YU162683A - Process for obtaining 5-(e)-(2-bromovinyl)-2'-deoxyuridine - Google Patents

Process for obtaining 5-(e)-(2-bromovinyl)-2'-deoxyuridine

Info

Publication number
YU162683A
YU162683A YU01626/83A YU162683A YU162683A YU 162683 A YU162683 A YU 162683A YU 01626/83 A YU01626/83 A YU 01626/83A YU 162683 A YU162683 A YU 162683A YU 162683 A YU162683 A YU 162683A
Authority
YU
Yugoslavia
Prior art keywords
bromovinyl
deoxyuridine
obtaining
Prior art date
Application number
YU01626/83A
Inventor
A Szabolcs
L Oetvoes
J Sagi
H Tuedoes
Z Ratonyi
T Gal
L Voroeshalzy
I Daroczy
D Barwolf
J Reefschlager
H Just
Original Assignee
Magyar Tudomanyos
Inst Molekularbiologie Ak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magyar Tudomanyos, Inst Molekularbiologie Ak filed Critical Magyar Tudomanyos
Publication of YU162683A publication Critical patent/YU162683A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
YU01626/83A 1982-08-04 1983-08-04 Process for obtaining 5-(e)-(2-bromovinyl)-2'-deoxyuridine YU162683A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (1)

Publication Number Publication Date
YU162683A true YU162683A (en) 1986-02-28

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
YU01626/83A YU162683A (en) 1982-08-04 1983-08-04 Process for obtaining 5-(e)-(2-bromovinyl)-2'-deoxyuridine

Country Status (12)

Country Link
AT (1) AT380688B (en)
BE (1) BE897434A (en)
CH (1) CH660486A5 (en)
CS (1) CS251078B2 (en)
DE (1) DE3328238A1 (en)
FI (1) FI74289C (en)
FR (1) FR2531437B1 (en)
GB (1) GB2125399B (en)
HU (1) HU187736B (en)
IT (1) IT1185759B (en)
PL (1) PL143289B1 (en)
YU (1) YU162683A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (en) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 Brivudine starting material isomer single crystal and preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (en) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Also Published As

Publication number Publication date
IT1185759B (en) 1987-11-18
DE3328238A1 (en) 1984-02-23
FR2531437A1 (en) 1984-02-10
IT8322401A0 (en) 1983-08-03
GB8321081D0 (en) 1983-09-07
PL243307A1 (en) 1984-11-08
FR2531437B1 (en) 1985-10-25
FI832809A (en) 1984-02-05
GB2125399B (en) 1987-04-01
ATA282583A (en) 1985-11-15
PL143289B1 (en) 1988-01-30
BE897434A (en) 1984-02-01
CS251078B2 (en) 1987-06-11
CH660486A5 (en) 1987-04-30
FI74289C (en) 1988-01-11
FI74289B (en) 1987-09-30
HU187736B (en) 1986-02-28
FI832809A0 (en) 1983-08-03
GB2125399A (en) 1984-03-07
AT380688B (en) 1986-06-25

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