FI832809A - PROCEDURE FOR FRAMSTATING AV 5- (E) - (2-BROMOINYL) -2'-DESOXYURIDINE AND DESSIVES SAMT 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE DERIVATIVES - Google Patents

PROCEDURE FOR FRAMSTATING AV 5- (E) - (2-BROMOINYL) -2'-DESOXYURIDINE AND DESSIVES SAMT 5- (E) - (2-BROMVINYL) -2'-DESOXYURIDINE DERIVATIVES Download PDF

Info

Publication number
FI832809A
FI832809A FI832809A FI832809A FI832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A
Authority
FI
Finland
Prior art keywords
desoxyuridine
dessives
bromoinyl
bromvinyl
framstating
Prior art date
Application number
FI832809A
Other languages
Finnish (fi)
Other versions
FI74289C (en
FI74289B (en
FI832809A0 (en
Inventor
Anna Szabolcs
Laszlo Oetvoes
Janos Sagi
Helga Tydoes
Zoltan Ratonyi
Tibor Gal
Lajos Voeroeshazy
Ivan Daroczy
Dieter Barwolf
Jyrgen Reefschlager
Hellmut Just
Original Assignee
Mta Koezponti Kemiai Kutato In
Inst Molekularbiologie Ak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mta Koezponti Kemiai Kutato In, Inst Molekularbiologie Ak filed Critical Mta Koezponti Kemiai Kutato In
Publication of FI832809A0 publication Critical patent/FI832809A0/en
Publication of FI832809A publication Critical patent/FI832809A/en
Application granted granted Critical
Publication of FI74289B publication Critical patent/FI74289B/en
Publication of FI74289C publication Critical patent/FI74289C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
FI832809A 1982-08-04 1983-08-03 Process for the preparation of 5- (E) - (2-bromovinyl) -2'-deoxyuridine and its derivatives. FI74289C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU250682 1982-08-04
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (4)

Publication Number Publication Date
FI832809A0 FI832809A0 (en) 1983-08-03
FI832809A true FI832809A (en) 1984-02-05
FI74289B FI74289B (en) 1987-09-30
FI74289C FI74289C (en) 1988-01-11

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832809A FI74289C (en) 1982-08-04 1983-08-03 Process for the preparation of 5- (E) - (2-bromovinyl) -2'-deoxyuridine and its derivatives.

Country Status (12)

Country Link
AT (1) AT380688B (en)
BE (1) BE897434A (en)
CH (1) CH660486A5 (en)
CS (1) CS251078B2 (en)
DE (1) DE3328238A1 (en)
FI (1) FI74289C (en)
FR (1) FR2531437B1 (en)
GB (1) GB2125399B (en)
HU (1) HU187736B (en)
IT (1) IT1185759B (en)
PL (1) PL143289B1 (en)
YU (1) YU162683A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (en) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 Brivudine starting material isomer single crystal and preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (en) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Also Published As

Publication number Publication date
IT8322401A0 (en) 1983-08-03
YU162683A (en) 1986-02-28
PL143289B1 (en) 1988-01-30
DE3328238A1 (en) 1984-02-23
BE897434A (en) 1984-02-01
PL243307A1 (en) 1984-11-08
FI74289C (en) 1988-01-11
FR2531437B1 (en) 1985-10-25
GB2125399A (en) 1984-03-07
FR2531437A1 (en) 1984-02-10
FI74289B (en) 1987-09-30
CH660486A5 (en) 1987-04-30
ATA282583A (en) 1985-11-15
CS251078B2 (en) 1987-06-11
HU187736B (en) 1986-02-28
FI832809A0 (en) 1983-08-03
GB2125399B (en) 1987-04-01
AT380688B (en) 1986-06-25
IT1185759B (en) 1987-11-18
GB8321081D0 (en) 1983-09-07

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MM Patent lapsed
MM Patent lapsed

Owner name: MAGYAR TUDOMANYOS AKADEMIA KOEZPONTI

Owner name: MOLEKULARBIOLOGIE