IL61561A - Somatostatin analogs,their production and pharmaceutical compositions containing them - Google Patents

Somatostatin analogs,their production and pharmaceutical compositions containing them

Info

Publication number
IL61561A
IL61561A IL61561A IL6156180A IL61561A IL 61561 A IL61561 A IL 61561A IL 61561 A IL61561 A IL 61561A IL 6156180 A IL6156180 A IL 6156180A IL 61561 A IL61561 A IL 61561A
Authority
IL
Israel
Prior art keywords
production
pharmaceutical compositions
compositions containing
somatostatin analogs
monocyclic
Prior art date
Application number
IL61561A
Other languages
English (en)
Other versions
IL61561A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL61561A0 publication Critical patent/IL61561A0/xx
Publication of IL61561A publication Critical patent/IL61561A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL61561A 1979-11-27 1980-11-25 Somatostatin analogs,their production and pharmaceutical compositions containing them IL61561A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1052479 1979-11-27
CH457480 1980-06-13

Publications (2)

Publication Number Publication Date
IL61561A0 IL61561A0 (en) 1980-12-31
IL61561A true IL61561A (en) 1985-02-28

Family

ID=25695798

Family Applications (1)

Application Number Title Priority Date Filing Date
IL61561A IL61561A (en) 1979-11-27 1980-11-25 Somatostatin analogs,their production and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4395403A (de)
EP (1) EP0029579B1 (de)
JP (1) JPS5690048A (de)
AT (1) ATE2512T1 (de)
AU (1) AU543198B2 (de)
CA (1) CA1182109A (de)
CS (1) CS228140B2 (de)
CY (1) CY1327A (de)
DE (2) DE19375086I2 (de)
DK (1) DK150146C (de)
ES (2) ES497113A0 (de)
FI (1) FI72981C (de)
GR (1) GR71636B (de)
HK (1) HK30686A (de)
HU (1) HU185920B (de)
IE (1) IE50571B1 (de)
IL (1) IL61561A (de)
KE (1) KE3606A (de)
LU (1) LU88344I2 (de)
MY (1) MY8500072A (de)
NL (1) NL930137I2 (de)
NZ (1) NZ195640A (de)
PH (1) PH22841A (de)
PT (1) PT72103B (de)
SG (1) SG8786G (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11849697B2 (en) 2020-08-07 2023-12-26 Interpuls S.P.A. Monitoring system

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
CH655505B (de) * 1982-08-24 1986-04-30
US4663435A (en) * 1982-12-06 1987-05-05 Merck & Co., Inc. Bridged cyclic hexapeptide somatostatin analogs
FR2554347B1 (fr) * 1983-11-07 1986-10-03 Immunotech Sa Acide pressinique, ses derives aminoacides substitues et homologues de configuration d ainsi que les derives n- et c- terminal-substitues et leurs applications dans les domaines therapeutique, biologique ou immunologique
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
NL8701143A (nl) * 1986-05-27 1987-12-16 Sandoz Ag Farmaceutische preparaten.
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
DE3726517A1 (de) * 1986-08-18 1988-03-03 Sandoz Ag Nasale zusammensetzungen, welche octreotid enthalten
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
GB8620035D0 (en) * 1986-08-18 1986-10-01 Sandoz Ltd Organic compounds
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
ZA895838B (en) * 1988-08-18 1991-03-27 Syntex Inc Pharmaceutical compounds
US5006510A (en) * 1989-06-20 1991-04-09 Ellis Wladislaw V Method for relieving chronic pain with a somatostatin analog composition
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
JP2925321B2 (ja) * 1989-12-08 1999-07-28 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド ６位にスレオニンを有するソマトスタチン類縁体オクタペプチド
PT100111B (pt) * 1991-02-08 1999-06-30 Biomeasure Inc Composicao para o tratamento de um mamifero sofrendo de doenca proliferativa dapele, benigna ou maligna, compreendendo um analogo de somatostatina
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9402767D0 (en) * 1994-02-14 1994-04-06 Sandoz Ltd Improvements in or relating to organic compounds
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0824103A1 (de) * 1996-08-13 1998-02-18 Chang-Shinn Su Verfahren zur Synthese von Tyr-3-octreotid
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
US7034003B1 (en) * 1997-05-13 2006-04-25 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Somatostatin and somatostatin agonists for decreasing body weight
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
ES2144357B1 (es) 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6159935A (en) 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
US7579435B2 (en) 2001-06-08 2009-08-25 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Somatostatin-dopamine chimeric analogs
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
US6987167B2 (en) 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
ATE334998T1 (de) * 2003-04-07 2006-08-15 Novetide Ltd Verfahren zur herstellung cyclischer peptide
CA2523197C (en) 2003-04-22 2016-05-24 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Peptide vectors
DK1709065T3 (da) * 2004-10-04 2010-08-23 Novetide Ltd Modion-bytningsfremgangsmåde til peptider
CN103251929A (zh) 2005-12-22 2013-08-21 诺瓦提斯公司 包含奥曲肽和两种或更多种聚丙交酯-共-乙交酯聚合物的缓释制剂
WO2007110765A2 (en) * 2006-03-28 2007-10-04 Wockhardt Ltd Processes for the preparation of octreotide
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
US20090082259A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched octreotide
EP2213307A1 (de) 2009-02-03 2010-08-04 Novartis AG Injizierbare Depotformulierungen
EP2172189A1 (de) 2008-10-01 2010-04-07 Novartis AG Pharmazeutische Zusammensetzungen
WO2010089757A2 (en) 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
WO2010093243A1 (en) 2009-02-12 2010-08-19 Coöperatieve Mirzorg U.A., Arnhem Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
US20140296144A1 (en) 2011-09-30 2014-10-02 Mylan Laboratories, Ltd. Process for the preparation of octreotide acetate
CN103102390B (zh) * 2011-11-09 2015-01-28 杭州华津允上医药有限公司 一种奥曲肽的制备方法
WO2013132505A1 (en) 2012-03-09 2013-09-12 Natco Pharma Limited Improved process for preparation of octreotide by solution phase peptide synthesis
JP6869720B2 (ja) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法
CN108395469A (zh) * 2018-02-01 2018-08-14 滨海吉尔多肽有限公司 一种假脯氨酸二肽的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105603A (en) * 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11849697B2 (en) 2020-08-07 2023-12-26 Interpuls S.P.A. Monitoring system

Also Published As

Publication number Publication date
NL930137I1 (nl) 1993-11-01
CS228140B2 (en) 1984-05-14
AU543198B2 (en) 1985-04-04
GR71636B (de) 1983-06-20
LU88344I2 (fr) 1994-05-04
DE19375086I2 (de) 2003-01-09
ES8301463A1 (es) 1982-12-01
ES510751A0 (es) 1983-04-16
NL930137I2 (nl) 1997-02-03
MY8500072A (en) 1985-12-31
AU6468880A (en) 1981-06-04
CA1182109A (en) 1985-02-05
NZ195640A (en) 1984-07-06
KE3606A (en) 1986-03-17
HK30686A (en) 1986-05-09
PH22841A (en) 1989-01-19
PT72103B (fr) 1982-01-28
FI72981C (fi) 1987-08-10
PT72103A (fr) 1980-12-01
DK150146C (da) 1987-06-01
DK150146B (da) 1986-12-15
EP0029579A1 (de) 1981-06-03
US4395403A (en) 1983-07-26
JPS6351159B2 (de) 1988-10-13
FI72981B (fi) 1987-04-30
ES8305701A1 (es) 1983-04-16
IL61561A0 (en) 1980-12-31
SG8786G (en) 1987-03-27
EP0029579B1 (de) 1983-02-16
HU185920B (en) 1985-04-28
JPS5690048A (en) 1981-07-21
DK501980A (da) 1981-05-28
IE802452L (en) 1981-05-27
ES497113A0 (es) 1982-12-01
ATE2512T1 (de) 1983-03-15
DE3062075D1 (en) 1983-03-24
IE50571B1 (en) 1986-05-14
FI803634L (fi) 1981-05-28
CY1327A (en) 1986-06-27

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Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
KB Patent renewed
EXP Patent expired