ATE110058T1 - Reinigungsverfahren für 1,2- bis(nicotinamido)propan. - Google Patents
Reinigungsverfahren für 1,2- bis(nicotinamido)propan.Info
- Publication number
- ATE110058T1 ATE110058T1 AT89123739T AT89123739T ATE110058T1 AT E110058 T1 ATE110058 T1 AT E110058T1 AT 89123739 T AT89123739 T AT 89123739T AT 89123739 T AT89123739 T AT 89123739T AT E110058 T1 ATE110058 T1 AT E110058T1
- Authority
- AT
- Austria
- Prior art keywords
- nicotinamido
- bis
- propane
- crude
- solvent
- Prior art date
Links
- KTXBOOWDLPUROC-UHFFFAOYSA-N n-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C)CNC(=O)C1=CC=CN=C1 KTXBOOWDLPUROC-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000746 purification Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 1
- 239000012670 alkaline solution Substances 0.000 abstract 1
- 229960003512 nicotinic acid Drugs 0.000 abstract 1
- 235000001968 nicotinic acid Nutrition 0.000 abstract 1
- 239000011664 nicotinic acid Substances 0.000 abstract 1
- IXUISNDFHCKDID-UHFFFAOYSA-N nitric acid;n-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide Chemical compound O[N+]([O-])=O.O[N+]([O-])=O.C=1C=CN=CC=1C(=O)NC(C)CNC(=O)C1=CC=CN=C1 IXUISNDFHCKDID-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- AOHJOMMDDJHIJH-UHFFFAOYSA-N propylenediamine Chemical compound CC(N)CN AOHJOMMDDJHIJH-UHFFFAOYSA-N 0.000 abstract 1
- 239000012264 purified product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33025588 | 1988-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110058T1 true ATE110058T1 (de) | 1994-09-15 |
Family
ID=18230595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89123739T ATE110058T1 (de) | 1988-12-27 | 1989-12-22 | Reinigungsverfahren für 1,2- bis(nicotinamido)propan. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5099022A (de) |
| EP (1) | EP0376185B1 (de) |
| AT (1) | ATE110058T1 (de) |
| CA (1) | CA2006665C (de) |
| DE (1) | DE68917574T2 (de) |
| ES (1) | ES2061918T3 (de) |
| HK (1) | HK1005027A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09315972A (ja) * | 1996-03-22 | 1997-12-09 | Chugai Pharmaceut Co Ltd | 脊髄損傷治療剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2681341A (en) * | 1952-08-19 | 1954-06-15 | S E Massengill Company | Solid acid salts of nu, nu-diethyl pyridine-3-carboxylic acid amide |
| JPS5675474A (en) * | 1979-11-22 | 1981-06-22 | Chugai Pharmaceut Co Ltd | Nicotinamide derivative and medicine containing the same |
| US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
-
1989
- 1989-12-22 AT AT89123739T patent/ATE110058T1/de not_active IP Right Cessation
- 1989-12-22 ES ES89123739T patent/ES2061918T3/es not_active Expired - Lifetime
- 1989-12-22 EP EP89123739A patent/EP0376185B1/de not_active Expired - Lifetime
- 1989-12-22 DE DE68917574T patent/DE68917574T2/de not_active Expired - Fee Related
- 1989-12-27 CA CA002006665A patent/CA2006665C/en not_active Expired - Fee Related
- 1989-12-27 US US07/456,794 patent/US5099022A/en not_active Expired - Lifetime
-
1998
- 1998-05-14 HK HK98104189A patent/HK1005027A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68917574D1 (de) | 1994-09-22 |
| US5099022A (en) | 1992-03-24 |
| DE68917574T2 (de) | 1994-12-15 |
| CA2006665A1 (en) | 1990-06-27 |
| CA2006665C (en) | 1998-02-17 |
| EP0376185A2 (de) | 1990-07-04 |
| EP0376185B1 (de) | 1994-08-17 |
| HK1005027A1 (en) | 1998-12-18 |
| ES2061918T3 (es) | 1994-12-16 |
| EP0376185A3 (de) | 1991-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |