CS227025B2 - Method of preparing benzodiazepine - Google Patents

Method of preparing benzodiazepine Download PDF

Info

Publication number
CS227025B2
CS227025B2 CS819186A CS918681A CS227025B2 CS 227025 B2 CS227025 B2 CS 227025B2 CS 819186 A CS819186 A CS 819186A CS 918681 A CS918681 A CS 918681A CS 227025 B2 CS227025 B2 CS 227025B2
Authority
CS
Czechoslovakia
Prior art keywords
methyl
alkyl
formula
hydrogen
compounds
Prior art date
Application number
CS819186A
Other languages
Czech (cs)
English (en)
Inventor
Jiban K Chakrabarti
Terrence M Hotten
David J Steggles
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Priority to CS828359A priority Critical patent/CS227050B2/cs
Publication of CS227025B2 publication Critical patent/CS227025B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS819186A 1980-12-11 1981-12-10 Method of preparing benzodiazepine CS227025B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS828359A CS227050B2 (cs) 1980-12-11 1982-11-22 Způsob výroby nových benzodiazepinů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8039659 1980-12-11

Publications (1)

Publication Number Publication Date
CS227025B2 true CS227025B2 (en) 1984-04-16

Family

ID=10517899

Family Applications (1)

Application Number Title Priority Date Filing Date
CS819186A CS227025B2 (en) 1980-12-11 1981-12-10 Method of preparing benzodiazepine

Country Status (29)

Country Link
US (2) US4431589A (da)
EP (1) EP0054416B1 (da)
JP (1) JPS57122087A (da)
KR (1) KR880000045B1 (da)
AR (1) AR229600A1 (da)
AT (1) ATE9093T1 (da)
AU (1) AU550943B2 (da)
BG (1) BG36935A3 (da)
CA (1) CA1167839A (da)
CS (1) CS227025B2 (da)
DD (1) DD208153A5 (da)
DE (1) DE3165712D1 (da)
DK (1) DK155940C (da)
EG (1) EG15462A (da)
ES (2) ES507863A0 (da)
FI (1) FI71150C (da)
GB (1) GB2091246B (da)
GR (1) GR74710B (da)
HU (1) HU183733B (da)
IE (1) IE51770B1 (da)
IL (1) IL64489A0 (da)
MX (1) MX6710E (da)
NZ (1) NZ199186A (da)
PH (1) PH17295A (da)
PL (2) PL131762B1 (da)
PT (1) PT74104B (da)
RO (1) RO84100B (da)
SU (2) SU1170971A3 (da)
ZA (1) ZA818586B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134842A1 (de) * 1981-09-03 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Neue anilino-1,2,3-triazol-derivate, diese enthaltende arzneimittel sowie verfahren zu deren herstellung und deren verwendung
US4595535A (en) * 1983-06-06 1986-06-17 Ciba-Geigy Corporation Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents
DE3331858A1 (de) * 1983-09-03 1985-03-21 Boehringer Ingelheim KG, 6507 Ingelheim Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel
US4596799A (en) * 1985-01-29 1986-06-24 Ciba-Geigy Corporation 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
GB8819059D0 (en) * 1988-08-11 1988-09-14 Lilly Industries Ltd Benzodiazepine compounds & their use as pharmaceuticals
EP1492794B1 (en) * 2002-03-28 2007-12-12 Eli Lilly And Company Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders
US8146310B2 (en) * 2009-03-11 2012-04-03 Keene Building Products Co., Inc. Noise control flooring system
US8528286B2 (en) * 2009-11-10 2013-09-10 Keene Building Products Co., Inc. Sound control mat
AU2014291142B2 (en) 2013-07-17 2018-10-11 Otsuka Pharmaceutical Co., Ltd. Cyanotriazole compounds

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH468400A (de) * 1965-12-23 1969-02-15 Sandoz Ag Verfahren zur Herstellung neuer Thieno(2,3-b)(1,5)benzothiazepin-4-on-Verbindungen
US3450694A (en) * 1966-02-23 1969-06-17 Abbott Lab Substituted benzoxazepines and benzothiazepines
US3793325A (en) * 1967-03-22 1974-02-19 Sandoz Ag 11-basically substituted dibenz(b,f)(1,4)thiazepine and dibenz(b,e)(1,4)diazepines
US3758479A (en) * 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
CH491956A (de) * 1967-11-30 1970-06-15 Geigy Ag J R Verfahren zur Herstellung von neuen Thiazepinderivaten
US3987052A (en) * 1969-03-17 1976-10-19 The Upjohn Company 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
CA918659A (en) * 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
GB1292410A (en) * 1970-05-13 1972-10-11 Yoshitomi Pharmaceutical Thienobenzothiazepine derivatives
BE791902A (fr) * 1971-11-26 1973-05-24 Wander Ag Dr A Nouveaux derives de la thieno (3,2-c) (1)benzazepine, leur preparation et leur application comme medicaments
US3962248A (en) * 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
NL7403657A (da) * 1973-03-23 1974-09-25
US4115568A (en) * 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US4172831A (en) * 1974-11-26 1979-10-30 Lilly Industries Limited Thieno-benzodiazepines
US3953430A (en) * 1975-02-24 1976-04-27 American Cyanamid Company Substituted benzodiazepin-10-ones and method of use
US3951981A (en) * 1975-02-24 1976-04-20 American Cyanamid Company Substituted benzodiazepines and method of use
DE2707270A1 (de) * 1977-02-19 1978-08-24 Hoechst Ag Pyrazolo-diazepine und verfahren zu ihrer herstellung
IT7851496A0 (it) * 1977-10-31 1978-10-13 Sandoz Ag Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) * 1979-05-11 1984-05-30 Sandoz Ag Benzodiazepine, ihre herstellung und verwendung.
NZ194529A (en) * 1979-08-03 1983-05-10 Byk Gulden Lomberg Chem Fab 9,10-dihydro-1h, 4h-pyrazolo (4,3-b)(1,5)benzodiazepin-10-ones
US4404137A (en) * 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Also Published As

Publication number Publication date
IE812890L (en) 1982-06-11
ES516582A0 (es) 1983-11-16
JPS57122087A (en) 1982-07-29
PH17295A (en) 1984-07-12
ZA818586B (en) 1983-07-27
PL131762B1 (en) 1984-12-31
GB2091246B (en) 1985-01-30
EP0054416A3 (en) 1982-09-08
AU550943B2 (en) 1986-04-10
FI71150C (fi) 1986-11-24
GB2091246A (en) 1982-07-28
PT74104A (en) 1982-01-01
DK155940B (da) 1989-06-05
KR880000045B1 (ko) 1988-02-20
IE51770B1 (en) 1987-03-18
KR830007655A (ko) 1983-11-04
DD208153A5 (de) 1984-03-28
AU7844081A (en) 1982-06-17
EP0054416B1 (en) 1984-08-22
EG15462A (en) 1990-10-30
EP0054416A2 (en) 1982-06-23
MX6710E (es) 1985-10-30
RO84100B (ro) 1984-06-30
HU183733B (en) 1984-05-28
US4492699A (en) 1985-01-08
PL136930B1 (en) 1986-04-30
PT74104B (en) 1983-05-16
US4431589A (en) 1984-02-14
DK155940C (da) 1989-10-23
DK548281A (da) 1982-06-12
CA1167839A (en) 1984-05-22
ES8303415A1 (es) 1983-02-01
NZ199186A (en) 1984-11-09
DE3165712D1 (en) 1984-09-27
SU1169538A3 (ru) 1985-07-23
ES8401073A1 (es) 1983-11-16
ATE9093T1 (de) 1984-09-15
JPH0337555B2 (da) 1991-06-05
AR229600A1 (es) 1983-09-30
BG36935A3 (en) 1985-02-15
PL234173A1 (en) 1983-01-17
ES507863A0 (es) 1983-02-01
RO84100A (ro) 1984-05-12
PL238268A1 (en) 1983-04-11
GR74710B (da) 1984-07-06
FI813892L (fi) 1982-06-12
FI71150B (fi) 1986-08-14
SU1170971A3 (ru) 1985-07-30
IL64489A0 (en) 1982-03-31

Similar Documents

Publication Publication Date Title
EP0465254B1 (en) Fused thiophene compounds and uses thereof
Chakrabarti et al. Heteroarenobenzodiazepines. 3. 4-Piperazinyl-10H-thieno [2, 3-b][1, 5] benzodiazepines as potential neuroleptics
US4325957A (en) 2-Acylaminomethyl-1,4-benzodiazepine derivatives and their salts and pharmaceutical compositions thereof
CS227025B2 (en) Method of preparing benzodiazepine
KR850000472B1 (ko) 벤조디아제핀 화합물의 제조방법
JP2010529144A (ja) 治療用ピラゾロキノリン尿素誘導体
JP2010529143A (ja) 治療用ピラゾロキノリン誘導体
US4661489A (en) Benzazepines, and their use as anthelminthics
CS236753B2 (en) Processing of thieno (1,5) benzodiazepine derivatives
US5466706A (en) 9H-imidazo[1,2-A]benzimidazole-3-acetamide derivatives, their preparation and their therapeutic application
WO1997003986A1 (fr) Composes fusionnes de triazole
JPH06763B2 (ja) ベンゾ〔ｈ〕シンノリン誘導体
US5051516A (en) Benzodiazepine compounds and their use as pharmaceuticals
FR2704547A1 (fr) Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
CA1249269A (en) Benzodiazepines, processes for their preparation and their use
CS227050B2 (cs) Způsob výroby nových benzodiazepinů
HU189129B (en) Process for preparing imidazo /1,2-a/quinoline derivatives
US5114944A (en) 2-phenylpyrazolo[1,5-a]pyrimidine-3-acetic acid derivatives exhibiting therapeutic effects
CA1087182A (en) Substituted 1-piperazinyl-triazolo-thieno-1,4- diazepines
JP2001512731A (ja) ＡＭＰＡ／Ｋａｉｎａｔｅ受容体阻害剤としての１，３−ジオキソロ／４，５−Ｈ／２，３／ベンゾジアゼピン誘導体
KR100826304B1 (ko) 피롤로[2,1-ｂ][1,3]벤조티아제핀 및 정신병 치료 활성을갖는 약제의 제조를 위한 그의 용도
Chakrabarti et al. Heteroarenobenzodiazepines. Part 7. Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo [3, 4-b] and [4, 3-b][1, 5] benzodiazepines as potential anxiolytics
AT395155B (de) Verfahren zur herstellung von neuen imidazo(1,5-a)(1,4)diazepinverbindungen
GB2063251A (en) Pyrazolobenzodiazepines
JPH04257589A (ja) トリアゾロピリダジン化合物