AT380688B - METHOD FOR PRODUCING 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE AND ITS DERIVATIVES - Google Patents

METHOD FOR PRODUCING 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE AND ITS DERIVATIVES

Info

Publication number
AT380688B
AT380688B AT0282583A AT282583A AT380688B AT 380688 B AT380688 B AT 380688B AT 0282583 A AT0282583 A AT 0282583A AT 282583 A AT282583 A AT 282583A AT 380688 B AT380688 B AT 380688B
Authority
AT
Austria
Prior art keywords
bromvinyl
desoxyuridine
derivatives
producing
Prior art date
Application number
AT0282583A
Other languages
German (de)
Other versions
ATA282583A (en
Inventor
Anna Dr Szabolcs
Laszlo Dr Oetvoes
Janos Dr Sagi
Helga Chem Ing Dr Tuedoes
Zoltan Ratonyi
Tibor Dipl Ing Gal
Lajos Voeroeshazy
Ivan Dr Daroczy
Dieter Dr Barwolf
Juergen Dr Reefschlager
Hellmut Dr Just
Original Assignee
Magyar Tudomanyos Akademia
Akad Wissenschaften Ddr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magyar Tudomanyos Akademia, Akad Wissenschaften Ddr filed Critical Magyar Tudomanyos Akademia
Publication of ATA282583A publication Critical patent/ATA282583A/en
Application granted granted Critical
Publication of AT380688B publication Critical patent/AT380688B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
AT0282583A 1982-08-04 1983-08-04 METHOD FOR PRODUCING 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE AND ITS DERIVATIVES AT380688B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (2)

Publication Number Publication Date
ATA282583A ATA282583A (en) 1985-11-15
AT380688B true AT380688B (en) 1986-06-25

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0282583A AT380688B (en) 1982-08-04 1983-08-04 METHOD FOR PRODUCING 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE AND ITS DERIVATIVES

Country Status (12)

Country Link
AT (1) AT380688B (en)
BE (1) BE897434A (en)
CH (1) CH660486A5 (en)
CS (1) CS251078B2 (en)
DE (1) DE3328238A1 (en)
FI (1) FI74289C (en)
FR (1) FR2531437B1 (en)
GB (1) GB2125399B (en)
HU (1) HU187736B (en)
IT (1) IT1185759B (en)
PL (1) PL143289B1 (en)
YU (1) YU162683A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (en) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 Brivudine starting material isomer single crystal and preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (en) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia

Also Published As

Publication number Publication date
PL243307A1 (en) 1984-11-08
CS251078B2 (en) 1987-06-11
IT8322401A0 (en) 1983-08-03
PL143289B1 (en) 1988-01-30
YU162683A (en) 1986-02-28
FR2531437B1 (en) 1985-10-25
FR2531437A1 (en) 1984-02-10
FI832809A (en) 1984-02-05
DE3328238A1 (en) 1984-02-23
GB8321081D0 (en) 1983-09-07
FI74289C (en) 1988-01-11
BE897434A (en) 1984-02-01
GB2125399B (en) 1987-04-01
IT1185759B (en) 1987-11-18
FI832809A0 (en) 1983-08-03
HU187736B (en) 1986-02-28
ATA282583A (en) 1985-11-15
FI74289B (en) 1987-09-30
GB2125399A (en) 1984-03-07
CH660486A5 (en) 1987-04-30

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee