JPS5695154A - Tyrosine-introduced-c-peptide f-ragements of proinsulin - Google Patents

Tyrosine-introduced-c-peptide f-ragements of proinsulin

Info

Publication number
JPS5695154A
JPS5695154A JP14835079A JP14835079A JPS5695154A JP S5695154 A JPS5695154 A JP S5695154A JP 14835079 A JP14835079 A JP 14835079A JP 14835079 A JP14835079 A JP 14835079A JP S5695154 A JPS5695154 A JP S5695154A
Authority
JP
Japan
Prior art keywords
peptide
gly
human
proinsulin
boc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14835079A
Other languages
Japanese (ja)
Other versions
JPS606359B2 (en
Inventor
Takeshi Inoue
Masao Kono
Nobuo Yoshida
Masuhisa Nakamura
Sunao Okabayashi
Kenichi Igano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP14835079A priority Critical patent/JPS606359B2/en
Publication of JPS5695154A publication Critical patent/JPS5695154A/en
Publication of JPS606359B2 publication Critical patent/JPS606359B2/en
Expired legal-status Critical Current

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  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The titled compound shown by the formula (Y is aminoprotecting group or H; Try is throsnie residue having at least one hydrogen of the phenyl ring, which is replacable by a radioactive iodine; Gly is glycine residue; R is a peptide having at least 15 amino acid residues from the seventh position to the twentyfirst position in the configuration of amino acid residues of human C-peptide).
EXAMPLE: Boc-Tyr-Gly-human C-peptide-(7-31).
USE: A compound for measuring proinsulin C-peptide for the functional evaluation of beta cells of pancreas. Having functions to be compared with a peptide consisting of 36 residues and stable. It can be prepared readily.
PROCESS: An azide [Boc-Iyr-Gly-N3] previously prepared is brought into contact with synthetic human C-peptide fragment, to give a compound shown by the formula.
COPYRIGHT: (C)1981,JPO&Japio
JP14835079A 1979-11-15 1979-11-15 Tyrosinated C-peptide fragments of proinsulin Expired JPS606359B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14835079A JPS606359B2 (en) 1979-11-15 1979-11-15 Tyrosinated C-peptide fragments of proinsulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14835079A JPS606359B2 (en) 1979-11-15 1979-11-15 Tyrosinated C-peptide fragments of proinsulin

Publications (2)

Publication Number Publication Date
JPS5695154A true JPS5695154A (en) 1981-08-01
JPS606359B2 JPS606359B2 (en) 1985-02-18

Family

ID=15450790

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14835079A Expired JPS606359B2 (en) 1979-11-15 1979-11-15 Tyrosinated C-peptide fragments of proinsulin

Country Status (1)

Country Link
JP (1) JPS606359B2 (en)

Also Published As

Publication number Publication date
JPS606359B2 (en) 1985-02-18

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