ES2091317T3 - Metodo para la deteccion cuantitativa de tirotropina (tsh) o de autoanticuerpos de receptores de antitirotropina (anti-tshr), utilizando un polipeptido receptor de tirotropina recombinante, y kit para realizar dicho metodo. - Google Patents

Metodo para la deteccion cuantitativa de tirotropina (tsh) o de autoanticuerpos de receptores de antitirotropina (anti-tshr), utilizando un polipeptido receptor de tirotropina recombinante, y kit para realizar dicho metodo.

Info

Publication number
ES2091317T3
ES2091317T3 ES91901286T ES91901286T ES2091317T3 ES 2091317 T3 ES2091317 T3 ES 2091317T3 ES 91901286 T ES91901286 T ES 91901286T ES 91901286 T ES91901286 T ES 91901286T ES 2091317 T3 ES2091317 T3 ES 2091317T3
Authority
ES
Spain
Prior art keywords
thyrotropin
antithrotropin
tshr
tsh
autoantibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91901286T
Other languages
English (en)
Inventor
Marc Parmentier
Frederic Libert
Jacques Dumont
Gilbert Vassart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRAHMS Diagnostica GmbH
Original Assignee
BRAHMS Diagnostica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRAHMS Diagnostica GmbH filed Critical BRAHMS Diagnostica GmbH
Application granted granted Critical
Publication of ES2091317T3 publication Critical patent/ES2091317T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/854—Glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

LA INVENCION SE REFIERE A UN POLIPEPTIDO POSEYENDO ACTIVIDAD THYROTROPINO-RECEPTORA CARACTERIZADA POR COMPRENDER LA SECUENCIA DE AMINOACIDO (VEASE FIG.11), O UNA PARTICULA DE LA MISMA O UNA SECUENCIA DE AMINOACIDO DERIVADA DE ESTA SECUENCIA POR SUSTITUCION O ELIMINACION DE ALGUNOS DE LOS RESIDUOS DE AMINOACIDOS (INDICADO FIG.11), O POR INSERCIONAL DE RESIDUOS DE AMINOACIDO.
ES91901286T 1989-12-14 1990-12-12 Metodo para la deteccion cuantitativa de tirotropina (tsh) o de autoanticuerpos de receptores de antitirotropina (anti-tshr), utilizando un polipeptido receptor de tirotropina recombinante, y kit para realizar dicho metodo. Expired - Lifetime ES2091317T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89403493A EP0433509B1 (en) 1989-12-14 1989-12-14 Polypeptides having thyrotropin receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides

Publications (1)

Publication Number Publication Date
ES2091317T3 true ES2091317T3 (es) 1996-11-01

Family

ID=8203015

Family Applications (2)

Application Number Title Priority Date Filing Date
ES89403493T Expired - Lifetime ES2092998T3 (es) 1989-12-14 1989-12-14 Polipeptidos que tienen actividad de receptores de tirotropina, secuencias de acidos nucleicos que codifican para tales receptores y polipeptidos, y aplicaciones de estos polipeptidos.
ES91901286T Expired - Lifetime ES2091317T3 (es) 1989-12-14 1990-12-12 Metodo para la deteccion cuantitativa de tirotropina (tsh) o de autoanticuerpos de receptores de antitirotropina (anti-tshr), utilizando un polipeptido receptor de tirotropina recombinante, y kit para realizar dicho metodo.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES89403493T Expired - Lifetime ES2092998T3 (es) 1989-12-14 1989-12-14 Polipeptidos que tienen actividad de receptores de tirotropina, secuencias de acidos nucleicos que codifican para tales receptores y polipeptidos, y aplicaciones de estos polipeptidos.

Country Status (10)

Country Link
US (1) US6228597B1 (es)
EP (2) EP0433509B1 (es)
JP (1) JP3090682B2 (es)
AT (2) ATE145240T1 (es)
AU (1) AU641209B2 (es)
CA (1) CA2046917C (es)
DE (2) DE68927461T2 (es)
DK (1) DK0458940T3 (es)
ES (2) ES2092998T3 (es)
WO (1) WO1991009121A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69015175T2 (de) * 1989-05-05 1995-06-29 Genentech Inc Glykoprotein-hormonrezeptor-moleküle.
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
CA2066263C (en) * 1989-09-08 1999-11-02 New England Medical Center Hospitals, Inc. Tsh receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor
EP0482598A3 (en) * 1990-10-24 1993-05-19 Ishihara Sangyo Kaisha, Ltd. Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism
EP0719858A3 (en) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma cell line expressing recombinant human thyroid stimulating hormone receptor
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19801154A1 (de) * 1998-01-14 1999-07-15 Brahms Diagnostica Gmbh Verfahren zur Herstellung von gereinigten und gegebenenfalls markierten TSH-Rezeptor-Präparaten, neue radioiodierte TSH-Rezeptor-Präparate, und die Verwendung derartiger Präparate in Diagnostik und Therapie
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
DE50010992D1 (de) * 1999-10-12 2005-09-22 Ulrich Loos Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor
AU2002231353A1 (en) * 2000-10-26 2002-05-06 Deltagen, Inc. Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
GB2376016A (en) * 2001-05-30 2002-12-04 Nadir R Farid Thyrotropin receptor (TSHR) domain cleavage catalysed by the metalloprotease ADAM 10
ES2736165T3 (es) 2001-08-23 2019-12-26 Rsr Ltd Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas
WO2004048415A1 (de) * 2002-11-26 2004-06-10 B.R.A.H.M.S Aktiengesellschaft Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern
MX2008000097A (es) 2005-06-24 2008-03-19 Bayer Bioscience Nv Metodos para alterar la reactividad de las paredes de las celulas vegetales.
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
WO2008091981A2 (en) * 2007-01-25 2008-07-31 Cedars-Sinai Medical Center Monoclonal antibody that suppresses thyrotropin receptor constitutive activity
GB201314052D0 (en) 2013-08-06 2013-09-18 Apitope Int Nv Peptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4448764A (en) * 1982-07-06 1984-05-15 Pierce Chemical Company Direct-acting iodinating reagent
HU195580B (en) * 1985-11-20 1988-05-30 Gyula Bako Method for detecting antibodies for thyroid antigens
DE3609271A1 (de) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper
US5144007A (en) * 1988-11-03 1992-09-01 La Jolla Cancer Research Foundation Thyroid hormone receptor
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
CA2066263C (en) * 1989-09-08 1999-11-02 New England Medical Center Hospitals, Inc. Tsh receptor
EP0506890A4 (en) * 1989-12-20 1993-06-30 Nichols Institute Diagnostics Recombinant thyrotropin receptor

Also Published As

Publication number Publication date
EP0458940A1 (en) 1991-12-04
JP3090682B2 (ja) 2000-09-25
AU7038691A (en) 1991-07-18
ES2092998T3 (es) 1996-12-16
EP0433509A3 (en) 1991-07-24
EP0433509B1 (en) 1996-11-13
US6228597B1 (en) 2001-05-08
DE69028695D1 (de) 1996-10-31
ATE145240T1 (de) 1996-11-15
WO1991009121A2 (en) 1991-06-27
ATE143375T1 (de) 1996-10-15
AU641209B2 (en) 1993-09-16
DK0458940T3 (da) 1996-11-11
EP0458940B1 (en) 1996-09-25
DE68927461D1 (de) 1996-12-19
JPH04506752A (ja) 1992-11-26
DE68927461T2 (de) 1997-03-20
EP0433509A2 (en) 1991-06-26
WO1991009121A3 (en) 1991-09-19
CA2046917C (en) 2003-07-01
DE69028695T2 (de) 1997-02-20
CA2046917A1 (en) 1991-06-15

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