CS214834B2 - Method of making the bis-amids of the 5-amino-2,4,6-triiodizophtale acid - Google Patents

Method of making the bis-amids of the 5-amino-2,4,6-triiodizophtale acid Download PDF

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Publication number
CS214834B2
CS214834B2 CS804924A CS492480A CS214834B2 CS 214834 B2 CS214834 B2 CS 214834B2 CS 804924 A CS804924 A CS 804924A CS 492480 A CS492480 A CS 492480A CS 214834 B2 CS214834 B2 CS 214834B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
methyl
hydrogen
bis
diamide
Prior art date
Application number
CS804924A
Other languages
Czech (cs)
English (en)
Inventor
Ulrich Speck
Erich Klieger
Wolfgang Muetzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to CS812133A priority Critical patent/CS214835B2/cs
Publication of CS214834B2 publication Critical patent/CS214834B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Dental Preparations (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
CS804924A 1979-07-12 1980-07-10 Method of making the bis-amids of the 5-amino-2,4,6-triiodizophtale acid CS214834B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS812133A CS214835B2 (cs) 1979-07-12 1981-03-24 Způsob výroby bis-amidu kyseliny 5-amino-2,4,B-trijodizoftalové

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792928417 DE2928417A1 (de) 1979-07-12 1979-07-12 Trijodierte basen

Publications (1)

Publication Number Publication Date
CS214834B2 true CS214834B2 (en) 1982-06-25

Family

ID=6075678

Family Applications (1)

Application Number Title Priority Date Filing Date
CS804924A CS214834B2 (en) 1979-07-12 1980-07-10 Method of making the bis-amids of the 5-amino-2,4,6-triiodizophtale acid

Country Status (21)

Country Link
US (1) US4283381A (da)
EP (1) EP0022744B1 (da)
JP (1) JPS5659717A (da)
AT (1) ATE2834T1 (da)
AU (1) AU536426B2 (da)
CA (1) CA1129438A (da)
CS (1) CS214834B2 (da)
DE (2) DE2928417A1 (da)
DK (1) DK154501C (da)
EG (1) EG14884A (da)
ES (2) ES493301A0 (da)
FI (1) FI68042C (da)
GR (1) GR69303B (da)
HU (1) HU182154B (da)
IE (1) IE50064B1 (da)
IL (1) IL60517A (da)
NO (1) NO150719C (da)
PH (1) PH16651A (da)
PT (1) PT71547A (da)
YU (1) YU177980A (da)
ZA (1) ZA804192B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
FR2541676A1 (fr) * 1983-02-25 1984-08-31 Guerbet Sa Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
IL96324A (en) * 1989-11-29 1995-01-24 Squibb & Sons Inc History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
WO1996009280A1 (fr) * 1994-09-22 1996-03-28 Guerbet S.A. Composes polyiodes, leur preparation et leur application en radiologie x
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT1312569B1 (it) * 1999-05-21 2002-04-22 Raffaele Ansovini Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv.
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
CN101654417B (zh) * 2009-09-01 2012-06-20 江苏省原子医学研究所 X线造影剂碘佛醇中间体的制备方法
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN115806498A (zh) * 2021-09-15 2023-03-17 大道隆达（北京）医药科技发展有限公司 5-氯乙酰胺基-2,4,6-三碘异酞酰氯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US3178473A (en) * 1962-03-02 1965-04-13 Nyegaard & Co As Process for the n-alkylation of acyl anilides halogen substituted in the nucleus
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
NO129093B (da) * 1969-06-27 1974-02-25 Nyegaard & Co As
BE795555A (fr) * 1972-02-16 1973-08-16 Schering Ag Amides de triiodo-isophtaloyl-monoamino-acide, leur procede de preparation et leur utilisation
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers

Also Published As

Publication number Publication date
ES8104791A1 (es) 1981-05-16
CA1129438A (en) 1982-08-10
DE3062428D1 (en) 1983-04-28
JPS5659717A (en) 1981-05-23
IE50064B1 (en) 1986-02-05
YU177980A (en) 1983-12-31
NO150719B (no) 1984-08-27
ES493302A0 (es) 1981-05-16
EP0022744B1 (de) 1983-03-23
DK300680A (da) 1981-01-13
IE801441L (en) 1981-01-12
EP0022744A2 (de) 1981-01-21
FI68042B (fi) 1985-03-29
DK154501B (da) 1988-11-21
IL60517A (en) 1984-06-29
ES8104792A1 (es) 1981-05-16
HU182154B (en) 1983-12-28
FI802215A (fi) 1981-01-13
US4283381A (en) 1981-08-11
GR69303B (da) 1982-05-14
ATE2834T1 (de) 1983-04-15
ES493301A0 (es) 1981-05-16
IL60517A0 (en) 1980-09-16
DK154501C (da) 1989-04-10
FI68042C (fi) 1985-07-10
PH16651A (en) 1983-12-06
AU536426B2 (en) 1984-05-10
DE2928417A1 (de) 1981-01-29
NO150719C (no) 1984-12-05
AU6029480A (en) 1981-01-15
NO802102L (no) 1981-01-13
PT71547A (en) 1980-08-01
EG14884A (en) 1985-06-30
ZA804192B (en) 1981-07-29
EP0022744A3 (en) 1981-03-11

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