CS249544B2 - Method of new imidazolylphenylamidines production - Google Patents

Method of new imidazolylphenylamidines production Download PDF

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Publication number
CS249544B2
CS249544B2 CS854409A CS440981A CS249544B2 CS 249544 B2 CS249544 B2 CS 249544B2 CS 854409 A CS854409 A CS 854409A CS 440981 A CS440981 A CS 440981A CS 249544 B2 CS249544 B2 CS 249544B2
Authority
CS
Czechoslovakia
Prior art keywords
group
compound
phenyl
formamidine
formula
Prior art date
Application number
CS854409A
Other languages
Czech (cs)
English (en)
Inventor
Enzo Cereda
Arturo Doneti
Soldato Piero Del
Mario Bergamaschi
Original Assignee
Angeli Inst Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeli Inst Spa filed Critical Angeli Inst Spa
Publication of CS249544B2 publication Critical patent/CS249544B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS854409A 1980-11-28 1981-10-20 Method of new imidazolylphenylamidines production CS249544B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8026323A IT1209431B (it) 1980-11-28 1980-11-28 Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.

Publications (1)

Publication Number Publication Date
CS249544B2 true CS249544B2 (en) 1987-03-12

Family

ID=11219229

Family Applications (2)

Application Number Title Priority Date Filing Date
CS854409A CS249544B2 (en) 1980-11-28 1981-10-20 Method of new imidazolylphenylamidines production
CS817691A CS249115B2 (en) 1980-11-28 1981-10-20 Method of new imidazolylphenylamides production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS817691A CS249115B2 (en) 1980-11-28 1981-10-20 Method of new imidazolylphenylamides production

Country Status (30)

Country Link
US (2) US4386099A (fr)
EP (1) EP0053407B1 (fr)
JP (1) JPS57120575A (fr)
KR (1) KR880001317B1 (fr)
AR (1) AR228468A1 (fr)
AT (1) ATE24495T1 (fr)
AU (1) AU554592B2 (fr)
CA (1) CA1171092A (fr)
CS (2) CS249544B2 (fr)
DD (1) DD201893A5 (fr)
DE (2) DE3175754D1 (fr)
DK (1) DK157862C (fr)
ES (6) ES8207148A1 (fr)
FI (1) FI73209C (fr)
GB (1) GB2088375B (fr)
GR (1) GR77310B (fr)
HK (1) HK88186A (fr)
HU (1) HU187478B (fr)
IE (1) IE51946B1 (fr)
IL (1) IL64388A (fr)
IT (1) IT1209431B (fr)
MY (1) MY8700146A (fr)
NO (1) NO158183C (fr)
NZ (1) NZ199093A (fr)
PH (2) PH17390A (fr)
PL (2) PL135749B1 (fr)
PT (1) PT74048B (fr)
SU (2) SU1110381A3 (fr)
YU (2) YU42447B (fr)
ZA (1) ZA818240B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200371B (it) * 1982-03-24 1989-01-18 Angeli Inst Spa Guanidino eterociclifenilamidine,processi per la loro preparazione e loro impiego farmaceutico
IT1201523B (it) * 1982-05-18 1989-02-02 Angeli Inst Spa Eterociclilfenilfomramidine,processi per la loro preparazione e loro uso farmaceutico
IT1210914B (it) * 1982-07-29 1989-09-29 Angeli Inst Spa Eterociclilfenilsolfonil e fosfonilamidine sostituite, procedimento per la loro preparazione e loro uso farmaceutico.
IT1206498B (it) * 1983-07-18 1989-04-27 Angeli Inst Spa Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.
IT1204910B (it) * 1987-01-28 1989-03-10 Angeli Inst Spa Composizioni farmaceutiche ad azione sinergica antisecretoria per la cicatrizzazione dell'ulcera gastroduodenale
KR920004935B1 (ko) * 1990-07-12 1992-06-22 일양약품공업 주식회사 N-디메톡시 페닐알킬-n'-이미다졸릴페닐 아미딘 유도체 및 그의 제조방법
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
TW460460B (en) * 1997-11-04 2001-10-21 Chugai Pharmaceutical Co Ltd Heterocyclic compounds having NOS inhibitory activities
DK1226819T3 (da) * 1999-11-01 2006-05-22 Taisho Pharmaceutical Co Ltd Inhibitor for 20-HETE-producerende enzym
EP1579862A1 (fr) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Utilisation des inhibiteurs de PDE III pour la réduction de la taille du coeur chez des mammifères souffrant d'insufficances cardiaques
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
WO2006071659A1 (fr) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivrance d'antagonistes h2
EA015245B1 (ru) * 2005-09-13 2011-06-30 Байер Кропсайенс Аг Пестицидные тиазолилоксизамещенные фениламидиновые производные
EP1920785A1 (fr) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Préparation liquide contenant un complexe du pimobendane et de la cyclodextrine
WO2013135852A1 (fr) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Formulation pharmaceutique de comprimé pour le secteur médical vétérinaire, son procédé de production et utilisation
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR122019024673B1 (pt) 2013-12-04 2023-04-11 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (fr) 2020-08-11 2023-06-21 Université de Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069340A (en) * 1976-01-30 1978-01-17 Hooker Chemicals & Plastics Corporation Immonium salts and derivatives thereof
DE2645477C2 (de) * 1976-10-08 1982-03-04 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von Orthoessigsäurealkylestern
US4225724A (en) * 1977-01-07 1980-09-30 Westwood Pharmaceuticals, Inc. 1-(2-Phenylureylene)imidazoles
US4236015A (en) * 1977-01-07 1980-11-25 Westwood Pharmaceuticals, Inc. 1-(2-Acylaminophenyl)imidazoles
US4160097A (en) * 1977-01-07 1979-07-03 Westwind Pharmaceuticals, Inc. 1-(2-Phenylureylene)imidazoles

Also Published As

Publication number Publication date
EP0053407A2 (fr) 1982-06-09
DK157862C (da) 1990-08-06
DE53407T1 (de) 1983-01-20
IL64388A (en) 1985-04-30
ES507506A0 (es) 1982-09-01
ES8207150A1 (es) 1982-09-01
YU175983A (en) 1984-06-30
GB2088375A (en) 1982-06-09
PL238422A1 (en) 1983-06-06
SU1110382A3 (ru) 1984-08-23
IE812790L (en) 1982-05-28
HU187478B (en) 1986-01-28
DD201893A5 (de) 1983-08-17
PT74048B (en) 1983-12-07
ES8207147A1 (es) 1982-09-01
ES507507A0 (es) 1982-09-01
SU1110381A3 (ru) 1984-08-23
EP0053407A3 (en) 1983-07-27
HK88186A (en) 1986-11-28
ES8207149A1 (es) 1982-09-01
EP0053407B1 (fr) 1986-12-30
PT74048A (en) 1981-12-01
ES8207152A1 (es) 1982-09-01
DK525581A (da) 1982-05-29
NO158183C (no) 1988-07-27
US4465841A (en) 1984-08-14
ES8207151A1 (es) 1982-09-01
JPH0233031B2 (fr) 1990-07-25
PL135749B1 (en) 1985-12-31
AR228468A1 (es) 1983-03-15
IE51946B1 (en) 1987-04-29
ES507501A0 (es) 1982-09-01
NO158183B (no) 1988-04-18
FI813794L (fi) 1982-05-29
CA1171092A (fr) 1984-07-17
AU554592B2 (en) 1986-08-28
ZA818240B (en) 1983-07-27
US4386099A (en) 1983-05-31
DK157862B (da) 1990-02-26
PH19032A (en) 1985-12-06
KR830007575A (ko) 1983-11-04
FI73209C (fi) 1987-09-10
IL64388A0 (en) 1982-02-28
ES507508A0 (es) 1982-09-01
DE3175754D1 (en) 1987-02-05
PL136015B1 (en) 1986-01-31
KR880001317B1 (ko) 1988-07-23
GB2088375B (en) 1985-01-09
GR77310B (fr) 1984-09-11
CS249115B2 (en) 1987-03-12
JPS57120575A (en) 1982-07-27
PH17390A (en) 1984-08-08
YU42447B (en) 1988-08-31
IT8026323A0 (it) 1980-11-28
ES507505A0 (es) 1982-09-01
NO814065L (no) 1982-06-01
PL234007A1 (en) 1983-03-14
ES8207148A1 (es) 1982-09-01
NZ199093A (en) 1985-05-31
YU42878B (en) 1988-12-31
MY8700146A (en) 1987-12-31
ATE24495T1 (de) 1987-01-15
ES507509A0 (es) 1982-09-01
YU278081A (en) 1984-06-30
FI73209B (fi) 1987-05-29
AU7794781A (en) 1982-06-03
IT1209431B (it) 1989-07-16

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