HK1006843A1 - Peptide antagonists of bradykinin - Google Patents

Peptide antagonists of bradykinin

Info

Publication number
HK1006843A1
HK1006843A1 HK98105879A HK98105879A HK1006843A1 HK 1006843 A1 HK1006843 A1 HK 1006843A1 HK 98105879 A HK98105879 A HK 98105879A HK 98105879 A HK98105879 A HK 98105879A HK 1006843 A1 HK1006843 A1 HK 1006843A1
Authority
HK
Hong Kong
Prior art keywords
amino acid
bradykinin
direct bond
peptides
formula
Prior art date
Application number
HK98105879A
Inventor
Gerhard Breipohl
Stephan Henke
Jochen Knolle
Bernward Scholkens
Franz Hock
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HK1006843A1 publication Critical patent/HK1006843A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aliphatic or alicyclic-aliphatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F, can be -NH-(CH2)2-8 or a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO-, or is a direct bond, have a bradykinin-antagonistic action. Their therapeutic uses comprise all pathological states which are mediated, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
HK98105879A 1990-04-26 1998-06-22 Peptide antagonists of bradykinin HK1006843A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4013270A DE4013270A1 (en) 1990-04-26 1990-04-26 PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT

Publications (1)

Publication Number Publication Date
HK1006843A1 true HK1006843A1 (en) 1999-03-19

Family

ID=6405107

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105879A HK1006843A1 (en) 1990-04-26 1998-06-22 Peptide antagonists of bradykinin

Country Status (25)

Country Link
EP (1) EP0455133B1 (en)
JP (1) JP2552402B2 (en)
KR (1) KR100195569B1 (en)
CN (1) CN1034416C (en)
AT (1) ATE149519T1 (en)
AU (1) AU641004B2 (en)
CA (1) CA2041268C (en)
CY (1) CY2113B1 (en)
CZ (1) CZ280682B6 (en)
DE (2) DE4013270A1 (en)
DK (1) DK0455133T3 (en)
ES (1) ES2099102T3 (en)
FI (1) FI109541B (en)
GR (1) GR3023172T3 (en)
HK (1) HK1006843A1 (en)
HU (1) HU208028B (en)
IE (1) IE911387A1 (en)
IL (1) IL97944A (en)
LV (1) LV10290B (en)
NO (1) NO300779B1 (en)
NZ (1) NZ237928A (en)
PT (1) PT97466B (en)
RU (1) RU2056432C1 (en)
SK (1) SK279286B6 (en)
ZA (1) ZA913121B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0586613A4 (en) * 1991-04-01 1994-08-24 Cortech Inc Bradykinin antagonists
TW199863B (en) * 1991-12-21 1993-02-11 Hoechst Ag
TW258739B (en) * 1992-04-04 1995-10-01 Hoechst Ag
ATE280777T1 (en) * 1994-03-09 2004-11-15 Cortech Inc BRADYKININ ANTAGONIST PEPTIDES WITH N-SUBSTITUTED GLYCINES
FR2739553B1 (en) 1995-10-06 1998-01-02 Oreal USE OF BRADYKININE ANTAGONISTS TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE HAIR LOSS
DE19612067A1 (en) * 1996-03-27 1997-10-02 Hoechst Ag Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
DE3926822A1 (en) * 1989-08-14 1991-02-21 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT

Also Published As

Publication number Publication date
CN1056105A (en) 1991-11-13
LV10290B (en) 1995-08-20
DK0455133T3 (en) 1997-08-25
JP2552402B2 (en) 1996-11-13
RU2056432C1 (en) 1996-03-20
ATE149519T1 (en) 1997-03-15
DE59108573D1 (en) 1997-04-10
CS9101165A2 (en) 1991-12-17
LV10290A (en) 1994-10-20
EP0455133A3 (en) 1992-01-08
CZ280682B6 (en) 1996-04-17
NO911649D0 (en) 1991-04-25
CN1034416C (en) 1997-04-02
AU7530491A (en) 1991-11-07
NO911649L (en) 1991-10-28
IE911387A1 (en) 1991-11-06
IL97944A0 (en) 1992-06-21
FI911978A (en) 1991-10-27
FI109541B (en) 2002-08-30
ZA913121B (en) 1992-02-26
NO300779B1 (en) 1997-07-21
EP0455133A2 (en) 1991-11-06
AU641004B2 (en) 1993-09-09
NZ237928A (en) 1993-09-27
FI911978A0 (en) 1991-04-24
CY2113B1 (en) 2002-04-26
CA2041268A1 (en) 1991-10-27
HUT60286A (en) 1992-08-28
ES2099102T3 (en) 1997-05-16
HU911392D0 (en) 1991-10-28
PT97466A (en) 1992-01-31
GR3023172T3 (en) 1997-07-30
KR100195569B1 (en) 1999-06-15
SK279286B6 (en) 1998-09-09
IL97944A (en) 1995-05-26
EP0455133B1 (en) 1997-03-05
PT97466B (en) 1998-08-31
KR910018405A (en) 1991-11-30
CA2041268C (en) 2001-10-02
DE4013270A1 (en) 1991-10-31
HU208028B (en) 1993-07-28
JPH04225997A (en) 1992-08-14

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20110424