01-02 Oreal USE OF BRADYKININE ANTAGONISTS TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE HAIR LOSS
DE19612067A1 (en) * 1996-03-27 1997-10-02 Hoechst Ag Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
DE3926822A1 (en) * 1989-08-14 1991-02-21 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action

Also Published As

Publication number Publication date
PT97466A (en) 1992-01-31
EP0455133B1 (en) 1997-03-05
HU208028B (en) 1993-07-28
JP2552402B2 (en) 1996-11-13
ATE149519T1 (en) 1997-03-15
GR3023172T3 (en) 1997-07-30
HK1006843A1 (en) 1999-03-19
FI911978A (en) 1991-10-27
IL97944A (en) 1995-05-26
NO911649L (en) 1991-10-28
AU7530491A (en) 1991-11-07
RU2056432C1 (en) 1996-03-20
EP0455133A3 (en) 1992-01-08
CA2041268C (en) 2001-10-02
LV10290B (en) 1995-08-20
NZ237928A (en) 1993-09-27
CN1034416C (en) 1997-04-02
ZA913121B (en) 1992-02-26
DE59108573D1 (en) 1997-04-10
CY2113B1 (en) 2002-04-26
DK0455133T3 (en) 1997-08-25
IE911387A1 (en) 1991-11-06
HU911392D0 (en) 1991-10-28
IL97944A0 (en) 1992-06-21
KR910018405A (en) 1991-11-30
HUT60286A (en) 1992-08-28
EP0455133A2 (en) 1991-11-06
LV10290A (en) 1994-10-20
SK279286B6 (en) 1998-09-09
NO300779B1 (en) 1997-07-21
CA2041268A1 (en) 1991-10-27
AU641004B2 (en) 1993-09-09
CN1056105A (en) 1991-11-13
JPH04225997A (en) 1992-08-14
ES2099102T3 (en) 1997-05-16
NO911649D0 (en) 1991-04-25
KR100195569B1 (en) 1999-06-15
DE4013270A1 (en) 1991-10-31
FI109541B (en) 2002-08-30
FI911978A0 (en) 1991-04-24
PT97466B (en) 1998-08-31
CZ280682B6 (en) 1996-04-17

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HUT52527A (en) Process for producing bradiquinine-antagonistic peptides and pharmaceutical compositions containing them as active components
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CS9101165A2 (en) Peptides with bradykinin-antagonistic effect, method of their production, their application and these peptides containing pharmaceutical

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20110424