ES8104791A1 - Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos - Google Patents

Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos

Info

Publication number
ES8104791A1
ES8104791A1 ES493301A ES493301A ES8104791A1 ES 8104791 A1 ES8104791 A1 ES 8104791A1 ES 493301 A ES493301 A ES 493301A ES 493301 A ES493301 A ES 493301A ES 8104791 A1 ES8104791 A1 ES 8104791A1
Authority
ES
Spain
Prior art keywords
alkyl
groups
ray contrast
iodated
tri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493301A
Other languages
English (en)
Other versions
ES493301A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES493301A0 publication Critical patent/ES493301A0/es
Publication of ES8104791A1 publication Critical patent/ES8104791A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE BIS-AMIDAS DE ACIDOS 5-AMINO-2-4,6-TRIYODO-ISOFTALICOS, DE FORMULA GENERAL (I). CONSISTENTE EN SOMETER A LA HIDRAZINOLISIS A UN COMPUESTO DE PARTIDA DE FORMULA GENERAL (II), EN CUYA FORMULA, ASI COMO E LA (I), X SIGNIFICA UN RADICAL ALCOHILENO INFERIOR; R1 SIGNIFICA UN HIDROGENO O UN RADICAL ALCOHILO INFERIOR; R2, R3, R4 Y R6 SIGNIFICAN HIDROGENO O RADICAL ALCOHILO INFERIOR EVENTUALMENTE HIDROXILADO; R5 SIGNIFICA UN RADICAL MONO-O POLI-HIDROXIALCOHILO, Y R7, SIGNIFICA UN RADICAL MONI-O POLI-HIDROXIALCOHILO Y SUS SALES CON ACIDOS DE AGENTES DE CONTRASTE. SE UTILIZAN COMO SOLUCIONES DE AGENTES DE CONTRASTE, PARA LA TOTAL REPRESENTACION POR RAYOS X DE, POR EJEMPLO, PARTES ESENCIALES DEL SISTEMA VASCULAR O DE LAS VIAS URINARIAS EFERENTES. *FORMULA* O
ES493301A 1979-07-12 1980-07-11 Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos Expired ES8104791A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792928417 DE2928417A1 (de) 1979-07-12 1979-07-12 Trijodierte basen

Publications (2)

Publication Number Publication Date
ES493301A0 ES493301A0 (es) 1981-05-16
ES8104791A1 true ES8104791A1 (es) 1981-05-16

Family

ID=6075678

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493302A Expired ES8104792A1 (es) 1979-07-12 1980-07-11 Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos
ES493301A Expired ES8104791A1 (es) 1979-07-12 1980-07-11 Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES493302A Expired ES8104792A1 (es) 1979-07-12 1980-07-11 Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos

Country Status (21)

Country Link
US (1) US4283381A (es)
EP (1) EP0022744B1 (es)
JP (1) JPS5659717A (es)
AT (1) ATE2834T1 (es)
AU (1) AU536426B2 (es)
CA (1) CA1129438A (es)
CS (1) CS214834B2 (es)
DE (2) DE2928417A1 (es)
DK (1) DK154501C (es)
EG (1) EG14884A (es)
ES (2) ES8104792A1 (es)
FI (1) FI68042C (es)
GR (1) GR69303B (es)
HU (1) HU182154B (es)
IE (1) IE50064B1 (es)
IL (1) IL60517A (es)
NO (1) NO150719C (es)
PH (1) PH16651A (es)
PT (1) PT71547A (es)
YU (1) YU177980A (es)
ZA (1) ZA804192B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
FR2541676A1 (fr) * 1983-02-25 1984-08-31 Guerbet Sa Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
GB8906130D0 (en) * 1989-03-17 1989-05-04 Nycomed As Compositions
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
CA2029830A1 (en) * 1989-11-29 1991-05-30 Ramachandran S. Ranganathan Nonionic radiographic contrast agents
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
ATE181547T1 (de) * 1994-09-22 1999-07-15 Guerbet Sa Iodo-verbindungen, ihre herstellung und verwendung als kontrastmittel für röntgen- radiologie
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT1312569B1 (it) * 1999-05-21 2002-04-22 Raffaele Ansovini Uso dell'enzima gssg reduttasi per il trattamento terapeutico e laprofilassi di pazienti infettati da hiv.
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
CN101654417B (zh) * 2009-09-01 2012-06-20 江苏省原子医学研究所 X线造影剂碘佛醇中间体的制备方法
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN115806498A (zh) * 2021-09-15 2023-03-17 大道隆达（北京）医药科技发展有限公司 5-氯乙酰胺基-2,4,6-三碘异酞酰氯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776241A (en) * 1952-08-06 1957-01-01 Schering Ag Injectable x-ray contrast agents comprising salts of n-acyl derivatives of 2, 4, 6-triiodo-3-aminobenzoic acid
US3178473A (en) * 1962-03-02 1965-04-13 Nyegaard & Co As Process for the n-alkylation of acyl anilides halogen substituted in the nucleus
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
ES381202A1 (es) * 1969-06-27 1973-04-16 Nyegaard & Co As Un procedimiento para la preparacion de agentes de contras-te de rayos x.
BE795555A (fr) * 1972-02-16 1973-08-16 Schering Ag Amides de triiodo-isophtaloyl-monoamino-acide, leur procede de preparation et leur utilisation
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers

Also Published As

Publication number Publication date
PH16651A (en) 1983-12-06
ZA804192B (en) 1981-07-29
EP0022744A3 (en) 1981-03-11
FI68042B (fi) 1985-03-29
IE50064B1 (en) 1986-02-05
NO802102L (no) 1981-01-13
ES493301A0 (es) 1981-05-16
EG14884A (en) 1985-06-30
YU177980A (en) 1983-12-31
HU182154B (en) 1983-12-28
DK300680A (da) 1981-01-13
IL60517A0 (en) 1980-09-16
AU6029480A (en) 1981-01-15
EP0022744A2 (de) 1981-01-21
NO150719B (no) 1984-08-27
PT71547A (en) 1980-08-01
ATE2834T1 (de) 1983-04-15
DK154501C (da) 1989-04-10
DK154501B (da) 1988-11-21
CA1129438A (en) 1982-08-10
ES493302A0 (es) 1981-05-16
JPS5659717A (en) 1981-05-23
CS214834B2 (en) 1982-06-25
NO150719C (no) 1984-12-05
AU536426B2 (en) 1984-05-10
US4283381A (en) 1981-08-11
FI802215A (fi) 1981-01-13
GR69303B (es) 1982-05-14
DE3062428D1 (en) 1983-04-28
ES8104792A1 (es) 1981-05-16
FI68042C (fi) 1985-07-10
DE2928417A1 (de) 1981-01-29
IE801441L (en) 1981-01-12
IL60517A (en) 1984-06-29
EP0022744B1 (de) 1983-03-23

Similar Documents

Publication Publication Date Title
ES8104792A1 (es) Procedimiento para la preparacion de bis-amidas de acidos 5-amino-2,4,6-triyodo-isoftalicos
ES460007A1 (es) Procedimiento para la preparacion de nuevas bis (3,5-dicar- bamoil-2,4,6-triyodoanilidas) de acidos dicarboxilicos.
FI884271A (fi) Dikarboksyylihappo-bis(3,5-dikarbamoyyli-2,4,6-trijodianilideja), menetelmä niiden valmistamiseksi sekä niitä sisältävät röntgenvarjoaineet
ES8102561A1 (es) Procedimiento de preparacion de los aril-1 arilsulfonil-4 a amino-propoxi-3 1h pirazoles
IL69292A0 (en) Muramyl peptides,their manufacture and pharmaceutical compositions containing them
ES476154A1 (es) Un procedimiento para la preparacion de nuevos derivados de cefalosporina
ES8503652A1 (es) Un procedimiento para la preparacion de un compuesto.
ES8200648A2 (es) Procedimiento de preparacion de compuestos opacificantes para radiografia y similares
ES8702379A1 (es) Un procedimiento para la produccion de 1h-tetrazol-5-carboxamidas-n-sustituidas.
AU8818882A (en) N-acyl-pyrimid-2-ones
ES461082A1 (es) Un procedimiento para la preparacion de compuestos polici- clicos.
ZA842505B (en) Iminosulphonamides and processes for the manufacture thereof,pharmaceutical preparations containing such compounds,and their use
DE3372963D1 (en) Novel aminonaphthacene derivatives and process for preparation thereof
TH1728EX (th) เฟนเนทธานอลลามีนชนิดใหม่

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201