CS241475B2 - Method of 1,2-bis/(nicotinamido/)-propane preparation - Google Patents

Method of 1,2-bis/(nicotinamido/)-propane preparation Download PDF

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Publication number
CS241475B2
CS241475B2 CS807657A CS765780A CS241475B2 CS 241475 B2 CS241475 B2 CS 241475B2 CS 807657 A CS807657 A CS 807657A CS 765780 A CS765780 A CS 765780A CS 241475 B2 CS241475 B2 CS 241475B2
Authority
CS
Czechoslovakia
Prior art keywords
compound
reaction
carried out
bis
acid
Prior art date
Application number
CS807657A
Other languages
Czech (cs)
English (en)
Other versions
CS765780A2 (en
Inventor
Takashi Mori
Sakae Takaku
Fumiaki Matsuura
Yasushi Murakami
Yukifumi Noda
Tamotsu Yamazaki
Tomohiro Neichi
Hiroshi Nakakimura
Shigeyuki Kataoka
Takashi Matsuno
Schun-Chi Hata
Shigeru Takanashi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CS765780A2 publication Critical patent/CS765780A2/cs
Publication of CS241475B2 publication Critical patent/CS241475B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CS807657A 1979-11-22 1980-11-12 Method of 1,2-bis/(nicotinamido/)-propane preparation CS241475B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15067479A JPS5675474A (en) 1979-11-22 1979-11-22 Nicotinamide derivative and medicine containing the same

Publications (2)

Publication Number Publication Date
CS765780A2 CS765780A2 (en) 1985-07-16
CS241475B2 true CS241475B2 (en) 1986-03-13

Family

ID=15501986

Family Applications (1)

Application Number Title Priority Date Filing Date
CS807657A CS241475B2 (en) 1979-11-22 1980-11-12 Method of 1,2-bis/(nicotinamido/)-propane preparation

Country Status (13)

Country Link
US (1) US4366161A (nl)
EP (1) EP0029602B1 (nl)
JP (1) JPS5675474A (nl)
AR (1) AR229954A1 (nl)
AU (1) AU540216B2 (nl)
CA (1) CA1147732A (nl)
CS (1) CS241475B2 (nl)
DE (1) DE3066874D1 (nl)
DK (1) DK149807C (nl)
ES (1) ES8203349A1 (nl)
HU (1) HU180617B (nl)
SU (1) SU1053749A3 (nl)
ZA (1) ZA807283B (nl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
FR2556722B1 (fr) * 1983-12-15 1986-09-26 Merck Clevenot Laboratoires N-valproyl-nicotinamide, procede de preparation et utilisation en therapeutique
ATE110058T1 (de) * 1988-12-27 1994-09-15 Chugai Pharmaceutical Co Ltd Reinigungsverfahren für 1,2- bis(nicotinamido)propan.
EP0697169B1 (en) * 1993-05-07 2000-11-15 Chugai Seiyaku Kabushiki Kaisha Organ preservative
JPH09315972A (ja) * 1996-03-22 1997-12-09 Chugai Pharmaceut Co Ltd 脊髄損傷治療剤
US20030032655A1 (en) * 2000-03-17 2003-02-13 Toshio Tanaka Heme oxygenase-1 inducers or induction enhancers
WO2002028392A1 (fr) * 2000-09-29 2002-04-11 Chugai Seiyaku Kabushiki Kaisha Remedes pour des troubles circulatoires cerebraux

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH392507A (de) * 1960-06-27 1965-05-31 Eprova Ag Verfahren zur Herstellung von Nicotinsäure-aminomethylamiden
FR1335517A (fr) * 1962-03-27 1963-08-23 Ciba Geigy Procédé de préparation d'amides hétérocycliques, notamment de la 3, 3-bis-(4-nicotinoylamino-phényl)-butane-2-one
US3697531A (en) * 1971-02-25 1972-10-10 Sterling Drug Inc N,n{40 -alkylenebis(pyridine-carboxamides)
GB1339764A (en) * 1971-03-29 1973-12-05 Ici Ltd Pyridine derivatives

Also Published As

Publication number Publication date
ES497065A0 (es) 1982-04-01
ES8203349A1 (es) 1982-04-01
CA1147732A (en) 1983-06-07
HU180617B (en) 1983-03-28
JPS5675474A (en) 1981-06-22
DK493780A (da) 1981-05-23
SU1053749A3 (ru) 1983-11-07
DK149807B (da) 1986-10-06
AU540216B2 (en) 1984-11-08
DE3066874D1 (en) 1984-04-12
EP0029602A1 (en) 1981-06-03
JPS6155911B2 (nl) 1986-11-29
AU6451780A (en) 1981-05-28
ZA807283B (en) 1981-11-25
CS765780A2 (en) 1985-07-16
EP0029602B1 (en) 1984-03-07
US4366161A (en) 1982-12-28
DK149807C (da) 1987-03-23
AR229954A1 (es) 1984-01-31

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