FI832809A - Foerfarande foer framstaellning av 5-(e)-(2-bromvinyl)-2'-desoxiuridin och dess derivat samt 5-(e)-(2-bromvinyl)-2'-desoxiuridin-derivat - Google Patents

Foerfarande foer framstaellning av 5-(e)-(2-bromvinyl)-2'-desoxiuridin och dess derivat samt 5-(e)-(2-bromvinyl)-2'-desoxiuridin-derivat Download PDF

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Publication number
FI832809A
FI832809A FI832809A FI832809A FI832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A FI 832809 A FI832809 A FI 832809A
Authority
FI
Finland
Prior art keywords
desoxyuridine
dessives
bromoinyl
bromvinyl
framstating
Prior art date
Application number
FI832809A
Other languages
English (en)
Other versions
FI74289C (fi
FI832809A0 (fi
FI74289B (fi
Inventor
Anna Szabolcs
Laszlo Oetvoes
Janos Sagi
Helga Tydoes
Zoltan Ratonyi
Tibor Gal
Lajos Voeroeshazy
Ivan Daroczy
Dieter Barwolf
Jyrgen Reefschlager
Hellmut Just
Original Assignee
Mta Koezponti Kemiai Kutato In
Inst Molekularbiologie Ak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mta Koezponti Kemiai Kutato In, Inst Molekularbiologie Ak filed Critical Mta Koezponti Kemiai Kutato In
Publication of FI832809A0 publication Critical patent/FI832809A0/fi
Publication of FI832809A publication Critical patent/FI832809A/fi
Application granted granted Critical
Publication of FI74289B publication Critical patent/FI74289B/fi
Publication of FI74289C publication Critical patent/FI74289C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI832809A 1982-08-04 1983-08-03 Foerfarande foer framstaellning av 5-(e)- (2-bromvinyl)-2'-desoxiuridin och dess derivat. FI74289C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU822506A HU187736B (en) 1982-08-04 1982-08-04 Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
HU250682 1982-08-04

Publications (4)

Publication Number Publication Date
FI832809A0 FI832809A0 (fi) 1983-08-03
FI832809A true FI832809A (fi) 1984-02-05
FI74289B FI74289B (fi) 1987-09-30
FI74289C FI74289C (fi) 1988-01-11

Family

ID=10959738

Family Applications (1)

Application Number Title Priority Date Filing Date
FI832809A FI74289C (fi) 1982-08-04 1983-08-03 Foerfarande foer framstaellning av 5-(e)- (2-bromvinyl)-2'-desoxiuridin och dess derivat.

Country Status (12)

Country Link
AT (1) AT380688B (fi)
BE (1) BE897434A (fi)
CH (1) CH660486A5 (fi)
CS (1) CS251078B2 (fi)
DE (1) DE3328238A1 (fi)
FI (1) FI74289C (fi)
FR (1) FR2531437B1 (fi)
GB (1) GB2125399B (fi)
HU (1) HU187736B (fi)
IT (1) IT1185759B (fi)
PL (1) PL143289B1 (fi)
YU (1) YU162683A (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005497B1 (ru) * 2001-01-03 2005-02-24 Берлин Хеми Аг Применение фармацевтической композиции, содержащей бривудин, для лечения герпесвирусных инфекций
DE10109657A1 (de) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
CN102432655A (zh) * 2011-10-28 2012-05-02 河南师范大学 一种合成5-((e)-2-溴乙烯基)-2′-脱氧尿嘧啶核苷(溴呋啶)的方法
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
CN115043894A (zh) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 一种溴夫定起始物料异构体单晶及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2721466A1 (de) * 1977-05-12 1978-11-16 Robugen Gmbh Verfahren zur herstellung von 2'-desoxyribofuranosylnucleosiden
GB1601020A (en) * 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
DE3002197A1 (de) * 1980-01-22 1981-07-23 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-alkylsubstituierte pyrimidin-nukleoside, verfahren zu deren herstellung und daraus hergestellte virostatische und cytostatische mittel
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections

Also Published As

Publication number Publication date
PL143289B1 (en) 1988-01-30
GB8321081D0 (en) 1983-09-07
IT8322401A0 (it) 1983-08-03
HU187736B (en) 1986-02-28
CH660486A5 (de) 1987-04-30
PL243307A1 (en) 1984-11-08
FR2531437A1 (fr) 1984-02-10
GB2125399A (en) 1984-03-07
FI74289C (fi) 1988-01-11
FI832809A0 (fi) 1983-08-03
DE3328238A1 (de) 1984-02-23
IT1185759B (it) 1987-11-18
FI74289B (fi) 1987-09-30
AT380688B (de) 1986-06-25
FR2531437B1 (fr) 1985-10-25
BE897434A (fr) 1984-02-01
CS251078B2 (en) 1987-06-11
ATA282583A (de) 1985-11-15
GB2125399B (en) 1987-04-01
YU162683A (en) 1986-02-28

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Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: MAGYAR TUDOMANYOS AKADEMIA KOEZPONTI

Owner name: MOLEKULARBIOLOGIE