CS228140B2 - Production of straight or monocyclic polypeptides - Google Patents
Production of straight or monocyclic polypeptides Download PDFInfo
- Publication number
- CS228140B2 CS228140B2 CS808184A CS818480A CS228140B2 CS 228140 B2 CS228140 B2 CS 228140B2 CS 808184 A CS808184 A CS 808184A CS 818480 A CS818480 A CS 818480A CS 228140 B2 CS228140 B2 CS 228140B2
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- CS
- Czechoslovakia
- Prior art keywords
- group
- formula
- hydrogen atom
- optionally
- carbon atoms
- Prior art date
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- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- PRZSXZWFJHEZBJ-UHFFFAOYSA-N thymol blue Chemical compound C1=C(O)C(C(C)C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C(=CC(O)=C(C(C)C)C=2)C)=C1C PRZSXZWFJHEZBJ-UHFFFAOYSA-N 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1052479 | 1979-11-27 | ||
| CH457480 | 1980-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS228140B2 true CS228140B2 (en) | 1984-05-14 |
Family
ID=25695798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS808184A CS228140B2 (en) | 1979-11-27 | 1980-11-26 | Production of straight or monocyclic polypeptides |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4395403A (enExample) |
| EP (1) | EP0029579B1 (enExample) |
| JP (1) | JPS5690048A (enExample) |
| AT (1) | ATE2512T1 (enExample) |
| AU (1) | AU543198B2 (enExample) |
| CA (1) | CA1182109A (enExample) |
| CS (1) | CS228140B2 (enExample) |
| CY (1) | CY1327A (enExample) |
| DE (2) | DE19375086I2 (enExample) |
| DK (1) | DK150146C (enExample) |
| ES (2) | ES8301463A1 (enExample) |
| FI (1) | FI72981C (enExample) |
| GR (1) | GR71636B (enExample) |
| HK (1) | HK30686A (enExample) |
| HU (1) | HU185920B (enExample) |
| IE (1) | IE50571B1 (enExample) |
| IL (1) | IL61561A (enExample) |
| KE (1) | KE3606A (enExample) |
| LU (1) | LU88344I2 (enExample) |
| MY (1) | MY8500072A (enExample) |
| NL (1) | NL930137I2 (enExample) |
| NZ (1) | NZ195640A (enExample) |
| PH (1) | PH22841A (enExample) |
| PT (1) | PT72103B (enExample) |
| SG (1) | SG8786G (enExample) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK81082A (da) * | 1981-03-06 | 1982-09-07 | Sandoz Ag | Fremgangsmaade til fremstilling af polypeptider |
| CH655505B (enExample) * | 1982-08-24 | 1986-04-30 | ||
| US4663435A (en) * | 1982-12-06 | 1987-05-05 | Merck & Co., Inc. | Bridged cyclic hexapeptide somatostatin analogs |
| FR2554347B1 (fr) * | 1983-11-07 | 1986-10-03 | Immunotech Sa | Acide pressinique, ses derives aminoacides substitues et homologues de configuration d ainsi que les derives n- et c- terminal-substitues et leurs applications dans les domaines therapeutique, biologique ou immunologique |
| US4684620A (en) * | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
| GB8423431D0 (en) * | 1984-09-17 | 1984-10-24 | Sandoz Ltd | Organic compounds |
| US4650787A (en) * | 1985-04-25 | 1987-03-17 | Schally Andrew Victor | Biologically active octapeptides |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US4904642A (en) * | 1985-09-12 | 1990-02-27 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| JPH085913B2 (ja) * | 1985-09-12 | 1996-01-24 | ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド | 治療用ソマトスタチン同族体 |
| GR862206B (en) * | 1985-09-12 | 1986-12-31 | Univ Tulane | Therapeutic somatostatin analogs |
| NL8701143A (nl) * | 1986-05-27 | 1987-12-16 | Sandoz Ag | Farmaceutische preparaten. |
| US4853371A (en) * | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
| DE3726517A1 (de) * | 1986-08-18 | 1988-03-03 | Sandoz Ag | Nasale zusammensetzungen, welche octreotid enthalten |
| GB8620035D0 (en) * | 1986-08-18 | 1986-10-01 | Sandoz Ltd | Organic compounds |
| GB2193891B (en) * | 1986-08-18 | 1990-07-25 | Sandoz Ltd | Nasal pharmaceutical composition containing a somatostatin anologue. |
| HU906340D0 (en) * | 1986-10-13 | 1991-04-29 | Sandoz Ag | Synthesis in solid phase for producing peptonic alcohols |
| DE3790635B4 (de) * | 1986-10-13 | 2007-11-22 | Novartis Ag | Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür |
| US4871717A (en) * | 1987-01-07 | 1989-10-03 | Administrators Of The Tulane Educational Fund | Peptides |
| US5073541A (en) * | 1987-11-18 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Treatment of small cell lung cancer with somatostatin analogs |
| ZA895838B (en) * | 1988-08-18 | 1991-03-27 | Syntex Inc | Pharmaceutical compounds |
| US5006510A (en) * | 1989-06-20 | 1991-04-09 | Ellis Wladislaw V | Method for relieving chronic pain with a somatostatin analog composition |
| HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
| US5084443A (en) * | 1989-12-04 | 1992-01-28 | Biomeasure, Inc. | Promoting expression of acetylcholine receptors with lhrh antagonist |
| EP0457888B1 (en) * | 1989-12-08 | 1996-07-10 | The Administrators of The Tulane Educational Fund | Octapeptide analogs of somatostatin having threonine at the sixth position |
| DE69229436T2 (de) * | 1991-02-08 | 1999-11-25 | Biomeasure, Inc. | Verwendung von somatostatinanalogen zur behandlung von melanomen |
| US5504069A (en) * | 1993-02-11 | 1996-04-02 | Biomeasure, Inc. | Inhibition of trauma-induced tumor growth |
| GB9402767D0 (en) * | 1994-02-14 | 1994-04-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5597894A (en) * | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
| US5830431A (en) * | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| EP0824103A1 (en) * | 1996-08-13 | 1998-02-18 | Chang-Shinn Su | Method for synthesis of Tyr-3-octreotide |
| US6262229B1 (en) | 1996-12-04 | 2001-07-17 | Biomeasure Incorporated | Somatostatin antagonists |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| AU8019898A (en) * | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome |
| AU7655098A (en) * | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Somatostatin and somatostatin agonists for decreasing body weight |
| US7026289B2 (en) * | 1997-05-13 | 2006-04-11 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Method and compositions for treating hyperlipidemia and other conditions |
| ES2144357B1 (es) * | 1998-01-29 | 2000-12-16 | Lipotec Sa | Procedimiento para la obtencion del analogo de somatostatina octreotide. |
| US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
| US6159935A (en) * | 1999-11-29 | 2000-12-12 | Pharmacia & Upjohn Co. | Method for preventing diarrhea |
| RU2196144C1 (ru) * | 2001-05-14 | 2003-01-10 | Самуков Владимир Васильевич | Защищенные производные октреотида |
| NZ530007A (en) | 2001-06-08 | 2006-02-24 | Sod Conseils Rech Applic | Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity |
| AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
| US6987167B2 (en) | 2002-05-22 | 2006-01-17 | Wockhardt Limited | Process for production of the somatostatin analog, octreotide |
| US20040097419A1 (en) | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
| DE04759123T1 (de) * | 2003-04-07 | 2005-08-18 | Novetide Ltd. | Verfahren zur herstellung cyclischer peptide |
| JP4578470B2 (ja) | 2003-04-22 | 2010-11-10 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | ソマトスタチンベクター |
| ES2344657T3 (es) * | 2004-10-04 | 2010-09-02 | Novetide, Ltd. | Procedimiento de intercambio de contraion para peptidos. |
| PT2359809T (pt) | 2005-12-22 | 2019-11-04 | Novartis Ag | Formulação de libertação sustentada que compreende octreótido e dois ou mais polímeros poliláctido-co-glicólido |
| EP2013226A2 (en) * | 2006-03-28 | 2009-01-14 | Wockhardt Limited | Processes for the preparation of octreotide |
| TW200819137A (en) * | 2006-10-31 | 2008-05-01 | Iner Aec Executive Yuan | Method for preparation of lipid-spacer radical- reactions of functional group-peptide |
| US20090082259A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched octreotide |
| EP2172189A1 (en) | 2008-10-01 | 2010-04-07 | Novartis AG | Pharmaceutical Compositions |
| EP2213307A1 (en) | 2009-02-03 | 2010-08-04 | Novartis AG | Injectable depot formulations |
| US8377891B2 (en) | 2008-11-07 | 2013-02-19 | Usv, Ltd. | Process for synthesis of cyclic octapeptide |
| EP2395987A1 (en) | 2009-02-12 | 2011-12-21 | Coöperatieve Mirzorg U.A., Arnhem | Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders |
| US20140296144A1 (en) | 2011-09-30 | 2014-10-02 | Mylan Laboratories, Ltd. | Process for the preparation of octreotide acetate |
| CN103102390B (zh) * | 2011-11-09 | 2015-01-28 | 杭州华津允上医药有限公司 | 一种奥曲肽的制备方法 |
| WO2013132505A1 (en) | 2012-03-09 | 2013-09-12 | Natco Pharma Limited | Improved process for preparation of octreotide by solution phase peptide synthesis |
| DK3007704T3 (da) | 2013-06-13 | 2021-03-29 | Antisense Therapeutics Ltd | Kombinationsterapi til akromegali |
| CN108395469A (zh) * | 2018-02-01 | 2018-08-14 | 滨海吉尔多肽有限公司 | 一种假脯氨酸二肽的合成方法 |
| GB202012334D0 (en) | 2020-08-07 | 2020-09-23 | Avon Polymer Prod Ltd | Monitoring system |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105603A (en) * | 1977-03-28 | 1978-08-08 | The Salk Institute For Biological Studies | Peptides which effect release of hormones |
| US4140767A (en) * | 1977-12-01 | 1979-02-20 | Merck & Co., Inc. | Somatostatin analogs |
| US4139526A (en) * | 1977-12-01 | 1979-02-13 | Merck & Co., Inc. | Somatostatin analogs |
| US4190648A (en) * | 1979-03-13 | 1980-02-26 | Merck & Co., Inc. | Peptides having somatostatin activity |
| US4225472A (en) * | 1979-05-29 | 1980-09-30 | American Home Products Corporation | Truncated somatostatin analogs |
| US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4282143A (en) * | 1980-06-13 | 1981-08-04 | American Home Products Corporation | Octapeptides lowering growth hormone |
-
1980
- 1980-11-19 AT AT80107181T patent/ATE2512T1/de active
- 1980-11-19 CY CY1327A patent/CY1327A/xx unknown
- 1980-11-19 DE DE1993175086 patent/DE19375086I2/de active Active
- 1980-11-19 EP EP80107181A patent/EP0029579B1/en not_active Expired
- 1980-11-19 DE DE8080107181T patent/DE3062075D1/de not_active Expired
- 1980-11-21 FI FI803634A patent/FI72981C/fi not_active IP Right Cessation
- 1980-11-25 ES ES497113A patent/ES8301463A1/es not_active Expired
- 1980-11-25 PH PH24898A patent/PH22841A/en unknown
- 1980-11-25 HU HU802817A patent/HU185920B/hu unknown
- 1980-11-25 NZ NZ195640A patent/NZ195640A/en unknown
- 1980-11-25 CA CA000365399A patent/CA1182109A/en not_active Expired
- 1980-11-25 GR GR63449A patent/GR71636B/el unknown
- 1980-11-25 DK DK501980A patent/DK150146C/da not_active IP Right Cessation
- 1980-11-25 AU AU64688/80A patent/AU543198B2/en not_active Expired
- 1980-11-25 IL IL61561A patent/IL61561A/xx not_active IP Right Cessation
- 1980-11-25 PT PT72103A patent/PT72103B/pt unknown
- 1980-11-26 IE IE2452/80A patent/IE50571B1/en not_active IP Right Cessation
- 1980-11-26 CS CS808184A patent/CS228140B2/cs unknown
- 1980-11-26 JP JP16736480A patent/JPS5690048A/ja active Granted
-
1981
- 1981-11-16 US US06/321,663 patent/US4395403A/en not_active Expired - Lifetime
-
1982
- 1982-03-24 ES ES510751A patent/ES8305701A1/es not_active Expired
-
1985
- 1985-12-30 MY MY72/85A patent/MY8500072A/xx unknown
-
1986
- 1986-01-31 SG SG87/86A patent/SG8786G/en unknown
- 1986-02-10 KE KE3606A patent/KE3606A/xx unknown
- 1986-05-01 HK HK306/86A patent/HK30686A/en not_active IP Right Cessation
-
1993
- 1993-06-30 LU LU88344C patent/LU88344I2/fr unknown
- 1993-07-02 NL NL930137C patent/NL930137I2/nl unknown
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