GB2125399B - Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine and new derivatives thereof - Google Patents

Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine and new derivatives thereof

Info

Publication number
GB2125399B
GB2125399B GB08321081A GB8321081A GB2125399B GB 2125399 B GB2125399 B GB 2125399B GB 08321081 A GB08321081 A GB 08321081A GB 8321081 A GB8321081 A GB 8321081A GB 2125399 B GB2125399 B GB 2125399B
Authority
GB
United Kingdom
Prior art keywords
bromovinyl
deoxyuridine
preparation
new derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08321081A
Other versions
GB2125399A (en
GB8321081D0 (en
Inventor
Dr Anna Szabolcs
Dr Laszlo Otvos
Dr Janos Sagi
Dr Helga Tudos
Zoltan Ratonyi
Tibor Gal
Lajos Voroshazy
Dr Ivan Daroczy
Dr Dieter Barwolf
Dr Jurgen Reefschlager
Dr Hellmut Just
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inst Molecularbiolog Ak
INST MOLEKULARBIOLOGIE AK
Mta Koezponti Kemiai Kutato In
Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezet
Original Assignee
Inst Molecularbiolog Ak
INST MOLEKULARBIOLOGIE AK
Mta Koezponti Kemiai Kutato In
Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Molecularbiolog Ak, INST MOLEKULARBIOLOGIE AK, Mta Koezponti Kemiai Kutato In, Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezet filed Critical Inst Molecularbiolog Ak
Publication of GB8321081D0 publication Critical patent/GB8321081D0/en
Publication of GB2125399A publication Critical patent/GB2125399A/en
Application granted granted Critical
Publication of GB2125399B publication Critical patent/GB2125399B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08321081A 1982-08-04 1983-08-04 Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine and new derivatives thereof Expired GB2125399B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives

Publications (3)

Publication Number Publication Date
GB8321081D0 GB8321081D0 (en) 1983-09-07
GB2125399A GB2125399A (en) 1984-03-07
GB2125399B true GB2125399B (en) 1987-04-01

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08321081A Expired GB2125399B (en) 1982-08-04 1983-08-04 Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine and new derivatives thereof

Country Status (12)

Country Link
AT (1) AT380688B (en)
BE (1) BE897434A (en)
CH (1) CH660486A5 (en)
CS (1) CS251078B2 (en)
DE (1) DE3328238A1 (en)
FI (1) FI74289C (en)
FR (1) FR2531437B1 (en)
GB (1) GB2125399B (en)
HU (1) HU187736B (en)
IT (1) IT1185759B (en)
PL (1) PL143289B1 (en)
YU (1) YU162683A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (en) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 Brivudine starting material isomer single crystal and preparation method and application thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (en) * 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (en) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Alkyl- and 5-alkenyl-uracil and -cytidine nucleoside derivs. - prepd. e.g. by reaction of 5'-chloro-5'-deoxy cpds. with ammonia
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Also Published As

Publication number Publication date
IT8322401A0 (en) 1983-08-03
YU162683A (en) 1986-02-28
PL143289B1 (en) 1988-01-30
DE3328238A1 (en) 1984-02-23
BE897434A (en) 1984-02-01
PL243307A1 (en) 1984-11-08
FI74289C (en) 1988-01-11
FR2531437B1 (en) 1985-10-25
GB2125399A (en) 1984-03-07
FR2531437A1 (en) 1984-02-10
FI832809A (en) 1984-02-05
FI74289B (en) 1987-09-30
CH660486A5 (en) 1987-04-30
ATA282583A (en) 1985-11-15
CS251078B2 (en) 1987-06-11
HU187736B (en) 1986-02-28
FI832809A0 (en) 1983-08-03
AT380688B (en) 1986-06-25
IT1185759B (en) 1987-11-18
GB8321081D0 (en) 1983-09-07

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930804