DK150146C - Analogifremgangsmaade til fremstilling af somatostatinanaloge hepta- eller octapeptider eller salte eller complexer deraf - Google Patents

Analogifremgangsmaade til fremstilling af somatostatinanaloge hepta- eller octapeptider eller salte eller complexer deraf

Info

Publication number
DK150146C
DK150146C DK501980A DK501980A DK150146C DK 150146 C DK150146 C DK 150146C DK 501980 A DK501980 A DK 501980A DK 501980 A DK501980 A DK 501980A DK 150146 C DK150146 C DK 150146C
Authority
DK
Denmark
Prior art keywords
analogue
preparation
somatostatin analogues
monocyclic
pancreatic
Prior art date
Application number
DK501980A
Other languages
English (en)
Other versions
DK501980A (da
DK150146B (da
Inventor
Wilfried Bauer
Janos Pless
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of DK501980A publication Critical patent/DK501980A/da
Publication of DK150146B publication Critical patent/DK150146B/da
Application granted granted Critical
Publication of DK150146C publication Critical patent/DK150146C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK501980A 1979-11-27 1980-11-25 Analogifremgangsmaade til fremstilling af somatostatinanaloge hepta- eller octapeptider eller salte eller complexer deraf DK150146C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1052479 1979-11-27
CH1052479 1979-11-27
CH457480 1980-06-13
CH457480 1980-06-13

Publications (3)

Publication Number Publication Date
DK501980A DK501980A (da) 1981-05-28
DK150146B DK150146B (da) 1986-12-15
DK150146C true DK150146C (da) 1987-06-01

Family

ID=25695798

Family Applications (1)

Application Number Title Priority Date Filing Date
DK501980A DK150146C (da) 1979-11-27 1980-11-25 Analogifremgangsmaade til fremstilling af somatostatinanaloge hepta- eller octapeptider eller salte eller complexer deraf

Country Status (25)

Country Link
US (1) US4395403A (da)
EP (1) EP0029579B1 (da)
JP (1) JPS5690048A (da)
AT (1) ATE2512T1 (da)
AU (1) AU543198B2 (da)
CA (1) CA1182109A (da)
CS (1) CS228140B2 (da)
CY (1) CY1327A (da)
DE (2) DE3062075D1 (da)
DK (1) DK150146C (da)
ES (2) ES8301463A1 (da)
FI (1) FI72981C (da)
GR (1) GR71636B (da)
HK (1) HK30686A (da)
HU (1) HU185920B (da)
IE (1) IE50571B1 (da)
IL (1) IL61561A (da)
KE (1) KE3606A (da)
LU (1) LU88344I2 (da)
MY (1) MY8500072A (da)
NL (1) NL930137I2 (da)
NZ (1) NZ195640A (da)
PH (1) PH22841A (da)
PT (1) PT72103B (da)
SG (1) SG8786G (da)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
CH655505B (da) * 1982-08-24 1986-04-30
US4663435A (en) * 1982-12-06 1987-05-05 Merck & Co., Inc. Bridged cyclic hexapeptide somatostatin analogs
FR2554347B1 (fr) * 1983-11-07 1986-10-03 Immunotech Sa Acide pressinique, ses derives aminoacides substitues et homologues de configuration d ainsi que les derives n- et c- terminal-substitues et leurs applications dans les domaines therapeutique, biologique ou immunologique
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
HU198626B (en) * 1986-05-27 1989-11-28 Sandoz Ag Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
GB8620035D0 (en) * 1986-08-18 1986-10-01 Sandoz Ltd Organic compounds
DE3726517A1 (de) * 1986-08-18 1988-03-03 Sandoz Ag Nasale zusammensetzungen, welche octreotid enthalten
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
NO893088L (no) * 1988-08-18 1990-02-19 Syntex Inc Fremgangsmaate for fremstilling av terapeutisk virksomme somatostatinlignende cykliske peptidforbindelser.
US5006510A (en) * 1989-06-20 1991-04-09 Ellis Wladislaw V Method for relieving chronic pain with a somatostatin analog composition
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
ATE140237T1 (de) * 1989-12-08 1996-07-15 Univ Tulane Oktapeptidanaloge von somatostatin mit threonin in position 6
IE920416A1 (en) * 1991-02-08 1992-08-12 Biomeasure Method of treating benign and malignant proliferative skin¹disease
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9402767D0 (en) * 1994-02-14 1994-04-06 Sandoz Ltd Improvements in or relating to organic compounds
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0824103A1 (en) * 1996-08-13 1998-02-18 Chang-Shinn Su Method for synthesis of Tyr-3-octreotide
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
WO1998051331A1 (en) 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
US7026289B2 (en) * 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
ES2144357B1 (es) * 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6159935A (en) * 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
JP3996897B2 (ja) 2001-06-08 2007-10-24 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス ソマトスタチン−ドーパミンキメラ類似体
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6987167B2 (en) 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
US20040097419A1 (en) 2002-11-19 2004-05-20 Holger Petersen Organic compounds
ES2237356T3 (es) * 2003-04-07 2007-04-01 Novetide Ltd. Procedimiento para la produccion de peptidos ciclicos.
AU2004232314B2 (en) 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
EP1709065B1 (en) * 2004-10-04 2010-06-02 Novetide Ltd. A counterion exchange process for peptides
KR101245919B1 (ko) 2005-12-22 2013-03-20 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드중합체를 포함하는 서방형 제제
WO2007110765A2 (en) * 2006-03-28 2007-10-04 Wockhardt Ltd Processes for the preparation of octreotide
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
US20090082259A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched octreotide
EP2213307A1 (en) 2009-02-03 2010-08-04 Novartis AG Injectable depot formulations
EP2172189A1 (en) 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
US8377891B2 (en) 2008-11-07 2013-02-19 Usv, Ltd. Process for synthesis of cyclic octapeptide
EP2395987A1 (en) 2009-02-12 2011-12-21 Coöperatieve Mirzorg U.A., Arnhem Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
WO2013046233A2 (en) 2011-09-30 2013-04-04 Mylan Laboratories Ltd Process for the preparation of octreotide acetate
CN103102390B (zh) * 2011-11-09 2015-01-28 杭州华津允上医药有限公司 一种奥曲肽的制备方法
WO2013132505A1 (en) 2012-03-09 2013-09-12 Natco Pharma Limited Improved process for preparation of octreotide by solution phase peptide synthesis
AU2014280847B2 (en) 2013-06-13 2019-07-04 Antisense Therapeutics Ltd Combination therapy
CN108395469A (zh) * 2018-02-01 2018-08-14 滨海吉尔多肽有限公司 一种假脯氨酸二肽的合成方法
GB202012334D0 (en) 2020-08-07 2020-09-23 Avon Polymer Prod Ltd Monitoring system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105603A (en) * 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Also Published As

Publication number Publication date
FI72981C (fi) 1987-08-10
IL61561A0 (en) 1980-12-31
EP0029579A1 (en) 1981-06-03
JPS5690048A (en) 1981-07-21
GR71636B (da) 1983-06-20
ES8305701A1 (es) 1983-04-16
ES497113A0 (es) 1982-12-01
SG8786G (en) 1987-03-27
ATE2512T1 (de) 1983-03-15
PT72103B (fr) 1982-01-28
IE50571B1 (en) 1986-05-14
EP0029579B1 (en) 1983-02-16
JPS6351159B2 (da) 1988-10-13
DE3062075D1 (en) 1983-03-24
US4395403A (en) 1983-07-26
NL930137I1 (nl) 1993-11-01
IL61561A (en) 1985-02-28
HK30686A (en) 1986-05-09
PH22841A (en) 1989-01-19
AU543198B2 (en) 1985-04-04
IE802452L (en) 1981-05-27
FI72981B (fi) 1987-04-30
HU185920B (en) 1985-04-28
NL930137I2 (nl) 1997-02-03
KE3606A (en) 1986-03-17
ES8301463A1 (es) 1982-12-01
PT72103A (fr) 1980-12-01
CY1327A (en) 1986-06-27
DE19375086I2 (de) 2003-01-09
LU88344I2 (fr) 1994-05-04
NZ195640A (en) 1984-07-06
AU6468880A (en) 1981-06-04
CA1182109A (en) 1985-02-05
FI803634L (fi) 1981-05-28
ES510751A0 (es) 1983-04-16
CS228140B2 (en) 1984-05-14
DK501980A (da) 1981-05-28
MY8500072A (en) 1985-12-31
DK150146B (da) 1986-12-15

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Legal Events

Date Code Title Description
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00033, 930624

CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00033, 930624

PUP Patent expired