CS220324B2 - Method of producing new mercaptoimidazole derivatives - Google Patents

Method of producing new mercaptoimidazole derivatives Download PDF

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Publication number
CS220324B2
CS220324B2 CS792438A CS243879A CS220324B2 CS 220324 B2 CS220324 B2 CS 220324B2 CS 792438 A CS792438 A CS 792438A CS 243879 A CS243879 A CS 243879A CS 220324 B2 CS220324 B2 CS 220324B2
Authority
CS
Czechoslovakia
Prior art keywords
acid addition
addition salt
group
optionally
free compound
Prior art date
Application number
CS792438A
Other languages
Czech (cs)
English (en)
Inventor
Pier G Ferrini
Richard Guschke
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CS807193A priority Critical patent/CS220333B2/cs
Priority to CS807195A priority patent/CS220335B2/cs
Priority to CS807194A priority patent/CS220334B2/cs
Priority to CS807192A priority patent/CS220332B2/cs
Publication of CS220324B2 publication Critical patent/CS220324B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS792438A 1978-04-11 1979-04-10 Method of producing new mercaptoimidazole derivatives CS220324B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CS807193A CS220333B2 (cs) 1979-04-10 1980-10-23 Způsob výroby nových derivátů merkaptoimidazolu
CS807195A CS220335B2 (cs) 1978-04-11 1980-10-23 Způsob výroby nových derivátů merkaptoimidazolu
CS807194A CS220334B2 (cs) 1979-04-10 1980-10-23 Způsob výroby nových derivátů merkaptoimidazolu
CS807192A CS220332B2 (cs) 1978-04-11 1980-10-23 Způsob výroby nových derivátů merkaptoimidazolu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU79412 1978-04-11

Publications (1)

Publication Number Publication Date
CS220324B2 true CS220324B2 (en) 1983-03-25

Family

ID=19728887

Family Applications (1)

Application Number Title Priority Date Filing Date
CS792438A CS220324B2 (en) 1978-04-11 1979-04-10 Method of producing new mercaptoimidazole derivatives

Country Status (24)

Country Link
US (3) US4461770A (hu)
EP (1) EP0004648B1 (hu)
JP (1) JPS54135769A (hu)
KR (2) KR820002314B1 (hu)
AT (1) AT376971B (hu)
AU (1) AU532402B2 (hu)
CS (1) CS220324B2 (hu)
CY (1) CY1302A (hu)
DD (1) DD142712A5 (hu)
DE (1) DE2963572D1 (hu)
DK (1) DK148879A (hu)
ES (5) ES479490A0 (hu)
FI (1) FI65066C (hu)
GR (1) GR71193B (hu)
HK (1) HK87285A (hu)
HU (1) HU182018B (hu)
IL (1) IL57040A (hu)
MY (1) MY8600271A (hu)
NO (1) NO148926C (hu)
NZ (1) NZ190153A (hu)
PL (2) PL125972B1 (hu)
PT (1) PT69460A (hu)
SU (2) SU1259962A3 (hu)
ZA (1) ZA791702B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
US5955480A (en) * 1996-11-20 1999-09-21 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
CN1211381C (zh) * 1997-04-24 2005-07-20 奥索·麦克尼尔药品公司 用于治疗炎性疾病的取代咪唑
US6040320A (en) * 1997-06-30 2000-03-21 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE19842833B4 (de) * 1998-09-18 2005-04-14 Merckle Gmbh 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) * 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
US8134029B2 (en) 2002-09-16 2012-03-13 Sunovion Pharmaceuticals Inc. Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
US20080293726A1 (en) 2005-07-06 2008-11-27 Sepracor Inc. Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
CN103588659A (zh) 2006-03-31 2014-02-19 赛诺维信制药公司 手性酰胺和胺的制备
EP1894925A1 (en) * 2006-08-24 2008-03-05 Merckle Gmbh Imidazole compounds having an antiinflammatory effect

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (hu) * 1972-07-29 1978-11-24
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
DK16778A (da) * 1977-02-09 1978-08-10 Du Pont Imidazolderivater deres anvendelser og fremstilling
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
LU77703A1 (de) * 1977-07-07 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
EP0004648B1 (de) 1982-08-25
ES8403877A1 (es) 1984-04-01
DE2963572D1 (en) 1982-10-21
ES8303355A1 (es) 1983-02-01
AU4599479A (en) 1979-10-18
ATA266179A (de) 1984-06-15
FI791158A (fi) 1979-10-12
KR820002315B1 (ko) 1982-12-17
ZA791702B (en) 1980-04-30
CY1302A (en) 1985-12-06
ES8505352A1 (es) 1985-05-16
PL125972B1 (en) 1983-06-30
NO148926B (no) 1983-10-03
AT376971B (de) 1985-01-25
ES8504737A1 (es) 1985-05-01
FI65066B (fi) 1983-11-30
EP0004648A2 (de) 1979-10-17
SU991945A3 (ru) 1983-01-23
NZ190153A (en) 1981-05-15
NO148926C (no) 1984-01-11
DD142712A5 (de) 1980-07-09
ES8504738A1 (es) 1985-05-01
US4608382A (en) 1986-08-26
DK148879A (da) 1979-10-12
PL125882B1 (en) 1983-06-30
IL57040A0 (en) 1979-07-25
JPS6339594B2 (hu) 1988-08-05
EP0004648A3 (en) 1979-11-14
ES528579A0 (es) 1985-05-01
ES515766A0 (es) 1984-04-01
IL57040A (en) 1984-08-31
ES528581A0 (es) 1985-05-16
US4461770A (en) 1984-07-24
ES528580A0 (es) 1985-05-01
US4584310A (en) 1986-04-22
HK87285A (en) 1985-11-15
PT69460A (en) 1979-05-01
JPS54135769A (en) 1979-10-22
PL214745A1 (hu) 1980-06-16
NO791228L (no) 1979-10-12
MY8600271A (en) 1986-12-31
SU1259962A3 (ru) 1986-09-23
FI65066C (fi) 1984-03-12
ES479490A0 (es) 1983-02-01
HU182018B (en) 1983-12-28
AU532402B2 (en) 1983-09-29
GR71193B (hu) 1983-04-11
KR820002314B1 (ko) 1982-12-17

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