CS251078B2 - Method of 5-(e)-(2-bromovinyl)-2-desoxyuridine derivatives production - Google Patents

Method of 5-(e)-(2-bromovinyl)-2-desoxyuridine derivatives production Download PDF

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Publication number
CS251078B2
CS251078B2 CS835756A CS575683A CS251078B2 CS 251078 B2 CS251078 B2 CS 251078B2 CS 835756 A CS835756 A CS 835756A CS 575683 A CS575683 A CS 575683A CS 251078 B2 CS251078 B2 CS 251078B2
Authority
CS
Czechoslovakia
Prior art keywords
desoxyuridine
ethyl
formula
chloroform
mixture
Prior art date
Application number
CS835756A
Other languages
Czech (cs)
English (en)
Inventor
Anna Szabolcs
Laszlo Oetvoes
Janos Sagi
Helga Tuedoes
Zoltan Ratonyi
Tibor Gal
Lajos Voeroeshazy
Ivan Daroczy
Dieter Barwolf
Juergen Reefschlager
Hellmut Just
Original Assignee
Mta Koezponti Kemiai Kutato In
Molekularbiolog Inst Of The Ac
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mta Koezponti Kemiai Kutato In, Molekularbiolog Inst Of The Ac filed Critical Mta Koezponti Kemiai Kutato In
Publication of CS251078B2 publication Critical patent/CS251078B2/cs

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS835756A 1982-08-04 1983-08-03 Method of 5-(e)-(2-bromovinyl)-2-desoxyuridine derivatives production CS251078B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (1)

Publication Number Publication Date
CS251078B2 true CS251078B2 (en) 1987-06-11

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
CS835756A CS251078B2 (en) 1982-08-04 1983-08-03 Method of 5-(e)-(2-bromovinyl)-2-desoxyuridine derivatives production

Country Status (12)

Country Link
AT (1) AT380688B (de)
BE (1) BE897434A (de)
CH (1) CH660486A5 (de)
CS (1) CS251078B2 (de)
DE (1) DE3328238A1 (de)
FI (1) FI74289C (de)
FR (1) FR2531437B1 (de)
GB (1) GB2125399B (de)
HU (1) HU187736B (de)
IT (1) IT1185759B (de)
PL (1) PL143289B1 (de)
YU (1) YU162683A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (ru) * 2001-01-03 2005-02-24 Берлин Хеми Аг Применение фармацевтической композиции, содержащей бривудин, для лечения герпесвирусных инфекций
DE10109657A1 (de) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
CN102432655A (zh) * 2011-10-28 2012-05-02 河南师范大学 一种合成5-((e)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法
EP3792271A1 (de) 2019-09-13 2021-03-17 Aurobindo Pharma Limited Verfahren zur herstellung von brivudin
CN115043894A (zh) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 一种溴夫定起始物料异构体单晶及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (de) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenvinyl)-2'-Deoxyuridinderivate, Verfahren zu ihrer Herstellung, die sie enthaltende pharmazeutische Präparate und ihre Verwendung bei der Bekämpfung von viralen Infektionen
EP0095294A1 (de) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridin-Derivate, ihre Herstellungsverfahren und ihre medizinische Anwendung
EP0097039A1 (de) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-Halovinyl)-2'-deoxyuridin-Derivate, Verfahren zur Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und ihre Anwendung bei der Behandlung von viralen Infektionen

Also Published As

Publication number Publication date
IT1185759B (it) 1987-11-18
DE3328238A1 (de) 1984-02-23
FR2531437A1 (fr) 1984-02-10
YU162683A (en) 1986-02-28
IT8322401A0 (it) 1983-08-03
GB8321081D0 (en) 1983-09-07
PL243307A1 (en) 1984-11-08
FR2531437B1 (fr) 1985-10-25
FI832809A (fi) 1984-02-05
GB2125399B (en) 1987-04-01
ATA282583A (de) 1985-11-15
PL143289B1 (en) 1988-01-30
BE897434A (fr) 1984-02-01
CH660486A5 (de) 1987-04-30
FI74289C (fi) 1988-01-11
FI74289B (fi) 1987-09-30
HU187736B (en) 1986-02-28
FI832809A0 (fi) 1983-08-03
GB2125399A (en) 1984-03-07
AT380688B (de) 1986-06-25

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