DE68927461D1 - Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide - Google Patents

Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide

Info

Publication number
DE68927461D1
DE68927461D1 DE68927461T DE68927461T DE68927461D1 DE 68927461 D1 DE68927461 D1 DE 68927461D1 DE 68927461 T DE68927461 T DE 68927461T DE 68927461 T DE68927461 T DE 68927461T DE 68927461 D1 DE68927461 D1 DE 68927461D1
Authority
DE
Germany
Prior art keywords
polypeptides
receptor activity
receptors
nucleic acid
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68927461T
Other languages
English (en)
Other versions
DE68927461T2 (de
Inventor
Marc Parmentier
Frederic Libert
Jacques Dumont
Gilbert Vassart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRAHMS GmbH
Original Assignee
BRAHMS Diagnostica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRAHMS Diagnostica GmbH filed Critical BRAHMS Diagnostica GmbH
Publication of DE68927461D1 publication Critical patent/DE68927461D1/de
Application granted granted Critical
Publication of DE68927461T2 publication Critical patent/DE68927461T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/854—Glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE68927461T 1989-12-14 1989-12-14 Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide Expired - Lifetime DE68927461T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP89403493A EP0433509B1 (de) 1989-12-14 1989-12-14 Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide

Publications (2)

Publication Number Publication Date
DE68927461D1 true DE68927461D1 (de) 1996-12-19
DE68927461T2 DE68927461T2 (de) 1997-03-20

Family

ID=8203015

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68927461T Expired - Lifetime DE68927461T2 (de) 1989-12-14 1989-12-14 Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
DE69028695T Expired - Lifetime DE69028695T2 (de) 1989-12-14 1990-12-12 Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69028695T Expired - Lifetime DE69028695T2 (de) 1989-12-14 1990-12-12 Methode zur quantitativen bestimmung von thyrotropin (tsh) oder anti-thryrotropin-rezeptor autoantikörper (anti-tshr) unter verwendung eines rekombinanten thyrotropin rezeptor polypeptides und kit zur durchführung dieser methode

Country Status (10)

Country Link
US (1) US6228597B1 (de)
EP (2) EP0433509B1 (de)
JP (1) JP3090682B2 (de)
AT (2) ATE145240T1 (de)
AU (1) AU641209B2 (de)
CA (1) CA2046917C (de)
DE (2) DE68927461T2 (de)
DK (1) DK0458940T3 (de)
ES (2) ES2092998T3 (de)
WO (1) WO1991009121A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
ES2068388T3 (es) * 1989-05-05 1995-04-16 Genentech Inc Moleculas de receptor de hormona de la glucoproteina.
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
WO1991009137A1 (en) * 1989-12-20 1991-06-27 Basil Rapoport Recombinant thyrotropin receptor
EP0482598A3 (en) * 1990-10-24 1993-05-19 Ishihara Sangyo Kaisha, Ltd. Peptide analog of human tsh receptor affective against autoimmune hyperthyroidism
EP0719858A3 (de) * 1994-12-27 1997-12-29 Tosoh Corporation Myeloma Zell-Linie die den rekombinanten menschlichen Rezeptor für das thyroid-stimulierenden Hormon exprimiert
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19801154A1 (de) * 1998-01-14 1999-07-15 Brahms Diagnostica Gmbh Verfahren zur Herstellung von gereinigten und gegebenenfalls markierten TSH-Rezeptor-Präparaten, neue radioiodierte TSH-Rezeptor-Präparate, und die Verwendung derartiger Präparate in Diagnostik und Therapie
DE19907094C1 (de) 1999-02-19 2000-04-13 Brahms Diagnostica Gmbh Verwendung von blockierenden Anti-TSH-Rezeptor-Antikörpern bei der Therapie von Hyperthyreosen sowie monoklonale Antikörper für eine solche Verwendung
ES2248133T3 (es) * 1999-10-12 2006-03-16 Ulrich Loos Procedimiento para la determinacion de autoanticuerpos contra el receptor de tsh.
WO2002034042A2 (en) * 2000-10-26 2002-05-02 Deltagen, Inc. Knockout mice thyroid stimulating hormone receptor (tsh-r) gene
GB2376016A (en) * 2001-05-30 2002-12-04 Nadir R Farid Thyrotropin receptor (TSHR) domain cleavage catalysed by the metalloprotease ADAM 10
CN1622958B (zh) 2001-08-23 2013-04-03 Rsr有限公司 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体
WO2004048415A1 (de) * 2002-11-26 2004-06-10 B.R.A.H.M.S Aktiengesellschaft Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern
KR101468830B1 (ko) 2005-06-24 2014-12-03 바이엘 크롭사이언스 엔.브이. 식물 세포벽의 반응성을 변경하는 방법
US8097699B2 (en) 2006-08-30 2012-01-17 Rsr Limited Crystal structure of thyroid stimulating hormone receptor
US8350012B2 (en) * 2007-01-25 2013-01-08 Cedars-Sinai Medical Center Inverse agonist monoclonal antibody that suppresses thyrotropin receptor constitutive activity
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4448764A (en) * 1982-07-06 1984-05-15 Pierce Chemical Company Direct-acting iodinating reagent
HU195580B (en) * 1985-11-20 1988-05-30 Gyula Bako Method for detecting antibodies for thyroid antigens
DE3609271A1 (de) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Verfahren und reagenz zum nachweis von autoimmunerkrankungen, arzneimittel zur behandlung von autoimmunerkrankungen sowie hierzu geeignete antiparatypische antikoerper
US5144007A (en) * 1988-11-03 1992-09-01 La Jolla Cancer Research Foundation Thyroid hormone receptor
US5614363A (en) 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
WO1991003483A1 (en) * 1989-09-08 1991-03-21 New England Medical Center Hospitals, Inc. Tsh receptor
WO1991009137A1 (en) * 1989-12-20 1991-06-27 Basil Rapoport Recombinant thyrotropin receptor

Also Published As

Publication number Publication date
ES2092998T3 (es) 1996-12-16
AU7038691A (en) 1991-07-18
ATE143375T1 (de) 1996-10-15
AU641209B2 (en) 1993-09-16
WO1991009121A3 (en) 1991-09-19
JP3090682B2 (ja) 2000-09-25
DE68927461T2 (de) 1997-03-20
EP0458940B1 (de) 1996-09-25
CA2046917A1 (en) 1991-06-15
DK0458940T3 (da) 1996-11-11
EP0433509A3 (en) 1991-07-24
EP0433509B1 (de) 1996-11-13
ATE145240T1 (de) 1996-11-15
JPH04506752A (ja) 1992-11-26
EP0433509A2 (de) 1991-06-26
ES2091317T3 (es) 1996-11-01
EP0458940A1 (de) 1991-12-04
US6228597B1 (en) 2001-05-08
DE69028695T2 (de) 1997-02-20
DE69028695D1 (de) 1996-10-31
WO1991009121A2 (en) 1991-06-27
CA2046917C (en) 2003-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: B.R.A.H.M.S AG, 16761 HENNIGSDORF, DE