CS274495B2 - Method of 2-aminotetrahydroisoquinoline derivatives production - Google Patents

Method of 2-aminotetrahydroisoquinoline derivatives production Download PDF

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Publication number
CS274495B2
CS274495B2 CS902588A CS902588A CS274495B2 CS 274495 B2 CS274495 B2 CS 274495B2 CS 902588 A CS902588 A CS 902588A CS 902588 A CS902588 A CS 902588A CS 274495 B2 CS274495 B2 CS 274495B2
Authority
CS
Czechoslovakia
Prior art keywords
water
hydrogen
formula
reaction
hours
Prior art date
Application number
CS902588A
Other languages
Czech (cs)
English (en)
Other versions
CS902588A2 (en
Inventor
Endre Ing Palosi
Dezso Dr Korbonits
Erzsebet Ing Molnar
Ida Ing Szvoboda
Laszlo Dr Harsing
Gyorgy Dr Simon
Vera Dr Gergely
Peter Dr Kormoczi
Sandor Dr Virag
Katalin Ing Marmarosi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of CS902588A2 publication Critical patent/CS902588A2/cs
Publication of CS274495B2 publication Critical patent/CS274495B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CS902588A 1987-12-30 1988-12-29 Method of 2-aminotetrahydroisoquinoline derivatives production CS274495B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU876132A HU198458B (en) 1987-12-30 1987-12-30 Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds

Publications (2)

Publication Number Publication Date
CS902588A2 CS902588A2 (en) 1990-09-12
CS274495B2 true CS274495B2 (en) 1991-04-11

Family

ID=10971251

Family Applications (1)

Application Number Title Priority Date Filing Date
CS902588A CS274495B2 (en) 1987-12-30 1988-12-29 Method of 2-aminotetrahydroisoquinoline derivatives production

Country Status (24)

Country Link
US (1) US4940716A (es)
EP (1) EP0324184B1 (es)
JP (1) JPH01213266A (es)
CN (1) CN1022917C (es)
AT (1) ATE112268T1 (es)
AU (1) AU635463B2 (es)
CA (1) CA1329209C (es)
CS (1) CS274495B2 (es)
DD (1) DD283382A5 (es)
DE (1) DE3851697D1 (es)
ES (1) ES2059485T3 (es)
FI (1) FI90536C (es)
HR (1) HRP920564A2 (es)
HU (1) HU198458B (es)
IE (1) IE883879L (es)
IL (1) IL88639A (es)
NO (1) NO176177C (es)
NZ (1) NZ227416A (es)
PH (1) PH25608A (es)
PL (1) PL155977B1 (es)
PT (1) PT89356B (es)
SU (2) SU1676444A3 (es)
YU (1) YU46720B (es)
ZA (1) ZA889285B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002130A1 (de) 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037984A (en) * 1960-01-27 1962-06-05 Lakeside Lab Inc Derivatives of n-amino-1, 2, 3, 4-tetrahydroisoquinoline
WO1988003137A1 (en) * 1986-10-28 1988-05-05 Smith Kline & French Laboratories Limited Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists

Also Published As

Publication number Publication date
FI90536B (fi) 1993-11-15
YU236088A (en) 1990-02-28
NO176177C (no) 1995-02-15
IL88639A (en) 1992-11-15
HRP920564A2 (hr) 1994-04-30
EP0324184B1 (de) 1994-09-28
US4940716A (en) 1990-07-10
NO176177B (no) 1994-11-07
FI90536C (fi) 1994-02-25
NO885811L (no) 1989-07-03
ES2059485T3 (es) 1994-11-16
PL155977B1 (en) 1992-01-31
AU2762888A (en) 1989-07-06
NZ227416A (en) 1990-11-27
DD283382A5 (de) 1990-10-10
DE3851697D1 (de) 1994-11-03
SU1705287A1 (ru) 1992-01-15
NO885811D0 (no) 1988-12-29
EP0324184A3 (en) 1990-05-02
PT89356A (pt) 1989-12-29
IL88639A0 (en) 1989-07-31
HU198458B (en) 1989-10-30
IE883879L (en) 1989-06-30
CS902588A2 (en) 1990-09-12
ZA889285B (en) 1989-09-27
EP0324184A2 (de) 1989-07-19
FI886046A (fi) 1989-07-01
PT89356B (pt) 1993-09-30
ATE112268T1 (de) 1994-10-15
CA1329209C (en) 1994-05-03
SU1676444A3 (ru) 1991-09-07
JPH01213266A (ja) 1989-08-28
PL276887A1 (en) 1989-09-04
CN1035502A (zh) 1989-09-13
PH25608A (en) 1991-08-08
CN1022917C (zh) 1993-12-01
AU635463B2 (en) 1993-03-18
YU46720B (sh) 1994-04-05
HUT48599A (en) 1989-06-28

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