ZA913121B - Peptides with a bradykinin-antagonistic action - Google Patents

Peptides with a bradykinin-antagonistic action

Info

Publication number
ZA913121B
ZA913121B ZA913121A ZA913121A ZA913121B ZA 913121 B ZA913121 B ZA 913121B ZA 913121 A ZA913121 A ZA 913121A ZA 913121 A ZA913121 A ZA 913121A ZA 913121 B ZA913121 B ZA 913121B
Authority
ZA
South Africa
Prior art keywords
amino acid
bradykinin
peptides
direct bond
antagonistic action
Prior art date
Application number
ZA913121A
Inventor
Gerhard Breipohl
Breipohl Gerhard
Franz Hock
Hock Franz
Stephan Henke
Henke Stephan
Jochen Knolle
Knolle Jochen
Bernward Scholkens
Scholkens Bernward
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA913121B publication Critical patent/ZA913121B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
ZA913121A 1990-04-26 1991-04-25 Peptides with a bradykinin-antagonistic action ZA913121B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4013270A DE4013270A1 (en) 1990-04-26 1990-04-26 PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT

Publications (1)

Publication Number Publication Date
ZA913121B true ZA913121B (en) 1992-02-26

Family

ID=6405107

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913121A ZA913121B (en) 1990-04-26 1991-04-25 Peptides with a bradykinin-antagonistic action

Country Status (25)

Country Link
EP (1) EP0455133B1 (en)
JP (1) JP2552402B2 (en)
KR (1) KR100195569B1 (en)
CN (1) CN1034416C (en)
AT (1) ATE149519T1 (en)
AU (1) AU641004B2 (en)
CA (1) CA2041268C (en)
CY (1) CY2113B1 (en)
CZ (1) CZ280682B6 (en)
DE (2) DE4013270A1 (en)
DK (1) DK0455133T3 (en)
ES (1) ES2099102T3 (en)
FI (1) FI109541B (en)
GR (1) GR3023172T3 (en)
HK (1) HK1006843A1 (en)
HU (1) HU208028B (en)
IE (1) IE911387A1 (en)
IL (1) IL97944A (en)
LV (1) LV10290B (en)
NO (1) NO300779B1 (en)
NZ (1) NZ237928A (en)
PT (1) PT97466B (en)
RU (1) RU2056432C1 (en)
SK (1) SK279286B6 (en)
ZA (1) ZA913121B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2106677A1 (en) * 1991-04-01 1992-10-02 John C. Cheronis Bradykinin antagonists
TW199863B (en) * 1991-12-21 1993-02-11 Hoechst Ag
TW258739B (en) * 1992-04-04 1995-10-01 Hoechst Ag
EP0813544B1 (en) * 1994-03-09 2004-10-27 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
FR2739553B1 (en) * 1995-10-06 1998-01-02 Oreal USE OF BRADYKININE ANTAGONISTS TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE HAIR LOSS
DE19612067A1 (en) * 1996-03-27 1997-10-02 Hoechst Ag Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
DE3926822A1 (en) * 1989-08-14 1991-02-21 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action

Also Published As

Publication number Publication date
PT97466A (en) 1992-01-31
EP0455133B1 (en) 1997-03-05
HU208028B (en) 1993-07-28
JP2552402B2 (en) 1996-11-13
ATE149519T1 (en) 1997-03-15
GR3023172T3 (en) 1997-07-30
HK1006843A1 (en) 1999-03-19
FI911978A (en) 1991-10-27
CS9101165A2 (en) 1991-12-17
IL97944A (en) 1995-05-26
NO911649L (en) 1991-10-28
AU7530491A (en) 1991-11-07
RU2056432C1 (en) 1996-03-20
EP0455133A3 (en) 1992-01-08
CA2041268C (en) 2001-10-02
LV10290B (en) 1995-08-20
NZ237928A (en) 1993-09-27
CN1034416C (en) 1997-04-02
DE59108573D1 (en) 1997-04-10
CY2113B1 (en) 2002-04-26
DK0455133T3 (en) 1997-08-25
IE911387A1 (en) 1991-11-06
HU911392D0 (en) 1991-10-28
IL97944A0 (en) 1992-06-21
KR910018405A (en) 1991-11-30
HUT60286A (en) 1992-08-28
EP0455133A2 (en) 1991-11-06
LV10290A (en) 1994-10-20
SK279286B6 (en) 1998-09-09
NO300779B1 (en) 1997-07-21
CA2041268A1 (en) 1991-10-27
AU641004B2 (en) 1993-09-09
CN1056105A (en) 1991-11-13
JPH04225997A (en) 1992-08-14
ES2099102T3 (en) 1997-05-16
NO911649D0 (en) 1991-04-25
KR100195569B1 (en) 1999-06-15
DE4013270A1 (en) 1991-10-31
FI109541B (en) 2002-08-30
FI911978A0 (en) 1991-04-24
PT97466B (en) 1998-08-31
CZ280682B6 (en) 1996-04-17

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