CS216523B2 - Diagnostic agent for the proof of esterolytic enzyms particularly leucocytic esterases in the body fluids - Google Patents
Diagnostic agent for the proof of esterolytic enzyms particularly leucocytic esterases in the body fluids Download PDFInfo
- Publication number
- CS216523B2 CS216523B2 CS80973A CS97380A CS216523B2 CS 216523 B2 CS216523 B2 CS 216523B2 CS 80973 A CS80973 A CS 80973A CS 97380 A CS97380 A CS 97380A CS 216523 B2 CS216523 B2 CS 216523B2
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- CS
- Czechoslovakia
- Prior art keywords
- optionally
- alkyl
- activators
- group
- solution
- Prior art date
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- 239000000032 diagnostic agent Substances 0.000 title claims description 14
- 229940039227 diagnostic agent Drugs 0.000 title claims description 14
- 210000001124 body fluid Anatomy 0.000 title claims description 8
- 230000000058 esterolytic effect Effects 0.000 title claims description 8
- 108090000371 Esterases Proteins 0.000 title claims description 7
- 239000010839 body fluid Substances 0.000 title claims description 7
- 230000001527 leucocytic effect Effects 0.000 title 1
- 239000012190 activator Substances 0.000 claims description 70
- 239000000758 substrate Substances 0.000 claims description 26
- -1 vinyl quinuclidylcarbinol Chemical compound 0.000 claims description 23
- 239000000872 buffer Substances 0.000 claims description 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 150000002500 ions Chemical class 0.000 claims description 6
- 239000007800 oxidant agent Substances 0.000 claims description 6
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 6
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- 239000000987 azo dye Substances 0.000 claims description 5
- 239000008139 complexing agent Substances 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 229910052804 chromium Inorganic materials 0.000 claims description 4
- 239000011651 chromium Substances 0.000 claims description 4
- 229910017052 cobalt Inorganic materials 0.000 claims description 4
- 239000010941 cobalt Substances 0.000 claims description 4
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 108010000849 leukocyte esterase Proteins 0.000 claims description 4
- 229910052759 nickel Inorganic materials 0.000 claims description 4
- 229910052700 potassium Inorganic materials 0.000 claims description 4
- 239000011591 potassium Substances 0.000 claims description 4
- 125000004076 pyridyl group Chemical group 0.000 claims description 4
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
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- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000001544 thienyl group Chemical group 0.000 claims description 2
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- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
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- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 1
- 239000000243 solution Substances 0.000 description 69
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- 230000035484 reaction time Effects 0.000 description 32
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- 238000001228 spectrum Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- AWDBHOZBRXWRKS-UHFFFAOYSA-N tetrapotassium;iron(6+);hexacyanide Chemical compound [K+].[K+].[K+].[K+].[Fe+6].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] AWDBHOZBRXWRKS-UHFFFAOYSA-N 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- ARTMVFXVHIDPDK-UHFFFAOYSA-K trisodium acetic acid triacetate Chemical compound [Na+].[Na+].[Na+].CC(O)=O.CC([O-])=O.CC([O-])=O.CC([O-])=O ARTMVFXVHIDPDK-UHFFFAOYSA-K 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
- C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B43/00—Preparation of azo dyes from other azo compounds
- C09B43/18—Preparation of azo dyes from other azo compounds by acylation of hydroxyl group or of mercapto group
- C09B43/20—Preparation of azo dyes from other azo compounds by acylation of hydroxyl group or of mercapto group with monocarboxylic acids, carbamic acid esters or halides, mono- isocyanates or haloformic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/40—Triphenylmethane dye chromogens, e.g. fluorescein derivatives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/50—Indoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792905531 DE2905531A1 (de) | 1979-02-14 | 1979-02-14 | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS216523B2 true CS216523B2 (en) | 1982-11-26 |
Family
ID=6062854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS80973A CS216523B2 (en) | 1979-02-14 | 1980-02-13 | Diagnostic agent for the proof of esterolytic enzyms particularly leucocytic esterases in the body fluids |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4299917A (fr) |
| EP (1) | EP0014929B1 (fr) |
| JP (1) | JPS581920B2 (fr) |
| AR (1) | AR223025A1 (fr) |
| AT (1) | ATE543T1 (fr) |
| AU (1) | AU519912B2 (fr) |
| BR (1) | BR8000886A (fr) |
| CA (1) | CA1148073A (fr) |
| CS (1) | CS216523B2 (fr) |
| DD (1) | DD149121A5 (fr) |
| DE (2) | DE2905531A1 (fr) |
| DK (1) | DK161340C (fr) |
| ES (1) | ES488402A0 (fr) |
| FI (1) | FI69869C (fr) |
| HK (1) | HK15285A (fr) |
| HU (1) | HU182102B (fr) |
| PL (1) | PL125796B1 (fr) |
| PT (1) | PT70813A (fr) |
| RU (1) | RU1784097C (fr) |
| SG (1) | SG79484G (fr) |
| YU (2) | YU45527B (fr) |
| ZA (1) | ZA80765B (fr) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3005845A1 (de) * | 1980-02-16 | 1981-09-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aminosaeure- und peptidester von leuko-indoanilinen, verfahren zu deren herstellung sowie diese verbindungen enthaltende mittel zum nachweis proteolytischer enzyme |
| DE3017721A1 (de) * | 1980-05-09 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate |
| DE3118381A1 (de) * | 1981-05-09 | 1982-11-25 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mehrschichtiges testmittel zum nachweis einer komponente einer fluessigen probe |
| DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| US4499185A (en) * | 1982-05-17 | 1985-02-12 | Miles Laboratories, Inc. | Test for esterase activity in a liquid sample |
| DE3309544A1 (de) * | 1983-03-17 | 1984-09-20 | Macherey-Nagel & Co Chemikalienhandel, 5160 Düren | Teststreifen zum nachweis von leukozyten im harn |
| US4637979A (en) * | 1984-04-06 | 1987-01-20 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes containing a zwitterion coupling agent |
| DE3413119A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| US4657855A (en) * | 1984-04-06 | 1987-04-14 | Miles Laboratories, Inc. | Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample |
| DE3413118A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| US4645842A (en) * | 1984-04-06 | 1987-02-24 | Miles Laboratories, Inc. | Pyrrole compounds for detecting the presence of hydrolytic analytes |
| DE3413120A1 (de) * | 1984-04-06 | 1985-10-24 | Miles Laboratories, Inc., Elkhart, Ind. | Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme |
| DD247808C2 (de) * | 1984-04-09 | 1989-01-11 | Dresden Arzneimittel | Teststreifen zur aufnahme von blutzuckertagesprofilen und verfahren zu seiner herstellung |
| DE3587636T2 (de) * | 1984-05-31 | 1994-03-10 | Coulter Corp | Reagenssystem und verfahren zum nachweis, aufzählen und prüfen der klassen und unterklassen von blutleukozyten. |
| US4672029A (en) * | 1984-12-06 | 1987-06-09 | Eastman Kodak Company | Color-forming couplers and their use in the analytical determination of hydrogen peroxide or other analytes |
| US5051358A (en) * | 1987-05-07 | 1991-09-24 | The Procter & Gamble Company | Diagnostic methods for detecting periodontal diseases |
| GB8713951D0 (en) * | 1987-06-15 | 1987-07-22 | Dewar M H | Enhanced chemiluminescent reaction |
| DE3732871A1 (de) * | 1987-09-30 | 1989-04-20 | Behringwerke Ag | Chromogene substrate |
| US5192688A (en) * | 1988-08-15 | 1993-03-09 | Switzer Iii Robert C | Histological analysis method |
| FR2657895A1 (fr) * | 1990-02-05 | 1991-08-09 | Inst Textile De France | Materiau antiseptique a greffons complexes par des ions metalliques et procede de preparation. |
| US6046019A (en) * | 1991-07-09 | 2000-04-04 | Goumeniouk; Alexander P. | Diagnostic kits and methods for making granulocyte cell counts |
| DE19500768C2 (de) * | 1994-01-17 | 2003-11-20 | Aventis Res & Tech Gmbh & Co | Phenanthren-Derivate und ihre Verwendung in flüssigkristallinen Mischungen |
| US5464739A (en) | 1994-08-22 | 1995-11-07 | Bayer Corporation | Composition method for determining the presence of leukocyte cells, esterase or protease in a test sample |
| CA2161574A1 (fr) | 1994-11-15 | 1996-05-16 | James Noffsinger | Methode pour determiner par colorimetrie la concentration des leucocytes dans un fluide biologique |
| DE19651886A1 (de) * | 1996-12-13 | 1998-06-18 | Merck Patent Gmbh | Mittel und Verfahren zur Bestimmung von hydrolytischen Enzymen |
| US6528652B1 (en) | 1999-01-21 | 2003-03-04 | Chronimed | Composition and device for detecting leukocytes in urine |
| US6348324B1 (en) | 1999-01-21 | 2002-02-19 | Hypoguard America Limited | Composition and device for detecting leukocytes in urine |
| US7781396B2 (en) * | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
| US20040052928A1 (en) * | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
| US6709868B2 (en) * | 2002-05-20 | 2004-03-23 | Portascience Inc. | Method and apparatus for measuring white blood cell count |
| AU2003261834A1 (en) * | 2002-08-30 | 2004-05-04 | Bf Research Institute, Inc. | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein |
| US7491699B2 (en) | 2002-12-09 | 2009-02-17 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
| US6963007B2 (en) * | 2002-12-19 | 2005-11-08 | 3M Innovative Properties Company | Diacetylenic materials for sensing applications |
| US20040126897A1 (en) | 2002-12-19 | 2004-07-01 | 3M Innovative Properties Company | Colorimetric sensors constructed of diacetylene materials |
| EP1583713B1 (fr) * | 2003-01-07 | 2009-03-25 | Ramot at Tel Aviv University Ltd. | Nanostructures de peptides encapsulant une matiere etrangere ainsi que procede de fabrication correspondant |
| CN101415724B (zh) * | 2003-06-30 | 2015-12-02 | 特拉维夫大学未来科技开发有限公司 | 肽、抗肽抗体以及用它们来诊断和治疗淀粉样蛋白相关疾病的方法 |
| WO2005027901A1 (fr) * | 2003-09-25 | 2005-03-31 | Tel Aviv University Future Technology Development L.P. | Compositions et methodes d'utilisation de ces compositions pour le traitement des maladies associees a la substance amyloide |
| WO2005031362A2 (fr) * | 2003-10-02 | 2005-04-07 | Ramot At Tel Aviv University Ltd. | Nouveaux agents antibacteriens et procedes permettant de les identifier et de les utiliser |
| WO2006006172A2 (fr) * | 2004-07-15 | 2006-01-19 | Ramot At Tel Aviv University Ltd. | Utilisation d'agents anti-amyloides pour traiter et determiner des infections pathogenes |
| WO2006013552A2 (fr) | 2004-08-02 | 2006-02-09 | Ramot At Tel Aviv University Ltd. | Articles de nanostructures a base de peptides et leur procede de formation |
| WO2006018850A2 (fr) * | 2004-08-19 | 2006-02-23 | Tel Aviv University Future Technology Development L.P. | Compositions et leurs methodes d'utilisation dans le traitement de maladies associees aux amyloides |
| WO2006027780A2 (fr) | 2004-09-08 | 2006-03-16 | Ramot At Tel Aviv University Ltd. | Nanostructures peptidiques contenant des peptides modifies par coiffage terminal, et procedes de generation et d'utilisation de celles-ci |
| JP2008524593A (ja) * | 2004-12-17 | 2008-07-10 | スリーエム イノベイティブ プロパティズ カンパニー | ジアセチレン材料で構築された比色センサー |
| GB2426334A (en) * | 2005-05-20 | 2006-11-22 | Orion Diagnostica Oy | Application of a reagent to a matrix material |
| US8003399B2 (en) * | 2005-08-31 | 2011-08-23 | Kimberly-Clark Worldwide, Inc. | Nitrite detection technique |
| US7504235B2 (en) * | 2005-08-31 | 2009-03-17 | Kimberly-Clark Worldwide, Inc. | Enzyme detection technique |
| US10004828B2 (en) * | 2005-10-11 | 2018-06-26 | Romat at Tel-Aviv University Ltd. | Self-assembled Fmoc-ff hydrogels |
| US7879212B2 (en) * | 2005-11-03 | 2011-02-01 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructure-coated electrodes |
| WO2009067595A1 (fr) * | 2007-11-20 | 2009-05-28 | 3M Innovative Properties Company | Procédé d'analyse d'un échantillon concernant une bactérie à l'aide d'un détecteur à polymère contenant du diacétylène |
| US9103796B2 (en) | 2007-12-14 | 2015-08-11 | Kimberly-Clark Worldwide, Inc. | Multi-layered devices for analyte detection |
| US11104933B1 (en) | 2016-03-22 | 2021-08-31 | Cleu Diagnostics, Llc | Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay |
| SG11201808598UA (en) * | 2016-03-30 | 2018-10-30 | Qualizyme Diagnostics Gmbh & Co Kg | Detecting microbial infection in wounds |
| JP6902416B2 (ja) * | 2016-07-05 | 2021-07-14 | ライオン株式会社 | 睡眠評価用マーカー及びその用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3087794A (en) * | 1960-05-23 | 1963-04-30 | Miles Lab | Chemical test for differentiating leucocytes from erythrocytes |
| NL126365C (fr) * | 1963-06-24 | |||
| US3378463A (en) * | 1965-06-22 | 1968-04-16 | Army Usa | Method of measuring enzyme activity |
| GB1128371A (en) * | 1965-10-04 | 1968-09-25 | Miles Lab | Diagnostic composition |
| CH506792A (de) * | 1968-09-20 | 1971-04-30 | Merck Ag E | Neues Mittel und Verfahren zur Lipasebestimmung |
| US3715325A (en) * | 1970-10-02 | 1973-02-06 | Miles Lab | Insoluble polymeric diazonium salt chromogen |
| CA1007555A (en) * | 1971-08-16 | 1977-03-29 | Robert E. Smith | Carbobenzoxydiglycyl-1-arginyl-4-methoxy-2-naphthylamide and process for determining enzyme concentrations |
| DE2235152C2 (de) * | 1972-07-18 | 1975-07-10 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nachweis von Blut und anderen peroxidatisch wirksamen Substanzen in Körperflüssigkeiten |
| AR204182A1 (es) * | 1973-12-20 | 1975-11-28 | Boehringer Mannheim Gmbh | Tira de ensayo para la comprobacion de substancias de actividad peroxidica en los liquidos del cuerpo |
| JPS5342438B2 (fr) * | 1974-05-20 | 1978-11-11 | ||
| US3874852A (en) * | 1974-07-05 | 1975-04-01 | Coulter Diagnostics Inc | Reagent and method for determining leukocytes and hemoglobin in the blood |
| CS176664B1 (fr) * | 1975-02-14 | 1977-06-30 | ||
| US4045290A (en) * | 1975-02-28 | 1977-08-30 | Princeton Biomedix Incorporated | Diagnostic method and compounds for use therewith |
| JPS6010261B2 (ja) * | 1975-07-31 | 1985-03-15 | 和光純薬工業株式会社 | 潜血検出用組成物 |
| JPS5263794A (en) * | 1975-11-21 | 1977-05-26 | Shionogi Seiyaku Kk | Test piece for latent blood |
| US4206280A (en) * | 1975-12-24 | 1980-06-03 | Hoffmann-La Roche Inc. | Determination of acid phosphatase |
| GB1530238A (en) * | 1976-05-04 | 1978-10-25 | Du Pont | Method of determining lipase activity using a triglyceride reagent and method for preparing that reagent |
| JPS584560B2 (ja) * | 1976-06-01 | 1983-01-26 | 三共株式会社 | 鉄錯塩を用いた酵素活性測定法 |
| JPS5389492A (en) * | 1977-01-13 | 1978-08-07 | Uni Arabama | Method and reagent for determination of carxylic esterhydrolase |
| JPS6058746B2 (ja) * | 1977-09-22 | 1985-12-21 | 中外製薬株式会社 | 高級脂肪酸エステル |
| US4184923A (en) * | 1977-11-03 | 1980-01-22 | Eastman Kodak Company | Reduction of gentisic acid interference in analytical elements |
| US4212939A (en) * | 1977-11-22 | 1980-07-15 | The University Of Alabama | Substrate solution for carboxylic ester hydrolase determination |
| DE2826965A1 (de) * | 1978-06-20 | 1980-01-17 | Boehringer Mannheim Gmbh | Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten und dafuer geeignete chromogene |
| US4251223A (en) * | 1979-12-17 | 1981-02-17 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
| US4251222A (en) * | 1979-12-17 | 1981-02-17 | Miles Laboratories, Inc. | Sensitizers for peroxidative activity tests |
-
1979
- 1979-02-14 DE DE19792905531 patent/DE2905531A1/de not_active Withdrawn
-
1980
- 1980-01-21 US US06/114,143 patent/US4299917A/en not_active Expired - Lifetime
- 1980-01-29 CA CA000344562A patent/CA1148073A/fr not_active Expired
- 1980-02-08 ES ES488402A patent/ES488402A0/es active Granted
- 1980-02-08 PL PL1980221884A patent/PL125796B1/pl unknown
- 1980-02-08 AR AR279906A patent/AR223025A1/es active
- 1980-02-08 AU AU55359/80A patent/AU519912B2/en not_active Expired
- 1980-02-11 ZA ZA00800765A patent/ZA80765B/xx unknown
- 1980-02-11 PT PT70813A patent/PT70813A/pt unknown
- 1980-02-11 EP EP80100671A patent/EP0014929B1/fr not_active Expired
- 1980-02-11 AT AT80100671T patent/ATE543T1/de not_active IP Right Cessation
- 1980-02-11 DE DE8080100671T patent/DE3060134D1/de not_active Expired
- 1980-02-12 DD DD80219016A patent/DD149121A5/de not_active IP Right Cessation
- 1980-02-13 BR BR8000886A patent/BR8000886A/pt unknown
- 1980-02-13 RU SU802882254A patent/RU1784097C/ru active
- 1980-02-13 CS CS80973A patent/CS216523B2/cs unknown
- 1980-02-13 HU HU80326A patent/HU182102B/hu unknown
- 1980-02-14 DK DK063480A patent/DK161340C/da not_active IP Right Cessation
- 1980-02-14 FI FI800444A patent/FI69869C/fi not_active IP Right Cessation
- 1980-02-14 JP JP55016082A patent/JPS581920B2/ja not_active Expired
- 1980-02-14 YU YU386/80A patent/YU45527B/xx unknown
-
1984
- 1984-11-09 SG SG794/84A patent/SG79484G/en unknown
-
1985
- 1985-03-07 HK HK152/85A patent/HK15285A/xx not_active IP Right Cessation
-
1988
- 1988-11-17 YU YU02128/88A patent/YU212888A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2905531A1 (de) | 1981-01-08 |
| AU5535980A (en) | 1981-01-15 |
| AU519912B2 (en) | 1982-01-07 |
| JPS581920B2 (ja) | 1983-01-13 |
| YU38680A (en) | 1989-02-28 |
| DE3060134D1 (en) | 1982-02-25 |
| HK15285A (en) | 1985-03-15 |
| HU182102B (en) | 1983-12-28 |
| DK63480A (da) | 1980-08-15 |
| FI69869B (fi) | 1985-12-31 |
| YU212888A (en) | 1990-04-30 |
| ES8102726A1 (es) | 1981-02-16 |
| ATE543T1 (de) | 1982-01-15 |
| CA1148073A (fr) | 1983-06-14 |
| EP0014929B1 (fr) | 1982-01-06 |
| DK161340C (da) | 1991-12-02 |
| AR223025A1 (es) | 1981-07-15 |
| FI69869C (fi) | 1986-05-26 |
| YU45527B (en) | 1992-05-28 |
| EP0014929A1 (fr) | 1980-09-03 |
| BR8000886A (pt) | 1980-10-21 |
| ES488402A0 (es) | 1981-02-16 |
| RU1784097C (ru) | 1992-12-23 |
| PT70813A (de) | 1980-03-01 |
| US4299917A (en) | 1981-11-10 |
| PL221884A1 (fr) | 1980-11-03 |
| PL125796B1 (en) | 1983-06-30 |
| ZA80765B (en) | 1981-03-25 |
| FI800444A (fi) | 1980-08-15 |
| SG79484G (en) | 1985-08-16 |
| DK161340B (da) | 1991-06-24 |
| JPS55108300A (en) | 1980-08-20 |
| DD149121A5 (de) | 1981-06-24 |
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