ES2054692T3 - Polipeptidos sinteticos y anticuerpos relacionados con el antigeno difuso temprano del virus de epstein-barr. - Google Patents

Polipeptidos sinteticos y anticuerpos relacionados con el antigeno difuso temprano del virus de epstein-barr.

Info

Publication number
ES2054692T3
ES2054692T3 ES87310609T ES87310609T ES2054692T3 ES 2054692 T3 ES2054692 T3 ES 2054692T3 ES 87310609 T ES87310609 T ES 87310609T ES 87310609 T ES87310609 T ES 87310609T ES 2054692 T3 ES2054692 T3 ES 2054692T3
Authority
ES
Spain
Prior art keywords
epstein
antigen
barr virus
synthetic polypeptides
antibodies related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87310609T
Other languages
English (en)
Inventor
Robert I Fox
Richard Houghton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of ES2054692T3 publication Critical patent/ES2054692T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)

Abstract

LA INVENCION SE REFIERE A UN POLIPEPTIDO QUE CONTIENE DE 6 A 40 RESIDUOS DE AMINOACIDO QUE INMUNOLOGICAMENTE REPLICA A LA PROTEINA DIFUSA DEL ANTIGENO PRECOZ (EA-D) DEL VIRUS DE EPSTEIN-BARR (EBV), ASI COMO A RECEPTORES QUE DAN LUGAR A ESE POLIPEPTIDO, A METODOS PARA SU EMPLEO Y A UN SISTEMA REACTIVO. UN POLIPEPTIDO DE LA PRESENTE INVENCION TIENE UNA SECUENCIA DE RESIDUOS DE AMINOACIDOS QUE CORRESPONDE A LA SECUENCIA DE LA PROTEINA EBV EA-D DESDE LA POSICION 350 HASTA LA POSICION 362 DEL TERMINO AMINO.
ES87310609T 1986-12-05 1987-12-02 Polipeptidos sinteticos y anticuerpos relacionados con el antigeno difuso temprano del virus de epstein-barr. Expired - Lifetime ES2054692T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/938,643 US4879213A (en) 1986-12-05 1986-12-05 Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse

Publications (1)

Publication Number Publication Date
ES2054692T3 true ES2054692T3 (es) 1994-08-16

Family

ID=25471727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87310609T Expired - Lifetime ES2054692T3 (es) 1986-12-05 1987-12-02 Polipeptidos sinteticos y anticuerpos relacionados con el antigeno difuso temprano del virus de epstein-barr.

Country Status (13)

Country Link
US (1) US4879213A (es)
EP (1) EP0280813B1 (es)
JP (2) JP2624973B2 (es)
AT (1) ATE107316T1 (es)
AU (1) AU610099B2 (es)
CA (1) CA1315481C (es)
DE (1) DE3750088T2 (es)
DK (1) DK173262B1 (es)
ES (1) ES2054692T3 (es)
IE (1) IE63368B1 (es)
IL (1) IL84690A (es)
NZ (1) NZ222794A (es)
ZA (1) ZA879025B (es)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351412B1 (en) * 1983-12-05 2008-04-01 Institut Pasteur Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated-virus (LAV) and proteins encoded by said LAV genomic RNA
US5116725A (en) * 1984-08-08 1992-05-26 Scripps Clinic And Research Foundation Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides
US6251634B1 (en) * 1985-11-26 2001-06-26 Pharmacia & Upjohn Company Pseudorabies virus protein
US5256768A (en) * 1985-12-13 1993-10-26 The Johns Hopkins University Expression of antigenic Epstein-Barr virus polypeptides in bacteria and their use in diagnostics
US6255078B1 (en) * 1986-03-26 2001-07-03 Pharmacia & Upjohn Company Pseudorabies virus protein cross reference to related applications
DE3706233A1 (de) * 1987-02-26 1988-09-08 Behringwerke Ag Immunogene fusionsproteine, die epstein-barr-virusproteine enthalten
NZ225295A (en) * 1987-07-07 1991-07-26 Biotech Australia Pty Ltd Nematode antigen, its production and vaccines containing it
US5948644A (en) * 1988-09-26 1999-09-07 Biotechnology Australia Pty Ltd. Polynucleotides encoding excretory/secretory proteins of parasitic nematodes, host cells transformed therewith
US5079172A (en) * 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US6572862B1 (en) * 1989-11-08 2003-06-03 Baylor College Of Medicine Methods and reagents to detect and characterize Norwalk and related viruses
EP0585216A1 (en) * 1989-11-24 1994-03-09 The Council Of The Queensland Institue Of Medical Research Im peptides
AU640430B2 (en) * 1989-11-24 1993-08-26 Council Of The Queensland Institute Of Medical Research, The Im peptides
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
JP2596466B2 (ja) * 1990-03-03 1997-04-02 アサヒビール株式会社 ダニの主要アレルゲンの還伝情報を有するｄｎａおよび該アレルゲンの製造方法
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
US5798105A (en) * 1990-06-06 1998-08-25 University Of Nijmegan DNA encoding a plasmodium 16kD protein
US5674735A (en) * 1990-07-06 1997-10-07 University Court Of The University Of Glasgow DNA encoding the EHV-4 gH or gC glycoprotein
GB9014950D0 (en) * 1990-07-06 1990-08-29 Univ Glasgow Ehv-4 glycoprotein vaccine
JPH05509231A (ja) * 1990-07-24 1993-12-22 ザ ユーエイビー リサーチ ファンデーション ウシｒｓウイルスの組換えｄｎａ、タンパク質ワクチン、抗体、および形質転換細胞の使用法
US6730305B1 (en) 2000-05-08 2004-05-04 The Uab Research Foundation Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins
GB9016315D0 (en) * 1990-07-25 1990-09-12 Burnie James P Medicaments
US5736362A (en) * 1990-10-26 1998-04-07 The University Of Melbourne Ryegrass pollen allergen
US5972337A (en) * 1990-11-01 1999-10-26 Cancer Research Fund Of Contra Costa 46 kilodalton human milk fat globule (HMFG) antigen, fragments and fusion protein
US5200344A (en) * 1990-11-13 1993-04-06 Blaser Martin J Diagnostic testing for campylobacter jejuni or campylobacter coli infections using novel antigens
JP3015969B2 (ja) * 1990-11-30 2000-03-06 ダイナボット株式会社 扁平上皮癌関連抗原蛋白質及び該蛋白質をコードするｄｎａ
GB9027728D0 (en) * 1990-12-20 1991-02-13 Smithkline Beecham Biolog Novel protein
US5741493A (en) * 1991-01-24 1998-04-21 Pasteur Merieux Serums Et Vaccins Vaccine composition against influenza, with synergic effects, containing influenza virus core as an additive
ATE128729T1 (de) * 1991-02-06 1995-10-15 Biotech Australia Pty Ltd Impfstoff gegen nematoden.
US5525508A (en) * 1991-02-06 1996-06-11 Biotech Australia Pty Limited Haemonchus contortus vaccine
US6099843A (en) * 1991-02-12 2000-08-08 Heska Corporation Parasitic helminth PLA2 proteins
US6673916B1 (en) 1991-02-12 2004-01-06 Colorado State University Research Foundation Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof
US6419923B1 (en) * 1991-02-12 2002-07-16 Heska Corporation Filariid nematode cysteine protease proteins, and uses thereof
DE69233441T2 (de) 1991-04-26 2005-10-13 Osaka Bioscience Institute, Suita Menschliches Zelloberflächen-Antigen codierende DNA
US5670362A (en) * 1991-06-18 1997-09-23 Akzo Nobel N.V. DNA encoding an Eimeria 100kD antigen
ZA924203B (en) * 1991-06-18 1993-03-31 Akzo Nv Coccidiosis poultry vaccine
US6146870A (en) * 1991-12-13 2000-11-14 Heska Corporation Flea protease proteins
GB9200117D0 (en) * 1992-01-06 1992-02-26 Connaught Lab Production of recombinant chimeric proteins for vaccine use
US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
GB9209993D0 (en) * 1992-05-08 1992-06-24 Munn Edward A Vaccines
USRE37224E1 (en) * 1992-06-05 2001-06-12 Dalhousie University Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and adjuvant
US5736141A (en) * 1992-06-05 1998-04-07 Dalhousie University Method to prevent fertilization in mammals by administering a single dose of zona pellucida derived antigens, liposome and Freund's adjuvant
US5980899A (en) * 1992-06-10 1999-11-09 The United States Of America As Represented By The Department Of Health And Human Services Identification of peptides that stimulate hepatitis C virus specific cytotoxic T cells
US7060283B1 (en) 1992-09-15 2006-06-13 Ortho Diagnostic Systems, Inc. Immunoreactive peptides from Epstein-Barr virus
CA2143642C (en) * 1992-09-15 2006-09-05 Richard S. Smith Immunoreactive peptides from epstein-barr virus
US7326535B2 (en) * 1993-09-15 2008-02-05 Ortho Diagnostic Systems Inc. Immunoreactive peptides from Epstein-Barr virus
US5962316A (en) * 1992-10-16 1999-10-05 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
DE69432513T2 (de) * 1993-01-22 2003-12-24 Sloan Kettering Inst Cancer Gangliosid-klh-konjugatimastoffe mit qs-21
DK0686195T3 (da) * 1993-02-26 2006-11-27 Novozymes As Fremgangsmåde og system til forhöjet produktion af kommercielt vigtige exoproteiner i grampositive bakterier
US6849427B1 (en) * 1993-03-12 2005-02-01 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
CA2116640A1 (en) * 1993-03-25 1994-09-26 Alexey Terskikh Carcinoembryonic antigen derivatives
US6632613B1 (en) * 1993-06-02 2003-10-14 University Of Utah Research Foundation Compositions and kits for fluorescence polarization assay of large molecules
GB9312324D0 (en) * 1993-06-15 1993-07-28 Pitman Moore Inc Vaccine
US5571711A (en) * 1993-06-17 1996-11-05 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors
AU7482694A (en) * 1993-08-27 1995-03-21 Enteric Research Laboratories, Inc. (campylobacter jejuni) antigens, and methods for their production and use
JPH09502091A (ja) * 1993-09-03 1997-03-04 マックギル ユニヴァーシティー 特異的に発現するリーシュマニア遺伝子及び蛋白質
GB9322702D0 (en) * 1993-11-03 1993-12-22 Agricultural & Food Res Vaccines
US7691632B2 (en) * 1993-11-18 2010-04-06 Cold Spring Harbor Laboratory Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression
US6740734B1 (en) 1994-01-14 2004-05-25 Biovitrum Ab Bacterial receptor structures
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
AUPM368994A0 (en) * 1994-02-04 1994-02-24 Saramane Pty Ltd Malaria merozoite antigen subunit vaccine
EP0746622B1 (en) * 1994-02-09 2002-10-16 Syngenta Mogen B.V. Antifungal proteins, dna coding therefor, and hosts incorporating same
WO1995021917A1 (en) 1994-02-14 1995-08-17 Amgen Inc. Mammalian cell cycle protein
US20030129204A1 (en) * 1994-03-25 2003-07-10 Moredun Scientific Limited Vaccines against helminthic parasites
US5693496A (en) * 1994-06-20 1997-12-02 Merck & Co., Inc. DNA encoding the mouse and human PH30 beta chain protein
AU696941B2 (en) * 1994-07-01 1998-09-24 Rican Limited Helicobacter pylori antigenic protein preparation and immunoassays
ZA958366B (en) * 1994-10-06 1996-04-24 Akzo Nobel Nv New toxoplasma gondii antigens
US8791237B2 (en) * 1994-11-08 2014-07-29 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of non-hodgkins lymphoma
US8114414B2 (en) * 1994-11-08 2012-02-14 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical cancer
US8956621B2 (en) 1994-11-08 2015-02-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical dysplasia
US6051237A (en) * 1994-11-08 2000-04-18 The Trustees Of The University Of Pennsylvania Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector
US5976543A (en) * 1994-12-04 1999-11-02 Yeda Research And Development Co., Ltd. 12-kDa protein derived from M. Tuberculosis useful for treatment of autoimmune diseases
FR2728904B1 (fr) * 1995-01-04 1997-03-14 Pasteur Institut Reactif peptidique permettant de detecter une infection primaire a virus d'epstein-barr par recherche des anticorps correspondants, et procede d'utilisation de ce reactif
US6287574B1 (en) 1995-03-17 2001-09-11 Biochem Pharma Inc. Proteinase K resistant surface protein of neisseria meningitidis
US6506553B1 (en) * 1995-03-30 2003-01-14 Ortho Diagnostics Systems, Inc. Method for diagnosis of Epstein-Barr virus associated disease
DK0747481T3 (da) * 1995-06-06 2002-04-08 Organon Teknika Bv Epstein-Barr-viruspeptider og antistoffer mod disse peptider
ZA964896B (en) * 1995-06-07 1997-01-08 Connaught Lab Expression of lipoproteins
US6251405B1 (en) * 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
US6936259B2 (en) 1995-06-08 2005-08-30 University Of Saskatchewan CAMP factor of Streptococcus uberis
US5863543A (en) * 1996-06-05 1999-01-26 University Of Saskatchewan Camp factor of streptococcus uberis
FR2736360B1 (fr) * 1995-07-04 1997-09-05 Pasteur Institut Clonage et caracterisation du gene fiba de h.pylori, production de souches aflagellees
US6458366B1 (en) * 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6290969B1 (en) 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6338852B1 (en) 1995-09-01 2002-01-15 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) * 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6022542A (en) * 1995-09-26 2000-02-08 University Of Washington Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses
US6610506B1 (en) * 1995-12-01 2003-08-26 University Technologies International, Inc. Transferrin binding proteins of Pasteurella haemolytica and vaccines containing same
GB9526356D0 (en) * 1995-12-22 1996-02-21 Smithkline Beecham Plc Novel compounds
GB9526359D0 (en) * 1995-12-22 1996-02-21 Smithkline Beecham Plc Novel compounds
US6001600A (en) * 1996-12-20 1999-12-14 Smithkline Beecham Plc DNA encoding tests polypeptides
EP0909323B1 (en) * 1996-01-04 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Helicobacter pylori bacterioferritin
US5910568A (en) * 1996-01-11 1999-06-08 The Penn State Research Foundation Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility
GB9600955D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Novel compounds
DE19601754A1 (de) * 1996-01-19 1997-07-24 Hoechst Ag Dictyocaulus viviparus Antigen zur Diagnose des Lungenwurmbefalls und zur Vakzinierung
US6087163A (en) 1997-02-06 2000-07-11 The Public Health Research Institute Of The City Of New York, Inc. Mycobacterium tuberculosis specific proteins and genes, mixtures of anitgens and uses thereof
US7341727B1 (en) * 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
US5952194A (en) * 1996-08-01 1999-09-14 Heska Corporation Flea nucleic acid sequences and uses thereof
EP0863981B1 (en) * 1996-08-01 2009-09-23 Dale Wallis Detection, prevention and treatment of papillomatous digital dermatitis
US6284255B1 (en) * 1996-08-29 2001-09-04 Genesis Research & Development Corporation Limited Compounds and methods for treatment and diagnosis of mycobacterial infections
US6190659B1 (en) * 1996-09-17 2001-02-20 The Rockefeller University Bacterial plasmin binding protein and methods of use thereof
US5976542A (en) * 1996-09-23 1999-11-02 New England Medical Center Compositions and methods for treatment of streptococcus pneumoniae infection
US20040023865A1 (en) * 1996-10-01 2004-02-05 Corixa Corporation Compounds and methods for the diagnosis and treatment of B. microti infection
US6183976B1 (en) 1996-10-01 2001-02-06 Corixa Corporation Compounds and methods for the diagnosis and treatment of B. microti infection
US6569433B1 (en) 1996-10-01 2003-05-27 Corixa Corporation Compounds and methods for the diagnosis and treatment of B. microti infection
US6306396B1 (en) * 1996-10-01 2001-10-23 Corixa Corporation Compounds and methods for the diagnosis and treatment of B. microti infection
US6451315B1 (en) 1996-10-01 2002-09-17 Corixa Corporation Compounds and methods for the diagnosis and treatment of B. microti infection
US6214971B1 (en) 1996-10-01 2001-04-10 Corixa Corporation Compounds and methods for the diagnosis and treatment of Babesia microti infection
US6653128B2 (en) 1996-10-17 2003-11-25 University Of Florida Nucleic acid vaccines against rickettsial diseases and methods of use
US6025338A (en) 1996-10-17 2000-02-15 University Of Florida Nucleic acid vaccines against rickettsial diseases and methods of use
US6593147B1 (en) 1996-10-17 2003-07-15 University Of Florida Research Foundation, Inc. Nucleic acid vaccines against rickettsial diseases and methods of use
US6372887B1 (en) * 1996-11-07 2002-04-16 Heska Corporation Flea serine protease inhibitor proteins
US5869290A (en) * 1996-11-21 1999-02-09 Smithkline Beecham Corporation Cayae1 polynucleotides
US6403093B1 (en) * 1997-03-21 2002-06-11 Mayo Foundation For Medical Education And Research Methods to detect granulocytic ehrlichiosis
US6555653B2 (en) 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
AUPO784197A0 (en) 1997-07-10 1997-08-07 Csl Limited Treatment of nasopharyngeal carcinoma
US7588766B1 (en) * 2000-05-26 2009-09-15 Elan Pharma International Limited Treatment of amyloidogenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
AU1157100A (en) * 1998-10-29 2000-05-22 Connex Gmbh Detection of acid-resistant micro-organisms in a stool
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
WO2000055326A1 (en) * 1999-03-12 2000-09-21 Aventis Pasteur Limited Chlamydia antigens and corresponding dna fragments and uses thereof
US8143386B2 (en) * 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
US6602977B1 (en) 1999-04-19 2003-08-05 Biovitrum Ab Receptor structures
AU779978B2 (en) * 1999-10-07 2005-02-24 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
AU2001241738A1 (en) 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
CA2404164A1 (en) * 2000-03-29 2001-10-04 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing immunogenicity of antigens
PT1542732E (pt) * 2000-06-20 2009-11-06 Corixa Corp Proteínas de fusão de mycobacterium tuberculosis
US6821739B2 (en) * 2000-10-13 2004-11-23 The Regents Of The University Of California Methods of diagnosing and treating Crohn's disease using Pseudomonas antigens
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
US7700344B2 (en) * 2001-03-26 2010-04-20 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
US8771702B2 (en) * 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
JP2005506322A (ja) * 2001-08-31 2005-03-03 カイロン ソチエタ ア レスポンサビリタ リミタータ Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉワクチン接種
NO318426B1 (no) 2001-10-02 2005-04-18 Neurozym Biotech As Et materiale for a senke konsentrasjonen av patogene tarmpeptider
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US7344718B2 (en) * 2003-01-31 2008-03-18 University Of North Dakota Yersinia species compositions
JP2006516639A (ja) * 2003-02-01 2006-07-06 ニユーララブ・リミテツド 可溶性Ａ−βに対する抗体を生成させるための能動免疫
PE20050627A1 (es) 2003-05-30 2005-08-10 Wyeth Corp Anticuerpos humanizados que reconocen el peptido beta amiloideo
ATE506963T1 (de) * 2003-10-02 2011-05-15 Novartis Vaccines & Diagnostic Kombinationsimpfstoffe gegen meningitis
PE20061329A1 (es) 2004-12-15 2006-12-08 Neuralab Ltd Anticuerpos ab humanizados para mejorar la cognicion
WO2006066049A2 (en) 2004-12-15 2006-06-22 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
GB0507632D0 (en) * 2005-04-15 2005-05-25 Secr Defence Vaccine
GB0519871D0 (en) * 2005-09-30 2005-11-09 Secr Defence Immunogenic agents
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
WO2008079172A2 (en) * 2006-08-15 2008-07-03 The Trustees Of The University Of Pennsylvania Compositions comprising hmw-maa and fragments thereof, and methods of use thereof
US8268326B2 (en) * 2006-08-15 2012-09-18 The Trustees Of The University Of Pennsylvania Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
PT2144924T (pt) * 2007-04-16 2016-08-17 Minervax Aps Vacina de proteína de fusão
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
PL2182983T3 (pl) 2007-07-27 2014-10-31 Janssen Alzheimer Immunotherap Leczenie chorób amyloidowych z wykorzystaniem humanizowanych przeciwciał specyficznych względem Abeta
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
US8758765B2 (en) * 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
GB0900455D0 (en) 2009-01-13 2009-02-11 Secr Defence Vaccine
PT2403935T (pt) 2009-03-04 2017-09-22 Univ Pennsylvania Composições compreendendo fatores angiogénicos e metedos para a sua utilização
ES2444693T3 (es) * 2009-05-05 2014-02-26 Universitätsklinikum Freiburg Polipéptido derivado de enterococo y su uso para vacunación
WO2012170356A1 (en) * 2011-06-04 2012-12-13 Rochester General Hospital Research Institute Compositions and methods related to p6 of haemophilus influenzae
US9211327B2 (en) 2011-06-22 2015-12-15 University Of North Dakota Use of YSCF, truncated YSCF and YSCF homologs as adjuvants
US9133525B2 (en) 2012-01-26 2015-09-15 Luc Montagnier Detection of DNA sequences as risk factors for HIV infection
WO2014025254A1 (en) 2012-08-10 2014-02-13 Stichting Vu-Vumc Ebv markers and systemic lupus erythematosus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707358A (en) * 1984-01-30 1987-11-17 The University Of Chicago Vaccine against Epstein-Barr Virus
US4654419A (en) * 1984-08-08 1987-03-31 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen

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IL84690A (en) 1992-11-15
NZ222794A (en) 1991-01-29
AU610099B2 (en) 1991-05-16
DK173262B1 (da) 2000-05-29
DK638887D0 (da) 1987-12-04
ATE107316T1 (de) 1994-07-15
JPH07233200A (ja) 1995-09-05
DE3750088D1 (de) 1994-07-21
JP2682959B2 (ja) 1997-11-26
JPS63225398A (ja) 1988-09-20
JP2624973B2 (ja) 1997-06-25
EP0280813A2 (en) 1988-09-07
DE3750088T2 (de) 1994-12-01
ZA879025B (en) 1988-05-27
IE873303L (en) 1988-06-05
IL84690A0 (en) 1988-05-31
IE63368B1 (en) 1995-04-19
US4879213A (en) 1989-11-07
EP0280813A3 (en) 1990-06-06
DK638887A (da) 1988-06-06
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CA1315481C (en) 1993-03-30
EP0280813B1 (en) 1994-06-15

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