DE3062075D1 - Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use - Google Patents

Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use

Info

Publication number
DE3062075D1
DE3062075D1 DE8080107181T DE3062075T DE3062075D1 DE 3062075 D1 DE3062075 D1 DE 3062075D1 DE 8080107181 T DE8080107181 T DE 8080107181T DE 3062075 T DE3062075 T DE 3062075T DE 3062075 D1 DE3062075 D1 DE 3062075D1
Authority
DE
Germany
Prior art keywords
polypeptides
processes
production
pharmaceutical compositions
monocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080107181T
Other languages
English (en)
Inventor
Wilfried Bauer
Janos Dr Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of DE3062075D1 publication Critical patent/DE3062075D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8080107181T 1979-11-27 1980-11-19 Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use Expired DE3062075D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1052479 1979-11-27
CH457480 1980-06-13

Publications (1)

Publication Number Publication Date
DE3062075D1 true DE3062075D1 (en) 1983-03-24

Family

ID=25695798

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8080107181T Expired DE3062075D1 (en) 1979-11-27 1980-11-19 Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
DE1993175086 Active DE19375086I2 (de) 1979-11-27 1980-11-19 Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1993175086 Active DE19375086I2 (de) 1979-11-27 1980-11-19 Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung

Country Status (25)

Country Link
US (1) US4395403A (de)
EP (1) EP0029579B1 (de)
JP (1) JPS5690048A (de)
AT (1) ATE2512T1 (de)
AU (1) AU543198B2 (de)
CA (1) CA1182109A (de)
CS (1) CS228140B2 (de)
CY (1) CY1327A (de)
DE (2) DE3062075D1 (de)
DK (1) DK150146C (de)
ES (2) ES8301463A1 (de)
FI (1) FI72981C (de)
GR (1) GR71636B (de)
HK (1) HK30686A (de)
HU (1) HU185920B (de)
IE (1) IE50571B1 (de)
IL (1) IL61561A (de)
KE (1) KE3606A (de)
LU (1) LU88344I2 (de)
MY (1) MY8500072A (de)
NL (1) NL930137I2 (de)
NZ (1) NZ195640A (de)
PH (1) PH22841A (de)
PT (1) PT72103B (de)
SG (1) SG8786G (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
CH655505B (de) * 1982-08-24 1986-04-30
US4663435A (en) * 1982-12-06 1987-05-05 Merck & Co., Inc. Bridged cyclic hexapeptide somatostatin analogs
FR2554347B1 (fr) * 1983-11-07 1986-10-03 Immunotech Sa Acide pressinique, ses derives aminoacides substitues et homologues de configuration d ainsi que les derives n- et c- terminal-substitues et leurs applications dans les domaines therapeutique, biologique ou immunologique
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
HU198626B (en) * 1986-05-27 1989-11-28 Sandoz Ag Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
DE3726517A1 (de) * 1986-08-18 1988-03-03 Sandoz Ag Nasale zusammensetzungen, welche octreotid enthalten
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
GB8620035D0 (en) * 1986-08-18 1986-10-01 Sandoz Ltd Organic compounds
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
NO893088L (no) * 1988-08-18 1990-02-19 Syntex Inc Fremgangsmaate for fremstilling av terapeutisk virksomme somatostatinlignende cykliske peptidforbindelser.
US5006510A (en) * 1989-06-20 1991-04-09 Ellis Wladislaw V Method for relieving chronic pain with a somatostatin analog composition
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
HUT59166A (en) * 1989-12-08 1992-04-28 Univ Tulane Process for producing octqpeptide somatostatine analogues with treonine at the 6 position and pharmaceutical compositions containing them
DE69229436T2 (de) * 1991-02-08 1999-11-25 Biomeasure, Inc. Verwendung von somatostatinanalogen zur behandlung von melanomen
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9402767D0 (en) * 1994-02-14 1994-04-06 Sandoz Ltd Improvements in or relating to organic compounds
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0824103A1 (de) * 1996-08-13 1998-02-18 Chang-Shinn Su Verfahren zur Synthese von Tyr-3-octreotid
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
CA2289499C (en) * 1997-05-13 2010-02-23 Michael Anthony Cawthorne Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome x
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
PT981363E (pt) * 1997-05-13 2003-12-31 Conseils De Rec Appl Scient S Somatostatina e agonistas da somatostatina para reduzir o peso corporal
ES2144357B1 (es) 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6159935A (en) * 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
NZ530007A (en) 2001-06-08 2006-02-24 Sod Conseils Rech Applic Somatostatin-dopamine chimeric analogues that retain both somatostatin and dopamine activity in vivo and display enhanced biological activity
EP2316468A1 (de) 2002-02-22 2011-05-04 Shire LLC Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Dextroamphetamin
US6987167B2 (en) 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
ES2237356T3 (es) * 2003-04-07 2007-04-01 Novetide Ltd. Procedimiento para la produccion de peptidos ciclicos.
NZ576739A (en) 2003-04-22 2011-01-28 Sod Conseils Rech Applic Peptide vectors for delivering paclitaxel
WO2006041945A2 (en) * 2004-10-04 2006-04-20 Novetide, Ltd. A counterion exchange process for peptides
KR101458728B1 (ko) 2005-12-22 2014-11-05 노파르티스 아게 옥트레오티드 및 ２종 이상의 폴리락티드-코-글리콜리드 중합체를 포함하는 서방형 제제
WO2007110765A2 (en) * 2006-03-28 2007-10-04 Wockhardt Ltd Processes for the preparation of octreotide
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
US20090082259A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched octreotide
EP2172189A1 (de) 2008-10-01 2010-04-07 Novartis AG Pharmazeutische Zusammensetzungen
EP2213307A1 (de) 2009-02-03 2010-08-04 Novartis AG Injizierbare Depotformulierungen
WO2010089757A2 (en) 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
EP2395987A1 (de) 2009-02-12 2011-12-21 Coöperatieve Mirzorg U.A., Arnhem Verwendung einer kombination aus diazoxid und metformin zur behandlung von adipositas bzw. erkrankungen im zusammenhang mit adipositas
US20140296144A1 (en) 2011-09-30 2014-10-02 Mylan Laboratories, Ltd. Process for the preparation of octreotide acetate
CN103102390B (zh) * 2011-11-09 2015-01-28 杭州华津允上医药有限公司 一种奥曲肽的制备方法
WO2013132505A1 (en) 2012-03-09 2013-09-12 Natco Pharma Limited Improved process for preparation of octreotide by solution phase peptide synthesis
WO2014197938A1 (en) 2013-06-13 2014-12-18 Antisense Therapeutics Ltd Combination therapy
CN108395469A (zh) * 2018-02-01 2018-08-14 滨海吉尔多肽有限公司 一种假脯氨酸二肽的合成方法
GB202012334D0 (en) 2020-08-07 2020-09-23 Avon Polymer Prod Ltd Monitoring system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105603A (en) * 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Also Published As

Publication number Publication date
FI72981B (fi) 1987-04-30
PH22841A (en) 1989-01-19
US4395403A (en) 1983-07-26
DK150146C (da) 1987-06-01
CY1327A (en) 1986-06-27
DK150146B (da) 1986-12-15
EP0029579A1 (de) 1981-06-03
EP0029579B1 (de) 1983-02-16
IL61561A0 (en) 1980-12-31
ES497113A0 (es) 1982-12-01
FI803634L (fi) 1981-05-28
IE802452L (en) 1981-05-27
KE3606A (en) 1986-03-17
HU185920B (en) 1985-04-28
NZ195640A (en) 1984-07-06
FI72981C (fi) 1987-08-10
PT72103B (fr) 1982-01-28
NL930137I1 (nl) 1993-11-01
PT72103A (fr) 1980-12-01
DE19375086I2 (de) 2003-01-09
SG8786G (en) 1987-03-27
JPS5690048A (en) 1981-07-21
LU88344I2 (fr) 1994-05-04
IE50571B1 (en) 1986-05-14
JPS6351159B2 (de) 1988-10-13
AU543198B2 (en) 1985-04-04
ATE2512T1 (de) 1983-03-15
CS228140B2 (en) 1984-05-14
ES510751A0 (es) 1983-04-16
ES8305701A1 (es) 1983-04-16
MY8500072A (en) 1985-12-31
AU6468880A (en) 1981-06-04
CA1182109A (en) 1985-02-05
IL61561A (en) 1985-02-28
ES8301463A1 (es) 1982-12-01
HK30686A (en) 1986-05-09
GR71636B (de) 1983-06-20
DK501980A (da) 1981-05-28
NL930137I2 (nl) 1997-02-03

Similar Documents

Publication Publication Date Title
DE3062075D1 (en) Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
GR80840B (en) Novel polypeptide with a - amylase inhibiting effect, method for the preparation thereof, use and pharmaceutical preparations thereof
ZA8410044B (en) Peptide production and use thereof
IL60185A (en) 6 beta,7 beta;15,16-dimethylene-1,4-androstadien-3-ones,process for their production and pharmaceutical preparations containing them
HK33395A (en) Substituted (quinoline-2-yl-methoxy)phenyl-acyl-sulphona-mides and cyanamides, process for their preparation and their use in medicines
DE3061733D1 (en) Novel heterocyclic substituted pyrazinoylguanidines, processes for preparing and a pharmaceutical composition containing the same
EP0155786A3 (en) New peptide, and production and use thereof
ZA836276B (en) Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides,and their use
GB1508682A (en) Peptide intermediates
GB1361779A (en) Vincamine salt and its use as a pharmaceutical composition
DE3275375D1 (en) Mercapto amino acids, process for their preparation and pharmaceutical compositions containing them
ZA807421B (en) Novel polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
YU43880A (en) Process for the chlorination of the carboxy group of amino acids
JPS52108086A (en) Preparation of alpha-keto-acid

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SANDOZ-PATENT-GMBH, 7850 LOERRACH, DE

V448 Application of spc

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

V457 Spc granted

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630

V464 Spc expired

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630