ES8207151A1 - Un procedimiento para la pre-paracion de imidazolilfenilami-dinas. - Google Patents

Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.

Info

Publication number
ES8207151A1
ES8207151A1 ES507508A ES507508A ES8207151A1 ES 8207151 A1 ES8207151 A1 ES 8207151A1 ES 507508 A ES507508 A ES 507508A ES 507508 A ES507508 A ES 507508A ES 8207151 A1 ES8207151 A1 ES 8207151A1
Authority
ES
Spain
Prior art keywords
group
preparation
substituted
compounds
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507508A
Other languages
English (en)
Other versions
ES507508A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto de Angeli SpA
Original Assignee
Instituto de Angeli SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto de Angeli SpA filed Critical Instituto de Angeli SpA
Publication of ES8207151A1 publication Critical patent/ES8207151A1/es
Publication of ES507508A0 publication Critical patent/ES507508A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE IMIDAZOLILFENILAMIDINAS Y DE SUS SALES DE ADICION DE ACIDO NO TOXICAS, DE FORMULA (I), EN LAS QUE R, R1 Y R3 PUEDEN SER HIDROGENO O ALCOHILO INFERIOR, Y R2 PUEDE SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R2 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UN ACIDO ORGANICO DEBIL, TAL COMO ACIDO FORMICO,ACETICO O PROPINICO. EL COMPUESTO OBTENIDO SE SEPARA Y PURIFICA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIHISTAMINICOS, INHIBIDORES DE LA SECRECION ACIDA GASTRICA Y COMO AGENTES ANTIULCERA.
ES507508A 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas. Granted ES507508A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8026323A IT1209431B (it) 1980-11-28 1980-11-28 Imidazolilfenil amidine, processi per la loro preparazione e loro impiego farmaceutico, ed intermedi di preparazione.

Publications (2)

Publication Number Publication Date
ES8207151A1 true ES8207151A1 (es) 1982-09-01
ES507508A0 ES507508A0 (es) 1982-09-01

Family

ID=11219229

Family Applications (6)

Application Number Title Priority Date Filing Date
ES507505A Expired ES8207148A1 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilami- dinas.
ES507507A Granted ES507507A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.
ES507501A Granted ES507501A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilamidinas.
ES507506A Expired ES8207149A1 (es) 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.
ES507509A Granted ES507509A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilamidinas.
ES507508A Granted ES507508A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
ES507505A Expired ES8207148A1 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilami- dinas.
ES507507A Granted ES507507A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.
ES507501A Granted ES507501A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilamidinas.
ES507506A Expired ES8207149A1 (es) 1980-11-28 1981-11-27 Un procedimiento para la pre-paracion de imidazolilfenilami-dinas.
ES507509A Granted ES507509A0 (es) 1980-11-28 1981-11-27 Un procedimiento para la preparacion de imidazolilfenilamidinas.

Country Status (30)

Country Link
US (2) US4386099A (es)
EP (1) EP0053407B1 (es)
JP (1) JPS57120575A (es)
KR (1) KR880001317B1 (es)
AR (1) AR228468A1 (es)
AT (1) ATE24495T1 (es)
AU (1) AU554592B2 (es)
CA (1) CA1171092A (es)
CS (2) CS249544B2 (es)
DD (1) DD201893A5 (es)
DE (2) DE3175754D1 (es)
DK (1) DK157862C (es)
ES (6) ES8207148A1 (es)
FI (1) FI73209C (es)
GB (1) GB2088375B (es)
GR (1) GR77310B (es)
HK (1) HK88186A (es)
HU (1) HU187478B (es)
IE (1) IE51946B1 (es)
IL (1) IL64388A (es)
IT (1) IT1209431B (es)
MY (1) MY8700146A (es)
NO (1) NO158183C (es)
NZ (1) NZ199093A (es)
PH (2) PH17390A (es)
PL (2) PL135749B1 (es)
PT (1) PT74048B (es)
SU (2) SU1110381A3 (es)
YU (2) YU42447B (es)
ZA (1) ZA818240B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200371B (it) * 1982-03-24 1989-01-18 Angeli Inst Spa Guanidino eterociclifenilamidine,processi per la loro preparazione e loro impiego farmaceutico
IT1201523B (it) * 1982-05-18 1989-02-02 Angeli Inst Spa Eterociclilfenilfomramidine,processi per la loro preparazione e loro uso farmaceutico
IT1210914B (it) * 1982-07-29 1989-09-29 Angeli Inst Spa Eterociclilfenilsolfonil e fosfonilamidine sostituite, procedimento per la loro preparazione e loro uso farmaceutico.
IT1206498B (it) * 1983-07-18 1989-04-27 Angeli Inst Spa Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.
IT1204910B (it) * 1987-01-28 1989-03-10 Angeli Inst Spa Composizioni farmaceutiche ad azione sinergica antisecretoria per la cicatrizzazione dell'ulcera gastroduodenale
KR920004935B1 (ko) * 1990-07-12 1992-06-22 일양약품공업 주식회사 N-디메톡시 페닐알킬-n'-이미다졸릴페닐 아미딘 유도체 및 그의 제조방법
US5294433A (en) * 1992-04-15 1994-03-15 The Procter & Gamble Company Use of H-2 antagonists for treatment of gingivitis
TW460460B (en) * 1997-11-04 2001-10-21 Chugai Pharmaceutical Co Ltd Heterocyclic compounds having NOS inhibitory activities
DK1226819T3 (da) * 1999-11-01 2006-05-22 Taisho Pharmaceutical Co Ltd Inhibitor for 20-HETE-producerende enzym
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
WO2006071659A1 (en) * 2004-12-29 2006-07-06 Trustees Of Boston University Delivery of h2 antagonists
EA015245B1 (ru) * 2005-09-13 2011-06-30 Байер Кропсайенс Аг Пестицидные тиазолилоксизамещенные фениламидиновые производные
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
WO2013135852A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
CN105377235A (zh) 2013-07-19 2016-03-02 勃林格殷格翰动物保健有限公司 含有防腐的醚化的环糊精衍生物的液体水性药物组合物
BR122019024673B1 (pt) 2013-12-04 2023-04-11 Boehringer Ingelheim Vetmedica Gmbh Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069340A (en) * 1976-01-30 1978-01-17 Hooker Chemicals & Plastics Corporation Immonium salts and derivatives thereof
DE2645477C2 (de) * 1976-10-08 1982-03-04 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von Orthoessigsäurealkylestern
US4225724A (en) * 1977-01-07 1980-09-30 Westwood Pharmaceuticals, Inc. 1-(2-Phenylureylene)imidazoles
US4236015A (en) * 1977-01-07 1980-11-25 Westwood Pharmaceuticals, Inc. 1-(2-Acylaminophenyl)imidazoles
US4160097A (en) * 1977-01-07 1979-07-03 Westwind Pharmaceuticals, Inc. 1-(2-Phenylureylene)imidazoles

Also Published As

Publication number Publication date
EP0053407A2 (en) 1982-06-09
DK157862C (da) 1990-08-06
DE53407T1 (de) 1983-01-20
IL64388A (en) 1985-04-30
ES507506A0 (es) 1982-09-01
ES8207150A1 (es) 1982-09-01
YU175983A (en) 1984-06-30
GB2088375A (en) 1982-06-09
PL238422A1 (en) 1983-06-06
SU1110382A3 (ru) 1984-08-23
IE812790L (en) 1982-05-28
HU187478B (en) 1986-01-28
DD201893A5 (de) 1983-08-17
PT74048B (en) 1983-12-07
ES8207147A1 (es) 1982-09-01
ES507507A0 (es) 1982-09-01
SU1110381A3 (ru) 1984-08-23
EP0053407A3 (en) 1983-07-27
HK88186A (en) 1986-11-28
ES8207149A1 (es) 1982-09-01
EP0053407B1 (en) 1986-12-30
PT74048A (en) 1981-12-01
ES8207152A1 (es) 1982-09-01
DK525581A (da) 1982-05-29
NO158183C (no) 1988-07-27
US4465841A (en) 1984-08-14
JPH0233031B2 (es) 1990-07-25
PL135749B1 (en) 1985-12-31
AR228468A1 (es) 1983-03-15
IE51946B1 (en) 1987-04-29
ES507501A0 (es) 1982-09-01
NO158183B (no) 1988-04-18
FI813794L (fi) 1982-05-29
CA1171092A (en) 1984-07-17
AU554592B2 (en) 1986-08-28
ZA818240B (en) 1983-07-27
US4386099A (en) 1983-05-31
DK157862B (da) 1990-02-26
PH19032A (en) 1985-12-06
KR830007575A (ko) 1983-11-04
FI73209C (fi) 1987-09-10
IL64388A0 (en) 1982-02-28
ES507508A0 (es) 1982-09-01
DE3175754D1 (en) 1987-02-05
PL136015B1 (en) 1986-01-31
KR880001317B1 (ko) 1988-07-23
GB2088375B (en) 1985-01-09
GR77310B (es) 1984-09-11
CS249115B2 (en) 1987-03-12
JPS57120575A (en) 1982-07-27
PH17390A (en) 1984-08-08
YU42447B (en) 1988-08-31
IT8026323A0 (it) 1980-11-28
ES507505A0 (es) 1982-09-01
CS249544B2 (en) 1987-03-12
NO814065L (no) 1982-06-01
PL234007A1 (en) 1983-03-14
ES8207148A1 (es) 1982-09-01
NZ199093A (en) 1985-05-31
YU42878B (en) 1988-12-31
MY8700146A (en) 1987-12-31
ATE24495T1 (de) 1987-01-15
ES507509A0 (es) 1982-09-01
YU278081A (en) 1984-06-30
FI73209B (fi) 1987-05-29
AU7794781A (en) 1982-06-03
IT1209431B (it) 1989-07-16

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